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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYP51A1
Full Name:
Lanosterol 14-alpha demethylase
Alias:
CYPLI;Cytochrome P450 51A1;Cytochrome P450-14DM;Cytochrome P450LI;Sterol 14-alpha demethylase
Type:
Mass (Da):
56806
Number AA:
503
UniProt ID:
Q16850
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S60
Q
L
P
A
G
V
K
S
P
P
Y
I
F
S
P
Site 2
S66
K
S
P
P
Y
I
F
S
P
I
P
F
L
G
H
Site 3
Y89
I
E
F
L
E
N
A
Y
E
K
Y
G
P
V
F
Site 4
Y92
L
E
N
A
Y
E
K
Y
G
P
V
F
S
F
T
Site 5
S97
E
K
Y
G
P
V
F
S
F
T
M
V
G
K
T
Site 6
Y131
D
L
N
A
E
D
V
Y
S
R
L
T
T
P
V
Site 7
S132
L
N
A
E
D
V
Y
S
R
L
T
T
P
V
F
Site 8
T135
E
D
V
Y
S
R
L
T
T
P
V
F
G
K
G
Site 9
S161
E
Q
K
K
M
L
K
S
G
L
N
I
A
H
F
Site 10
S173
A
H
F
K
Q
H
V
S
I
I
E
K
E
T
K
Site 11
Y182
I
E
K
E
T
K
E
Y
F
E
S
W
G
E
S
Site 12
S185
E
T
K
E
Y
F
E
S
W
G
E
S
G
E
K
Site 13
S189
Y
F
E
S
W
G
E
S
G
E
K
N
V
F
E
Site 14
Y227
N
E
K
V
A
Q
L
Y
A
D
L
D
G
G
F
Site 15
S249
P
G
W
L
P
L
P
S
F
R
R
R
D
R
A
Site 16
Y265
R
E
I
K
D
I
F
Y
K
A
I
Q
K
R
R
Site 17
S274
A
I
Q
K
R
R
Q
S
Q
E
K
I
D
D
I
Site 18
T284
K
I
D
D
I
L
Q
T
L
L
D
A
T
Y
K
Site 19
T289
L
Q
T
L
L
D
A
T
Y
K
D
G
R
P
L
Site 20
Y290
Q
T
L
L
D
A
T
Y
K
D
G
R
P
L
T
Site 21
T297
Y
K
D
G
R
P
L
T
D
D
E
V
A
G
M
Site 22
T315
L
L
L
A
G
Q
H
T
S
S
T
T
S
A
W
Site 23
S316
L
L
A
G
Q
H
T
S
S
T
T
S
A
W
M
Site 24
S317
L
A
G
Q
H
T
S
S
T
T
S
A
W
M
G
Site 25
T318
A
G
Q
H
T
S
S
T
T
S
A
W
M
G
F
Site 26
T332
F
F
L
A
R
D
K
T
L
Q
K
K
C
Y
L
Site 27
Y338
K
T
L
Q
K
K
C
Y
L
E
Q
K
T
V
C
Site 28
T343
K
C
Y
L
E
Q
K
T
V
C
G
E
N
L
P
Site 29
T353
G
E
N
L
P
P
L
T
Y
D
Q
L
K
D
L
Site 30
T370
L
D
R
C
I
K
E
T
L
R
L
R
P
P
I
Site 31
T389
R
M
A
R
T
P
Q
T
V
A
G
Y
T
I
P
Site 32
Y393
T
P
Q
T
V
A
G
Y
T
I
P
P
G
H
Q
Site 33
T394
P
Q
T
V
A
G
Y
T
I
P
P
G
H
Q
V
Site 34
S404
P
G
H
Q
V
C
V
S
P
T
V
N
Q
R
L
Site 35
T406
H
Q
V
C
V
S
P
T
V
N
Q
R
L
K
D
Site 36
S414
V
N
Q
R
L
K
D
S
W
V
E
R
L
D
F
Site 37
Y426
L
D
F
N
P
D
R
Y
L
Q
D
N
P
A
S
Site 38
S433
Y
L
Q
D
N
P
A
S
G
E
K
F
A
Y
V
Site 39
Y439
A
S
G
E
K
F
A
Y
V
P
F
G
A
G
R
Site 40
Y478
E
F
D
L
I
D
G
Y
F
P
T
V
N
Y
T
Site 41
T490
N
Y
T
T
M
I
H
T
P
E
N
P
V
I
R
Site 42
Y498
P
E
N
P
V
I
R
Y
K
R
R
S
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation