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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ME3
Full Name:
NADP-dependent malic enzyme, mitochondrial
Alias:
Malic enzyme 3
Type:
Mass (Da):
67068
Number AA:
604
UniProt ID:
Q16798
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T26
C
G
A
L
P
R
W
T
P
T
A
P
A
Q
G
Site 2
S36
A
P
A
Q
G
C
H
S
K
P
G
P
A
R
P
Site 3
Y51
V
P
L
K
K
R
G
Y
D
V
T
R
N
P
H
Site 4
T54
K
K
R
G
Y
D
V
T
R
N
P
H
L
N
K
Site 5
Y96
Q
L
L
R
I
M
R
Y
Y
E
R
Q
Q
S
D
Site 6
Y97
L
L
R
I
M
R
Y
Y
E
R
Q
Q
S
D
L
Site 7
S102
R
Y
Y
E
R
Q
Q
S
D
L
D
K
Y
I
I
Site 8
Y107
Q
Q
S
D
L
D
K
Y
I
I
L
M
T
L
Q
Site 9
Y122
D
R
N
E
K
L
F
Y
R
V
L
T
S
D
V
Site 10
Y148
V
G
L
A
C
Q
H
Y
G
L
T
F
R
R
P
Site 11
T151
A
C
Q
H
Y
G
L
T
F
R
R
P
R
G
L
Site 12
T161
R
P
R
G
L
F
I
T
I
H
D
K
G
H
L
Site 13
T232
P
V
L
L
D
V
G
T
N
N
E
E
L
L
R
Site 14
Y243
E
L
L
R
D
P
L
Y
I
G
L
K
H
Q
R
Site 15
Y294
A
F
R
L
L
N
K
Y
R
N
K
Y
C
M
F
Site 16
Y298
L
N
K
Y
R
N
K
Y
C
M
F
N
D
D
I
Site 17
T323
I
L
A
A
L
R
I
T
K
N
K
L
S
N
H
Site 18
S431
Q
I
L
R
D
M
A
S
F
H
E
R
P
I
I
Site 19
S442
R
P
I
I
F
A
L
S
N
P
T
S
K
A
E
Site 20
S446
F
A
L
S
N
P
T
S
K
A
E
C
T
A
E
Site 21
T459
A
E
K
C
Y
R
V
T
E
G
R
G
I
F
A
Site 22
S467
E
G
R
G
I
F
A
S
G
S
P
F
K
S
V
Site 23
S473
A
S
G
S
P
F
K
S
V
T
L
E
D
G
K
Site 24
T475
G
S
P
F
K
S
V
T
L
E
D
G
K
T
F
Site 25
T481
V
T
L
E
D
G
K
T
F
I
P
G
Q
G
N
Site 26
S525
E
Q
I
A
Q
E
V
S
E
Q
H
L
S
Q
G
Site 27
S530
E
V
S
E
Q
H
L
S
Q
G
R
L
Y
P
P
Site 28
Y535
H
L
S
Q
G
R
L
Y
P
P
L
S
T
I
R
Site 29
S539
G
R
L
Y
P
P
L
S
T
I
R
D
V
S
L
Site 30
T540
R
L
Y
P
P
L
S
T
I
R
D
V
S
L
R
Site 31
S545
L
S
T
I
R
D
V
S
L
R
I
A
I
K
V
Site 32
Y557
I
K
V
L
D
Y
A
Y
K
H
N
L
A
S
Y
Site 33
S563
A
Y
K
H
N
L
A
S
Y
Y
P
E
P
K
D
Site 34
Y565
K
H
N
L
A
S
Y
Y
P
E
P
K
D
K
E
Site 35
S577
D
K
E
A
F
V
R
S
L
V
Y
T
P
D
Y
Site 36
T581
F
V
R
S
L
V
Y
T
P
D
Y
D
S
F
T
Site 37
Y584
S
L
V
Y
T
P
D
Y
D
S
F
T
L
D
S
Site 38
S586
V
Y
T
P
D
Y
D
S
F
T
L
D
S
Y
T
Site 39
T588
T
P
D
Y
D
S
F
T
L
D
S
Y
T
W
P
Site 40
S591
Y
D
S
F
T
L
D
S
Y
T
W
P
K
E
A
Site 41
Y592
D
S
F
T
L
D
S
Y
T
W
P
K
E
A
M
Site 42
T593
S
F
T
L
D
S
Y
T
W
P
K
E
A
M
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation