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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RTN1
Full Name:
Reticulon-1
Alias:
Neuroendocrine-specific protein; NSP; reticulon 1
Type:
Mass (Da):
83618
Number AA:
776
UniProt ID:
Q16799
International Prot ID:
IPI00003971
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030176
Uniprot
OncoNet
Molecular Function:
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0030182
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
L
P
L
A
G
P
G
S
Q
W
L
R
H
R
G
Site 2
T34
E
G
E
N
E
A
V
T
P
K
G
A
T
P
A
Site 3
T39
A
V
T
P
K
G
A
T
P
A
P
Q
A
G
E
Site 4
S48
A
P
Q
A
G
E
P
S
P
G
L
G
A
R
A
Site 5
S60
A
R
A
R
E
A
A
S
R
E
A
G
S
G
P
Site 6
S71
G
S
G
P
A
R
Q
S
P
V
A
M
E
T
A
Site 7
T92
V
S
S
A
M
D
H
T
F
S
T
T
S
K
D
Site 8
S94
S
A
M
D
H
T
F
S
T
T
S
K
D
G
E
Site 9
S97
D
H
T
F
S
T
T
S
K
D
G
E
G
S
C
Site 10
S103
T
S
K
D
G
E
G
S
C
Y
T
S
L
I
S
Site 11
Y105
K
D
G
E
G
S
C
Y
T
S
L
I
S
D
I
Site 12
T106
D
G
E
G
S
C
Y
T
S
L
I
S
D
I
C
Site 13
Y114
S
L
I
S
D
I
C
Y
P
P
Q
E
D
S
T
Site 14
T121
Y
P
P
Q
E
D
S
T
Y
F
T
G
I
L
Q
Site 15
Y122
P
P
Q
E
D
S
T
Y
F
T
G
I
L
Q
K
Site 16
T135
Q
K
E
N
G
H
V
T
I
S
E
S
P
E
E
Site 17
S137
E
N
G
H
V
T
I
S
E
S
P
E
E
L
G
Site 18
S139
G
H
V
T
I
S
E
S
P
E
E
L
G
T
P
Site 19
T145
E
S
P
E
E
L
G
T
P
G
P
S
L
P
D
Site 20
S149
E
L
G
T
P
G
P
S
L
P
D
V
P
G
I
Site 21
S158
P
D
V
P
G
I
E
S
R
G
L
F
S
S
D
Site 22
S164
E
S
R
G
L
F
S
S
D
S
G
I
E
M
T
Site 23
S166
R
G
L
F
S
S
D
S
G
I
E
M
T
P
A
Site 24
T171
S
D
S
G
I
E
M
T
P
A
E
S
T
E
V
Site 25
Y196
M
K
A
E
A
Y
K
Y
I
D
I
T
R
P
E
Site 26
T200
A
Y
K
Y
I
D
I
T
R
P
E
E
V
K
H
Site 27
S230
K
N
K
D
T
D
I
S
I
K
P
E
G
V
R
Site 28
T259
D
H
L
L
E
E
S
T
F
A
P
Y
I
D
D
Site 29
S268
A
P
Y
I
D
D
L
S
E
E
Q
R
R
A
P
Site 30
T278
Q
R
R
A
P
Q
I
T
T
P
V
K
I
T
L
Site 31
T279
R
R
A
P
Q
I
T
T
P
V
K
I
T
L
T
Site 32
S291
T
L
T
E
I
E
P
S
V
E
T
T
T
Q
E
Site 33
T300
E
T
T
T
Q
E
K
T
P
E
K
Q
D
I
C
Site 34
S311
Q
D
I
C
L
K
P
S
P
D
T
V
P
T
V
Site 35
T317
P
S
P
D
T
V
P
T
V
T
V
S
E
P
E
Site 36
T319
P
D
T
V
P
T
V
T
V
S
E
P
E
D
D
Site 37
S321
T
V
P
T
V
T
V
S
E
P
E
D
D
S
P
Site 38
S327
V
S
E
P
E
D
D
S
P
G
S
I
T
P
P
Site 39
S330
P
E
D
D
S
P
G
S
I
T
P
P
S
S
G
Site 40
T332
D
D
S
P
G
S
I
T
P
P
S
S
G
T
E
Site 41
S335
P
G
S
I
T
P
P
S
S
G
T
E
P
S
A
Site 42
S336
G
S
I
T
P
P
S
S
G
T
E
P
S
A
A
Site 43
S341
P
S
S
G
T
E
P
S
A
A
E
S
Q
G
K
Site 44
S345
T
E
P
S
A
A
E
S
Q
G
K
G
S
I
S
Site 45
S350
A
E
S
Q
G
K
G
S
I
S
E
D
E
L
I
Site 46
S352
S
Q
G
K
G
S
I
S
E
D
E
L
I
T
A
Site 47
Y368
K
E
A
K
G
L
S
Y
E
T
A
E
N
P
R
Site 48
S390
R
P
E
V
K
A
R
S
G
P
P
T
I
P
S
Site 49
T394
K
A
R
S
G
P
P
T
I
P
S
P
L
D
H
Site 50
S397
S
G
P
P
T
I
P
S
P
L
D
H
E
A
S
Site 51
S404
S
P
L
D
H
E
A
S
S
A
E
S
G
D
S
Site 52
S405
P
L
D
H
E
A
S
S
A
E
S
G
D
S
E
Site 53
S408
H
E
A
S
S
A
E
S
G
D
S
E
I
E
L
Site 54
S411
S
S
A
E
S
G
D
S
E
I
E
L
V
S
E
Site 55
S429
A
A
E
D
A
L
P
S
G
Y
V
S
F
G
H
Site 56
Y431
E
D
A
L
P
S
G
Y
V
S
F
G
H
V
G
Site 57
S443
H
V
G
G
P
P
P
S
P
A
S
P
S
I
Q
Site 58
S446
G
P
P
P
S
P
A
S
P
S
I
Q
Y
S
I
Site 59
S448
P
P
S
P
A
S
P
S
I
Q
Y
S
I
L
R
Site 60
S452
A
S
P
S
I
Q
Y
S
I
L
R
E
E
R
E
Site 61
S464
E
R
E
A
E
L
D
S
E
L
I
I
E
S
C
Site 62
S470
D
S
E
L
I
I
E
S
C
D
A
S
S
A
S
Site 63
S474
I
I
E
S
C
D
A
S
S
A
S
E
E
S
P
Site 64
S475
I
E
S
C
D
A
S
S
A
S
E
E
S
P
K
Site 65
S477
S
C
D
A
S
S
A
S
E
E
S
P
K
R
E
Site 66
S480
A
S
S
A
S
E
E
S
P
K
R
E
Q
D
S
Site 67
S487
S
P
K
R
E
Q
D
S
P
P
M
K
P
S
A
Site 68
T502
L
D
A
I
R
E
E
T
G
V
R
A
E
E
R
Site 69
S512
R
A
E
E
R
A
P
S
R
R
G
L
A
E
P
Site 70
S521
R
G
L
A
E
P
G
S
F
L
D
Y
P
S
T
Site 71
Y525
E
P
G
S
F
L
D
Y
P
S
T
E
P
Q
P
Site 72
S527
G
S
F
L
D
Y
P
S
T
E
P
Q
P
G
P
Site 73
T528
S
F
L
D
Y
P
S
T
E
P
Q
P
G
P
E
Site 74
T547
D
G
A
L
E
P
E
T
P
M
L
P
R
K
P
Site 75
S558
P
R
K
P
E
E
D
S
S
S
N
Q
S
P
A
Site 76
S559
R
K
P
E
E
D
S
S
S
N
Q
S
P
A
A
Site 77
S560
K
P
E
E
D
S
S
S
N
Q
S
P
A
A
T
Site 78
S563
E
D
S
S
S
N
Q
S
P
A
A
T
K
G
P
Site 79
T567
S
N
Q
S
P
A
A
T
K
G
P
G
P
L
G
Site 80
Y594
Q
K
A
I
D
L
L
Y
W
R
D
I
K
Q
T
Site 81
T651
V
L
Q
A
V
Q
K
T
D
E
G
H
P
F
K
Site 82
Y660
E
G
H
P
F
K
A
Y
L
E
L
E
I
T
L
Site 83
T666
A
Y
L
E
L
E
I
T
L
S
Q
E
Q
I
Q
Site 84
S668
L
E
L
E
I
T
L
S
Q
E
Q
I
Q
K
Y
Site 85
Y675
S
Q
E
Q
I
Q
K
Y
T
D
C
L
Q
F
Y
Site 86
Y682
Y
T
D
C
L
Q
F
Y
V
N
S
T
L
K
E
Site 87
Y749
H
Q
A
Q
I
D
Q
Y
L
G
L
V
R
T
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation