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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ABCB5
Full Name:
ATP-binding cassette sub-family B member 5
Alias:
ABCB5 P-gp;P-glycoprotein ABCB5
Type:
Mass (Da):
89831
Number AA:
812
UniProt ID:
Q2M3G0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y15
R
A
L
N
V
R
H
Y
R
D
H
I
G
V
V
Site 2
S34
V
L
F
G
T
T
I
S
N
N
I
K
Y
G
R
Site 3
Y39
T
I
S
N
N
I
K
Y
G
R
D
D
V
T
D
Site 4
T45
K
Y
G
R
D
D
V
T
D
E
E
M
E
R
A
Site 5
Y59
A
A
R
E
A
N
A
Y
D
F
I
M
E
F
P
Site 6
T71
E
F
P
N
K
F
N
T
L
V
G
E
K
G
A
Site 7
S108
L
I
L
D
E
A
T
S
A
L
D
S
E
S
K
Site 8
S112
E
A
T
S
A
L
D
S
E
S
K
S
A
V
Q
Site 9
S114
T
S
A
L
D
S
E
S
K
S
A
V
Q
A
A
Site 10
S116
A
L
D
S
E
S
K
S
A
V
Q
A
A
L
E
Site 11
T130
E
K
A
S
K
G
R
T
T
I
V
V
A
H
R
Site 12
T131
K
A
S
K
G
R
T
T
I
V
V
A
H
R
L
Site 13
S173
A
K
R
G
L
Y
Y
S
L
V
M
S
Q
D
I
Site 14
S177
L
Y
Y
S
L
V
M
S
Q
D
I
K
K
A
D
Site 15
S189
K
A
D
E
Q
M
E
S
M
T
Y
S
T
E
R
Site 16
Y192
E
Q
M
E
S
M
T
Y
S
T
E
R
K
T
N
Site 17
S193
Q
M
E
S
M
T
Y
S
T
E
R
K
T
N
S
Site 18
T194
M
E
S
M
T
Y
S
T
E
R
K
T
N
S
L
Site 19
T198
T
Y
S
T
E
R
K
T
N
S
L
P
L
H
S
Site 20
S200
S
T
E
R
K
T
N
S
L
P
L
H
S
V
K
Site 21
S205
T
N
S
L
P
L
H
S
V
K
S
I
K
S
D
Site 22
S208
L
P
L
H
S
V
K
S
I
K
S
D
F
I
D
Site 23
S211
H
S
V
K
S
I
K
S
D
F
I
D
K
A
E
Site 24
S223
K
A
E
E
S
T
Q
S
K
E
I
S
L
P
E
Site 25
S227
S
T
Q
S
K
E
I
S
L
P
E
V
S
L
L
Site 26
T281
M
F
G
N
N
D
K
T
T
L
K
H
D
A
E
Site 27
T282
F
G
N
N
D
K
T
T
L
K
H
D
A
E
I
Site 28
T320
G
R
A
G
E
I
L
T
M
R
L
R
H
L
A
Site 29
S345
W
F
D
E
K
E
N
S
T
G
G
L
T
T
I
Site 30
S366
Q
I
Q
G
A
T
G
S
R
I
G
V
L
T
Q
Site 31
T372
G
S
R
I
G
V
L
T
Q
N
A
T
N
M
G
Site 32
T441
E
A
L
E
N
I
R
T
I
V
S
L
T
R
E
Site 33
S444
E
N
I
R
T
I
V
S
L
T
R
E
K
A
F
Site 34
Y455
E
K
A
F
E
Q
M
Y
E
E
M
L
Q
T
Q
Site 35
T461
M
Y
E
E
M
L
Q
T
Q
H
R
N
T
S
K
Site 36
T466
L
Q
T
Q
H
R
N
T
S
K
K
A
Q
I
I
Site 37
S467
Q
T
Q
H
R
N
T
S
K
K
A
Q
I
I
G
Site 38
S538
P
E
Y
S
K
A
K
S
G
A
A
H
L
F
A
Site 39
S555
E
K
K
P
N
I
D
S
R
S
Q
E
G
K
K
Site 40
S557
K
P
N
I
D
S
R
S
Q
E
G
K
K
P
D
Site 41
T565
Q
E
G
K
K
P
D
T
C
E
G
N
L
E
F
Site 42
S576
N
L
E
F
R
E
V
S
F
F
Y
P
C
R
P
Site 43
Y579
F
R
E
V
S
F
F
Y
P
C
R
P
D
V
F
Site 44
S612
G
S
S
G
C
G
K
S
T
S
V
Q
L
L
Q
Site 45
T613
S
S
G
C
G
K
S
T
S
V
Q
L
L
Q
R
Site 46
S614
S
G
C
G
K
S
T
S
V
Q
L
L
Q
R
L
Site 47
Y622
V
Q
L
L
Q
R
L
Y
D
P
V
Q
G
Q
V
Site 48
Y668
S
I
A
E
N
I
A
Y
G
D
N
S
R
V
V
Site 49
S672
N
I
A
Y
G
D
N
S
R
V
V
P
L
D
E
Site 50
S691
A
N
A
A
N
I
H
S
F
I
E
G
L
P
E
Site 51
Y700
I
E
G
L
P
E
K
Y
N
T
Q
V
G
L
K
Site 52
T702
G
L
P
E
K
Y
N
T
Q
V
G
L
K
G
A
Site 53
S712
G
L
K
G
A
Q
L
S
G
G
Q
K
Q
R
L
Site 54
S745
T
S
A
L
D
N
D
S
E
K
V
V
Q
H
A
Site 55
Y802
L
L
R
N
R
D
I
Y
F
K
L
V
N
A
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation