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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SGSM1
Full Name:
Small G protein signaling modulator 1
Alias:
RUN and TBC1 domain-containing protein 2
Type:
Mass (Da):
129718
Number AA:
1148
UniProt ID:
Q2NKQ1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
T
R
Q
R
L
L
R
T
V
K
K
E
V
K
Q
Site 2
T31
Q
I
M
E
E
A
V
T
R
K
F
V
H
E
D
Site 3
S67
R
A
A
G
F
L
R
S
N
K
I
A
A
L
F
Site 4
S100
D
L
E
Q
L
I
E
S
A
R
N
Q
I
Q
G
Site 5
Y146
V
L
D
K
I
V
H
Y
L
V
E
N
S
S
K
Site 6
Y154
L
V
E
N
S
S
K
Y
Y
E
K
E
A
L
L
Site 7
Y155
V
E
N
S
S
K
Y
Y
E
K
E
A
L
L
M
Site 8
S172
V
D
G
P
I
L
A
S
L
L
V
G
P
C
A
Site 9
Y182
V
G
P
C
A
L
E
Y
T
K
M
K
T
A
D
Site 10
T183
G
P
C
A
L
E
Y
T
K
M
K
T
A
D
H
Site 11
S196
D
H
F
W
T
D
P
S
A
D
E
L
V
Q
R
Site 12
S208
V
Q
R
H
R
I
H
S
S
H
V
R
Q
D
S
Site 13
S209
Q
R
H
R
I
H
S
S
H
V
R
Q
D
S
P
Site 14
S215
S
S
H
V
R
Q
D
S
P
T
K
R
P
A
L
Site 15
T217
H
V
R
Q
D
S
P
T
K
R
P
A
L
C
I
Site 16
S229
L
C
I
Q
K
R
H
S
S
G
S
M
D
D
R
Site 17
S230
C
I
Q
K
R
H
S
S
G
S
M
D
D
R
P
Site 18
S232
Q
K
R
H
S
S
G
S
M
D
D
R
P
S
L
Site 19
S238
G
S
M
D
D
R
P
S
L
S
A
R
D
Y
V
Site 20
S240
M
D
D
R
P
S
L
S
A
R
D
Y
V
E
S
Site 21
Y244
P
S
L
S
A
R
D
Y
V
E
S
L
H
Q
N
Site 22
S247
S
A
R
D
Y
V
E
S
L
H
Q
N
S
R
A
Site 23
S252
V
E
S
L
H
Q
N
S
R
A
T
L
L
Y
G
Site 24
T255
L
H
Q
N
S
R
A
T
L
L
Y
G
K
N
N
Site 25
Y258
N
S
R
A
T
L
L
Y
G
K
N
N
V
L
V
Site 26
Y277
D
M
E
A
V
P
G
Y
L
S
L
H
Q
T
A
Site 27
S279
E
A
V
P
G
Y
L
S
L
H
Q
T
A
D
V
Site 28
T283
G
Y
L
S
L
H
Q
T
A
D
V
M
T
L
K
Site 29
S300
P
N
Q
L
M
N
G
S
V
G
D
L
D
Y
E
Site 30
Y306
G
S
V
G
D
L
D
Y
E
K
S
V
Y
W
D
Site 31
Y311
L
D
Y
E
K
S
V
Y
W
D
Y
A
M
T
I
Site 32
Y314
E
K
S
V
Y
W
D
Y
A
M
T
I
R
L
E
Site 33
S382
Q
L
D
P
P
L
W
S
Q
R
G
K
G
K
V
Site 34
S397
F
P
K
L
R
K
R
S
P
Q
G
S
A
E
S
Site 35
S401
R
K
R
S
P
Q
G
S
A
E
S
T
S
S
D
Site 36
S404
S
P
Q
G
S
A
E
S
T
S
S
D
K
D
D
Site 37
T405
P
Q
G
S
A
E
S
T
S
S
D
K
D
D
D
Site 38
S407
G
S
A
E
S
T
S
S
D
K
D
D
D
E
A
Site 39
T415
D
K
D
D
D
E
A
T
D
Y
V
F
R
I
I
Site 40
Y417
D
D
D
E
A
T
D
Y
V
F
R
I
I
Y
P
Site 41
Y423
D
Y
V
F
R
I
I
Y
P
G
M
Q
S
E
F
Site 42
S464
M
L
V
V
A
R
G
S
Q
W
E
P
A
R
W
Site 43
T473
W
E
P
A
R
W
D
T
T
L
P
T
P
S
P
Site 44
T474
E
P
A
R
W
D
T
T
L
P
T
P
S
P
K
Site 45
T477
R
W
D
T
T
L
P
T
P
S
P
K
E
Q
P
Site 46
S479
D
T
T
L
P
T
P
S
P
K
E
Q
P
P
M
Site 47
S494
P
Q
D
L
M
D
V
S
V
S
N
L
P
S
L
Site 48
S496
D
L
M
D
V
S
V
S
N
L
P
S
L
W
Q
Site 49
S500
V
S
V
S
N
L
P
S
L
W
Q
P
S
P
R
Site 50
S505
L
P
S
L
W
Q
P
S
P
R
K
S
S
C
S
Site 51
S509
W
Q
P
S
P
R
K
S
S
C
S
S
C
S
Q
Site 52
S510
Q
P
S
P
R
K
S
S
C
S
S
C
S
Q
S
Site 53
S512
S
P
R
K
S
S
C
S
S
C
S
Q
S
G
S
Site 54
S513
P
R
K
S
S
C
S
S
C
S
Q
S
G
S
A
Site 55
S515
K
S
S
C
S
S
C
S
Q
S
G
S
A
D
G
Site 56
S517
S
C
S
S
C
S
Q
S
G
S
A
D
G
S
S
Site 57
S519
S
S
C
S
Q
S
G
S
A
D
G
S
S
T
N
Site 58
S523
Q
S
G
S
A
D
G
S
S
T
N
G
C
N
H
Site 59
S524
S
G
S
A
D
G
S
S
T
N
G
C
N
H
E
Site 60
S562
L
A
Y
C
R
H
L
S
T
V
R
T
H
L
S
Site 61
T563
A
Y
C
R
H
L
S
T
V
R
T
H
L
S
A
Site 62
T566
R
H
L
S
T
V
R
T
H
L
S
A
L
V
N
Site 63
Y597
T
A
R
I
W
E
Q
Y
L
H
D
S
T
S
Y
Site 64
S601
W
E
Q
Y
L
H
D
S
T
S
Y
E
E
Q
E
Site 65
S603
Q
Y
L
H
D
S
T
S
Y
E
E
Q
E
L
L
Site 66
Y614
Q
E
L
L
R
L
I
Y
Y
G
G
I
Q
P
E
Site 67
S675
V
R
Q
R
E
R
E
S
H
A
A
A
L
A
K
Site 68
S684
A
A
A
L
A
K
C
S
S
G
A
S
L
D
S
Site 69
S685
A
A
L
A
K
C
S
S
G
A
S
L
D
S
H
Site 70
S688
A
K
C
S
S
G
A
S
L
D
S
H
L
H
R
Site 71
S691
S
S
G
A
S
L
D
S
H
L
H
R
M
L
H
Site 72
S701
H
R
M
L
H
R
D
S
T
I
S
N
E
S
S
Site 73
T702
R
M
L
H
R
D
S
T
I
S
N
E
S
S
Q
Site 74
S704
L
H
R
D
S
T
I
S
N
E
S
S
Q
S
C
Site 75
S707
D
S
T
I
S
N
E
S
S
Q
S
C
S
S
G
Site 76
S708
S
T
I
S
N
E
S
S
Q
S
C
S
S
G
R
Site 77
S710
I
S
N
E
S
S
Q
S
C
S
S
G
R
Q
N
Site 78
S712
N
E
S
S
Q
S
C
S
S
G
R
Q
N
I
R
Site 79
S713
E
S
S
Q
S
C
S
S
G
R
Q
N
I
R
L
Site 80
S722
R
Q
N
I
R
L
H
S
D
S
S
S
S
T
Q
Site 81
S724
N
I
R
L
H
S
D
S
S
S
S
T
Q
V
F
Site 82
S725
I
R
L
H
S
D
S
S
S
S
T
Q
V
F
E
Site 83
S726
R
L
H
S
D
S
S
S
S
T
Q
V
F
E
S
Site 84
S727
L
H
S
D
S
S
S
S
T
Q
V
F
E
S
V
Site 85
T728
H
S
D
S
S
S
S
T
Q
V
F
E
S
V
D
Site 86
S733
S
S
T
Q
V
F
E
S
V
D
E
V
E
Q
V
Site 87
T762
N
G
N
L
V
N
G
T
C
S
P
D
S
G
H
Site 88
S764
N
L
V
N
G
T
C
S
P
D
S
G
H
P
S
Site 89
S767
N
G
T
C
S
P
D
S
G
H
P
S
S
H
N
Site 90
S771
S
P
D
S
G
H
P
S
S
H
N
F
S
S
G
Site 91
S772
P
D
S
G
H
P
S
S
H
N
F
S
S
G
L
Site 92
S776
H
P
S
S
H
N
F
S
S
G
L
S
E
H
S
Site 93
S777
P
S
S
H
N
F
S
S
G
L
S
E
H
S
E
Site 94
S780
H
N
F
S
S
G
L
S
E
H
S
E
P
S
L
Site 95
S783
S
S
G
L
S
E
H
S
E
P
S
L
S
T
E
Site 96
S786
L
S
E
H
S
E
P
S
L
S
T
E
D
S
V
Site 97
S788
E
H
S
E
P
S
L
S
T
E
D
S
V
L
D
Site 98
S792
P
S
L
S
T
E
D
S
V
L
D
A
Q
R
N
Site 99
T800
V
L
D
A
Q
R
N
T
P
T
V
L
R
P
R
Site 100
S810
V
L
R
P
R
D
G
S
V
D
D
R
Q
S
S
Site 101
S816
G
S
V
D
D
R
Q
S
S
E
A
T
T
S
Q
Site 102
S817
S
V
D
D
R
Q
S
S
E
A
T
T
S
Q
D
Site 103
S822
Q
S
S
E
A
T
T
S
Q
D
E
A
P
R
E
Site 104
S836
E
E
L
A
V
Q
D
S
L
E
S
D
L
L
A
Site 105
S846
S
D
L
L
A
N
E
S
M
D
E
F
M
S
I
Site 106
S852
E
S
M
D
E
F
M
S
I
T
G
S
L
D
M
Site 107
S874
V
V
M
E
G
W
R
S
S
E
T
E
K
H
G
Site 108
S875
V
M
E
G
W
R
S
S
E
T
E
K
H
G
Q
Site 109
S885
E
K
H
G
Q
A
D
S
E
D
N
L
S
E
E
Site 110
S890
A
D
S
E
D
N
L
S
E
E
P
E
M
E
S
Site 111
S897
S
E
E
P
E
M
E
S
L
F
P
A
L
A
S
Site 112
S915
T
T
S
A
N
E
V
S
P
V
S
S
S
G
V
Site 113
S918
A
N
E
V
S
P
V
S
S
S
G
V
T
Y
S
Site 114
S919
N
E
V
S
P
V
S
S
S
G
V
T
Y
S
P
Site 115
S920
E
V
S
P
V
S
S
S
G
V
T
Y
S
P
E
Site 116
T923
P
V
S
S
S
G
V
T
Y
S
P
E
L
L
D
Site 117
S925
S
S
S
G
V
T
Y
S
P
E
L
L
D
L
Y
Site 118
Y932
S
P
E
L
L
D
L
Y
T
V
N
L
H
R
I
Site 119
T933
P
E
L
L
D
L
Y
T
V
N
L
H
R
I
E
Site 120
Y952
R
C
D
R
N
Y
W
Y
F
T
P
A
N
L
E
Site 121
T954
D
R
N
Y
W
Y
F
T
P
A
N
L
E
K
L
Site 122
T1127
E
M
A
E
R
H
N
T
K
Q
V
L
K
L
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation