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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GEN1
Full Name:
Flap endonuclease GEN homolog 1
Alias:
FLJ40869; Gen; Gen 1, endonuclease; gen1, endonuclease; LOC348654
Type:
EC 3.1.-.-; Hydrolase
Mass (Da):
102884
Number AA:
908
UniProt ID:
Q17RS7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0004519
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S47
T
V
K
K
M
M
G
S
V
M
K
P
H
L
R
Site 2
S87
K
L
K
A
D
V
I
S
K
R
N
Q
T
R
Y
Site 3
T92
V
I
S
K
R
N
Q
T
R
Y
G
S
S
G
K
Site 4
Y94
S
K
R
N
Q
T
R
Y
G
S
S
G
K
S
W
Site 5
S96
R
N
Q
T
R
Y
G
S
S
G
K
S
W
S
Q
Site 6
S100
R
Y
G
S
S
G
K
S
W
S
Q
K
T
G
R
Site 7
S102
G
S
S
G
K
S
W
S
Q
K
T
G
R
S
H
Site 8
T105
G
K
S
W
S
Q
K
T
G
R
S
H
F
K
S
Site 9
S108
W
S
Q
K
T
G
R
S
H
F
K
S
V
L
R
Site 10
S112
T
G
R
S
H
F
K
S
V
L
R
E
C
L
H
Site 11
T153
G
H
V
D
G
C
L
T
N
D
G
D
T
F
L
Site 12
T158
C
L
T
N
D
G
D
T
F
L
Y
G
A
Q
T
Site 13
Y161
N
D
G
D
T
F
L
Y
G
A
Q
T
V
Y
R
Site 14
Y167
L
Y
G
A
Q
T
V
Y
R
N
F
T
M
N
T
Site 15
Y182
K
D
P
H
V
D
C
Y
T
M
S
S
I
K
S
Site 16
T183
D
P
H
V
D
C
Y
T
M
S
S
I
K
S
K
Site 17
S185
H
V
D
C
Y
T
M
S
S
I
K
S
K
L
G
Site 18
S189
Y
T
M
S
S
I
K
S
K
L
G
L
D
R
D
Site 19
S249
N
E
T
S
C
N
S
S
P
Q
L
L
V
T
K
Site 20
S262
T
K
K
L
A
H
C
S
V
C
S
H
P
G
S
Site 21
S265
L
A
H
C
S
V
C
S
H
P
G
S
P
K
D
Site 22
S269
S
V
C
S
H
P
G
S
P
K
D
H
E
R
N
Site 23
Y286
R
L
C
K
S
D
K
Y
C
E
P
H
D
Y
E
Site 24
Y292
K
Y
C
E
P
H
D
Y
E
Y
C
C
P
C
E
Site 25
Y294
C
E
P
H
D
Y
E
Y
C
C
P
C
E
W
H
Site 26
Y370
K
M
E
W
P
N
H
Y
A
C
E
K
L
L
V
Site 27
T380
E
K
L
L
V
L
L
T
H
Y
D
M
I
E
R
Site 28
Y382
L
L
V
L
L
T
H
Y
D
M
I
E
R
K
L
Site 29
S394
R
K
L
G
S
R
N
S
N
Q
L
Q
P
I
R
Site 30
T405
Q
P
I
R
I
V
K
T
R
I
R
N
G
V
H
Site 31
Y449
E
S
L
F
E
A
A
Y
P
E
I
V
A
V
Y
Site 32
S486
P
E
P
D
E
V
M
S
F
Q
S
H
M
T
L
Site 33
S505
E
I
F
H
K
Q
N
S
K
L
N
S
G
I
S
Site 34
S509
K
Q
N
S
K
L
N
S
G
I
S
P
D
P
T
Site 35
S512
S
K
L
N
S
G
I
S
P
D
P
T
L
P
Q
Site 36
T516
S
G
I
S
P
D
P
T
L
P
Q
E
S
I
S
Site 37
S521
D
P
T
L
P
Q
E
S
I
S
A
S
L
N
S
Site 38
T535
S
L
L
L
P
K
N
T
P
C
L
N
A
Q
E
Site 39
S546
N
A
Q
E
Q
F
M
S
S
L
R
P
L
A
I
Site 40
S547
A
Q
E
Q
F
M
S
S
L
R
P
L
A
I
Q
Site 41
S560
I
Q
Q
I
K
A
V
S
K
S
L
I
S
E
S
Site 42
S562
Q
I
K
A
V
S
K
S
L
I
S
E
S
S
Q
Site 43
S565
A
V
S
K
S
L
I
S
E
S
S
Q
P
N
T
Site 44
S567
S
K
S
L
I
S
E
S
S
Q
P
N
T
S
S
Site 45
S568
K
S
L
I
S
E
S
S
Q
P
N
T
S
S
H
Site 46
T572
S
E
S
S
Q
P
N
T
S
S
H
N
I
S
V
Site 47
S573
E
S
S
Q
P
N
T
S
S
H
N
I
S
V
I
Site 48
S574
S
S
Q
P
N
T
S
S
H
N
I
S
V
I
A
Site 49
S578
N
T
S
S
H
N
I
S
V
I
A
D
L
H
L
Site 50
S594
T
I
D
W
E
G
T
S
F
S
N
S
P
A
I
Site 51
S596
D
W
E
G
T
S
F
S
N
S
P
A
I
Q
R
Site 52
S598
E
G
T
S
F
S
N
S
P
A
I
Q
R
N
T
Site 53
T605
S
P
A
I
Q
R
N
T
F
S
H
D
L
K
S
Site 54
S607
A
I
Q
R
N
T
F
S
H
D
L
K
S
E
V
Site 55
S612
T
F
S
H
D
L
K
S
E
V
E
S
E
L
S
Site 56
S616
D
L
K
S
E
V
E
S
E
L
S
A
I
P
D
Site 57
S619
S
E
V
E
S
E
L
S
A
I
P
D
G
F
E
Site 58
S633
E
N
I
P
E
Q
L
S
C
E
S
E
R
Y
T
Site 59
S636
P
E
Q
L
S
C
E
S
E
R
Y
T
A
N
I
Site 60
Y639
L
S
C
E
S
E
R
Y
T
A
N
I
K
K
V
Site 61
T640
S
C
E
S
E
R
Y
T
A
N
I
K
K
V
L
Site 62
S651
K
K
V
L
D
E
D
S
D
G
I
S
P
E
E
Site 63
S655
D
E
D
S
D
G
I
S
P
E
E
H
L
L
S
Site 64
S683
E
R
I
F
I
K
L
S
Y
P
Q
D
N
L
Q
Site 65
Y684
R
I
F
I
K
L
S
Y
P
Q
D
N
L
Q
P
Site 66
T697
Q
P
D
V
N
L
K
T
L
S
I
L
S
V
K
Site 67
S699
D
V
N
L
K
T
L
S
I
L
S
V
K
E
S
Site 68
S711
K
E
S
C
I
A
N
S
G
S
D
C
T
S
H
Site 69
S713
S
C
I
A
N
S
G
S
D
C
T
S
H
L
S
Site 70
S717
N
S
G
S
D
C
T
S
H
L
S
K
D
L
P
Site 71
S720
S
D
C
T
S
H
L
S
K
D
L
P
G
I
P
Site 72
S732
G
I
P
L
Q
N
E
S
R
D
S
K
I
L
K
Site 73
S735
L
Q
N
E
S
R
D
S
K
I
L
K
G
D
Q
Site 74
Y748
D
Q
L
L
Q
E
D
Y
K
V
N
T
S
V
P
Site 75
S753
E
D
Y
K
V
N
T
S
V
P
Y
S
V
S
N
Site 76
Y756
K
V
N
T
S
V
P
Y
S
V
S
N
T
V
V
Site 77
T765
V
S
N
T
V
V
K
T
C
N
V
R
P
P
N
Site 78
T785
S
R
K
V
D
M
Q
T
T
R
K
I
L
M
K
Site 79
T786
R
K
V
D
M
Q
T
T
R
K
I
L
M
K
K
Site 80
S794
R
K
I
L
M
K
K
S
V
C
L
D
R
H
S
Site 81
S801
S
V
C
L
D
R
H
S
S
D
E
Q
S
A
P
Site 82
S802
V
C
L
D
R
H
S
S
D
E
Q
S
A
P
V
Site 83
S806
R
H
S
S
D
E
Q
S
A
P
V
F
G
K
A
Site 84
Y815
P
V
F
G
K
A
K
Y
T
T
Q
R
M
K
H
Site 85
T816
V
F
G
K
A
K
Y
T
T
Q
R
M
K
H
S
Site 86
T817
F
G
K
A
K
Y
T
T
Q
R
M
K
H
S
S
Site 87
S824
T
Q
R
M
K
H
S
S
Q
K
H
N
S
S
H
Site 88
S829
H
S
S
Q
K
H
N
S
S
H
F
K
E
S
G
Site 89
S830
S
S
Q
K
H
N
S
S
H
F
K
E
S
G
H
Site 90
S835
N
S
S
H
F
K
E
S
G
H
N
K
L
S
S
Site 91
S841
E
S
G
H
N
K
L
S
S
P
K
I
H
I
K
Site 92
S842
S
G
H
N
K
L
S
S
P
K
I
H
I
K
E
Site 93
Y857
T
E
Q
C
V
R
S
Y
E
T
A
E
N
E
E
Site 94
S865
E
T
A
E
N
E
E
S
C
F
P
D
S
T
K
Site 95
S870
E
E
S
C
F
P
D
S
T
K
S
S
L
S
S
Site 96
T871
E
S
C
F
P
D
S
T
K
S
S
L
S
S
L
Site 97
S873
C
F
P
D
S
T
K
S
S
L
S
S
L
Q
C
Site 98
S874
F
P
D
S
T
K
S
S
L
S
S
L
Q
C
H
Site 99
S877
S
T
K
S
S
L
S
S
L
Q
C
H
K
K
E
Site 100
T889
K
K
E
N
N
S
G
T
C
L
D
S
P
L
P
Site 101
S893
N
S
G
T
C
L
D
S
P
L
P
L
R
Q
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation