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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CSPP1
Full Name:
Centrosome and spindle pole-associated protein 1
Alias:
Centrosome and spindle pole associated protein 1; Centrosome spindle pole associated protein 1; CSPP; FLJ22490
Type:
Mass (Da):
141751
Number AA:
1221
UniProt ID:
Q1MSJ5
International Prot ID:
IPI00424603
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005874
GO:0005819
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
Q
V
A
A
V
T
S
S
V
R
D
D
P
L
E
Site 2
S24
D
P
L
E
H
C
V
S
P
R
T
R
A
R
S
Site 3
T27
E
H
C
V
S
P
R
T
R
A
R
S
P
E
I
Site 4
S31
S
P
R
T
R
A
R
S
P
E
I
C
K
M
A
Site 5
S61
E
D
K
A
E
L
E
S
D
P
P
Y
M
E
M
Site 6
Y65
E
L
E
S
D
P
P
Y
M
E
M
K
G
K
L
Site 7
S73
M
E
M
K
G
K
L
S
A
K
L
S
E
N
S
Site 8
S77
G
K
L
S
A
K
L
S
E
N
S
K
I
L
I
Site 9
S95
K
E
N
I
P
P
N
S
Q
Q
T
R
G
S
L
Site 10
S101
N
S
Q
Q
T
R
G
S
L
G
I
D
Y
G
L
Site 11
Y116
S
L
P
L
G
E
D
Y
E
R
K
K
H
K
L
Site 12
Y131
K
E
E
L
R
Q
D
Y
R
R
Y
L
T
Q
E
Site 13
Y134
L
R
Q
D
Y
R
R
Y
L
T
Q
E
R
L
K
Site 14
T136
Q
D
Y
R
R
Y
L
T
Q
E
R
L
K
L
E
Site 15
S158
F
L
R
G
K
E
E
S
S
E
K
F
R
Q
V
Site 16
S168
K
F
R
Q
V
E
K
S
T
E
P
K
S
Q
R
Site 17
S173
E
K
S
T
E
P
K
S
Q
R
N
K
K
P
I
Site 18
T188
G
Q
V
K
P
D
L
T
S
Q
I
Q
T
S
C
Site 19
S189
Q
V
K
P
D
L
T
S
Q
I
Q
T
S
C
E
Site 20
T193
D
L
T
S
Q
I
Q
T
S
C
E
N
S
E
G
Site 21
S194
L
T
S
Q
I
Q
T
S
C
E
N
S
E
G
P
Site 22
S198
I
Q
T
S
C
E
N
S
E
G
P
R
K
D
V
Site 23
T207
G
P
R
K
D
V
L
T
P
S
E
A
Y
E
E
Site 24
S209
R
K
D
V
L
T
P
S
E
A
Y
E
E
L
L
Site 25
Y226
R
R
L
E
E
D
R
Y
R
Q
L
D
D
E
I
Site 26
S260
L
K
H
Q
R
F
A
S
K
A
G
I
P
D
R
Site 27
Y282
D
R
V
F
D
R
R
Y
H
R
P
D
Q
D
P
Site 28
S292
P
D
Q
D
P
E
V
S
E
E
M
D
E
R
F
Site 29
Y301
E
M
D
E
R
F
R
Y
E
S
D
F
D
R
R
Site 30
S303
D
E
R
F
R
Y
E
S
D
F
D
R
R
L
S
Site 31
S310
S
D
F
D
R
R
L
S
R
V
Y
T
N
D
R
Site 32
Y313
D
R
R
L
S
R
V
Y
T
N
D
R
M
H
R
Site 33
T314
R
R
L
S
R
V
Y
T
N
D
R
M
H
R
N
Site 34
S339
D
G
D
V
I
E
Q
S
N
I
R
I
S
S
A
Site 35
S344
E
Q
S
N
I
R
I
S
S
A
E
N
K
S
A
Site 36
S345
Q
S
N
I
R
I
S
S
A
E
N
K
S
A
P
Site 37
S357
S
A
P
D
N
E
T
S
K
S
A
N
Q
D
T
Site 38
S359
P
D
N
E
T
S
K
S
A
N
Q
D
T
C
S
Site 39
T364
S
K
S
A
N
Q
D
T
C
S
P
F
A
G
M
Site 40
Y388
I
Q
R
R
K
E
K
Y
R
L
E
L
L
E
Q
Site 41
S424
G
A
Q
D
P
E
K
S
P
D
R
L
K
Q
F
Site 42
S432
P
D
R
L
K
Q
F
S
V
A
P
R
H
F
E
Site 43
T453
R
P
R
I
A
F
Q
T
P
L
P
P
L
S
A
Site 44
S468
P
S
V
P
P
I
P
S
V
H
P
V
P
S
Q
Site 45
S474
P
S
V
H
P
V
P
S
Q
N
E
D
L
R
S
Site 46
S481
S
Q
N
E
D
L
R
S
G
L
S
S
A
L
G
Site 47
T509
P
L
L
P
P
L
A
T
N
Y
R
T
P
Y
D
Site 48
Y511
L
P
P
L
A
T
N
Y
R
T
P
Y
D
D
A
Site 49
T513
P
L
A
T
N
Y
R
T
P
Y
D
D
A
Y
Y
Site 50
Y515
A
T
N
Y
R
T
P
Y
D
D
A
Y
Y
F
Y
Site 51
Y519
R
T
P
Y
D
D
A
Y
Y
F
Y
G
S
R
N
Site 52
Y520
T
P
Y
D
D
A
Y
Y
F
Y
G
S
R
N
T
Site 53
Y522
Y
D
D
A
Y
Y
F
Y
G
S
R
N
T
F
D
Site 54
T527
Y
F
Y
G
S
R
N
T
F
D
P
S
L
A
Y
Site 55
S531
S
R
N
T
F
D
P
S
L
A
Y
Y
G
S
G
Site 56
Y534
T
F
D
P
S
L
A
Y
Y
G
S
G
M
M
G
Site 57
S537
P
S
L
A
Y
Y
G
S
G
M
M
G
V
Q
P
Site 58
T572
G
Q
N
E
L
K
I
T
S
D
Q
V
I
N
S
Site 59
S590
F
E
D
K
P
K
P
S
K
Q
S
L
Q
S
Y
Site 60
S593
K
P
K
P
S
K
Q
S
L
Q
S
Y
Q
E
A
Site 61
S596
P
S
K
Q
S
L
Q
S
Y
Q
E
A
L
Q
Q
Site 62
Y597
S
K
Q
S
L
Q
S
Y
Q
E
A
L
Q
Q
Q
Site 63
Y622
E
R
E
E
K
E
E
Y
E
A
K
L
E
A
E
Site 64
T632
K
L
E
A
E
M
R
T
Y
N
P
W
G
K
G
Site 65
Y633
L
E
A
E
M
R
T
Y
N
P
W
G
K
G
G
Site 66
Y667
H
R
Q
N
I
D
A
Y
H
N
P
D
A
R
T
Site 67
Y675
H
N
P
D
A
R
T
Y
E
D
K
R
A
V
V
Site 68
S683
E
D
K
R
A
V
V
S
L
D
P
N
L
A
T
Site 69
S691
L
D
P
N
L
A
T
S
N
A
E
N
L
E
D
Site 70
T709
K
S
S
G
H
M
Q
T
Q
S
S
P
F
A
R
Site 71
S711
S
G
H
M
Q
T
Q
S
S
P
F
A
R
G
N
Site 72
S712
G
H
M
Q
T
Q
S
S
P
F
A
R
G
N
V
Site 73
Y735
Q
I
K
Q
Q
E
L
Y
K
N
F
L
R
F
Q
Site 74
Y779
R
A
R
I
Q
Q
E
Y
E
E
E
Q
E
K
K
Site 75
Y822
K
K
E
E
E
G
K
Y
N
L
Q
L
Q
H
Y
Site 76
Y829
Y
N
L
Q
L
Q
H
Y
C
E
R
D
N
L
I
Site 77
S847
T
K
H
M
R
Q
P
S
P
I
V
P
A
L
Q
Site 78
S866
S
K
L
Q
R
P
P
S
V
D
S
I
I
R
S
Site 79
S869
Q
R
P
P
S
V
D
S
I
I
R
S
F
I
H
Site 80
S873
S
V
D
S
I
I
R
S
F
I
H
E
S
S
M
Site 81
S879
R
S
F
I
H
E
S
S
M
S
R
A
Q
S
P
Site 82
S881
F
I
H
E
S
S
M
S
R
A
Q
S
P
P
V
Site 83
S885
S
S
M
S
R
A
Q
S
P
P
V
P
A
R
K
Site 84
S917
E
M
R
K
Q
L
R
S
E
E
R
R
L
Q
E
Site 85
S931
E
R
L
L
H
M
D
S
D
D
E
I
P
I
R
Site 86
S963
Q
A
P
V
R
R
Q
S
P
K
G
L
D
A
A
Site 87
T971
P
K
G
L
D
A
A
T
F
Q
N
V
H
D
F
Site 88
S986
N
E
L
K
D
R
D
S
E
T
R
V
D
L
K
Site 89
T988
L
K
D
R
D
S
E
T
R
V
D
L
K
F
M
Site 90
Y996
R
V
D
L
K
F
M
Y
L
D
P
P
R
D
H
Site 91
T1005
D
P
P
R
D
H
H
T
L
E
I
Q
Q
Q
A
Site 92
T1052
Q
R
M
P
R
D
D
T
S
D
F
L
K
N
S
Site 93
S1053
R
M
P
R
D
D
T
S
D
F
L
K
N
S
L
Site 94
S1059
T
S
D
F
L
K
N
S
L
L
E
S
D
S
A
Site 95
Y1075
I
G
A
Y
G
E
T
Y
P
A
I
E
D
D
V
Site 96
S1087
D
D
V
L
P
P
P
S
Q
L
P
S
A
R
E
Site 97
S1091
P
P
P
S
Q
L
P
S
A
R
E
R
R
R
N
Site 98
S1107
W
K
G
L
D
I
D
S
S
R
P
N
V
A
P
Site 99
S1108
K
G
L
D
I
D
S
S
R
P
N
V
A
P
D
Site 100
S1121
P
D
G
L
S
L
K
S
I
S
S
V
N
V
D
Site 101
S1124
L
S
L
K
S
I
S
S
V
N
V
D
E
L
R
Site 102
T1151
F
H
N
K
P
I
N
T
D
D
E
S
S
L
V
Site 103
S1155
P
I
N
T
D
D
E
S
S
L
V
D
P
D
D
Site 104
S1156
I
N
T
D
D
E
S
S
L
V
D
P
D
D
I
Site 105
S1172
K
H
I
G
D
D
G
S
N
S
V
A
T
E
P
Site 106
S1174
I
G
D
D
G
S
N
S
V
A
T
E
P
W
L
Site 107
T1185
E
P
W
L
R
P
G
T
S
E
T
L
K
R
F
Site 108
S1186
P
W
L
R
P
G
T
S
E
T
L
K
R
F
M
Site 109
T1188
L
R
P
G
T
S
E
T
L
K
R
F
M
A
E
Site 110
T1210
Q
I
P
G
K
P
G
T
F
T
W
Q
G
L
S
Site 111
T1212
P
G
K
P
G
T
F
T
W
Q
G
L
S
T
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation