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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GAB4
Full Name:
GRB2-associated-binding protein 4
Alias:
Gab4; Grb2-associated binding protein family, member 4
Type:
Uncharacterized protein
Mass (Da):
62367
Number AA:
574
UniProt ID:
Q2WGN9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
S
L
P
S
P
S
P
S
R
E
L
Site 2
S7
_
M
S
L
P
S
P
S
P
S
R
E
L
C
P
Site 3
S9
S
L
P
S
P
S
P
S
R
E
L
C
P
P
D
Site 4
S23
D
P
A
F
A
P
L
S
S
W
P
G
S
G
P
Site 5
S24
P
A
F
A
P
L
S
S
W
P
G
S
G
P
A
Site 6
S28
P
L
S
S
W
P
G
S
G
P
A
G
G
S
T
Site 7
S34
G
S
G
P
A
G
G
S
T
R
S
G
H
V
L
Site 8
T35
S
G
P
A
G
G
S
T
R
S
G
H
V
L
Y
Site 9
S37
P
A
G
G
S
T
R
S
G
H
V
L
Y
S
G
Site 10
S43
R
S
G
H
V
L
Y
S
G
W
L
R
K
S
P
Site 11
S49
Y
S
G
W
L
R
K
S
P
P
E
K
K
L
R
Site 12
T72
F
I
L
R
R
G
Q
T
S
S
D
P
D
V
L
Site 13
S73
I
L
R
R
G
Q
T
S
S
D
P
D
V
L
E
Site 14
S74
L
R
R
G
Q
T
S
S
D
P
D
V
L
E
Y
Site 15
Y81
S
D
P
D
V
L
E
Y
Y
K
N
D
G
S
K
Site 16
Y82
D
P
D
V
L
E
Y
Y
K
N
D
G
S
K
K
Site 17
S87
E
Y
Y
K
N
D
G
S
K
K
P
L
R
T
I
Site 18
T107
E
Q
L
D
V
D
V
T
L
N
F
N
K
K
E
Site 19
T125
G
Y
M
F
D
I
K
T
S
E
R
T
F
Y
L
Site 20
Y131
K
T
S
E
R
T
F
Y
L
V
A
E
T
R
E
Site 21
S158
C
G
F
R
Q
E
E
S
T
G
F
L
G
N
I
Site 22
T159
G
F
R
Q
E
E
S
T
G
F
L
G
N
I
S
Site 23
S169
L
G
N
I
S
S
A
S
H
G
L
C
S
S
P
Site 24
S174
S
A
S
H
G
L
C
S
S
P
A
E
P
S
C
Site 25
S175
A
S
H
G
L
C
S
S
P
A
E
P
S
C
S
Site 26
S180
C
S
S
P
A
E
P
S
C
S
H
Q
H
L
P
Site 27
S182
S
P
A
E
P
S
C
S
H
Q
H
L
P
Q
E
Site 28
T193
L
P
Q
E
Q
E
P
T
S
E
P
P
V
S
H
Site 29
S194
P
Q
E
Q
E
P
T
S
E
P
P
V
S
H
C
Site 30
S199
P
T
S
E
P
P
V
S
H
C
V
P
P
T
W
Site 31
S217
A
P
P
G
C
L
R
S
H
Q
H
A
S
Q
R
Site 32
S222
L
R
S
H
Q
H
A
S
Q
R
A
E
H
A
R
Site 33
S230
Q
R
A
E
H
A
R
S
A
S
F
S
Q
G
S
Site 34
S232
A
E
H
A
R
S
A
S
F
S
Q
G
S
E
A
Site 35
S234
H
A
R
S
A
S
F
S
Q
G
S
E
A
P
F
Site 36
S237
S
A
S
F
S
Q
G
S
E
A
P
F
I
M
R
Site 37
T247
P
F
I
M
R
R
N
T
A
M
Q
N
L
A
Q
Site 38
S259
L
A
Q
H
S
G
Y
S
V
D
G
V
S
G
H
Site 39
S272
G
H
I
H
G
F
H
S
L
S
K
P
S
Q
H
Site 40
S274
I
H
G
F
H
S
L
S
K
P
S
Q
H
N
A
Site 41
S286
H
N
A
E
F
R
G
S
T
H
R
I
P
W
S
Site 42
T287
N
A
E
F
R
G
S
T
H
R
I
P
W
S
L
Site 43
S293
S
T
H
R
I
P
W
S
L
A
S
H
G
H
T
Site 44
T300
S
L
A
S
H
G
H
T
R
G
S
L
T
G
S
Site 45
S303
S
H
G
H
T
R
G
S
L
T
G
S
E
A
D
Site 46
S307
T
R
G
S
L
T
G
S
E
A
D
N
E
A
S
Site 47
Y318
N
E
A
S
S
G
K
Y
T
Q
H
G
G
G
N
Site 48
T319
E
A
S
S
G
K
Y
T
Q
H
G
G
G
N
A
Site 49
S327
Q
H
G
G
G
N
A
S
R
P
A
E
S
M
H
Site 50
S350
G
R
T
L
V
G
L
S
D
S
I
A
S
E
G
Site 51
S358
D
S
I
A
S
E
G
S
C
V
P
M
N
P
G
Site 52
S379
V
K
Q
A
G
D
D
S
Q
G
V
C
I
P
V
Site 53
T401
D
L
L
G
S
P
L
T
E
L
S
M
H
Q
D
Site 54
S404
G
S
P
L
T
E
L
S
M
H
Q
D
L
S
Q
Site 55
S410
L
S
M
H
Q
D
L
S
Q
G
H
E
V
Q
L
Site 56
T433
P
N
Q
K
A
N
P
T
P
P
N
L
R
N
N
Site 57
S447
N
R
V
I
N
E
L
S
F
K
P
P
V
T
E
Site 58
T453
L
S
F
K
P
P
V
T
E
P
W
S
G
T
S
Site 59
S457
P
P
V
T
E
P
W
S
G
T
S
H
T
F
D
Site 60
S460
T
E
P
W
S
G
T
S
H
T
F
D
S
S
S
Site 61
T462
P
W
S
G
T
S
H
T
F
D
S
S
S
S
Q
Site 62
S465
G
T
S
H
T
F
D
S
S
S
S
Q
H
P
I
Site 63
S466
T
S
H
T
F
D
S
S
S
S
Q
H
P
I
S
Site 64
S467
S
H
T
F
D
S
S
S
S
Q
H
P
I
S
T
Site 65
S468
H
T
F
D
S
S
S
S
Q
H
P
I
S
T
Q
Site 66
S473
S
S
S
Q
H
P
I
S
T
Q
S
I
T
N
T
Site 67
T474
S
S
Q
H
P
I
S
T
Q
S
I
T
N
T
D
Site 68
S476
Q
H
P
I
S
T
Q
S
I
T
N
T
D
S
E
Site 69
T478
P
I
S
T
Q
S
I
T
N
T
D
S
E
D
S
Site 70
T480
S
T
Q
S
I
T
N
T
D
S
E
D
S
G
E
Site 71
S482
Q
S
I
T
N
T
D
S
E
D
S
G
E
R
Y
Site 72
S485
T
N
T
D
S
E
D
S
G
E
R
Y
L
F
P
Site 73
Y489
S
E
D
S
G
E
R
Y
L
F
P
N
P
A
S
Site 74
S501
P
A
S
A
F
P
V
S
G
G
T
S
S
S
A
Site 75
S505
F
P
V
S
G
G
T
S
S
S
A
P
P
R
S
Site 76
S506
P
V
S
G
G
T
S
S
S
A
P
P
R
S
T
Site 77
S507
V
S
G
G
T
S
S
S
A
P
P
R
S
T
G
Site 78
S512
S
S
S
A
P
P
R
S
T
G
N
I
H
Y
A
Site 79
T513
S
S
A
P
P
R
S
T
G
N
I
H
Y
A
A
Site 80
Y518
R
S
T
G
N
I
H
Y
A
A
L
D
F
Q
P
Site 81
S526
A
A
L
D
F
Q
P
S
K
P
S
I
G
S
V
Site 82
S529
D
F
Q
P
S
K
P
S
I
G
S
V
T
S
G
Site 83
S532
P
S
K
P
S
I
G
S
V
T
S
G
K
K
V
Site 84
S535
P
S
I
G
S
V
T
S
G
K
K
V
D
Y
V
Site 85
Y541
T
S
G
K
K
V
D
Y
V
Q
V
D
L
E
K
Site 86
S565
E
Q
M
C
L
R
Q
S
S
E
P
P
R
G
A
Site 87
S566
Q
M
C
L
R
Q
S
S
E
P
P
R
G
A
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation