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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LAMA4
Full Name:
Laminin subunit alpha-4
Alias:
LAMA3; laminin, alpha 4
Type:
Extracellular matrix
Mass (Da):
202524
Number AA:
1823
UniProt ID:
Q16363
International Prot ID:
IPI00329482
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005606
Uniprot
OncoNet
Molecular Function:
GO:0005201
GO:0005102
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0030155
GO:0030334
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
L
L
W
S
A
A
C
S
R
A
A
S
G
D
D
Site 2
S26
A
A
C
S
R
A
A
S
G
D
D
N
A
F
P
Site 3
T50
G
R
Q
D
P
P
E
T
S
E
P
R
V
A
L
Site 4
S51
R
Q
D
P
P
E
T
S
E
P
R
V
A
L
G
Site 5
Y97
E
C
L
D
G
S
G
Y
C
V
H
C
Q
R
N
Site 6
T106
V
H
C
Q
R
N
T
T
G
E
H
C
E
K
C
Site 7
Y117
C
E
K
C
L
D
G
Y
I
G
D
S
I
R
G
Site 8
S121
L
D
G
Y
I
G
D
S
I
R
G
A
P
Q
F
Site 9
Y161
R
C
I
C
N
E
N
Y
A
G
P
N
C
E
R
Site 10
Y174
E
R
C
A
P
G
Y
Y
G
N
P
L
L
I
G
Site 11
S193
K
C
D
C
S
G
N
S
D
P
N
L
I
F
E
Site 12
T217
R
N
C
L
R
N
T
T
G
F
K
C
E
R
C
Site 13
Y228
C
E
R
C
A
P
G
Y
Y
G
D
A
R
I
A
Site 14
S250
C
G
G
G
P
C
D
S
V
T
G
E
C
L
E
Site 15
T252
G
G
P
C
D
S
V
T
G
E
C
L
E
E
G
Site 16
T264
E
E
G
F
E
P
P
T
G
M
D
C
P
T
I
Site 17
S302
K
S
G
V
L
S
V
S
S
G
A
A
A
H
R
Site 18
T317
H
V
N
E
I
N
A
T
I
Y
L
L
K
T
K
Site 19
Y319
N
E
I
N
A
T
I
Y
L
L
K
T
K
L
S
Site 20
T323
A
T
I
Y
L
L
K
T
K
L
S
E
R
E
N
Site 21
S326
Y
L
L
K
T
K
L
S
E
R
E
N
Q
Y
A
Site 22
Y332
L
S
E
R
E
N
Q
Y
A
L
R
K
I
Q
I
Site 23
S348
N
A
E
N
T
M
K
S
L
L
S
D
V
E
E
Site 24
S351
N
T
M
K
S
L
L
S
D
V
E
E
L
V
E
Site 25
S374
G
Q
L
V
Q
K
E
S
M
D
T
I
N
H
A
Site 26
T377
V
Q
K
E
S
M
D
T
I
N
H
A
S
Q
L
Site 27
Y404
E
I
N
N
K
M
L
Y
Y
G
E
E
H
E
L
Site 28
S412
Y
G
E
E
H
E
L
S
P
K
E
I
S
E
K
Site 29
S432
K
M
L
E
E
I
R
S
R
Q
P
F
F
T
Q
Site 30
T438
R
S
R
Q
P
F
F
T
Q
R
E
L
V
D
E
Site 31
Y451
D
E
E
A
D
E
A
Y
E
L
L
S
Q
A
E
Site 32
S455
D
E
A
Y
E
L
L
S
Q
A
E
S
W
Q
R
Site 33
S459
E
L
L
S
Q
A
E
S
W
Q
R
L
H
N
E
Site 34
T467
W
Q
R
L
H
N
E
T
R
T
L
F
P
V
V
Site 35
T469
R
L
H
N
E
T
R
T
L
F
P
V
V
L
E
Site 36
Y481
V
L
E
Q
L
D
D
Y
N
A
K
L
S
D
L
Site 37
S486
D
D
Y
N
A
K
L
S
D
L
Q
E
A
L
D
Site 38
T509
A
E
D
M
N
R
A
T
A
A
R
Q
R
D
H
Site 39
S533
Q
M
E
V
V
N
M
S
L
S
T
S
A
D
S
Site 40
S537
V
N
M
S
L
S
T
S
A
D
S
L
T
T
P
Site 41
S540
S
L
S
T
S
A
D
S
L
T
T
P
R
L
T
Site 42
T542
S
T
S
A
D
S
L
T
T
P
R
L
T
L
S
Site 43
T543
T
S
A
D
S
L
T
T
P
R
L
T
L
S
E
Site 44
T547
S
L
T
T
P
R
L
T
L
S
E
L
D
D
I
Site 45
S549
T
T
P
R
L
T
L
S
E
L
D
D
I
I
K
Site 46
S570
A
E
I
D
G
A
K
S
E
L
Q
V
K
L
S
Site 47
S577
S
E
L
Q
V
K
L
S
N
L
S
N
L
S
H
Site 48
S580
Q
V
K
L
S
N
L
S
N
L
S
H
D
L
V
Site 49
S605
Q
Q
E
A
N
E
L
S
R
K
L
H
S
S
D
Site 50
S611
L
S
R
K
L
H
S
S
D
M
N
G
L
V
Q
Site 51
Y633
V
Y
E
N
I
V
N
Y
V
S
E
A
N
E
T
Site 52
T640
Y
V
S
E
A
N
E
T
A
E
F
A
L
N
T
Site 53
Y652
L
N
T
T
D
R
I
Y
D
A
V
S
G
I
D
Site 54
T660
D
A
V
S
G
I
D
T
Q
I
I
Y
H
K
D
Site 55
Y664
G
I
D
T
Q
I
I
Y
H
K
D
E
S
E
N
Site 56
T694
S
D
E
A
V
A
D
T
S
R
R
V
G
G
A
Site 57
S695
D
E
A
V
A
D
T
S
R
R
V
G
G
A
L
Site 58
S706
G
G
A
L
A
R
K
S
A
L
K
T
R
L
S
Site 59
T710
A
R
K
S
A
L
K
T
R
L
S
D
A
V
K
Site 60
S713
S
A
L
K
T
R
L
S
D
A
V
K
Q
L
Q
Site 61
T738
L
G
Q
S
R
L
I
T
E
E
A
N
R
T
T
Site 62
T745
T
E
E
A
N
R
T
T
M
E
V
Q
Q
A
T
Site 63
S771
Q
N
L
Q
H
F
D
S
S
A
Y
N
T
A
V
Site 64
T776
F
D
S
S
A
Y
N
T
A
V
N
S
A
R
D
Site 65
S780
A
Y
N
T
A
V
N
S
A
R
D
A
V
R
N
Site 66
T789
R
D
A
V
R
N
L
T
E
V
V
P
Q
L
L
Site 67
T801
Q
L
L
D
Q
L
R
T
V
E
Q
K
R
P
A
Site 68
S809
V
E
Q
K
R
P
A
S
N
V
S
A
S
I
Q
Site 69
S814
P
A
S
N
V
S
A
S
I
Q
R
I
R
E
L
Site 70
S842
S
M
M
F
D
G
Q
S
A
V
E
V
H
S
R
Site 71
S851
V
E
V
H
S
R
T
S
M
D
D
L
K
A
F
Site 72
S860
D
D
L
K
A
F
T
S
L
S
L
Y
M
K
P
Site 73
Y864
A
F
T
S
L
S
L
Y
M
K
P
P
V
K
R
Site 74
T877
K
R
P
E
L
T
E
T
A
D
Q
F
I
L
Y
Site 75
Y884
T
A
D
Q
F
I
L
Y
L
G
S
K
N
A
K
Site 76
S887
Q
F
I
L
Y
L
G
S
K
N
A
K
K
E
Y
Site 77
Y894
S
K
N
A
K
K
E
Y
M
G
L
A
I
K
N
Site 78
Y906
I
K
N
D
N
L
V
Y
V
Y
N
L
G
T
K
Site 79
S921
D
V
E
I
P
L
D
S
K
P
V
S
S
W
P
Site 80
S925
P
L
D
S
K
P
V
S
S
W
P
A
Y
F
S
Site 81
S926
L
D
S
K
P
V
S
S
W
P
A
Y
F
S
I
Site 82
T948
K
H
G
K
V
F
L
T
V
P
S
L
S
S
T
Site 83
T955
T
V
P
S
L
S
S
T
A
E
E
K
F
I
K
Site 84
S967
F
I
K
K
G
E
F
S
G
D
D
S
L
L
D
Site 85
S971
G
E
F
S
G
D
D
S
L
L
D
L
D
P
E
Site 86
Y983
D
P
E
D
T
V
F
Y
V
G
G
V
P
S
N
Site 87
Y1019
N
N
D
V
I
S
L
Y
N
F
K
H
I
Y
N
Site 88
Y1025
L
Y
N
F
K
H
I
Y
N
M
D
P
S
T
S
Site 89
T1031
I
Y
N
M
D
P
S
T
S
V
P
C
A
R
D
Site 90
S1032
Y
N
M
D
P
S
T
S
V
P
C
A
R
D
K
Site 91
T1043
A
R
D
K
L
A
F
T
Q
S
R
A
A
S
Y
Site 92
S1045
D
K
L
A
F
T
Q
S
R
A
A
S
Y
F
F
Site 93
S1049
F
T
Q
S
R
A
A
S
Y
F
F
D
G
S
G
Site 94
Y1050
T
Q
S
R
A
A
S
Y
F
F
D
G
S
G
Y
Site 95
T1064
Y
A
V
V
R
D
I
T
R
R
G
K
F
G
Q
Site 96
T1081
R
F
D
I
E
V
R
T
P
A
D
N
G
L
I
Site 97
Y1106
R
L
E
M
R
N
G
Y
L
H
V
F
Y
D
F
Site 98
Y1111
N
G
Y
L
H
V
F
Y
D
F
G
F
S
S
G
Site 99
S1117
F
Y
D
F
G
F
S
S
G
P
V
H
L
E
D
Site 100
T1125
G
P
V
H
L
E
D
T
L
K
K
A
Q
I
N
Site 101
Y1136
A
Q
I
N
D
A
K
Y
H
E
I
S
I
I
Y
Site 102
Y1143
Y
H
E
I
S
I
I
Y
H
N
D
K
K
M
I
Site 103
S1160
V
D
R
R
H
V
K
S
M
D
N
E
K
M
K
Site 104
Y1174
K
I
P
F
T
D
I
Y
I
G
G
A
P
P
E
Site 105
S1185
A
P
P
E
I
L
Q
S
R
A
L
R
A
H
L
Site 106
T1220
N
L
L
E
Q
T
E
T
L
G
V
G
Y
G
C
Site 107
Y1225
T
E
T
L
G
V
G
Y
G
C
P
E
D
S
L
Site 108
S1231
G
Y
G
C
P
E
D
S
L
I
S
R
R
A
Y
Site 109
Y1238
S
L
I
S
R
R
A
Y
F
N
G
Q
S
F
I
Site 110
S1243
R
A
Y
F
N
G
Q
S
F
I
A
S
I
Q
K
Site 111
T1265
E
G
G
F
N
F
R
T
L
Q
P
N
G
L
L
Site 112
Y1274
Q
P
N
G
L
L
F
Y
Y
A
S
G
S
D
V
Site 113
S1283
A
S
G
S
D
V
F
S
I
S
L
D
N
G
T
Site 114
S1302
V
K
G
I
K
V
Q
S
V
D
K
Q
Y
N
D
Site 115
Y1307
V
Q
S
V
D
K
Q
Y
N
D
G
L
S
H
F
Site 116
S1312
K
Q
Y
N
D
G
L
S
H
F
V
I
S
S
V
Site 117
S1318
L
S
H
F
V
I
S
S
V
S
P
T
R
Y
E
Site 118
Y1324
S
S
V
S
P
T
R
Y
E
L
I
V
D
K
S
Site 119
S1331
Y
E
L
I
V
D
K
S
R
V
G
S
K
N
P
Site 120
S1335
V
D
K
S
R
V
G
S
K
N
P
T
K
G
K
Site 121
T1339
R
V
G
S
K
N
P
T
K
G
K
I
E
Q
T
Site 122
S1349
K
I
E
Q
T
Q
A
S
E
K
K
F
Y
F
G
Site 123
Y1354
Q
A
S
E
K
K
F
Y
F
G
G
S
P
I
S
Site 124
S1358
K
K
F
Y
F
G
G
S
P
I
S
A
Q
Y
A
Site 125
S1361
Y
F
G
G
S
P
I
S
A
Q
Y
A
N
F
T
Site 126
T1368
S
A
Q
Y
A
N
F
T
G
C
I
S
N
A
Y
Site 127
Y1375
T
G
C
I
S
N
A
Y
F
T
R
V
D
R
D
Site 128
T1392
V
E
D
F
Q
R
Y
T
E
K
V
H
T
S
L
Site 129
T1397
R
Y
T
E
K
V
H
T
S
L
Y
E
C
P
I
Site 130
Y1400
E
K
V
H
T
S
L
Y
E
C
P
I
E
S
S
Site 131
S1407
Y
E
C
P
I
E
S
S
P
L
F
L
L
H
K
Site 132
S1420
H
K
K
G
K
N
L
S
K
P
K
A
S
Q
N
Site 133
S1425
N
L
S
K
P
K
A
S
Q
N
K
K
G
G
K
Site 134
S1433
Q
N
K
K
G
G
K
S
K
D
A
P
S
W
D
Site 135
S1438
G
K
S
K
D
A
P
S
W
D
P
V
A
L
K
Site 136
T1451
L
K
L
P
E
R
N
T
P
R
N
S
H
C
H
Site 137
S1455
E
R
N
T
P
R
N
S
H
C
H
L
S
N
S
Site 138
S1460
R
N
S
H
C
H
L
S
N
S
P
R
A
I
E
Site 139
S1462
S
H
C
H
L
S
N
S
P
R
A
I
E
H
A
Site 140
Y1470
P
R
A
I
E
H
A
Y
Q
Y
G
G
T
A
N
Site 141
S1478
Q
Y
G
G
T
A
N
S
R
Q
E
F
E
H
L
Site 142
S1493
K
G
D
F
G
A
K
S
Q
F
S
I
R
L
R
Site 143
S1496
F
G
A
K
S
Q
F
S
I
R
L
R
T
R
S
Site 144
T1501
Q
F
S
I
R
L
R
T
R
S
S
H
G
M
I
Site 145
S1503
S
I
R
L
R
T
R
S
S
H
G
M
I
F
Y
Site 146
S1504
I
R
L
R
T
R
S
S
H
G
M
I
F
Y
V
Site 147
Y1510
S
S
H
G
M
I
F
Y
V
S
D
Q
E
E
N
Site 148
T1521
Q
E
E
N
D
F
M
T
L
F
L
A
H
G
R
Site 149
S1544
H
K
K
L
K
I
R
S
Q
E
K
Y
N
D
G
Site 150
Y1548
K
I
R
S
Q
E
K
Y
N
D
G
L
W
H
D
Site 151
S1563
V
I
F
I
R
E
R
S
S
G
R
L
V
I
D
Site 152
S1564
I
F
I
R
E
R
S
S
G
R
L
V
I
D
G
Site 153
S1578
G
L
R
V
L
E
E
S
L
P
P
T
E
A
T
Site 154
T1582
L
E
E
S
L
P
P
T
E
A
T
W
K
I
K
Site 155
S1636
T
S
A
S
Q
T
F
S
V
T
P
C
F
E
G
Site 156
T1649
E
G
P
M
E
T
G
T
Y
F
S
T
E
G
G
Site 157
Y1650
G
P
M
E
T
G
T
Y
F
S
T
E
G
G
Y
Site 158
Y1657
Y
F
S
T
E
G
G
Y
V
V
L
D
E
S
F
Site 159
S1680
A
F
E
V
R
P
R
S
S
S
G
T
L
V
H
Site 160
S1681
F
E
V
R
P
R
S
S
S
G
T
L
V
H
G
Site 161
S1682
E
V
R
P
R
S
S
S
G
T
L
V
H
G
H
Site 162
T1684
R
P
R
S
S
S
G
T
L
V
H
G
H
S
V
Site 163
S1690
G
T
L
V
H
G
H
S
V
N
G
E
Y
L
N
Site 164
Y1695
G
H
S
V
N
G
E
Y
L
N
V
H
M
K
N
Site 165
S1717
N
N
G
I
R
D
F
S
T
S
V
T
P
K
Q
Site 166
T1718
N
G
I
R
D
F
S
T
S
V
T
P
K
Q
S
Site 167
S1719
G
I
R
D
F
S
T
S
V
T
P
K
Q
S
L
Site 168
T1721
R
D
F
S
T
S
V
T
P
K
Q
S
L
C
D
Site 169
S1725
T
S
V
T
P
K
Q
S
L
C
D
G
R
W
H
Site 170
T1735
D
G
R
W
H
R
I
T
V
I
R
D
S
N
V
Site 171
T1780
G
V
P
E
S
L
L
T
P
R
L
A
P
S
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation