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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Tbr1
Full Name:
T-box brain protein 1
Alias:
Mgc141978; T-box, brain, 1; TES-56; Tes-56
Type:
Mass (Da):
74035
Number AA:
682
UniProt ID:
Q16650
International Prot ID:
IPI00003421
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
S
K
K
F
L
N
V
S
S
S
Y
P
H
S
G
Site 2
S22
K
K
F
L
N
V
S
S
S
Y
P
H
S
G
G
Site 3
S23
K
F
L
N
V
S
S
S
Y
P
H
S
G
G
S
Site 4
Y24
F
L
N
V
S
S
S
Y
P
H
S
G
G
S
E
Site 5
S27
V
S
S
S
Y
P
H
S
G
G
S
E
L
V
L
Site 6
S41
L
H
D
H
P
I
I
S
T
T
D
N
L
E
R
Site 7
S50
T
D
N
L
E
R
S
S
P
L
K
K
I
T
R
Site 8
T60
K
K
I
T
R
G
M
T
N
Q
S
D
T
D
N
Site 9
T65
G
M
T
N
Q
S
D
T
D
N
F
P
D
S
K
Site 10
S71
D
T
D
N
F
P
D
S
K
D
S
P
G
D
V
Site 11
S74
N
F
P
D
S
K
D
S
P
G
D
V
Q
R
S
Site 12
S81
S
P
G
D
V
Q
R
S
K
L
S
P
V
L
D
Site 13
S84
D
V
Q
R
S
K
L
S
P
V
L
D
G
V
S
Site 14
S91
S
P
V
L
D
G
V
S
E
L
R
H
S
F
D
Site 15
S96
G
V
S
E
L
R
H
S
F
D
G
S
A
A
D
Site 16
S100
L
R
H
S
F
D
G
S
A
A
D
R
Y
L
L
Site 17
Y105
D
G
S
A
A
D
R
Y
L
L
S
Q
S
S
Q
Site 18
S108
A
A
D
R
Y
L
L
S
Q
S
S
Q
P
Q
S
Site 19
S110
D
R
Y
L
L
S
Q
S
S
Q
P
Q
S
A
A
Site 20
S111
R
Y
L
L
S
Q
S
S
Q
P
Q
S
A
A
T
Site 21
S115
S
Q
S
S
Q
P
Q
S
A
A
T
A
P
S
A
Site 22
Y126
A
P
S
A
M
F
P
Y
P
G
Q
H
G
P
A
Site 23
S138
G
P
A
H
P
A
F
S
I
G
S
P
S
R
Y
Site 24
S141
H
P
A
F
S
I
G
S
P
S
R
Y
M
A
H
Site 25
S143
A
F
S
I
G
S
P
S
R
Y
M
A
H
H
P
Site 26
Y145
S
I
G
S
P
S
R
Y
M
A
H
H
P
V
I
Site 27
Y157
P
V
I
T
N
G
A
Y
N
S
L
L
S
N
S
Site 28
S159
I
T
N
G
A
Y
N
S
L
L
S
N
S
S
P
Site 29
S162
G
A
Y
N
S
L
L
S
N
S
S
P
Q
G
Y
Site 30
S165
N
S
L
L
S
N
S
S
P
Q
G
Y
P
T
A
Site 31
Y169
S
N
S
S
P
Q
G
Y
P
T
A
G
Y
P
Y
Site 32
Y174
Q
G
Y
P
T
A
G
Y
P
Y
P
Q
Q
Y
G
Site 33
Y176
Y
P
T
A
G
Y
P
Y
P
Q
Q
Y
G
H
S
Site 34
Y180
G
Y
P
Y
P
Q
Q
Y
G
H
S
Y
Q
G
A
Site 35
Y190
S
Y
Q
G
A
P
F
Y
Q
F
S
S
T
Q
P
Site 36
S193
G
A
P
F
Y
Q
F
S
S
T
Q
P
G
L
V
Site 37
S194
A
P
F
Y
Q
F
S
S
T
Q
P
G
L
V
P
Site 38
T195
P
F
Y
Q
F
S
S
T
Q
P
G
L
V
P
G
Site 39
Y207
V
P
G
K
A
Q
V
Y
L
C
N
R
P
L
W
Site 40
T222
L
K
F
H
R
H
Q
T
E
M
I
I
T
K
Q
Site 41
T279
V
P
C
G
K
A
D
T
N
V
Q
G
N
R
V
Site 42
Y287
N
V
Q
G
N
R
V
Y
M
H
P
D
S
P
N
Site 43
T312
S
F
G
K
L
K
L
T
N
N
K
G
A
S
N
Site 44
S329
G
Q
M
V
V
L
Q
S
L
H
K
Y
Q
P
R
Site 45
Y333
V
L
Q
S
L
H
K
Y
Q
P
R
L
H
V
V
Site 46
T347
V
E
V
N
E
D
G
T
E
D
T
S
Q
P
G
Site 47
T350
N
E
D
G
T
E
D
T
S
Q
P
G
R
V
Q
Site 48
S351
E
D
G
T
E
D
T
S
Q
P
G
R
V
Q
T
Site 49
T358
S
Q
P
G
R
V
Q
T
F
T
F
P
E
T
Q
Site 50
T360
P
G
R
V
Q
T
F
T
F
P
E
T
Q
F
I
Site 51
T378
A
Y
Q
N
T
D
I
T
Q
L
K
I
D
H
N
Site 52
Y395
A
K
G
F
R
D
N
Y
D
T
I
Y
T
G
C
Site 53
Y399
R
D
N
Y
D
T
I
Y
T
G
C
D
M
D
R
Site 54
T408
G
C
D
M
D
R
L
T
P
S
P
N
D
S
P
Site 55
S410
D
M
D
R
L
T
P
S
P
N
D
S
P
R
S
Site 56
S414
L
T
P
S
P
N
D
S
P
R
S
Q
I
V
P
Site 57
S417
S
P
N
D
S
P
R
S
Q
I
V
P
G
A
R
Site 58
T457
G
A
G
P
G
P
G
T
D
R
S
V
P
H
T
Site 59
S460
P
G
P
G
T
D
R
S
V
P
H
T
N
G
L
Site 60
T464
T
D
R
S
V
P
H
T
N
G
L
L
S
P
Q
Site 61
S469
P
H
T
N
G
L
L
S
P
Q
Q
A
E
D
P
Site 62
S480
A
E
D
P
G
A
P
S
P
Q
R
W
F
V
T
Site 63
T487
S
P
Q
R
W
F
V
T
P
A
N
N
R
L
D
Site 64
S498
N
R
L
D
F
A
A
S
A
Y
D
T
A
T
D
Site 65
T502
F
A
A
S
A
Y
D
T
A
T
D
F
A
G
N
Site 66
T504
A
S
A
Y
D
T
A
T
D
F
A
G
N
A
A
Site 67
T532
P
L
Q
A
A
G
C
T
G
R
P
L
G
Y
Y
Site 68
Y538
C
T
G
R
P
L
G
Y
Y
A
D
P
S
G
W
Site 69
Y539
T
G
R
P
L
G
Y
Y
A
D
P
S
G
W
G
Site 70
S543
L
G
Y
Y
A
D
P
S
G
W
G
A
R
S
P
Site 71
S549
P
S
G
W
G
A
R
S
P
P
Q
Y
C
G
T
Site 72
Y553
G
A
R
S
P
P
Q
Y
C
G
T
K
S
G
S
Site 73
T556
S
P
P
Q
Y
C
G
T
K
S
G
S
V
L
P
Site 74
S594
E
G
L
A
A
E
R
S
P
L
P
P
G
A
A
Site 75
S610
D
A
K
P
K
D
L
S
D
S
S
W
I
E
T
Site 76
S612
K
P
K
D
L
S
D
S
S
W
I
E
T
P
S
Site 77
S613
P
K
D
L
S
D
S
S
W
I
E
T
P
S
S
Site 78
T617
S
D
S
S
W
I
E
T
P
S
S
I
K
S
I
Site 79
S619
S
S
W
I
E
T
P
S
S
I
K
S
I
D
S
Site 80
S620
S
W
I
E
T
P
S
S
I
K
S
I
D
S
S
Site 81
S623
E
T
P
S
S
I
K
S
I
D
S
S
D
S
G
Site 82
S626
S
S
I
K
S
I
D
S
S
D
S
G
I
Y
E
Site 83
S627
S
I
K
S
I
D
S
S
D
S
G
I
Y
E
Q
Site 84
S629
K
S
I
D
S
S
D
S
G
I
Y
E
Q
A
K
Site 85
Y632
D
S
S
D
S
G
I
Y
E
Q
A
K
R
R
R
Site 86
S641
Q
A
K
R
R
R
I
S
P
A
D
T
P
V
S
Site 87
T645
R
R
I
S
P
A
D
T
P
V
S
E
S
S
S
Site 88
S648
S
P
A
D
T
P
V
S
E
S
S
S
P
L
K
Site 89
S650
A
D
T
P
V
S
E
S
S
S
P
L
K
S
E
Site 90
S652
T
P
V
S
E
S
S
S
P
L
K
S
E
V
L
Site 91
S656
E
S
S
S
P
L
K
S
E
V
L
A
Q
R
D
Site 92
Y675
C
A
K
D
I
S
G
Y
Y
G
F
Y
S
H
S
Site 93
Y676
A
K
D
I
S
G
Y
Y
G
F
Y
S
H
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation