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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RFX7
Full Name:
DNA-binding protein RFX7
Alias:
FLJ12994; FLJ21104; Regulatory factor X, 7; RFXDC2
Type:
Unknown function
Mass (Da):
146896
Number AA:
1363
UniProt ID:
Q2KHR2
International Prot ID:
IPI00640136
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003677
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0009889
GO:0010468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
A
F
S
W
I
R
N
T
L
E
E
H
P
E
T
Site 2
T25
T
L
E
E
H
P
E
T
S
L
P
K
Q
E
V
Site 3
S26
L
E
E
H
P
E
T
S
L
P
K
Q
E
V
Y
Site 4
Y33
S
L
P
K
Q
E
V
Y
D
E
Y
K
S
Y
C
Site 5
Y36
K
Q
E
V
Y
D
E
Y
K
S
Y
C
D
N
L
Site 6
Y39
V
Y
D
E
Y
K
S
Y
C
D
N
L
G
Y
H
Site 7
Y45
S
Y
C
D
N
L
G
Y
H
P
L
S
A
A
D
Site 8
S49
N
L
G
Y
H
P
L
S
A
A
D
F
G
K
I
Site 9
T71
M
K
A
R
R
L
G
T
R
G
K
S
K
Y
C
Site 10
S75
R
L
G
T
R
G
K
S
K
Y
C
Y
S
G
L
Site 11
Y77
G
T
R
G
K
S
K
Y
C
Y
S
G
L
R
K
Site 12
Y79
R
G
K
S
K
Y
C
Y
S
G
L
R
K
K
A
Site 13
S80
G
K
S
K
Y
C
Y
S
G
L
R
K
K
A
F
Site 14
T101
P
N
L
D
F
H
K
T
G
D
G
L
E
G
A
Site 15
S138
E
W
A
Q
K
V
L
S
Q
P
F
D
T
V
L
Site 16
S154
L
A
R
F
L
V
K
S
H
Y
I
G
T
K
S
Site 17
Y156
R
F
L
V
K
S
H
Y
I
G
T
K
S
M
A
Site 18
S190
A
F
I
P
T
A
E
S
N
S
F
Q
P
Q
V
Site 19
S192
I
P
T
A
E
S
N
S
F
Q
P
Q
V
K
T
Site 20
T199
S
F
Q
P
Q
V
K
T
L
P
S
P
I
D
A
Site 21
S202
P
Q
V
K
T
L
P
S
P
I
D
A
K
Q
Q
Site 22
S225
Q
Q
E
Q
K
L
Q
S
P
L
P
G
E
S
A
Site 23
S231
Q
S
P
L
P
G
E
S
A
A
K
K
S
E
S
Site 24
S236
G
E
S
A
A
K
K
S
E
S
A
T
S
N
G
Site 25
S238
S
A
A
K
K
S
E
S
A
T
S
N
G
V
T
Site 26
T240
A
K
K
S
E
S
A
T
S
N
G
V
T
N
L
Site 27
T245
S
A
T
S
N
G
V
T
N
L
P
N
G
N
P
Site 28
S253
N
L
P
N
G
N
P
S
I
L
S
P
Q
P
I
Site 29
S282
R
T
R
Q
L
V
T
S
P
S
P
M
S
S
S
Site 30
S284
R
Q
L
V
T
S
P
S
P
M
S
S
S
D
G
Site 31
S287
V
T
S
P
S
P
M
S
S
S
D
G
K
V
L
Site 32
S288
T
S
P
S
P
M
S
S
S
D
G
K
V
L
P
Site 33
S289
S
P
S
P
M
S
S
S
D
G
K
V
L
P
L
Site 34
S307
V
V
T
Q
H
M
Q
S
V
K
Q
A
P
K
T
Site 35
T314
S
V
K
Q
A
P
K
T
P
Q
N
V
P
A
S
Site 36
S321
T
P
Q
N
V
P
A
S
P
G
G
D
R
S
A
Site 37
S327
A
S
P
G
G
D
R
S
A
R
H
R
Y
P
Q
Site 38
Y332
D
R
S
A
R
H
R
Y
P
Q
I
L
P
K
P
Site 39
T346
P
A
N
T
S
A
L
T
I
R
S
P
T
T
V
Site 40
S349
T
S
A
L
T
I
R
S
P
T
T
V
L
F
T
Site 41
S358
T
T
V
L
F
T
S
S
P
I
K
T
A
V
V
Site 42
S382
V
V
K
M
T
T
I
S
L
T
P
S
N
S
N
Site 43
T384
K
M
T
T
I
S
L
T
P
S
N
S
N
T
P
Site 44
S386
T
T
I
S
L
T
P
S
N
S
N
T
P
L
K
Site 45
S388
I
S
L
T
P
S
N
S
N
T
P
L
K
H
S
Site 46
T390
L
T
P
S
N
S
N
T
P
L
K
H
S
A
S
Site 47
S395
S
N
T
P
L
K
H
S
A
S
V
S
S
A
T
Site 48
S397
T
P
L
K
H
S
A
S
V
S
S
A
T
G
T
Site 49
S399
L
K
H
S
A
S
V
S
S
A
T
G
T
T
E
Site 50
T404
S
V
S
S
A
T
G
T
T
E
E
S
R
S
V
Site 51
S408
A
T
G
T
T
E
E
S
R
S
V
P
Q
I
K
Site 52
S410
G
T
T
E
E
S
R
S
V
P
Q
I
K
N
G
Site 53
S418
V
P
Q
I
K
N
G
S
V
V
S
L
Q
S
P
Site 54
S421
I
K
N
G
S
V
V
S
L
Q
S
P
G
S
R
Site 55
S424
G
S
V
V
S
L
Q
S
P
G
S
R
S
S
S
Site 56
S427
V
S
L
Q
S
P
G
S
R
S
S
S
A
G
G
Site 57
S429
L
Q
S
P
G
S
R
S
S
S
A
G
G
T
S
Site 58
S430
Q
S
P
G
S
R
S
S
S
A
G
G
T
S
A
Site 59
S431
S
P
G
S
R
S
S
S
A
G
G
T
S
A
V
Site 60
S447
V
K
V
E
P
E
T
S
S
D
E
H
P
V
Q
Site 61
S448
K
V
E
P
E
T
S
S
D
E
H
P
V
Q
C
Site 62
S459
P
V
Q
C
Q
E
N
S
D
E
A
K
A
P
Q
Site 63
T467
D
E
A
K
A
P
Q
T
P
S
A
L
L
G
Q
Site 64
S476
S
A
L
L
G
Q
K
S
N
T
D
G
A
L
Q
Site 65
T496
G
V
I
E
I
K
A
T
K
V
C
D
Q
R
T
Site 66
S507
D
Q
R
T
K
C
K
S
R
C
N
E
M
L
P
Site 67
T518
E
M
L
P
G
T
S
T
G
N
N
Q
S
T
I
Site 68
S523
T
S
T
G
N
N
Q
S
T
I
T
L
S
V
A
Site 69
T524
S
T
G
N
N
Q
S
T
I
T
L
S
V
A
S
Site 70
T526
G
N
N
Q
S
T
I
T
L
S
V
A
S
Q
N
Site 71
S528
N
Q
S
T
I
T
L
S
V
A
S
Q
N
L
T
Site 72
T535
S
V
A
S
Q
N
L
T
F
T
S
S
S
S
P
Site 73
T537
A
S
Q
N
L
T
F
T
S
S
S
S
P
P
N
Site 74
S538
S
Q
N
L
T
F
T
S
S
S
S
P
P
N
G
Site 75
S539
Q
N
L
T
F
T
S
S
S
S
P
P
N
G
D
Site 76
S540
N
L
T
F
T
S
S
S
S
P
P
N
G
D
S
Site 77
S541
L
T
F
T
S
S
S
S
P
P
N
G
D
S
I
Site 78
S547
S
S
P
P
N
G
D
S
I
N
K
D
P
K
L
Site 79
T556
N
K
D
P
K
L
C
T
K
S
P
R
K
R
L
Site 80
S558
D
P
K
L
C
T
K
S
P
R
K
R
L
S
S
Site 81
S564
K
S
P
R
K
R
L
S
S
T
L
Q
E
T
Q
Site 82
S565
S
P
R
K
R
L
S
S
T
L
Q
E
T
Q
V
Site 83
T566
P
R
K
R
L
S
S
T
L
Q
E
T
Q
V
P
Site 84
T570
L
S
S
T
L
Q
E
T
Q
V
P
P
V
K
K
Site 85
S605
K
D
Q
K
V
P
H
S
G
K
T
E
G
S
T
Site 86
S626
S
K
V
S
V
N
V
S
S
H
I
G
A
N
Q
Site 87
S638
A
N
Q
P
L
N
S
S
A
L
V
I
S
D
S
Site 88
S643
N
S
S
A
L
V
I
S
D
S
A
L
E
Q
Q
Site 89
S645
S
A
L
V
I
S
D
S
A
L
E
Q
Q
T
T
Site 90
T651
D
S
A
L
E
Q
Q
T
T
P
S
S
S
P
D
Site 91
T652
S
A
L
E
Q
Q
T
T
P
S
S
S
P
D
I
Site 92
S654
L
E
Q
Q
T
T
P
S
S
S
P
D
I
K
V
Site 93
S655
E
Q
Q
T
T
P
S
S
S
P
D
I
K
V
K
Site 94
S656
Q
Q
T
T
P
S
S
S
P
D
I
K
V
K
L
Site 95
S672
G
S
V
F
L
L
D
S
D
S
K
S
V
G
S
Site 96
S674
V
F
L
L
D
S
D
S
K
S
V
G
S
F
N
Site 97
S676
L
L
D
S
D
S
K
S
V
G
S
F
N
P
N
Site 98
S679
S
D
S
K
S
V
G
S
F
N
P
N
G
W
Q
Site 99
S696
T
K
D
S
E
F
I
S
A
S
C
E
Q
Q
Q
Site 100
S714
V
M
T
I
P
E
H
S
D
I
N
D
L
E
K
Site 101
S722
D
I
N
D
L
E
K
S
V
W
E
L
E
G
M
Site 102
T733
L
E
G
M
P
Q
D
T
Y
S
Q
Q
L
H
S
Site 103
Y734
E
G
M
P
Q
D
T
Y
S
Q
Q
L
H
S
Q
Site 104
S735
G
M
P
Q
D
T
Y
S
Q
Q
L
H
S
Q
I
Site 105
S740
T
Y
S
Q
Q
L
H
S
Q
I
Q
E
S
S
L
Site 106
S746
H
S
Q
I
Q
E
S
S
L
N
Q
I
Q
A
H
Site 107
S770
E
L
K
E
F
E
P
S
V
S
Q
T
N
E
S
Site 108
S772
K
E
F
E
P
S
V
S
Q
T
N
E
S
Y
F
Site 109
T774
F
E
P
S
V
S
Q
T
N
E
S
Y
F
P
F
Site 110
Y778
V
S
Q
T
N
E
S
Y
F
P
F
D
D
E
L
Site 111
T786
F
P
F
D
D
E
L
T
Q
D
S
I
V
E
E
Site 112
S789
D
D
E
L
T
Q
D
S
I
V
E
E
L
V
L
Site 113
Y809
S
M
N
N
S
H
S
Y
G
N
C
L
G
M
T
Site 114
S821
G
M
T
L
Q
S
Q
S
V
T
P
G
A
P
M
Site 115
T823
T
L
Q
S
Q
S
V
T
P
G
A
P
M
S
S
Site 116
S829
V
T
P
G
A
P
M
S
S
H
T
S
S
T
H
Site 117
S830
T
P
G
A
P
M
S
S
H
T
S
S
T
H
F
Site 118
S833
A
P
M
S
S
H
T
S
S
T
H
F
Y
H
P
Site 119
S834
P
M
S
S
H
T
S
S
T
H
F
Y
H
P
I
Site 120
Y838
H
T
S
S
T
H
F
Y
H
P
I
H
S
N
G
Site 121
T846
H
P
I
H
S
N
G
T
P
I
H
T
P
T
P
Site 122
T850
S
N
G
T
P
I
H
T
P
T
P
T
P
T
P
Site 123
T852
G
T
P
I
H
T
P
T
P
T
P
T
P
T
P
Site 124
T854
P
I
H
T
P
T
P
T
P
T
P
T
P
T
P
Site 125
T856
H
T
P
T
P
T
P
T
P
T
P
T
P
T
P
Site 126
T858
P
T
P
T
P
T
P
T
P
T
P
T
P
T
P
Site 127
T862
P
T
P
T
P
T
P
T
P
T
P
T
P
T
S
Site 128
T864
P
T
P
T
P
T
P
T
P
T
P
T
S
E
M
Site 129
T866
P
T
P
T
P
T
P
T
P
T
S
E
M
I
A
Site 130
S869
T
P
T
P
T
P
T
S
E
M
I
A
G
S
Q
Site 131
S875
T
S
E
M
I
A
G
S
Q
S
L
S
R
E
S
Site 132
S877
E
M
I
A
G
S
Q
S
L
S
R
E
S
P
C
Site 133
S879
I
A
G
S
Q
S
L
S
R
E
S
P
C
S
R
Site 134
S882
S
Q
S
L
S
R
E
S
P
C
S
R
L
A
Q
Site 135
S885
L
S
R
E
S
P
C
S
R
L
A
Q
T
T
P
Site 136
T890
P
C
S
R
L
A
Q
T
T
P
V
D
S
A
L
Site 137
T891
C
S
R
L
A
Q
T
T
P
V
D
S
A
L
G
Site 138
S895
A
Q
T
T
P
V
D
S
A
L
G
S
S
R
H
Site 139
S899
P
V
D
S
A
L
G
S
S
R
H
T
P
I
G
Site 140
T903
A
L
G
S
S
R
H
T
P
I
G
T
P
H
S
Site 141
T907
S
R
H
T
P
I
G
T
P
H
S
N
C
S
S
Site 142
S910
T
P
I
G
T
P
H
S
N
C
S
S
S
V
P
Site 143
S913
G
T
P
H
S
N
C
S
S
S
V
P
P
S
P
Site 144
S914
T
P
H
S
N
C
S
S
S
V
P
P
S
P
V
Site 145
S915
P
H
S
N
C
S
S
S
V
P
P
S
P
V
E
Site 146
S919
C
S
S
S
V
P
P
S
P
V
E
C
R
N
P
Site 147
S933
P
F
A
F
T
P
I
S
S
S
M
A
Y
H
D
Site 148
S935
A
F
T
P
I
S
S
S
M
A
Y
H
D
A
S
Site 149
S945
Y
H
D
A
S
I
V
S
S
S
P
V
K
P
M
Site 150
S946
H
D
A
S
I
V
S
S
S
P
V
K
P
M
Q
Site 151
S947
D
A
S
I
V
S
S
S
P
V
K
P
M
Q
R
Site 152
Y972
L
E
W
M
N
N
G
Y
S
G
V
G
N
S
S
Site 153
S978
G
Y
S
G
V
G
N
S
S
V
S
G
H
G
I
Site 154
S981
G
V
G
N
S
S
V
S
G
H
G
I
L
P
S
Site 155
S988
S
G
H
G
I
L
P
S
Y
Q
E
L
V
E
D
Site 156
Y989
G
H
G
I
L
P
S
Y
Q
E
L
V
E
D
R
Site 157
S1009
A
F
A
V
P
G
Q
S
Y
Q
S
Q
S
R
H
Site 158
Y1010
F
A
V
P
G
Q
S
Y
Q
S
Q
S
R
H
H
Site 159
S1012
V
P
G
Q
S
Y
Q
S
Q
S
R
H
H
D
T
Site 160
T1019
S
Q
S
R
H
H
D
T
H
F
G
R
L
T
P
Site 161
T1025
D
T
H
F
G
R
L
T
P
V
S
P
V
Q
H
Site 162
S1028
F
G
R
L
T
P
V
S
P
V
Q
H
Q
G
A
Site 163
T1057
A
P
L
D
N
K
G
T
N
S
S
A
S
S
N
Site 164
S1059
L
D
N
K
G
T
N
S
S
A
S
S
N
F
R
Site 165
S1060
D
N
K
G
T
N
S
S
A
S
S
N
F
R
C
Site 166
S1063
G
T
N
S
S
A
S
S
N
F
R
C
R
S
V
Site 167
S1069
S
S
N
F
R
C
R
S
V
S
P
A
V
H
R
Site 168
S1071
N
F
R
C
R
S
V
S
P
A
V
H
R
Q
R
Site 169
S1081
V
H
R
Q
R
N
L
S
G
S
T
L
Y
P
V
Site 170
S1083
R
Q
R
N
L
S
G
S
T
L
Y
P
V
S
N
Site 171
T1084
Q
R
N
L
S
G
S
T
L
Y
P
V
S
N
I
Site 172
Y1086
N
L
S
G
S
T
L
Y
P
V
S
N
I
P
R
Site 173
S1089
G
S
T
L
Y
P
V
S
N
I
P
R
S
N
V
Site 174
S1094
P
V
S
N
I
P
R
S
N
V
T
P
F
G
S
Site 175
T1097
N
I
P
R
S
N
V
T
P
F
G
S
P
V
T
Site 176
S1101
S
N
V
T
P
F
G
S
P
V
T
P
E
V
H
Site 177
S1126
A
N
N
I
A
Q
R
S
Q
S
V
P
L
T
V
Site 178
S1128
N
I
A
Q
R
S
Q
S
V
P
L
T
V
M
M
Site 179
T1153
Q
A
N
S
K
K
I
T
N
V
L
L
S
K
L
Site 180
S1158
K
I
T
N
V
L
L
S
K
L
D
S
D
N
D
Site 181
S1162
V
L
L
S
K
L
D
S
D
N
D
D
A
V
R
Site 182
S1178
L
G
M
N
N
L
P
S
N
Y
T
A
R
M
N
Site 183
T1181
N
N
L
P
S
N
Y
T
A
R
M
N
L
T
Q
Site 184
T1187
Y
T
A
R
M
N
L
T
Q
I
L
E
P
S
T
Site 185
T1194
T
Q
I
L
E
P
S
T
V
F
P
S
A
N
P
Site 186
S1198
E
P
S
T
V
F
P
S
A
N
P
Q
N
M
I
Site 187
S1207
N
P
Q
N
M
I
D
S
S
T
S
V
Y
E
F
Site 188
S1208
P
Q
N
M
I
D
S
S
T
S
V
Y
E
F
Q
Site 189
Y1212
I
D
S
S
T
S
V
Y
E
F
Q
T
P
S
Y
Site 190
T1216
T
S
V
Y
E
F
Q
T
P
S
Y
L
T
K
S
Site 191
S1218
V
Y
E
F
Q
T
P
S
Y
L
T
K
S
N
S
Site 192
Y1219
Y
E
F
Q
T
P
S
Y
L
T
K
S
N
S
T
Site 193
T1221
F
Q
T
P
S
Y
L
T
K
S
N
S
T
G
Q
Site 194
S1223
T
P
S
Y
L
T
K
S
N
S
T
G
Q
I
N
Site 195
S1225
S
Y
L
T
K
S
N
S
T
G
Q
I
N
F
S
Site 196
S1232
S
T
G
Q
I
N
F
S
P
G
D
N
Q
A
Q
Site 197
S1240
P
G
D
N
Q
A
Q
S
E
I
G
E
Q
Q
L
Site 198
S1251
E
Q
Q
L
D
F
N
S
T
V
K
D
L
L
S
Site 199
T1252
Q
Q
L
D
F
N
S
T
V
K
D
L
L
S
G
Site 200
S1258
S
T
V
K
D
L
L
S
G
D
S
L
Q
T
N
Site 201
S1261
K
D
L
L
S
G
D
S
L
Q
T
N
Q
Q
L
Site 202
T1277
G
Q
G
A
S
D
L
T
N
T
A
S
D
F
S
Site 203
T1279
G
A
S
D
L
T
N
T
A
S
D
F
S
S
D
Site 204
S1281
S
D
L
T
N
T
A
S
D
F
S
S
D
I
R
Site 205
S1284
T
N
T
A
S
D
F
S
S
D
I
R
L
S
S
Site 206
S1285
N
T
A
S
D
F
S
S
D
I
R
L
S
S
E
Site 207
S1290
F
S
S
D
I
R
L
S
S
E
L
S
G
S
I
Site 208
S1291
S
S
D
I
R
L
S
S
E
L
S
G
S
I
N
Site 209
S1294
I
R
L
S
S
E
L
S
G
S
I
N
D
L
N
Site 210
S1296
L
S
S
E
L
S
G
S
I
N
D
L
N
T
L
Site 211
T1322
Q
G
Q
D
D
E
A
T
L
E
E
L
K
N
D
Site 212
S1339
F
Q
Q
I
C
S
E
S
M
N
S
M
T
S
S
Site 213
S1342
I
C
S
E
S
M
N
S
M
T
S
S
G
F
E
Site 214
T1344
S
E
S
M
N
S
M
T
S
S
G
F
E
W
I
Site 215
S1346
S
M
N
S
M
T
S
S
G
F
E
W
I
E
S
Site 216
S1353
S
G
F
E
W
I
E
S
K
D
H
P
T
V
E
Site 217
T1358
I
E
S
K
D
H
P
T
V
E
M
L
G
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation