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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTPRO
Full Name:
Receptor-type tyrosine-protein phosphatase O
Alias:
Glomerular epithelial protein 1;Protein tyrosine phosphatase U2
Type:
Mass (Da):
138344
Number AA:
1216
UniProt ID:
Q16827
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T840
L
I
G
L
L
L
V
T
L
I
I
L
R
K
K
Site 2
S865
G
T
F
V
N
F
A
S
L
E
R
D
G
K
L
Site 3
Y874
E
R
D
G
K
L
P
Y
N
W
R
R
S
I
F
Site 4
Y900
T
D
Y
L
L
A
F
Y
I
N
P
W
S
K
N
Site 5
T915
G
L
K
K
R
K
L
T
N
P
V
Q
L
D
D
Site 6
Y926
Q
L
D
D
F
D
A
Y
I
K
D
M
A
K
D
Site 7
S934
I
K
D
M
A
K
D
S
D
Y
K
F
S
L
Q
Site 8
Y936
D
M
A
K
D
S
D
Y
K
F
S
L
Q
F
E
Site 9
Y968
L
N
R
C
K
N
R
Y
T
N
I
L
P
Y
D
Site 10
Y974
R
Y
T
N
I
L
P
Y
D
F
S
R
V
R
L
Site 11
S983
F
S
R
V
R
L
V
S
M
N
E
E
E
G
A
Site 12
Y992
N
E
E
E
G
A
D
Y
I
N
A
N
Y
I
P
Site 13
Y997
A
D
Y
I
N
A
N
Y
I
P
G
Y
N
S
P
Site 14
Y1001
N
A
N
Y
I
P
G
Y
N
S
P
Q
E
Y
I
Site 15
S1003
N
Y
I
P
G
Y
N
S
P
Q
E
Y
I
A
T
Site 16
Y1007
G
Y
N
S
P
Q
E
Y
I
A
T
Q
G
P
L
Site 17
T1010
S
P
Q
E
Y
I
A
T
Q
G
P
L
P
E
T
Site 18
T1017
T
Q
G
P
L
P
E
T
R
N
D
F
W
K
M
Site 19
T1037
S
Q
I
I
V
M
L
T
Q
C
N
E
K
R
R
Site 20
Y1050
R
R
V
K
C
D
H
Y
W
P
F
T
E
E
P
Site 21
Y1085
C
R
H
F
R
I
N
Y
A
D
E
M
Q
D
V
Site 22
S1128
V
R
Q
Q
A
T
K
S
K
G
P
M
I
I
H
Site 23
S1173
G
L
V
S
E
M
R
S
Y
R
M
S
M
V
Q
Site 24
Y1174
L
V
S
E
M
R
S
Y
R
M
S
M
V
Q
T
Site 25
S1177
E
M
R
S
Y
R
M
S
M
V
Q
T
E
E
Q
Site 26
T1181
Y
R
M
S
M
V
Q
T
E
E
Q
Y
I
F
I
Site 27
Y1185
M
V
Q
T
E
E
Q
Y
I
F
I
H
Q
C
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation