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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RPE65
Full Name:
Retinoid isomerohydrolase
Alias:
LCA2; RBP-binding membrane protein; rd12; retinal pigment epithelium-specific 65 kDa protein; retinal pigment epithelium-specific protein 65kDa; RP20
Type:
Cofactor and Vitamin Metabolism - retinol
Mass (Da):
60950
Number AA:
UniProt ID:
Q16518
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031225
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007601
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
G
Y
K
K
L
F
E
T
V
E
E
L
S
S
P
Site 2
S24
E
T
V
E
E
L
S
S
P
L
T
A
H
V
T
Site 3
T27
E
E
L
S
S
P
L
T
A
H
V
T
G
R
I
Site 4
Y58
E
V
G
S
E
P
F
Y
H
L
F
D
G
Q
A
Site 5
Y79
F
K
E
G
H
V
T
Y
H
R
R
F
I
R
T
Site 6
Y89
R
F
I
R
T
D
A
Y
V
R
A
M
T
E
K
Site 7
T94
D
A
Y
V
R
A
M
T
E
K
R
I
V
I
T
Site 8
T101
T
E
K
R
I
V
I
T
E
F
G
T
C
A
F
Site 9
T105
I
V
I
T
E
F
G
T
C
A
F
P
D
P
C
Site 10
S117
D
P
C
K
N
I
F
S
R
F
F
S
Y
F
R
Site 11
Y137
D
N
A
L
V
N
V
Y
P
V
G
E
D
Y
Y
Site 12
Y143
V
Y
P
V
G
E
D
Y
Y
A
C
T
E
T
N
Site 13
Y144
Y
P
V
G
E
D
Y
Y
A
C
T
E
T
N
F
Site 14
T162
I
N
P
E
T
L
E
T
I
K
Q
V
D
L
C
Site 15
Y171
K
Q
V
D
L
C
N
Y
V
S
V
N
G
A
T
Site 16
S221
A
D
K
E
D
P
I
S
K
S
E
I
V
V
Q
Site 17
S223
K
E
D
P
I
S
K
S
E
I
V
V
Q
F
P
Site 18
S232
I
V
V
Q
F
P
C
S
D
R
F
K
P
S
Y
Site 19
S238
C
S
D
R
F
K
P
S
Y
V
H
S
F
G
L
Site 20
Y239
S
D
R
F
K
P
S
Y
V
H
S
F
G
L
T
Site 21
S242
F
K
P
S
Y
V
H
S
F
G
L
T
P
N
Y
Site 22
Y299
A
D
K
K
R
K
K
Y
L
N
N
K
Y
R
T
Site 23
Y304
K
K
Y
L
N
N
K
Y
R
T
S
P
F
N
L
Site 24
Y318
L
F
H
H
I
N
T
Y
E
D
N
G
F
L
I
Site 25
Y338
W
K
G
F
E
F
V
Y
N
Y
L
Y
L
A
N
Site 26
Y342
E
F
V
Y
N
Y
L
Y
L
A
N
L
R
E
N
Site 27
Y368
P
Q
P
E
V
R
R
Y
V
L
P
L
N
I
D
Site 28
T379
L
N
I
D
K
A
D
T
G
K
N
L
V
T
L
Site 29
S410
L
E
P
E
V
L
F
S
G
P
R
Q
A
F
E
Site 30
Y423
F
E
F
P
Q
I
N
Y
Q
K
Y
C
G
K
P
Site 31
Y426
P
Q
I
N
Y
Q
K
Y
C
G
K
P
Y
T
Y
Site 32
Y431
Q
K
Y
C
G
K
P
Y
T
Y
A
Y
G
L
G
Site 33
T432
K
Y
C
G
K
P
Y
T
Y
A
Y
G
L
G
L
Site 34
Y433
Y
C
G
K
P
Y
T
Y
A
Y
G
L
G
L
N
Site 35
Y435
G
K
P
Y
T
Y
A
Y
G
L
G
L
N
H
F
Site 36
Y466
V
W
Q
E
P
D
S
Y
P
S
E
P
I
F
V
Site 37
S468
Q
E
P
D
S
Y
P
S
E
P
I
F
V
S
H
Site 38
S474
P
S
E
P
I
F
V
S
H
P
D
A
L
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation