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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CdGAP
Full Name:
Rho GTPase-activating protein 31
Alias:
KIAA1204
Type:
Intracellular, Lamellipodium, Cell junction protein
Mass (Da):
157015
Number AA:
1444
UniProt ID:
Q2M1Z3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005925
GO:0005622
GO:0030027
Uniprot
OncoNet
Molecular Function:
GO:0005096
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
L
K
R
K
G
A
A
S
A
F
G
C
D
L
T
Site 2
T24
S
A
F
G
C
D
L
T
E
Y
L
E
S
S
G
Site 3
Y26
F
G
C
D
L
T
E
Y
L
E
S
S
G
Q
D
Site 4
S29
D
L
T
E
Y
L
E
S
S
G
Q
D
V
P
Y
Site 5
S30
L
T
E
Y
L
E
S
S
G
Q
D
V
P
Y
V
Site 6
Y36
S
S
G
Q
D
V
P
Y
V
L
K
S
C
A
E
Site 7
S58
V
D
G
I
Y
R
L
S
G
V
T
S
N
I
Q
Site 8
S62
Y
R
L
S
G
V
T
S
N
I
Q
R
L
R
Q
Site 9
S73
R
L
R
Q
E
F
G
S
D
Q
C
P
D
L
T
Site 10
T80
S
D
Q
C
P
D
L
T
R
E
V
Y
L
Q
D
Site 11
Y84
P
D
L
T
R
E
V
Y
L
Q
D
I
H
C
V
Site 12
Y98
V
G
S
L
C
K
L
Y
F
R
E
L
P
N
P
Site 13
Y112
P
L
L
T
Y
E
L
Y
E
K
F
T
E
A
V
Site 14
S120
E
K
F
T
E
A
V
S
H
C
P
E
E
G
Q
Site 15
S141
V
I
Q
E
L
P
P
S
H
Y
R
T
L
E
Y
Site 16
T145
L
P
P
S
H
Y
R
T
L
E
Y
L
I
R
H
Site 17
Y148
S
H
Y
R
T
L
E
Y
L
I
R
H
L
A
H
Site 18
S158
R
H
L
A
H
I
A
S
F
S
S
K
T
N
M
Site 19
S160
L
A
H
I
A
S
F
S
S
K
T
N
M
H
A
Site 20
S161
A
H
I
A
S
F
S
S
K
T
N
M
H
A
R
Site 21
T187
R
S
K
E
I
E
A
T
G
C
N
G
D
A
A
Site 22
S223
F
N
N
G
A
P
G
S
L
E
N
D
E
N
R
Site 23
S235
E
N
R
P
I
M
K
S
L
T
L
P
A
L
S
Site 24
S249
S
L
P
M
K
L
V
S
L
E
E
A
Q
A
R
Site 25
S272
R
K
E
R
R
E
N
S
L
P
E
I
V
P
P
Site 26
S298
P
D
N
K
R
K
L
S
S
K
S
K
K
W
K
Site 27
S299
D
N
K
R
K
L
S
S
K
S
K
K
W
K
S
Site 28
S301
K
R
K
L
S
S
K
S
K
K
W
K
S
I
F
Site 29
S306
S
K
S
K
K
W
K
S
I
F
N
L
G
R
S
Site 30
S313
S
I
F
N
L
G
R
S
G
S
D
S
K
S
K
Site 31
S315
F
N
L
G
R
S
G
S
D
S
K
S
K
L
S
Site 32
S317
L
G
R
S
G
S
D
S
K
S
K
L
S
R
N
Site 33
S319
R
S
G
S
D
S
K
S
K
L
S
R
N
G
S
Site 34
S322
S
D
S
K
S
K
L
S
R
N
G
S
V
F
V
Site 35
S326
S
K
L
S
R
N
G
S
V
F
V
R
G
Q
R
Site 36
S335
F
V
R
G
Q
R
L
S
V
E
K
A
T
I
R
Site 37
T340
R
L
S
V
E
K
A
T
I
R
P
A
K
S
M
Site 38
S346
A
T
I
R
P
A
K
S
M
D
S
L
C
S
V
Site 39
S349
R
P
A
K
S
M
D
S
L
C
S
V
P
V
E
Site 40
S352
K
S
M
D
S
L
C
S
V
P
V
E
G
K
E
Site 41
T360
V
P
V
E
G
K
E
T
K
G
N
F
N
R
T
Site 42
T367
T
K
G
N
F
N
R
T
V
T
T
G
G
F
F
Site 43
T378
G
G
F
F
I
P
A
T
K
M
H
S
T
G
T
Site 44
T383
P
A
T
K
M
H
S
T
G
T
G
S
S
C
D
Site 45
S387
M
H
S
T
G
T
G
S
S
C
D
L
T
K
Q
Site 46
T392
T
G
S
S
C
D
L
T
K
Q
E
G
E
W
G
Site 47
S414
A
E
G
G
F
D
V
S
S
D
R
S
H
L
Q
Site 48
S415
E
G
G
F
D
V
S
S
D
R
S
H
L
Q
G
Site 49
S418
F
D
V
S
S
D
R
S
H
L
Q
G
A
Q
A
Site 50
S443
R
P
V
E
D
P
E
S
E
Q
T
A
P
K
M
Site 51
T446
E
D
P
E
S
E
Q
T
A
P
K
M
L
G
M
Site 52
Y455
P
K
M
L
G
M
F
Y
T
S
N
D
S
P
S
Site 53
T456
K
M
L
G
M
F
Y
T
S
N
D
S
P
S
K
Site 54
S457
M
L
G
M
F
Y
T
S
N
D
S
P
S
K
S
Site 55
S460
M
F
Y
T
S
N
D
S
P
S
K
S
V
F
T
Site 56
S462
Y
T
S
N
D
S
P
S
K
S
V
F
T
S
S
Site 57
S464
S
N
D
S
P
S
K
S
V
F
T
S
S
L
F
Site 58
S468
P
S
K
S
V
F
T
S
S
L
F
Q
M
E
P
Site 59
S469
S
K
S
V
F
T
S
S
L
F
Q
M
E
P
S
Site 60
S476
S
L
F
Q
M
E
P
S
P
R
N
Q
R
K
A
Site 61
T507
A
V
I
S
T
N
S
T
P
C
R
T
P
P
K
Site 62
T511
T
N
S
T
P
C
R
T
P
P
K
E
L
Q
S
Site 63
S518
T
P
P
K
E
L
Q
S
L
S
S
L
E
E
F
Site 64
S520
P
K
E
L
Q
S
L
S
S
L
E
E
F
S
F
Site 65
S521
K
E
L
Q
S
L
S
S
L
E
E
F
S
F
H
Site 66
S526
L
S
S
L
E
E
F
S
F
H
G
S
E
S
G
Site 67
S530
E
E
F
S
F
H
G
S
E
S
G
G
W
P
E
Site 68
S547
K
P
L
G
A
E
T
S
A
A
S
V
P
K
K
Site 69
S550
G
A
E
T
S
A
A
S
V
P
K
K
A
G
L
Site 70
S577
V
E
C
S
K
G
L
S
Q
E
P
G
A
H
L
Site 71
T589
A
H
L
E
E
K
K
T
P
E
S
S
L
S
S
Site 72
S592
E
E
K
K
T
P
E
S
S
L
S
S
Q
H
L
Site 73
S593
E
K
K
T
P
E
S
S
L
S
S
Q
H
L
N
Site 74
S595
K
T
P
E
S
S
L
S
S
Q
H
L
N
E
L
Site 75
S596
T
P
E
S
S
L
S
S
Q
H
L
N
E
L
E
Site 76
S624
E
A
G
E
M
E
S
S
T
L
Q
E
S
P
R
Site 77
T625
A
G
E
M
E
S
S
T
L
Q
E
S
P
R
A
Site 78
S629
E
S
S
T
L
Q
E
S
P
R
A
R
A
E
A
Site 79
S665
Q
E
L
K
I
I
E
S
E
E
E
L
S
S
L
Site 80
S670
I
E
S
E
E
E
L
S
S
L
P
P
P
A
L
Site 81
S671
E
S
E
E
E
L
S
S
L
P
P
P
A
L
K
Site 82
S680
P
P
P
A
L
K
T
S
P
I
Q
P
I
L
E
Site 83
S696
S
L
G
P
F
I
P
S
E
P
P
G
S
L
P
Site 84
S701
I
P
S
E
P
P
G
S
L
P
C
G
S
F
P
Site 85
T713
S
F
P
A
P
V
S
T
P
L
E
V
W
T
R
Site 86
T727
R
D
P
A
N
Q
S
T
Q
G
A
S
T
A
A
Site 87
S735
Q
G
A
S
T
A
A
S
R
E
K
P
E
P
E
Site 88
T768
E
K
A
S
P
Q
A
T
V
E
V
G
G
P
G
Site 89
S778
V
G
G
P
G
N
L
S
P
P
L
P
P
A
P
Site 90
T789
P
P
A
P
P
P
P
T
P
L
E
E
S
T
P
Site 91
S794
P
P
T
P
L
E
E
S
T
P
V
L
L
S
K
Site 92
T795
P
T
P
L
E
E
S
T
P
V
L
L
S
K
G
Site 93
S800
E
S
T
P
V
L
L
S
K
G
S
P
E
R
E
Site 94
S803
P
V
L
L
S
K
G
S
P
E
R
E
D
S
S
Site 95
S809
G
S
P
E
R
E
D
S
S
R
K
L
R
T
D
Site 96
S810
S
P
E
R
E
D
S
S
R
K
L
R
T
D
L
Site 97
Y818
R
K
L
R
T
D
L
Y
I
D
Q
L
K
S
Q
Site 98
S824
L
Y
I
D
Q
L
K
S
Q
D
S
P
E
I
S
Site 99
S827
D
Q
L
K
S
Q
D
S
P
E
I
S
S
L
C
Site 100
S831
S
Q
D
S
P
E
I
S
S
L
C
Q
G
E
E
Site 101
T840
L
C
Q
G
E
E
A
T
P
R
H
S
D
K
Q
Site 102
S844
E
E
A
T
P
R
H
S
D
K
Q
N
S
K
N
Site 103
S849
R
H
S
D
K
Q
N
S
K
N
A
A
S
E
G
Site 104
S854
Q
N
S
K
N
A
A
S
E
G
K
G
C
G
F
Site 105
S863
G
K
G
C
G
F
P
S
P
T
R
E
V
E
I
Site 106
T879
S
Q
E
E
E
D
V
T
H
S
V
Q
E
P
S
Site 107
S881
E
E
E
D
V
T
H
S
V
Q
E
P
S
D
C
Site 108
S886
T
H
S
V
Q
E
P
S
D
C
D
E
D
D
T
Site 109
T893
S
D
C
D
E
D
D
T
V
T
D
I
A
Q
H
Site 110
S916
E
E
P
Q
W
V
T
S
P
L
H
S
P
T
L
Site 111
S920
W
V
T
S
P
L
H
S
P
T
L
K
D
A
H
Site 112
S944
H
Q
L
E
K
R
L
S
H
R
P
S
L
R
Q
Site 113
S948
K
R
L
S
H
R
P
S
L
R
Q
S
H
S
L
Site 114
S952
H
R
P
S
L
R
Q
S
H
S
L
D
S
K
P
Site 115
S954
P
S
L
R
Q
S
H
S
L
D
S
K
P
T
V
Site 116
S957
R
Q
S
H
S
L
D
S
K
P
T
V
K
S
Q
Site 117
S963
D
S
K
P
T
V
K
S
Q
W
T
L
E
V
P
Site 118
T966
P
T
V
K
S
Q
W
T
L
E
V
P
S
S
S
Site 119
S972
W
T
L
E
V
P
S
S
S
S
C
A
N
L
E
Site 120
S973
T
L
E
V
P
S
S
S
S
C
A
N
L
E
T
Site 121
T980
S
S
C
A
N
L
E
T
E
R
N
S
D
P
L
Site 122
S984
N
L
E
T
E
R
N
S
D
P
L
Q
P
Q
A
Site 123
T997
Q
A
P
R
R
E
I
T
G
W
D
E
K
A
L
Site 124
S1006
W
D
E
K
A
L
R
S
F
R
E
F
S
G
L
Site 125
S1011
L
R
S
F
R
E
F
S
G
L
K
G
A
E
A
Site 126
S1036
Q
P
N
P
A
E
T
S
P
I
S
L
A
E
G
Site 127
S1039
P
A
E
T
S
P
I
S
L
A
E
G
K
E
L
Site 128
S1053
L
G
T
H
L
G
H
S
S
P
Q
I
R
Q
G
Site 129
S1054
G
T
H
L
G
H
S
S
P
Q
I
R
Q
G
G
Site 130
S1067
G
G
V
P
G
P
E
S
S
K
E
S
S
P
S
Site 131
S1068
G
V
P
G
P
E
S
S
K
E
S
S
P
S
V
Site 132
S1071
G
P
E
S
S
K
E
S
S
P
S
V
Q
D
S
Site 133
S1072
P
E
S
S
K
E
S
S
P
S
V
Q
D
S
T
Site 134
S1074
S
S
K
E
S
S
P
S
V
Q
D
S
T
S
P
Site 135
S1078
S
S
P
S
V
Q
D
S
T
S
P
G
E
H
P
Site 136
T1079
S
P
S
V
Q
D
S
T
S
P
G
E
H
P
A
Site 137
S1080
P
S
V
Q
D
S
T
S
P
G
E
H
P
A
K
Site 138
S1092
P
A
K
L
Q
L
K
S
T
E
C
G
P
P
K
Site 139
T1093
A
K
L
Q
L
K
S
T
E
C
G
P
P
K
G
Site 140
S1105
P
K
G
K
N
R
P
S
S
L
N
L
D
P
A
Site 141
S1106
P
K
G
K
N
R
P
S
S
L
N
L
D
P
A
Site 142
S1129
E
N
V
A
S
F
S
S
P
G
M
Q
V
S
E
Site 143
S1135
S
S
P
G
M
Q
V
S
E
P
G
D
P
K
V
Site 144
T1143
E
P
G
D
P
K
V
T
W
M
T
S
S
Y
C
Site 145
Y1158
K
A
D
P
W
R
V
Y
S
Q
D
P
Q
D
L
Site 146
S1159
A
D
P
W
R
V
Y
S
Q
D
P
Q
D
L
D
Site 147
T1173
D
I
V
A
H
A
L
T
G
R
R
N
S
A
P
Site 148
S1178
A
L
T
G
R
R
N
S
A
P
V
S
V
S
A
Site 149
S1182
R
R
N
S
A
P
V
S
V
S
A
V
R
T
S
Site 150
S1184
N
S
A
P
V
S
V
S
A
V
R
T
S
F
M
Site 151
T1210
I
P
P
K
I
Q
Y
T
Q
I
P
Q
P
L
P
Site 152
S1218
Q
I
P
Q
P
L
P
S
Q
S
S
G
E
N
G
Site 153
S1220
P
Q
P
L
P
S
Q
S
S
G
E
N
G
V
Q
Site 154
S1232
G
V
Q
P
L
E
R
S
Q
E
G
P
S
S
T
Site 155
S1238
R
S
Q
E
G
P
S
S
T
S
G
T
T
Q
K
Site 156
T1242
G
P
S
S
T
S
G
T
T
Q
K
P
A
K
D
Site 157
S1251
Q
K
P
A
K
D
D
S
P
S
S
L
E
S
S
Site 158
S1253
P
A
K
D
D
S
P
S
S
L
E
S
S
K
E
Site 159
S1254
A
K
D
D
S
P
S
S
L
E
S
S
K
E
E
Site 160
S1257
D
S
P
S
S
L
E
S
S
K
E
E
K
P
K
Site 161
S1258
S
P
S
S
L
E
S
S
K
E
E
K
P
K
Q
Site 162
S1272
Q
D
P
G
A
I
K
S
S
P
V
D
A
T
A
Site 163
S1273
D
P
G
A
I
K
S
S
P
V
D
A
T
A
P
Site 164
T1287
P
C
M
C
E
G
P
T
L
S
P
E
P
G
S
Site 165
S1289
M
C
E
G
P
T
L
S
P
E
P
G
S
S
N
Site 166
S1294
T
L
S
P
E
P
G
S
S
N
L
L
S
T
Q
Site 167
S1295
L
S
P
E
P
G
S
S
N
L
L
S
T
Q
D
Site 168
S1299
P
G
S
S
N
L
L
S
T
Q
D
A
V
V
Q
Site 169
S1312
V
Q
C
R
K
R
M
S
E
T
E
P
S
G
D
Site 170
S1317
R
M
S
E
T
E
P
S
G
D
N
L
L
S
S
Site 171
S1323
P
S
G
D
N
L
L
S
S
K
L
E
R
P
S
Site 172
S1324
S
G
D
N
L
L
S
S
K
L
E
R
P
S
G
Site 173
S1330
S
S
K
L
E
R
P
S
G
G
S
K
P
F
H
Site 174
S1333
L
E
R
P
S
G
G
S
K
P
F
H
R
S
R
Site 175
S1339
G
S
K
P
F
H
R
S
R
P
G
R
P
Q
S
Site 176
S1346
S
R
P
G
R
P
Q
S
L
I
L
F
S
P
P
Site 177
S1363
I
M
D
H
L
P
P
S
S
T
V
T
D
S
K
Site 178
S1364
M
D
H
L
P
P
S
S
T
V
T
D
S
K
V
Site 179
T1365
D
H
L
P
P
S
S
T
V
T
D
S
K
V
L
Site 180
S1374
T
D
S
K
V
L
L
S
P
I
R
S
P
T
Q
Site 181
T1380
L
S
P
I
R
S
P
T
Q
T
V
S
P
G
L
Site 182
S1384
R
S
P
T
Q
T
V
S
P
G
L
L
C
G
E
Site 183
T1399
L
A
E
N
T
W
V
T
P
E
G
V
T
L
R
Site 184
T1410
V
T
L
R
N
K
M
T
I
P
K
N
G
Q
R
Site 185
T1420
K
N
G
Q
R
L
E
T
S
T
S
C
F
Y
Q
Site 186
T1422
G
Q
R
L
E
T
S
T
S
C
F
Y
Q
P
Q
Site 187
S1423
Q
R
L
E
T
S
T
S
C
F
Y
Q
P
Q
R
Site 188
S1432
F
Y
Q
P
Q
R
R
S
V
I
L
D
G
R
S
Site 189
S1439
S
V
I
L
D
G
R
S
G
R
Q
I
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation