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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SHROOM1
Full Name:
Protein Shroom1
Alias:
Apical protein 2; APXL2; KIAA1960; SHRM1; Shroom 1; Shroom family member 1
Type:
Actin binding protein
Mass (Da):
90786
Number AA:
852
UniProt ID:
Q2M3G4
International Prot ID:
IPI00328184
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0000902
GO:0007015
GO:0009653
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
G
P
G
G
D
R
A
S
P
A
S
S
T
S
S
Site 2
S15
G
D
R
A
S
P
A
S
S
T
S
S
L
D
L
Site 3
S16
D
R
A
S
P
A
S
S
T
S
S
L
D
L
W
Site 4
S18
A
S
P
A
S
S
T
S
S
L
D
L
W
H
L
Site 5
S19
S
P
A
S
S
T
S
S
L
D
L
W
H
L
S
Site 6
S26
S
L
D
L
W
H
L
S
M
R
A
D
S
A
Y
Site 7
S31
H
L
S
M
R
A
D
S
A
Y
S
S
F
S
A
Site 8
Y33
S
M
R
A
D
S
A
Y
S
S
F
S
A
A
S
Site 9
S35
R
A
D
S
A
Y
S
S
F
S
A
A
S
G
G
Site 10
S37
D
S
A
Y
S
S
F
S
A
A
S
G
G
P
E
Site 11
S40
Y
S
S
F
S
A
A
S
G
G
P
E
P
R
T
Site 12
T47
S
G
G
P
E
P
R
T
Q
S
P
G
T
D
L
Site 13
S49
G
P
E
P
R
T
Q
S
P
G
T
D
L
L
P
Site 14
Y57
P
G
T
D
L
L
P
Y
L
D
W
D
Y
V
R
Site 15
Y62
L
P
Y
L
D
W
D
Y
V
R
V
V
W
G
G
Site 16
S82
P
D
A
A
L
C
T
S
P
R
P
R
P
A
V
Site 17
S93
R
P
A
V
A
A
R
S
G
P
Q
P
T
E
V
Site 18
T98
A
R
S
G
P
Q
P
T
E
V
P
G
T
P
G
Site 19
T103
Q
P
T
E
V
P
G
T
P
G
P
L
N
R
Q
Site 20
S133
A
Q
A
A
E
P
P
S
P
P
A
S
R
A
A
Site 21
S137
E
P
P
S
P
P
A
S
R
A
A
Y
R
Q
R
Site 22
Y141
P
P
A
S
R
A
A
Y
R
Q
R
L
Q
G
A
Site 23
T156
Q
R
R
V
L
R
E
T
S
F
Q
R
K
E
L
Site 24
S157
R
R
V
L
R
E
T
S
F
Q
R
K
E
L
R
Site 25
S166
Q
R
K
E
L
R
M
S
L
P
A
R
L
R
P
Site 26
T174
L
P
A
R
L
R
P
T
V
P
A
R
P
P
A
Site 27
T182
V
P
A
R
P
P
A
T
H
P
R
S
A
S
L
Site 28
S186
P
P
A
T
H
P
R
S
A
S
L
S
H
P
G
Site 29
S188
A
T
H
P
R
S
A
S
L
S
H
P
G
G
E
Site 30
S190
H
P
R
S
A
S
L
S
H
P
G
G
E
G
E
Site 31
S201
G
E
G
E
P
A
R
S
R
A
P
A
P
G
T
Site 32
T208
S
R
A
P
A
P
G
T
A
G
R
G
P
L
A
Site 33
S224
Q
Q
R
K
W
C
F
S
E
P
G
K
L
D
R
Site 34
S248
E
C
L
G
E
A
C
S
S
S
G
L
P
G
P
Site 35
S250
L
G
E
A
C
S
S
S
G
L
P
G
P
E
P
Site 36
T279
E
V
G
W
L
P
E
T
Q
P
Q
G
S
M
N
Site 37
S284
P
E
T
Q
P
Q
G
S
M
N
L
D
S
G
S
Site 38
S289
Q
G
S
M
N
L
D
S
G
S
L
K
L
G
D
Site 39
S291
S
M
N
L
D
S
G
S
L
K
L
G
D
A
F
Site 40
S302
G
D
A
F
R
P
A
S
R
S
R
S
A
S
G
Site 41
S304
A
F
R
P
A
S
R
S
R
S
A
S
G
E
V
Site 42
S306
R
P
A
S
R
S
R
S
A
S
G
E
V
L
G
Site 43
S308
A
S
R
S
R
S
A
S
G
E
V
L
G
S
W
Site 44
S314
A
S
G
E
V
L
G
S
W
G
G
S
G
G
T
Site 45
T334
A
V
P
Q
G
A
E
T
P
R
P
L
F
Q
T
Site 46
T341
T
P
R
P
L
F
Q
T
K
L
S
R
F
L
P
Site 47
S344
P
L
F
Q
T
K
L
S
R
F
L
P
Q
K
E
Site 48
Y356
Q
K
E
A
A
V
M
Y
P
A
E
L
P
Q
S
Site 49
S363
Y
P
A
E
L
P
Q
S
S
P
A
D
S
E
Q
Site 50
S364
P
A
E
L
P
Q
S
S
P
A
D
S
E
Q
R
Site 51
S368
P
Q
S
S
P
A
D
S
E
Q
R
V
S
E
T
Site 52
S373
A
D
S
E
Q
R
V
S
E
T
C
I
V
P
A
Site 53
S401
A
P
L
V
R
M
R
S
P
P
D
P
H
A
S
Site 54
S408
S
P
P
D
P
H
A
S
Q
G
P
P
A
S
V
Site 55
S414
A
S
Q
G
P
P
A
S
V
H
A
S
D
Q
P
Site 56
S418
P
P
A
S
V
H
A
S
D
Q
P
Y
G
T
G
Site 57
Y422
V
H
A
S
D
Q
P
Y
G
T
G
L
G
Q
R
Site 58
T434
G
Q
R
T
G
Q
V
T
V
P
T
E
Y
P
L
Site 59
T437
T
G
Q
V
T
V
P
T
E
Y
P
L
H
E
C
Site 60
Y439
Q
V
T
V
P
T
E
Y
P
L
H
E
C
P
G
Site 61
T447
P
L
H
E
C
P
G
T
A
G
A
D
D
C
W
Site 62
S460
C
W
Q
G
V
N
G
S
V
G
I
S
R
P
T
Site 63
S464
V
N
G
S
V
G
I
S
R
P
T
S
H
T
P
Site 64
T467
S
V
G
I
S
R
P
T
S
H
T
P
T
G
T
Site 65
S468
V
G
I
S
R
P
T
S
H
T
P
T
G
T
A
Site 66
T470
I
S
R
P
T
S
H
T
P
T
G
T
A
N
D
Site 67
T472
R
P
T
S
H
T
P
T
G
T
A
N
D
N
I
Site 68
T488
T
I
D
P
T
G
L
T
T
N
P
P
T
A
A
Site 69
T493
G
L
T
T
N
P
P
T
A
A
E
S
D
L
L
Site 70
S497
N
P
P
T
A
A
E
S
D
L
L
K
P
V
P
Site 71
S511
P
A
D
A
L
G
L
S
G
N
D
T
P
G
P
Site 72
T515
L
G
L
S
G
N
D
T
P
G
P
S
H
N
T
Site 73
T528
N
T
A
L
A
R
G
T
G
Q
P
G
S
R
P
Site 74
S533
R
G
T
G
Q
P
G
S
R
P
T
W
P
S
Q
Site 75
T536
G
Q
P
G
S
R
P
T
W
P
S
Q
C
L
E
Site 76
S539
G
S
R
P
T
W
P
S
Q
C
L
E
E
L
V
Site 77
S555
E
L
A
R
L
D
P
S
L
C
D
P
L
A
S
Site 78
S562
S
L
C
D
P
L
A
S
Q
P
S
P
E
P
P
Site 79
S565
D
P
L
A
S
Q
P
S
P
E
P
P
L
G
L
Site 80
S599
E
A
G
E
E
A
A
S
T
F
E
P
G
S
Y
Site 81
T600
A
G
E
E
A
A
S
T
F
E
P
G
S
Y
Q
Site 82
S605
A
S
T
F
E
P
G
S
Y
Q
F
S
F
T
Q
Site 83
Y606
S
T
F
E
P
G
S
Y
Q
F
S
F
T
Q
L
Site 84
S609
E
P
G
S
Y
Q
F
S
F
T
Q
L
L
P
A
Site 85
T621
L
P
A
P
R
E
E
T
R
L
E
N
P
A
T
Site 86
T628
T
R
L
E
N
P
A
T
H
P
V
L
D
Q
P
Site 87
T667
K
M
L
Q
D
L
H
T
E
Q
E
R
L
Q
G
Site 88
S703
P
Q
E
L
E
R
F
S
R
F
M
A
D
L
E
Site 89
S735
R
A
L
A
R
A
A
S
D
S
D
P
D
E
Q
Site 90
S737
L
A
R
A
A
S
D
S
D
P
D
E
Q
A
S
Site 91
S744
S
D
P
D
E
Q
A
S
L
L
Q
R
L
R
L
Site 92
S830
D
L
G
H
H
A
P
S
P
S
P
A
R
P
P
Site 93
S832
G
H
H
A
P
S
P
S
P
A
R
P
P
G
T
Site 94
T839
S
P
A
R
P
P
G
T
C
P
P
V
Q
P
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation