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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GUK1
Full Name:
Guanylate kinase
Alias:
EC 2.7.4.8; GMK; GMP kinase; Guanylate kinase 1; KGUA
Type:
Kinase (non-protein), Nucleotide Metabolism group, Purine metabolism family
Mass (Da):
21726
Number AA:
197
UniProt ID:
Q16774
International Prot ID:
IPI00182293
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004385
GO:0019206
PhosphoSite+
KinaseNET
Biological Process:
GO:0006163
Phosida
TranscriptoNet
STRING
Kinexus Products
Guanylate kinase Y53 phosphosite-specific antibody AB-PK652#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK652#Guanylate kinase (G50-V56, human) pY53 phosphopeptide - Powder PE-04AMT99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AMT99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
G
P
R
P
V
V
L
S
G
P
S
G
A
G
K
Site 2
S18
G
P
S
G
A
G
K
S
T
L
L
K
R
L
L
Site 3
T19
P
S
G
A
G
K
S
T
L
L
K
R
L
L
Q
Site 4
S29
K
R
L
L
Q
E
H
S
G
I
F
G
F
S
V
Site 5
S35
H
S
G
I
F
G
F
S
V
S
H
T
T
R
N
Site 6
S37
G
I
F
G
F
S
V
S
H
T
T
R
N
P
R
Site 7
T39
F
G
F
S
V
S
H
T
T
R
N
P
R
P
G
Site 8
Y53
E
E
N
G
K
D
Y
Y
F
V
T
R
E
V
M
Guanylate kinase Y53 phosphosite-specific antibody AB-PK652#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK652#Guanylate kinase (G50-V56, human) pY53 phosphopeptide - Powder PE-04AMT99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AMT99
Site 9
Y54
E
E
N
G
K
D
Y
Y
F
V
T
R
E
V
M
Site 10
T113
G
V
R
N
I
K
A
T
D
L
R
P
I
Y
I
Site 11
Y119
A
T
D
L
R
P
I
Y
I
S
V
Q
P
P
S
Site 12
S121
D
L
R
P
I
Y
I
S
V
Q
P
P
S
L
H
Site 13
S126
Y
I
S
V
Q
P
P
S
L
H
V
L
E
Q
R
Site 14
T139
Q
R
L
R
Q
R
N
T
E
T
E
E
S
L
V
Site 15
S144
R
N
T
E
T
E
E
S
L
V
K
R
L
A
A
Site 16
S158
A
A
Q
A
D
M
E
S
S
K
E
P
G
L
F
Site 17
S159
A
Q
A
D
M
E
S
S
K
E
P
G
L
F
D
Site 18
S173
D
V
V
I
I
N
D
S
L
D
Q
A
Y
A
E
Site 19
Y178
N
D
S
L
D
Q
A
Y
A
E
L
K
E
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation