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Updated November 2019
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Protein Info
Short Name:
RALGAPA2
Full Name:
Ral GTPase-activating protein subunit alpha-2
Alias:
Akt substrate AS250; AS250; C20orf74; dJ1049G11.4; FLJ12819; KIAA1272; Ral GTPase activating protein, alpha subunit 2 (catalytic); RapGAPalpha2
Type:
GTPase activating protein, misc.
Mass (Da):
210770
Number AA:
1873
UniProt ID:
Q2PPJ7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005096
PhosphoSite+
KinaseNET
Biological Process:
GO:0051056
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
F
S
R
R
S
H
G
D
V
K
K
S
Site 2
S13
S
H
G
D
V
K
K
S
T
Q
K
V
L
D
P
Site 3
T26
D
P
K
K
D
V
L
T
R
L
K
H
L
R
A
Site 4
Y51
K
Q
F
F
E
T
N
Y
S
Q
I
Y
F
I
F
Site 5
Y55
E
T
N
Y
S
Q
I
Y
F
I
F
Y
E
N
F
Site 6
S77
K
L
K
G
N
N
K
S
Q
R
E
E
L
D
S
Site 7
S84
S
Q
R
E
E
L
D
S
I
L
F
L
F
E
K
Site 8
Y106
R
I
F
F
R
W
H
Y
Q
S
I
G
S
T
L
Site 9
T112
H
Y
Q
S
I
G
S
T
L
K
K
L
L
H
T
Site 10
T170
M
S
S
R
G
P
C
T
L
E
T
L
I
N
P
Site 11
T173
R
G
P
C
T
L
E
T
L
I
N
P
S
P
S
Site 12
S199
T
P
L
L
P
A
I
S
G
E
K
I
A
E
D
Site 13
T236
K
N
K
E
N
Q
D
T
G
F
K
F
L
F
T
Site 14
Y249
F
T
L
F
R
K
Y
Y
L
P
H
L
F
P
S
Site 15
Y279
H
L
R
P
K
P
V
Y
I
T
T
T
R
D
N
Site 16
Y290
T
R
D
N
E
N
I
Y
S
T
K
I
P
Y
M
Site 17
Y296
I
Y
S
T
K
I
P
Y
M
A
A
R
V
V
F
Site 18
Y316
T
F
F
L
E
K
K
Y
L
T
A
T
Q
N
T
Site 19
T355
E
L
D
G
G
G
P
T
E
Q
D
K
S
H
S
Site 20
S360
G
P
T
E
Q
D
K
S
H
S
N
S
S
T
L
Site 21
S362
T
E
Q
D
K
S
H
S
N
S
S
T
L
S
D
Site 22
S364
Q
D
K
S
H
S
N
S
S
T
L
S
D
R
R
Site 23
T366
K
S
H
S
N
S
S
T
L
S
D
R
R
L
S
Site 24
S368
H
S
N
S
S
T
L
S
D
R
R
L
S
N
S
Site 25
S373
T
L
S
D
R
R
L
S
N
S
S
L
C
S
I
Site 26
S375
S
D
R
R
L
S
N
S
S
L
C
S
I
E
E
Site 27
S376
D
R
R
L
S
N
S
S
L
C
S
I
E
E
E
Site 28
S379
L
S
N
S
S
L
C
S
I
E
E
E
H
R
M
Site 29
Y388
E
E
E
H
R
M
V
Y
E
M
V
Q
R
I
L
Site 30
S461
D
A
E
K
L
G
F
S
E
T
D
S
K
E
A
Site 31
T463
E
K
L
G
F
S
E
T
D
S
K
E
A
S
S
Site 32
S465
L
G
F
S
E
T
D
S
K
E
A
S
S
E
S
Site 33
S469
E
T
D
S
K
E
A
S
S
E
S
S
G
H
K
Site 34
S470
T
D
S
K
E
A
S
S
E
S
S
G
H
K
R
Site 35
S472
S
K
E
A
S
S
E
S
S
G
H
K
R
S
S
Site 36
S473
K
E
A
S
S
E
S
S
G
H
K
R
S
S
S
Site 37
S478
E
S
S
G
H
K
R
S
S
S
W
G
R
T
Y
Site 38
S479
S
S
G
H
K
R
S
S
S
W
G
R
T
Y
S
Site 39
S480
S
G
H
K
R
S
S
S
W
G
R
T
Y
S
F
Site 40
T484
R
S
S
S
W
G
R
T
Y
S
F
T
S
A
M
Site 41
Y485
S
S
S
W
G
R
T
Y
S
F
T
S
A
M
S
Site 42
S486
S
S
W
G
R
T
Y
S
F
T
S
A
M
S
R
Site 43
T488
W
G
R
T
Y
S
F
T
S
A
M
S
R
G
C
Site 44
S489
G
R
T
Y
S
F
T
S
A
M
S
R
G
C
V
Site 45
S492
Y
S
F
T
S
A
M
S
R
G
C
V
T
E
E
Site 46
T502
C
V
T
E
E
E
N
T
N
V
K
A
G
V
Q
Site 47
T690
L
D
P
Q
K
G
T
T
V
G
R
S
F
S
L
Site 48
S694
K
G
T
T
V
G
R
S
F
S
L
S
W
R
S
Site 49
S696
T
T
V
G
R
S
F
S
L
S
W
R
S
H
P
Site 50
S698
V
G
R
S
F
S
L
S
W
R
S
H
P
D
V
Site 51
S701
S
F
S
L
S
W
R
S
H
P
D
V
T
E
P
Site 52
S713
T
E
P
M
R
F
R
S
A
T
T
S
G
A
P
Site 53
T715
P
M
R
F
R
S
A
T
T
S
G
A
P
G
V
Site 54
T716
M
R
F
R
S
A
T
T
S
G
A
P
G
V
E
Site 55
S717
R
F
R
S
A
T
T
S
G
A
P
G
V
E
K
Site 56
S742
E
V
E
E
C
Q
Q
S
E
N
A
P
A
A
G
Site 57
T754
A
A
G
S
G
H
L
T
V
G
Q
Q
Q
Q
V
Site 58
S764
Q
Q
Q
Q
V
L
R
S
S
S
T
S
D
I
P
Site 59
S765
Q
Q
Q
V
L
R
S
S
S
T
S
D
I
P
E
Site 60
S766
Q
Q
V
L
R
S
S
S
T
S
D
I
P
E
P
Site 61
T767
Q
V
L
R
S
S
S
T
S
D
I
P
E
P
L
Site 62
S768
V
L
R
S
S
S
T
S
D
I
P
E
P
L
C
Site 63
S776
D
I
P
E
P
L
C
S
D
S
S
Q
G
Q
K
Site 64
S778
P
E
P
L
C
S
D
S
S
Q
G
Q
K
A
E
Site 65
S779
E
P
L
C
S
D
S
S
Q
G
Q
K
A
E
N
Site 66
T787
Q
G
Q
K
A
E
N
T
Q
N
S
S
S
S
E
Site 67
S790
K
A
E
N
T
Q
N
S
S
S
S
E
P
Q
P
Site 68
S792
E
N
T
Q
N
S
S
S
S
E
P
Q
P
I
Q
Site 69
T813
K
R
E
H
E
G
I
T
I
L
V
R
R
S
S
Site 70
S819
I
T
I
L
V
R
R
S
S
S
P
A
E
L
D
Site 71
S820
T
I
L
V
R
R
S
S
S
P
A
E
L
D
L
Site 72
S821
I
L
V
R
R
S
S
S
P
A
E
L
D
L
K
Site 73
S844
K
C
R
E
R
Q
K
S
E
S
T
N
S
D
T
Site 74
S846
R
E
R
Q
K
S
E
S
T
N
S
D
T
T
L
Site 75
T847
E
R
Q
K
S
E
S
T
N
S
D
T
T
L
G
Site 76
S849
Q
K
S
E
S
T
N
S
D
T
T
L
G
C
T
Site 77
T851
S
E
S
T
N
S
D
T
T
L
G
C
T
N
E
Site 78
T852
E
S
T
N
S
D
T
T
L
G
C
T
N
E
A
Site 79
T877
E
E
D
P
E
L
N
T
P
T
D
V
V
A
D
Site 80
S894
A
R
H
W
L
Q
L
S
P
T
D
A
S
N
L
Site 81
T896
H
W
L
Q
L
S
P
T
D
A
S
N
L
T
D
Site 82
S899
Q
L
S
P
T
D
A
S
N
L
T
D
S
S
E
Site 83
T902
P
T
D
A
S
N
L
T
D
S
S
E
C
L
T
Site 84
S904
D
A
S
N
L
T
D
S
S
E
C
L
T
D
D
Site 85
S905
A
S
N
L
T
D
S
S
E
C
L
T
D
D
C
Site 86
T909
T
D
S
S
E
C
L
T
D
D
C
S
I
I
A
Site 87
S927
L
T
G
W
H
P
D
S
A
A
V
L
W
R
R
Site 88
S947
G
D
V
N
N
I
Q
S
P
K
I
H
A
R
V
Site 89
S975
I
R
D
N
L
A
I
S
L
D
N
Q
S
S
P
Site 90
S980
A
I
S
L
D
N
Q
S
S
P
S
P
P
V
L
Site 91
S981
I
S
L
D
N
Q
S
S
P
S
P
P
V
L
I
Site 92
S983
L
D
N
Q
S
S
P
S
P
P
V
L
I
P
P
Site 93
T1003
S
W
L
F
K
A
A
T
L
P
N
E
Y
K
E
Site 94
S1033
R
Q
D
V
L
P
N
S
D
F
L
V
H
F
Y
Site 95
S1123
Q
E
I
P
L
L
Q
S
V
P
E
V
N
E
A
Site 96
T1150
N
I
L
L
K
N
A
T
E
E
P
N
E
Y
A
Site 97
Y1156
A
T
E
E
P
N
E
Y
A
R
C
I
A
V
C
Site 98
T1223
E
K
L
Q
M
F
E
T
S
L
P
R
K
M
A
Site 99
S1224
K
L
Q
M
F
E
T
S
L
P
R
K
M
A
E
Site 100
S1247
L
L
P
S
A
E
Y
S
S
V
E
T
D
K
K
Site 101
T1251
A
E
Y
S
S
V
E
T
D
K
K
F
I
V
S
Site 102
S1289
A
V
L
E
E
Q
H
S
A
R
A
P
L
L
D
Site 103
T1313
V
C
G
S
S
T
Y
T
Q
Q
S
H
Y
I
L
Site 104
T1321
Q
Q
S
H
Y
I
L
T
L
A
D
L
S
S
T
Site 105
Y1330
A
D
L
S
S
T
D
Y
D
P
F
L
P
L
A
Site 106
S1341
L
P
L
A
N
V
K
S
S
E
P
V
Q
Y
H
Site 107
S1342
P
L
A
N
V
K
S
S
E
P
V
Q
Y
H
S
Site 108
Y1347
K
S
S
E
P
V
Q
Y
H
S
S
A
E
L
G
Site 109
S1349
S
E
P
V
Q
Y
H
S
S
A
E
L
G
N
L
Site 110
T1358
A
E
L
G
N
L
L
T
V
E
E
E
K
K
R
Site 111
S1367
E
E
E
K
K
R
R
S
L
E
L
I
P
L
T
Site 112
Y1389
L
V
N
H
L
G
H
Y
P
L
S
G
G
P
A
Site 113
S1400
G
G
P
A
I
L
H
S
L
V
S
E
N
H
D
Site 114
S1403
A
I
L
H
S
L
V
S
E
N
H
D
N
A
H
Site 115
S1417
H
V
E
G
S
E
L
S
F
E
V
F
R
S
P
Site 116
S1438
F
N
D
S
T
L
I
S
Y
L
Q
T
P
T
E
Site 117
T1442
T
L
I
S
Y
L
Q
T
P
T
E
G
P
V
G
Site 118
T1444
I
S
Y
L
Q
T
P
T
E
G
P
V
G
G
S
Site 119
S1451
T
E
G
P
V
G
G
S
P
V
G
S
L
S
D
Site 120
S1467
R
V
I
V
R
D
I
S
G
K
Y
S
W
D
G
Site 121
S1471
R
D
I
S
G
K
Y
S
W
D
G
K
V
L
Y
Site 122
S1493
A
P
N
G
R
N
P
S
F
L
I
S
S
W
H
Site 123
S1497
R
N
P
S
F
L
I
S
S
W
H
R
D
T
F
Site 124
S1498
N
P
S
F
L
I
S
S
W
H
R
D
T
F
G
Site 125
T1503
I
S
S
W
H
R
D
T
F
G
P
Q
K
D
S
Site 126
S1510
T
F
G
P
Q
K
D
S
S
Q
V
E
E
G
D
Site 127
S1511
F
G
P
Q
K
D
S
S
Q
V
E
E
G
D
D
Site 128
S1531
L
E
N
I
G
H
T
S
P
E
C
L
L
P
S
Site 129
S1538
S
P
E
C
L
L
P
S
Q
L
N
L
N
E
P
Site 130
S1546
Q
L
N
L
N
E
P
S
L
T
P
C
G
M
N
Site 131
T1548
N
L
N
E
P
S
L
T
P
C
G
M
N
Y
D
Site 132
Y1554
L
T
P
C
G
M
N
Y
D
Q
E
K
E
I
I
Site 133
Y1574
Q
N
A
Q
E
D
E
Y
I
Q
S
H
N
F
D
Site 134
S1582
I
Q
S
H
N
F
D
S
A
M
K
V
T
S
Q
Site 135
S1588
D
S
A
M
K
V
T
S
Q
G
Q
P
S
P
V
Site 136
S1593
V
T
S
Q
G
Q
P
S
P
V
E
P
R
G
P
Site 137
S1640
R
E
L
K
N
L
D
S
R
Q
C
R
E
T
H
Site 138
T1646
D
S
R
Q
C
R
E
T
H
K
I
A
V
F
Y
Site 139
S1663
E
G
Q
E
D
K
C
S
I
L
S
N
E
R
G
Site 140
S1666
E
D
K
C
S
I
L
S
N
E
R
G
S
Q
A
Site 141
S1671
I
L
S
N
E
R
G
S
Q
A
Y
E
D
F
V
Site 142
Y1674
N
E
R
G
S
Q
A
Y
E
D
F
V
A
G
L
Site 143
S1702
G
G
L
Q
R
N
G
S
T
G
Q
T
A
P
Y
Site 144
T1706
R
N
G
S
T
G
Q
T
A
P
Y
Y
A
T
S
Site 145
Y1709
S
T
G
Q
T
A
P
Y
Y
A
T
S
T
V
E
Site 146
Y1710
T
G
Q
T
A
P
Y
Y
A
T
S
T
V
E
V
Site 147
S1722
V
E
V
I
F
H
V
S
T
R
M
P
S
D
S
Site 148
T1723
E
V
I
F
H
V
S
T
R
M
P
S
D
S
D
Site 149
S1727
H
V
S
T
R
M
P
S
D
S
D
D
S
L
T
Site 150
S1729
S
T
R
M
P
S
D
S
D
D
S
L
T
K
K
Site 151
S1732
M
P
S
D
S
D
D
S
L
T
K
K
L
R
H
Site 152
T1734
S
D
S
D
D
S
L
T
K
K
L
R
H
L
G
Site 153
Y1756
W
S
E
H
S
R
D
Y
R
R
G
I
I
P
T
Site 154
Y1829
V
K
C
L
I
P
L
Y
Q
S
F
Y
E
E
R
Site 155
Y1833
I
P
L
Y
Q
S
F
Y
E
E
R
A
L
Y
L
Site 156
Y1839
F
Y
E
E
R
A
L
Y
L
E
A
I
I
Q
N
Site 157
T1852
Q
N
H
R
E
V
M
T
F
E
D
F
A
A
Q
Site 158
S1862
D
F
A
A
Q
V
F
S
P
S
P
S
Y
S
L
Site 159
S1864
A
A
Q
V
F
S
P
S
P
S
Y
S
L
S
G
Site 160
S1866
Q
V
F
S
P
S
P
S
Y
S
L
S
G
T
D
Site 161
Y1867
V
F
S
P
S
P
S
Y
S
L
S
G
T
D
_
Site 162
S1868
F
S
P
S
P
S
Y
S
L
S
G
T
D
_
_
Site 163
S1870
P
S
P
S
Y
S
L
S
G
T
D
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation