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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RICH2
Full Name:
Rho GTPase-activating protein RICH2
Alias:
KIAA0672; NPC-A-10; RhoGAP interacting with CIP4 homologs protein 2; Rho-type GTPase-activating protein RICH2; RICH-2
Type:
Mass (Da):
89247
Number AA:
818
UniProt ID:
Q17R89
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
T
V
G
R
A
E
K
T
E
V
L
S
E
D
L
Site 2
S43
L
E
L
V
K
Q
V
S
H
S
T
H
K
K
L
Site 3
S151
K
L
V
L
D
M
D
S
S
R
T
R
W
Q
Q
Site 4
S152
L
V
L
D
M
D
S
S
R
T
R
W
Q
Q
T
Site 5
T159
S
R
T
R
W
Q
Q
T
S
K
S
S
G
L
S
Site 6
S160
R
T
R
W
Q
Q
T
S
K
S
S
G
L
S
S
Site 7
S162
R
W
Q
Q
T
S
K
S
S
G
L
S
S
S
L
Site 8
S163
W
Q
Q
T
S
K
S
S
G
L
S
S
S
L
Q
Site 9
S166
T
S
K
S
S
G
L
S
S
S
L
Q
P
A
G
Site 10
S167
S
K
S
S
G
L
S
S
S
L
Q
P
A
G
A
Site 11
S168
K
S
S
G
L
S
S
S
L
Q
P
A
G
A
K
Site 12
Y202
D
Q
L
S
A
D
M
Y
S
F
V
A
K
E
I
Site 13
S203
Q
L
S
A
D
M
Y
S
F
V
A
K
E
I
D
Site 14
Y211
F
V
A
K
E
I
D
Y
A
N
Y
F
Q
T
L
Site 15
Y214
K
E
I
D
Y
A
N
Y
F
Q
T
L
I
E
V
Site 16
Y225
L
I
E
V
Q
A
E
Y
H
R
K
S
L
T
L
Site 17
S229
Q
A
E
Y
H
R
K
S
L
T
L
L
Q
A
V
Site 18
T231
E
Y
H
R
K
S
L
T
L
L
Q
A
V
L
P
Site 19
S252
E
A
W
V
E
K
P
S
F
G
K
P
L
E
E
Site 20
T262
K
P
L
E
E
H
L
T
I
S
G
R
E
I
A
Site 21
S264
L
E
E
H
L
T
I
S
G
R
E
I
A
F
P
Site 22
Y330
I
A
G
A
L
K
S
Y
L
R
E
L
P
E
P
Site 23
T340
E
L
P
E
P
L
M
T
F
E
L
Y
D
E
W
Site 24
Y344
P
L
M
T
F
E
L
Y
D
E
W
I
Q
A
S
Site 25
Y380
A
N
H
N
N
I
R
Y
L
I
K
F
L
S
K
Site 26
S386
R
Y
L
I
K
F
L
S
K
L
S
E
Y
Q
D
Site 27
T398
Y
Q
D
V
N
K
M
T
P
S
N
M
A
I
V
Site 28
T420
P
Q
A
E
G
N
I
T
E
M
M
T
T
V
S
Site 29
T454
G
E
I
E
F
N
I
T
G
N
Y
G
S
P
V
Site 30
Y457
E
F
N
I
T
G
N
Y
G
S
P
V
H
V
N
Site 31
S470
V
N
H
N
A
N
Y
S
S
M
P
S
P
D
M
Site 32
S471
N
H
N
A
N
Y
S
S
M
P
S
P
D
M
D
Site 33
S474
A
N
Y
S
S
M
P
S
P
D
M
D
P
A
D
Site 34
S493
E
Q
A
R
R
P
L
S
V
A
T
D
N
M
M
Site 35
Y504
D
N
M
M
L
E
F
Y
K
K
D
G
L
R
K
Site 36
S514
D
G
L
R
K
I
Q
S
M
G
V
R
V
M
D
Site 37
S530
N
W
V
A
R
R
G
S
S
A
G
R
K
V
S
Site 38
S531
W
V
A
R
R
G
S
S
A
G
R
K
V
S
C
Site 39
S537
S
S
A
G
R
K
V
S
C
A
P
P
S
M
Q
Site 40
S542
K
V
S
C
A
P
P
S
M
Q
P
P
A
P
P
Site 41
S558
E
L
A
A
P
L
P
S
P
L
P
E
Q
P
L
Site 42
S567
L
P
E
Q
P
L
D
S
P
A
A
P
A
L
S
Site 43
S588
Q
P
G
P
E
R
T
S
T
T
K
S
K
E
L
Site 44
T589
P
G
P
E
R
T
S
T
T
K
S
K
E
L
S
Site 45
T590
G
P
E
R
T
S
T
T
K
S
K
E
L
S
P
Site 46
S592
E
R
T
S
T
T
K
S
K
E
L
S
P
G
S
Site 47
S596
T
T
K
S
K
E
L
S
P
G
S
A
Q
K
G
Site 48
S599
S
K
E
L
S
P
G
S
A
Q
K
G
S
P
G
Site 49
S604
P
G
S
A
Q
K
G
S
P
G
S
S
Q
G
T
Site 50
S607
A
Q
K
G
S
P
G
S
S
Q
G
T
A
C
A
Site 51
S608
Q
K
G
S
P
G
S
S
Q
G
T
A
C
A
G
Site 52
T611
S
P
G
S
S
Q
G
T
A
C
A
G
T
Q
P
Site 53
S629
P
G
A
Q
P
G
A
S
P
S
P
S
Q
P
P
Site 54
S631
A
Q
P
G
A
S
P
S
P
S
Q
P
P
A
D
Site 55
S633
P
G
A
S
P
S
P
S
Q
P
P
A
D
Q
S
Site 56
S640
S
Q
P
P
A
D
Q
S
P
H
T
L
R
K
V
Site 57
T643
P
A
D
Q
S
P
H
T
L
R
K
V
S
K
K
Site 58
S648
P
H
T
L
R
K
V
S
K
K
L
A
P
I
P
Site 59
S670
P
G
A
M
A
D
Q
S
A
G
Q
P
S
P
V
Site 60
S675
D
Q
S
A
G
Q
P
S
P
V
S
L
S
P
T
Site 61
S678
A
G
Q
P
S
P
V
S
L
S
P
T
P
P
S
Site 62
S680
Q
P
S
P
V
S
L
S
P
T
P
P
S
T
P
Site 63
T682
S
P
V
S
L
S
P
T
P
P
S
T
P
S
P
Site 64
S685
S
L
S
P
T
P
P
S
T
P
S
P
Y
G
L
Site 65
T686
L
S
P
T
P
P
S
T
P
S
P
Y
G
L
S
Site 66
S688
P
T
P
P
S
T
P
S
P
Y
G
L
S
Y
P
Site 67
Y690
P
P
S
T
P
S
P
Y
G
L
S
Y
P
Q
G
Site 68
S693
T
P
S
P
Y
G
L
S
Y
P
Q
G
Y
S
L
Site 69
Y694
P
S
P
Y
G
L
S
Y
P
Q
G
Y
S
L
A
Site 70
S699
L
S
Y
P
Q
G
Y
S
L
A
S
G
Q
L
S
Site 71
S702
P
Q
G
Y
S
L
A
S
G
Q
L
S
P
A
A
Site 72
S721
A
S
P
S
V
F
T
S
T
L
S
K
S
R
P
Site 73
T722
S
P
S
V
F
T
S
T
L
S
K
S
R
P
T
Site 74
S724
S
V
F
T
S
T
L
S
K
S
R
P
T
P
K
Site 75
S726
F
T
S
T
L
S
K
S
R
P
T
P
K
P
R
Site 76
T729
T
L
S
K
S
R
P
T
P
K
P
R
Q
R
P
Site 77
T737
P
K
P
R
Q
R
P
T
L
P
P
P
Q
P
P
Site 78
T745
L
P
P
P
Q
P
P
T
V
N
L
S
A
S
S
Site 79
S749
Q
P
P
T
V
N
L
S
A
S
S
P
Q
S
T
Site 80
S751
P
T
V
N
L
S
A
S
S
P
Q
S
T
E
A
Site 81
S752
T
V
N
L
S
A
S
S
P
Q
S
T
E
A
P
Site 82
S755
L
S
A
S
S
P
Q
S
T
E
A
P
M
L
D
Site 83
T756
S
A
S
S
P
Q
S
T
E
A
P
M
L
D
G
Site 84
S765
A
P
M
L
D
G
M
S
P
G
E
S
M
S
T
Site 85
S769
D
G
M
S
P
G
E
S
M
S
T
D
L
V
H
Site 86
S771
M
S
P
G
E
S
M
S
T
D
L
V
H
F
D
Site 87
T772
S
P
G
E
S
M
S
T
D
L
V
H
F
D
I
Site 88
S793
L
G
S
T
L
R
L
S
P
L
E
H
M
R
R
Site 89
S802
L
E
H
M
R
R
H
S
V
T
D
K
R
D
S
Site 90
T804
H
M
R
R
H
S
V
T
D
K
R
D
S
E
E
Site 91
S809
S
V
T
D
K
R
D
S
E
E
E
S
E
S
T
Site 92
S813
K
R
D
S
E
E
E
S
E
S
T
A
L
_
_
Site 93
S815
D
S
E
E
E
S
E
S
T
A
L
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation