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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRTG
Full Name:
Protogenin
Alias:
Flj25756; protogenin homolog (gallus gallus); prtg; shen-dan
Type:
Mass (Da):
127076
Number AA:
1150
UniProt ID:
Q2VWP7
International Prot ID:
IPI00658004
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S40
V
W
C
F
S
E
L
S
F
V
K
E
P
Q
D
Site 2
T49
V
K
E
P
Q
D
V
T
V
T
R
K
D
P
V
Site 3
S80
L
K
N
G
A
K
M
S
E
N
K
R
I
E
V
Site 4
S89
N
K
R
I
E
V
L
S
N
G
S
L
Y
I
S
Site 5
Y94
V
L
S
N
G
S
L
Y
I
S
E
V
E
G
R
Site 6
S96
S
N
G
S
L
Y
I
S
E
V
E
G
R
R
G
Site 7
S106
E
G
R
R
G
E
Q
S
D
E
G
F
Y
Q
C
Site 8
Y111
E
Q
S
D
E
G
F
Y
Q
C
L
A
M
N
K
Site 9
Y119
Q
C
L
A
M
N
K
Y
G
A
I
L
S
Q
K
Site 10
S124
N
K
Y
G
A
I
L
S
Q
K
A
H
L
A
L
Site 11
S143
A
F
E
V
Q
P
I
S
T
E
V
H
E
G
G
Site 12
T178
N
R
T
T
L
P
M
T
M
D
R
I
T
A
L
Site 13
Y193
P
T
G
V
L
Q
I
Y
D
V
S
Q
R
D
S
Site 14
S196
V
L
Q
I
Y
D
V
S
Q
R
D
S
G
N
Y
Site 15
S200
Y
D
V
S
Q
R
D
S
G
N
Y
R
C
I
A
Site 16
Y203
S
Q
R
D
S
G
N
Y
R
C
I
A
A
T
V
Site 17
T209
N
Y
R
C
I
A
A
T
V
A
H
R
R
K
S
Site 18
S216
T
V
A
H
R
R
K
S
M
E
A
S
L
T
V
Site 19
S220
R
R
K
S
M
E
A
S
L
T
V
I
P
A
K
Site 20
T222
K
S
M
E
A
S
L
T
V
I
P
A
K
E
S
Site 21
S231
I
P
A
K
E
S
K
S
F
H
T
P
T
I
I
Site 22
T234
K
E
S
K
S
F
H
T
P
T
I
I
A
G
P
Site 23
T236
S
K
S
F
H
T
P
T
I
I
A
G
P
Q
N
Site 24
S267
G
N
P
K
P
I
I
S
W
S
R
L
D
H
K
Site 25
S269
P
K
P
I
I
S
W
S
R
L
D
H
K
S
I
Site 26
S275
W
S
R
L
D
H
K
S
I
D
V
F
N
T
R
Site 27
S292
G
N
G
N
L
M
I
S
D
V
R
L
Q
H
A
Site 28
Y302
R
L
Q
H
A
G
V
Y
V
C
R
A
T
T
P
Site 29
T307
G
V
Y
V
C
R
A
T
T
P
G
T
R
N
F
Site 30
T308
V
Y
V
C
R
A
T
T
P
G
T
R
N
F
T
Site 31
S335
S
F
V
E
W
P
E
S
L
T
R
P
R
A
G
Site 32
T343
L
T
R
P
R
A
G
T
A
R
F
V
C
Q
A
Site 33
S355
C
Q
A
E
G
I
P
S
P
K
M
S
W
L
K
Site 34
S359
G
I
P
S
P
K
M
S
W
L
K
N
G
R
K
Site 35
Y376
S
N
G
R
I
K
M
Y
N
S
K
L
V
I
N
Site 36
Y393
I
P
E
D
D
A
I
Y
Q
C
M
A
E
N
S
Site 37
S400
Y
Q
C
M
A
E
N
S
Q
G
S
I
L
S
R
Site 38
S406
N
S
Q
G
S
I
L
S
R
A
R
L
T
V
V
Site 39
T411
I
L
S
R
A
R
L
T
V
V
M
S
E
D
R
Site 40
S415
A
R
L
T
V
V
M
S
E
D
R
P
S
A
P
Site 41
S420
V
M
S
E
D
R
P
S
A
P
Y
N
V
H
A
Site 42
Y423
E
D
R
P
S
A
P
Y
N
V
H
A
E
T
M
Site 43
T429
P
Y
N
V
H
A
E
T
M
S
S
S
A
I
L
Site 44
Y444
L
A
W
E
R
P
L
Y
N
S
D
K
V
I
A
Site 45
S446
W
E
R
P
L
Y
N
S
D
K
V
I
A
Y
S
Site 46
S453
S
D
K
V
I
A
Y
S
V
H
Y
M
K
A
E
Site 47
Y467
E
G
L
N
N
E
E
Y
Q
V
V
I
G
N
D
Site 48
Y478
I
G
N
D
T
T
H
Y
I
I
D
D
L
E
P
Site 49
T509
S
Q
M
S
D
H
V
T
Q
N
T
L
E
D
V
Site 50
T512
S
D
H
V
T
Q
N
T
L
E
D
V
P
L
R
Site 51
S524
P
L
R
P
P
E
I
S
L
T
S
R
S
P
T
Site 52
T526
R
P
P
E
I
S
L
T
S
R
S
P
T
D
I
Site 53
S527
P
P
E
I
S
L
T
S
R
S
P
T
D
I
L
Site 54
S529
E
I
S
L
T
S
R
S
P
T
D
I
L
I
S
Site 55
Y544
W
L
P
I
P
A
K
Y
R
R
G
Q
V
V
L
Site 56
Y552
R
R
G
Q
V
V
L
Y
R
L
S
F
R
L
S
Site 57
S555
Q
V
V
L
Y
R
L
S
F
R
L
S
T
E
N
Site 58
S559
Y
R
L
S
F
R
L
S
T
E
N
S
I
Q
V
Site 59
T560
R
L
S
F
R
L
S
T
E
N
S
I
Q
V
L
Site 60
S563
F
R
L
S
T
E
N
S
I
Q
V
L
E
L
P
Site 61
T572
Q
V
L
E
L
P
G
T
T
H
E
Y
L
L
E
Site 62
Y576
L
P
G
T
T
H
E
Y
L
L
E
G
L
K
P
Site 63
T592
S
V
Y
L
V
R
I
T
A
A
T
R
V
G
L
Site 64
S602
T
R
V
G
L
G
E
S
S
V
W
T
S
H
R
Site 65
S603
R
V
G
L
G
E
S
S
V
W
T
S
H
R
T
Site 66
T606
L
G
E
S
S
V
W
T
S
H
R
T
P
K
A
Site 67
S607
G
E
S
S
V
W
T
S
H
R
T
P
K
A
T
Site 68
T610
S
V
W
T
S
H
R
T
P
K
A
T
S
V
K
Site 69
T614
S
H
R
T
P
K
A
T
S
V
K
A
P
K
S
Site 70
S621
T
S
V
K
A
P
K
S
P
E
L
H
L
E
P
Site 71
Y654
A
I
Q
G
Y
K
L
Y
Y
K
E
E
G
Q
Q
Site 72
Y675
L
D
T
K
D
L
L
Y
T
L
S
G
L
D
P
Site 73
T676
D
T
K
D
L
L
Y
T
L
S
G
L
D
P
R
Site 74
S678
K
D
L
L
Y
T
L
S
G
L
D
P
R
R
K
Site 75
Y686
G
L
D
P
R
R
K
Y
H
V
R
L
L
A
Y
Site 76
Y700
Y
N
N
I
D
D
G
Y
Q
A
D
Q
T
V
S
Site 77
T705
D
G
Y
Q
A
D
Q
T
V
S
T
P
G
C
V
Site 78
S707
Y
Q
A
D
Q
T
V
S
T
P
G
C
V
S
V
Site 79
T708
Q
A
D
Q
T
V
S
T
P
G
C
V
S
V
R
Site 80
Y729
P
P
P
P
H
H
L
Y
A
K
A
N
T
S
S
Site 81
S735
L
Y
A
K
A
N
T
S
S
S
I
F
L
H
W
Site 82
S737
A
K
A
N
T
S
S
S
I
F
L
H
W
R
R
Site 83
Y772
Q
N
A
S
L
V
L
Y
L
Q
T
S
E
T
H
Site 84
Y791
G
L
E
P
N
T
K
Y
E
F
A
V
R
L
H
Site 85
S803
R
L
H
V
D
Q
L
S
S
P
W
S
P
V
V
Site 86
S804
L
H
V
D
Q
L
S
S
P
W
S
P
V
V
Y
Site 87
S807
D
Q
L
S
S
P
W
S
P
V
V
Y
H
S
T
Site 88
Y811
S
P
W
S
P
V
V
Y
H
S
T
L
P
E
A
Site 89
S813
W
S
P
V
V
Y
H
S
T
L
P
E
A
P
A
Site 90
T814
S
P
V
V
Y
H
S
T
L
P
E
A
P
A
G
Site 91
S839
E
D
D
T
A
L
V
S
W
K
P
P
D
G
P
Site 92
T848
K
P
P
D
G
P
E
T
V
V
T
R
Y
T
I
Site 93
T851
D
G
P
E
T
V
V
T
R
Y
T
I
L
Y
A
Site 94
T854
E
T
V
V
T
R
Y
T
I
L
Y
A
S
R
K
Site 95
S898
Y
I
V
K
I
S
A
S
N
E
V
G
E
G
P
Site 96
S920
A
V
L
P
K
E
T
S
E
S
N
Q
R
P
K
Site 97
S922
L
P
K
E
T
S
E
S
N
Q
R
P
K
R
L
Site 98
S931
Q
R
P
K
R
L
D
S
A
D
A
K
V
Y
S
Site 99
S938
S
A
D
A
K
V
Y
S
G
Y
Y
H
L
D
Q
Site 100
S978
Y
R
S
K
A
R
K
S
S
A
S
K
T
A
Q
Site 101
S979
R
S
K
A
R
K
S
S
A
S
K
T
A
Q
N
Site 102
S981
K
A
R
K
S
S
A
S
K
T
A
Q
N
G
T
Site 103
T983
R
K
S
S
A
S
K
T
A
Q
N
G
T
Q
Q
Site 104
T994
G
T
Q
Q
L
P
R
T
S
A
S
L
A
S
G
Site 105
S995
T
Q
Q
L
P
R
T
S
A
S
L
A
S
G
N
Site 106
S997
Q
L
P
R
T
S
A
S
L
A
S
G
N
E
V
Site 107
T1072
E
Q
P
Q
R
R
F
T
P
A
V
C
F
Y
Q
Site 108
S1087
P
G
T
T
V
L
I
S
D
E
D
S
P
S
S
Site 109
S1091
V
L
I
S
D
E
D
S
P
S
S
P
G
Q
T
Site 110
S1093
I
S
D
E
D
S
P
S
S
P
G
Q
T
T
S
Site 111
S1094
S
D
E
D
S
P
S
S
P
G
Q
T
T
S
F
Site 112
T1098
S
P
S
S
P
G
Q
T
T
S
F
S
R
P
F
Site 113
T1099
P
S
S
P
G
Q
T
T
S
F
S
R
P
F
G
Site 114
S1100
S
S
P
G
Q
T
T
S
F
S
R
P
F
G
V
Site 115
S1102
P
G
Q
T
T
S
F
S
R
P
F
G
V
A
A
Site 116
T1111
P
F
G
V
A
A
D
T
E
H
S
A
N
S
E
Site 117
S1114
V
A
A
D
T
E
H
S
A
N
S
E
G
S
H
Site 118
S1126
G
S
H
E
T
G
D
S
G
R
F
S
H
E
S
Site 119
S1130
T
G
D
S
G
R
F
S
H
E
S
N
D
E
I
Site 120
S1133
S
G
R
F
S
H
E
S
N
D
E
I
H
L
S
Site 121
S1140
S
N
D
E
I
H
L
S
S
V
I
S
T
T
P
Site 122
S1141
N
D
E
I
H
L
S
S
V
I
S
T
T
P
P
Site 123
T1145
H
L
S
S
V
I
S
T
T
P
P
N
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation