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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HAGH
Full Name:
Hydroxyacylglutathione hydrolase, mitochondrial
Alias:
GLO2; GLX II; GLXII; glyoxalase II; HAGH1; hydroxyacyl glutathione hydrolase; hydroxyacylglutathione hydrolase
Type:
Hydrolase; Carbohydrate Metabolism - pyruvate; EC 3.1.2.6
Mass (Da):
33806
Number AA:
308
UniProt ID:
Q16775
International Prot ID:
IPI00745553
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0004416
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006750
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T43
T
D
L
R
K
N
L
T
V
D
E
G
T
M
K
Site 2
Y61
L
P
A
L
T
D
N
Y
M
Y
L
V
I
D
D
Site 3
T96
R
K
H
G
V
K
L
T
T
V
L
T
T
H
H
Site 4
T97
K
H
G
V
K
L
T
T
V
L
T
T
H
H
H
Site 5
S119
E
K
L
V
K
L
E
S
G
L
K
V
Y
G
G
Site 6
T134
D
D
R
I
G
A
L
T
H
K
I
T
H
L
S
Site 7
T142
H
K
I
T
H
L
S
T
L
Q
V
G
S
L
N
Site 8
T155
L
N
V
K
C
L
A
T
P
C
H
T
S
G
H
Site 9
Y165
H
T
S
G
H
I
C
Y
F
V
S
K
P
G
G
Site 10
S168
G
H
I
C
Y
F
V
S
K
P
G
G
S
E
P
Site 11
S173
F
V
S
K
P
G
G
S
E
P
P
A
V
F
T
Site 12
T215
L
G
R
L
P
P
D
T
R
V
Y
C
G
H
E
Site 13
Y218
L
P
P
D
T
R
V
Y
C
G
H
E
Y
T
I
Site 14
Y223
R
V
Y
C
G
H
E
Y
T
I
N
N
L
K
F
Site 15
T224
V
Y
C
G
H
E
Y
T
I
N
N
L
K
F
A
Site 16
Y252
L
A
W
A
K
E
K
Y
S
I
G
E
P
T
V
Site 17
T258
K
Y
S
I
G
E
P
T
V
P
S
T
L
A
E
Site 18
T262
G
E
P
T
V
P
S
T
L
A
E
E
F
T
Y
Site 19
T268
S
T
L
A
E
E
F
T
Y
N
P
F
M
R
V
Site 20
Y269
T
L
A
E
E
F
T
Y
N
P
F
M
R
V
R
Site 21
T279
F
M
R
V
R
E
K
T
V
Q
Q
H
A
G
E
Site 22
T291
A
G
E
T
D
P
V
T
T
M
R
A
V
R
R
Site 23
T292
G
E
T
D
P
V
T
T
M
R
A
V
R
R
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation