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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PCK2
Full Name:
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial
Alias:
EC 4.1.1.32; PEPCK; PEPCK2; PPCKM; Vacuolar protein sorting 72 homologue
Type:
Enzyme- phosphoenolpyruvate carboxykinase [GTP] family
Mass (Da):
70730
Number AA:
640
UniProt ID:
Q16822
International Prot ID:
IPI00294380
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0030145
GO:0004613
PhosphoSite+
KinaseNET
Biological Process:
GO:0006094
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
R
L
N
W
H
G
L
S
P
L
G
W
P
S
C
Site 2
S23
L
S
P
L
G
W
P
S
C
R
S
I
Q
T
L
Site 3
T29
P
S
C
R
S
I
Q
T
L
R
V
L
S
G
D
Site 4
S51
I
R
D
F
V
E
H
S
A
R
L
C
Q
P
E
Site 5
T66
G
I
H
I
C
D
G
T
E
A
E
N
T
A
T
Site 6
T71
D
G
T
E
A
E
N
T
A
T
L
T
L
L
E
Site 7
T73
T
E
A
E
N
T
A
T
L
T
L
L
E
Q
Q
Site 8
Y89
L
I
R
K
L
P
K
Y
N
N
C
W
L
A
R
Site 9
T97
N
N
C
W
L
A
R
T
D
P
K
D
V
A
R
Site 10
S107
K
D
V
A
R
V
E
S
K
T
V
I
V
T
P
Site 11
T113
E
S
K
T
V
I
V
T
P
S
Q
R
D
T
V
Site 12
S115
K
T
V
I
V
T
P
S
Q
R
D
T
V
P
L
Site 13
T119
V
T
P
S
Q
R
D
T
V
P
L
P
P
G
G
Site 14
S136
G
Q
L
G
N
W
M
S
P
A
D
F
Q
R
A
Site 15
S187
D
S
A
Y
V
V
A
S
M
R
I
M
T
R
L
Site 16
T192
V
A
S
M
R
I
M
T
R
L
G
T
P
V
L
Site 17
T219
H
S
V
G
Q
P
L
T
G
Q
G
E
P
V
S
Site 18
S226
T
G
Q
G
E
P
V
S
Q
W
P
C
N
P
E
Site 19
T235
W
P
C
N
P
E
K
T
L
I
G
H
V
P
D
Site 20
S248
P
D
Q
R
E
I
I
S
F
G
S
G
Y
G
G
Site 21
S251
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
Site 22
Y253
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
Site 23
S257
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
Site 24
S270
C
F
A
L
R
I
A
S
R
L
A
R
D
E
G
Site 25
S304
L
C
A
A
A
F
P
S
A
C
G
K
T
N
L
Site 26
T309
F
P
S
A
C
G
K
T
N
L
A
M
M
R
P
Site 27
S337
I
A
W
M
R
F
D
S
E
G
R
L
R
A
I
Site 28
T400
Q
P
L
P
P
G
V
T
V
T
S
W
L
G
K
Site 29
S403
P
P
G
V
T
V
T
S
W
L
G
K
P
W
K
Site 30
S422
E
P
C
A
H
P
N
S
R
F
C
A
P
A
R
Site 31
Y463
P
K
G
V
P
L
V
Y
E
A
F
N
W
R
H
Site 32
S482
G
R
A
M
R
S
E
S
T
A
A
A
E
H
K
Site 33
Y506
A
M
R
P
F
F
G
Y
N
F
G
H
Y
L
E
Site 34
S567
R
R
L
E
G
E
D
S
A
R
E
T
P
I
G
Site 35
T571
G
E
D
S
A
R
E
T
P
I
G
L
V
P
K
Site 36
S585
K
E
G
A
L
D
L
S
G
L
R
A
I
D
T
Site 37
T593
G
L
R
A
I
D
T
T
Q
L
F
S
L
P
K
Site 38
Y613
E
V
R
D
I
R
S
Y
L
T
E
Q
V
N
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation