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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EXT1
Full Name:
Exostosin-1
Alias:
EC 2.4.1.224; EC 2.4.1.225; Exostoses (multiple) 1; EXT; Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase; Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; LGCR; LGS; Multiple exostoses protein 1; Multiple exostoses type 1 gene; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase; Ttv
Type:
Transferase, Glycan Biosynthesis and Metabolism group, Glycan structures - biosynthesis 1 family, Heparan sulfate biosynthesis family
Mass (Da):
86255
Number AA:
746
UniProt ID:
Q16394
International Prot ID:
IPI00293128
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000139
GO:0030176
Uniprot
OncoNet
Molecular Function:
GO:0050509
GO:0050508
GO:0042328
PhosphoSite+
KinaseNET
Biological Process:
GO:0006024
GO:0015014
GO:0001503
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
G
G
L
Q
F
R
A
S
R
S
H
S
R
R
E
Site 2
S33
L
Q
F
R
A
S
R
S
H
S
R
R
E
E
H
Site 3
S35
F
R
A
S
R
S
H
S
R
R
E
E
H
S
G
Site 4
S41
H
S
R
R
E
E
H
S
G
R
N
G
L
H
H
Site 5
S50
R
N
G
L
H
H
P
S
P
D
H
F
W
P
R
Site 6
S76
D
Q
L
E
N
E
D
S
S
V
H
I
S
P
R
Site 7
S77
Q
L
E
N
E
D
S
S
V
H
I
S
P
R
Q
Site 8
S81
E
D
S
S
V
H
I
S
P
R
Q
K
R
D
A
Site 9
S90
R
Q
K
R
D
A
N
S
S
I
Y
K
G
K
K
Site 10
S91
Q
K
R
D
A
N
S
S
I
Y
K
G
K
K
C
Site 11
Y117
K
K
N
G
F
K
V
Y
V
Y
P
Q
Q
K
G
Site 12
Y119
N
G
F
K
V
Y
V
Y
P
Q
Q
K
G
E
K
Site 13
S130
K
G
E
K
I
A
E
S
Y
Q
N
I
L
A
A
Site 14
Y131
G
E
K
I
A
E
S
Y
Q
N
I
L
A
A
I
Site 15
S141
I
L
A
A
I
E
G
S
R
F
Y
T
S
D
P
Site 16
Y144
A
I
E
G
S
R
F
Y
T
S
D
P
S
Q
A
Site 17
T145
I
E
G
S
R
F
Y
T
S
D
P
S
Q
A
C
Site 18
S146
E
G
S
R
F
Y
T
S
D
P
S
Q
A
C
L
Site 19
S167
T
L
D
R
D
Q
L
S
P
Q
Y
V
H
N
L
Site 20
Y170
R
D
Q
L
S
P
Q
Y
V
H
N
L
R
S
K
Site 21
S176
Q
Y
V
H
N
L
R
S
K
V
Q
S
L
H
L
Site 22
S180
N
L
R
S
K
V
Q
S
L
H
L
W
N
N
G
Site 23
Y196
N
H
L
I
F
N
L
Y
S
G
T
W
P
D
Y
Site 24
Y203
Y
S
G
T
W
P
D
Y
T
E
D
V
G
F
D
Site 25
T204
S
G
T
W
P
D
Y
T
E
D
V
G
F
D
I
Site 26
S233
F
R
P
N
F
D
V
S
I
P
L
F
S
K
D
Site 27
T255
R
G
F
L
K
F
N
T
I
P
P
L
R
K
Y
Site 28
Y262
T
I
P
P
L
R
K
Y
M
L
V
F
K
G
K
Site 29
Y271
L
V
F
K
G
K
R
Y
L
T
G
I
G
S
D
Site 30
T273
F
K
G
K
R
Y
L
T
G
I
G
S
D
T
R
Site 31
S277
R
Y
L
T
G
I
G
S
D
T
R
N
A
L
Y
Site 32
T279
L
T
G
I
G
S
D
T
R
N
A
L
Y
H
V
Site 33
Y284
S
D
T
R
N
A
L
Y
H
V
H
N
G
E
D
Site 34
T296
G
E
D
V
V
L
L
T
T
C
K
H
G
K
D
Site 35
T317
S
R
C
D
R
D
N
T
E
Y
E
K
Y
D
Y
Site 36
Y319
C
D
R
D
N
T
E
Y
E
K
Y
D
Y
R
E
Site 37
Y322
D
N
T
E
Y
E
K
Y
D
Y
R
E
M
L
H
Site 38
Y324
T
E
Y
E
K
Y
D
Y
R
E
M
L
H
N
A
Site 39
T332
R
E
M
L
H
N
A
T
F
C
L
V
P
R
G
Site 40
S344
P
R
G
R
R
L
G
S
F
R
F
L
E
A
L
Site 41
S391
R
L
L
L
Q
I
P
S
T
I
R
S
I
H
Q
Site 42
S395
Q
I
P
S
T
I
R
S
I
H
Q
D
K
I
L
Site 43
Y415
T
Q
F
L
W
E
A
Y
F
S
S
V
E
K
I
Site 44
T426
V
E
K
I
V
L
T
T
L
E
I
I
Q
D
R
Site 45
S460
F
V
L
P
Q
Y
S
S
Y
L
G
D
F
P
Y
Site 46
Y461
V
L
P
Q
Y
S
S
Y
L
G
D
F
P
Y
Y
Site 47
Y467
S
Y
L
G
D
F
P
Y
Y
Y
A
N
L
G
L
Site 48
Y468
Y
L
G
D
F
P
Y
Y
Y
A
N
L
G
L
K
Site 49
Y469
L
G
D
F
P
Y
Y
Y
A
N
L
G
L
K
P
Site 50
S478
N
L
G
L
K
P
P
S
K
F
T
A
V
I
H
Site 51
S547
E
G
E
S
K
V
M
S
S
R
F
L
P
Y
D
Site 52
T580
T
E
V
D
F
A
F
T
V
W
Q
S
F
P
E
Site 53
Y592
F
P
E
R
I
V
G
Y
P
A
R
S
H
F
W
Site 54
Y608
N
S
K
E
R
W
G
Y
T
S
K
W
T
N
D
Site 55
Y616
T
S
K
W
T
N
D
Y
S
M
V
L
T
G
A
Site 56
S617
S
K
W
T
N
D
Y
S
M
V
L
T
G
A
A
Site 57
T621
N
D
Y
S
M
V
L
T
G
A
A
I
Y
H
K
Site 58
Y626
V
L
T
G
A
A
I
Y
H
K
Y
Y
H
Y
L
Site 59
Y629
G
A
A
I
Y
H
K
Y
Y
H
Y
L
Y
S
H
Site 60
Y630
A
A
I
Y
H
K
Y
Y
H
Y
L
Y
S
H
Y
Site 61
Y632
I
Y
H
K
Y
Y
H
Y
L
Y
S
H
Y
L
P
Site 62
Y634
H
K
Y
Y
H
Y
L
Y
S
H
Y
L
P
A
S
Site 63
Y637
Y
H
Y
L
Y
S
H
Y
L
P
A
S
L
K
N
Site 64
S641
Y
S
H
Y
L
P
A
S
L
K
N
M
V
D
Q
Site 65
T686
K
E
T
M
M
G
Q
T
S
R
A
S
R
W
A
Site 66
S690
M
G
Q
T
S
R
A
S
R
W
A
D
P
D
H
Site 67
S720
G
Y
M
P
L
I
H
S
Q
M
R
L
D
P
V
Site 68
S734
V
L
F
K
D
Q
V
S
I
L
R
K
K
Y
R
Site 69
Y740
V
S
I
L
R
K
K
Y
R
D
I
E
R
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation