KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ZNF423
Full Name:
Zinc finger protein 423
Alias:
Early B-cell factor associated zinc finger protein; Ebfaz; KIAA0760; OAZ; OLF-1/EBF associated zinc finger gene; Olf1/EBF-associated zinc finger protein; Roaz; Smad- and Olf-interacting zinc finger protein; Zfp104; Zinc finger 423
Type:
Mass (Da):
144605
Number AA:
1284
UniProt ID:
Q2M1K9
International Prot ID:
IPI00100660
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0016563
GO:0016564
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0016481
GO:0007399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
R
V
E
E
G
E
A
S
D
F
S
L
A
W
D
Site 2
S15
E
G
E
A
S
D
F
S
L
A
W
D
S
S
V
Site 3
T38
E
P
E
C
D
Q
K
T
S
R
A
L
E
D
R
Site 4
S47
R
A
L
E
D
R
N
S
V
T
S
Q
E
E
R
Site 5
S50
E
D
R
N
S
V
T
S
Q
E
E
R
N
E
D
Site 6
Y67
D
M
E
D
E
S
I
Y
T
C
D
H
C
Q
Q
Site 7
T83
F
E
S
L
A
D
L
T
D
H
R
A
H
R
C
Site 8
S101
G
D
D
D
P
Q
L
S
W
V
A
S
S
P
S
Site 9
S105
P
Q
L
S
W
V
A
S
S
P
S
S
K
D
V
Site 10
S106
Q
L
S
W
V
A
S
S
P
S
S
K
D
V
A
Site 11
S108
S
W
V
A
S
S
P
S
S
K
D
V
A
S
P
Site 12
S109
W
V
A
S
S
P
S
S
K
D
V
A
S
P
T
Site 13
S114
P
S
S
K
D
V
A
S
P
T
Q
M
I
G
D
Site 14
T116
S
K
D
V
A
S
P
T
Q
M
I
G
D
G
C
Site 15
T134
L
G
E
E
E
G
G
T
G
L
P
Y
P
C
Q
Site 16
Y138
E
G
G
T
G
L
P
Y
P
C
Q
F
C
D
K
Site 17
S151
D
K
S
F
I
R
L
S
Y
L
K
R
H
E
Q
Site 18
Y152
K
S
F
I
R
L
S
Y
L
K
R
H
E
Q
I
Site 19
S161
K
R
H
E
Q
I
H
S
D
K
L
P
F
K
C
Site 20
Y170
K
L
P
F
K
C
T
Y
C
S
R
L
F
K
H
Site 21
S180
R
L
F
K
H
K
R
S
R
D
R
H
I
K
L
Site 22
T189
D
R
H
I
K
L
H
T
G
D
K
K
Y
H
C
Site 23
Y194
L
H
T
G
D
K
K
Y
H
C
H
E
C
E
A
Site 24
S204
H
E
C
E
A
A
F
S
R
S
D
H
L
K
I
Site 25
T215
H
L
K
I
H
L
K
T
H
S
S
S
K
P
F
Site 26
S217
K
I
H
L
K
T
H
S
S
S
K
P
F
K
C
Site 27
S218
I
H
L
K
T
H
S
S
S
K
P
F
K
C
T
Site 28
S219
H
L
K
T
H
S
S
S
K
P
F
K
C
T
V
Site 29
T225
S
S
K
P
F
K
C
T
V
C
K
R
G
F
S
Site 30
S232
T
V
C
K
R
G
F
S
S
T
S
S
L
Q
S
Site 31
S233
V
C
K
R
G
F
S
S
T
S
S
L
Q
S
H
Site 32
T234
C
K
R
G
F
S
S
T
S
S
L
Q
S
H
M
Site 33
S235
K
R
G
F
S
S
T
S
S
L
Q
S
H
M
Q
Site 34
S236
R
G
F
S
S
T
S
S
L
Q
S
H
M
Q
A
Site 35
S239
S
S
T
S
S
L
Q
S
H
M
Q
A
H
K
K
Site 36
S254
N
K
E
H
L
A
K
S
E
K
E
A
K
K
D
Site 37
Y267
K
D
D
F
M
C
D
Y
C
E
D
T
F
S
Q
Site 38
S273
D
Y
C
E
D
T
F
S
Q
T
E
E
L
E
K
Site 39
T284
E
L
E
K
H
V
L
T
R
H
P
Q
L
S
E
Site 40
S290
L
T
R
H
P
Q
L
S
E
K
A
D
L
Q
C
Site 41
T309
E
V
F
V
D
E
N
T
L
L
A
H
I
H
Q
Site 42
Y339
F
S
S
V
E
G
V
Y
C
H
L
D
S
H
R
Site 43
S344
G
V
Y
C
H
L
D
S
H
R
Q
P
D
S
S
Site 44
S350
D
S
H
R
Q
P
D
S
S
N
H
S
V
S
P
Site 45
S351
S
H
R
Q
P
D
S
S
N
H
S
V
S
P
D
Site 46
S354
Q
P
D
S
S
N
H
S
V
S
P
D
P
V
L
Site 47
S356
D
S
S
N
H
S
V
S
P
D
P
V
L
G
S
Site 48
S368
L
G
S
V
A
S
M
S
S
A
T
P
D
S
S
Site 49
S369
G
S
V
A
S
M
S
S
A
T
P
D
S
S
A
Site 50
T371
V
A
S
M
S
S
A
T
P
D
S
S
A
S
V
Site 51
S374
M
S
S
A
T
P
D
S
S
A
S
V
E
R
G
Site 52
S375
S
S
A
T
P
D
S
S
A
S
V
E
R
G
S
Site 53
S377
A
T
P
D
S
S
A
S
V
E
R
G
S
T
P
Site 54
S382
S
A
S
V
E
R
G
S
T
P
D
S
T
L
K
Site 55
T383
A
S
V
E
R
G
S
T
P
D
S
T
L
K
P
Site 56
S386
E
R
G
S
T
P
D
S
T
L
K
P
L
R
G
Site 57
T387
R
G
S
T
P
D
S
T
L
K
P
L
R
G
Q
Site 58
Y409
Q
G
W
T
K
V
V
Y
S
C
P
Y
C
S
K
Site 59
Y413
K
V
V
Y
S
C
P
Y
C
S
K
R
D
F
N
Site 60
S421
C
S
K
R
D
F
N
S
L
A
V
L
E
I
H
Site 61
Y454
L
D
S
M
P
T
L
Y
N
L
N
E
H
V
R
Site 62
Y469
K
L
H
K
N
H
A
Y
P
V
M
Q
F
G
N
Site 63
S511
C
G
P
N
A
N
P
S
D
G
N
N
A
F
F
Site 64
T528
Q
C
S
M
G
F
L
T
E
S
S
L
T
E
H
Site 65
S530
S
M
G
F
L
T
E
S
S
L
T
E
H
I
Q
Site 66
S531
M
G
F
L
T
E
S
S
L
T
E
H
I
Q
Q
Site 67
T533
F
L
T
E
S
S
L
T
E
H
I
Q
Q
A
H
Site 68
S550
V
G
S
A
K
L
E
S
P
V
V
Q
P
T
Q
Site 69
T556
E
S
P
V
V
Q
P
T
Q
S
F
M
E
V
Y
Site 70
Y563
T
Q
S
F
M
E
V
Y
S
C
P
Y
C
T
N
Site 71
S576
T
N
S
P
I
F
G
S
I
L
K
L
T
K
H
Site 72
T581
F
G
S
I
L
K
L
T
K
H
I
K
E
N
H
Site 73
S599
P
L
A
H
S
K
K
S
K
A
E
Q
S
P
V
Site 74
S604
K
K
S
K
A
E
Q
S
P
V
S
S
D
V
E
Site 75
S607
K
A
E
Q
S
P
V
S
S
D
V
E
V
S
S
Site 76
S608
A
E
Q
S
P
V
S
S
D
V
E
V
S
S
P
Site 77
S613
V
S
S
D
V
E
V
S
S
P
K
R
Q
R
L
Site 78
S614
S
S
D
V
E
V
S
S
P
K
R
Q
R
L
S
Site 79
S621
S
P
K
R
Q
R
L
S
A
S
A
N
S
I
S
Site 80
S623
K
R
Q
R
L
S
A
S
A
N
S
I
S
N
G
Site 81
S626
R
L
S
A
S
A
N
S
I
S
N
G
E
Y
P
Site 82
Y632
N
S
I
S
N
G
E
Y
P
C
N
Q
C
D
L
Site 83
S646
L
K
F
S
N
F
E
S
F
Q
T
H
L
K
L
Site 84
S673
Q
C
K
E
D
F
D
S
Q
E
S
L
L
Q
H
Site 85
S676
E
D
F
D
S
Q
E
S
L
L
Q
H
L
T
V
Site 86
T682
E
S
L
L
Q
H
L
T
V
H
Y
M
T
T
S
Site 87
Y685
L
Q
H
L
T
V
H
Y
M
T
T
S
T
H
Y
Site 88
Y692
Y
M
T
T
S
T
H
Y
V
C
E
S
C
D
K
Site 89
S702
E
S
C
D
K
Q
F
S
S
V
D
D
L
Q
K
Site 90
S703
S
C
D
K
Q
F
S
S
V
D
D
L
Q
K
H
Site 91
Y807
I
T
T
H
S
K
K
Y
N
C
K
F
C
S
K
Site 92
T837
H
C
V
F
D
A
A
T
E
N
G
T
A
N
G
Site 93
S871
K
N
P
E
A
P
N
S
H
E
A
S
E
D
D
Site 94
S875
A
P
N
S
H
E
A
S
E
D
D
V
D
A
S
Site 95
S882
S
E
D
D
V
D
A
S
E
P
M
Y
G
C
D
Site 96
S919
R
P
G
E
D
D
G
S
R
K
K
A
E
F
I
Site 97
T938
K
C
N
V
C
S
R
T
F
F
S
E
N
G
L
Site 98
S941
V
C
S
R
T
F
F
S
E
N
G
L
R
E
H
Site 99
T951
G
L
R
E
H
L
Q
T
H
R
G
P
A
K
H
Site 100
Y959
H
R
G
P
A
K
H
Y
M
C
P
I
C
G
E
Site 101
T975
F
P
S
L
L
T
L
T
E
H
K
V
T
H
S
Site 102
T980
T
L
T
E
H
K
V
T
H
S
K
S
L
D
T
Site 103
S984
H
K
V
T
H
S
K
S
L
D
T
G
T
C
R
Site 104
T989
S
K
S
L
D
T
G
T
C
R
I
C
K
M
P
Site 105
S1016
M
H
P
D
L
R
N
S
L
T
G
F
R
C
V
Site 106
T1040
L
E
L
K
I
H
G
T
F
H
M
Q
K
L
A
Site 107
S1049
H
M
Q
K
L
A
G
S
S
A
A
S
S
P
N
Site 108
S1050
M
Q
K
L
A
G
S
S
A
A
S
S
P
N
G
Site 109
S1053
L
A
G
S
S
A
A
S
S
P
N
G
Q
G
L
Site 110
S1054
A
G
S
S
A
A
S
S
P
N
G
Q
G
L
Q
Site 111
S1075
L
C
L
K
E
F
R
S
K
Q
D
L
V
K
L
Site 112
S1126
G
L
R
C
P
E
C
S
V
K
F
E
S
A
E
Site 113
S1131
E
C
S
V
K
F
E
S
A
E
D
L
E
S
H
Site 114
S1137
E
S
A
E
D
L
E
S
H
M
Q
V
D
H
R
Site 115
T1147
Q
V
D
H
R
D
L
T
P
E
T
S
G
P
R
Site 116
S1151
R
D
L
T
P
E
T
S
G
P
R
K
G
T
Q
Site 117
T1157
T
S
G
P
R
K
G
T
Q
T
S
P
V
P
R
Site 118
T1159
G
P
R
K
G
T
Q
T
S
P
V
P
R
K
K
Site 119
S1160
P
R
K
G
T
Q
T
S
P
V
P
R
K
K
T
Site 120
T1167
S
P
V
P
R
K
K
T
Y
Q
C
I
K
C
Q
Site 121
Y1168
P
V
P
R
K
K
T
Y
Q
C
I
K
C
Q
M
Site 122
Y1259
H
G
Q
E
D
K
I
Y
D
C
S
Q
C
P
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation