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Updated November 2019
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Protein Info
Short Name:
ZFHX3
Full Name:
Zinc finger homeobox protein 3
Alias:
Alpha-fetoprotein enhancer-binding; AT motif-binding factor 1; ATBF1; AT-binding transcription factor 1; ATBT; Zinc finger homeobox 3
Type:
Transcription regulation protein, activator
Mass (Da):
404419
Number AA:
3703
UniProt ID:
Q15911
International Prot ID:
IPI00014186
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005667
Uniprot
OncoNet
Molecular Function:
GO:0003705
GO:0019899
GO:0010843
PhosphoSite+
KinaseNET
Biological Process:
GO:0045662
GO:0000122
GO:0045663
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
E
G
C
D
S
P
V
V
S
G
K
D
Site 2
S10
G
C
D
S
P
V
V
S
G
K
D
N
G
C
G
Site 3
T30
Q
W
T
E
L
N
S
T
H
L
P
D
K
P
S
Site 4
S37
T
H
L
P
D
K
P
S
S
M
E
Q
S
T
G
Site 5
S38
H
L
P
D
K
P
S
S
M
E
Q
S
T
G
E
Site 6
S42
K
P
S
S
M
E
Q
S
T
G
E
S
H
G
P
Site 7
S46
M
E
Q
S
T
G
E
S
H
G
P
L
D
S
L
Site 8
S52
E
S
H
G
P
L
D
S
L
R
A
P
F
N
E
Site 9
T65
N
E
R
L
A
E
S
T
A
S
A
G
P
P
S
Site 10
S67
R
L
A
E
S
T
A
S
A
G
P
P
S
E
P
Site 11
S72
T
A
S
A
G
P
P
S
E
P
A
S
K
E
V
Site 12
S76
G
P
P
S
E
P
A
S
K
E
V
T
C
N
E
Site 13
T80
E
P
A
S
K
E
V
T
C
N
E
C
S
A
S
Site 14
S87
T
C
N
E
C
S
A
S
F
A
S
L
Q
T
Y
Site 15
S90
E
C
S
A
S
F
A
S
L
Q
T
Y
M
E
H
Site 16
Y94
S
F
A
S
L
Q
T
Y
M
E
H
H
C
P
S
Site 17
S101
Y
M
E
H
H
C
P
S
A
R
P
P
P
P
L
Site 18
S112
P
P
P
L
R
E
E
S
A
S
D
T
G
E
E
Site 19
S114
P
L
R
E
E
S
A
S
D
T
G
E
E
G
D
Site 20
T116
R
E
E
S
A
S
D
T
G
E
E
G
D
E
E
Site 21
S124
G
E
E
G
D
E
E
S
D
V
E
N
L
A
G
Site 22
Y135
N
L
A
G
E
I
V
Y
Q
P
D
G
S
A
Y
Site 23
Y142
Y
Q
P
D
G
S
A
Y
I
V
E
S
L
S
Q
Site 24
S146
G
S
A
Y
I
V
E
S
L
S
Q
L
T
Q
G
Site 25
S159
Q
G
G
G
A
C
G
S
G
S
G
S
G
P
L
Site 26
S161
G
G
A
C
G
S
G
S
G
S
G
P
L
P
S
Site 27
S185
G
G
K
Q
G
D
P
S
C
A
A
P
V
Y
P
Site 28
S240
V
F
D
V
R
H
K
S
N
K
D
Y
L
N
S
Site 29
Y244
R
H
K
S
N
K
D
Y
L
N
S
D
G
S
A
Site 30
S247
S
N
K
D
Y
L
N
S
D
G
S
A
K
S
S
Site 31
S250
D
Y
L
N
S
D
G
S
A
K
S
S
C
V
S
Site 32
S253
N
S
D
G
S
A
K
S
S
C
V
S
K
D
V
Site 33
S254
S
D
G
S
A
K
S
S
C
V
S
K
D
V
P
Site 34
S257
S
A
K
S
S
C
V
S
K
D
V
P
N
N
V
Site 35
S267
V
P
N
N
V
D
L
S
K
F
D
G
F
V
L
Site 36
Y275
K
F
D
G
F
V
L
Y
G
K
R
K
P
I
L
Site 37
Y293
L
C
K
L
S
F
G
Y
V
R
S
F
V
T
H
Site 38
T308
A
V
H
D
H
R
M
T
L
S
E
D
E
R
K
Site 39
S310
H
D
H
R
M
T
L
S
E
D
E
R
K
I
L
Site 40
S318
E
D
E
R
K
I
L
S
N
K
N
I
S
A
I
Site 41
S338
K
D
K
E
P
L
V
S
F
L
E
P
K
N
K
Site 42
S363
N
L
I
G
P
G
H
S
F
Y
G
K
F
S
G
Site 43
Y365
I
G
P
G
H
S
F
Y
G
K
F
S
G
I
R
Site 44
S425
V
P
L
G
P
L
A
S
S
P
T
K
S
S
E
Site 45
S426
P
L
G
P
L
A
S
S
P
T
K
S
S
E
G
Site 46
T428
G
P
L
A
S
S
P
T
K
S
S
E
G
K
D
Site 47
S430
L
A
S
S
P
T
K
S
S
E
G
K
D
S
G
Site 48
S431
A
S
S
P
T
K
S
S
E
G
K
D
S
G
A
Site 49
S436
K
S
S
E
G
K
D
S
G
A
A
E
G
E
K
Site 50
S453
V
G
D
G
D
C
F
S
E
K
V
E
P
A
E
Site 51
S497
G
C
K
G
L
F
P
S
E
L
D
E
E
L
E
Site 52
S517
E
P
G
A
A
A
G
S
S
S
K
K
D
L
A
Site 53
S526
S
K
K
D
L
A
L
S
N
Q
S
I
S
N
S
Site 54
S529
D
L
A
L
S
N
Q
S
I
S
N
S
P
L
M
Site 55
S531
A
L
S
N
Q
S
I
S
N
S
P
L
M
P
N
Site 56
S533
S
N
Q
S
I
S
N
S
P
L
M
P
N
V
L
Site 57
S544
P
N
V
L
Q
T
L
S
R
G
T
A
S
T
S
Site 58
T547
L
Q
T
L
S
R
G
T
A
S
T
S
S
N
S
Site 59
S549
T
L
S
R
G
T
A
S
T
S
S
N
S
A
S
Site 60
T550
L
S
R
G
T
A
S
T
S
S
N
S
A
S
S
Site 61
S551
S
R
G
T
A
S
T
S
S
N
S
A
S
S
F
Site 62
S552
R
G
T
A
S
T
S
S
N
S
A
S
S
F
V
Site 63
S556
S
T
S
S
N
S
A
S
S
F
V
V
F
D
G
Site 64
S571
A
N
R
R
N
R
L
S
F
N
S
E
G
V
R
Site 65
S574
R
N
R
L
S
F
N
S
E
G
V
R
A
N
V
Site 66
S608
T
A
P
E
P
N
E
S
T
E
G
D
D
G
G
Site 67
S625
P
H
H
Q
H
A
G
S
L
C
E
L
G
V
G
Site 68
S638
V
G
E
C
P
S
G
S
G
V
E
C
P
K
C
Site 69
T647
V
E
C
P
K
C
D
T
V
L
G
S
S
R
S
Site 70
S651
K
C
D
T
V
L
G
S
S
R
S
L
G
G
H
Site 71
S652
C
D
T
V
L
G
S
S
R
S
L
G
G
H
M
Site 72
S654
T
V
L
G
S
S
R
S
L
G
G
H
M
T
M
Site 73
T660
R
S
L
G
G
H
M
T
M
M
H
S
R
N
S
Site 74
T670
H
S
R
N
S
C
K
T
L
K
C
P
K
C
N
Site 75
S700
K
H
P
E
P
G
G
S
C
V
Y
C
K
S
G
Site 76
Y703
E
P
G
G
S
C
V
Y
C
K
S
G
Q
P
H
Site 77
S706
G
S
C
V
Y
C
K
S
G
Q
P
H
P
R
L
Site 78
S718
P
R
L
A
R
G
E
S
Y
T
C
G
Y
K
P
Site 79
Y719
R
L
A
R
G
E
S
Y
T
C
G
Y
K
P
F
Site 80
T720
L
A
R
G
E
S
Y
T
C
G
Y
K
P
F
R
Site 81
Y733
F
R
C
E
V
C
N
Y
S
T
T
T
K
G
N
Site 82
S742
T
T
T
K
G
N
L
S
I
H
M
Q
S
D
K
Site 83
S767
G
G
G
E
Q
V
F
S
H
T
A
G
A
A
A
Site 84
S789
A
A
A
N
I
S
S
S
C
G
A
P
S
P
T
Site 85
S794
S
S
S
C
G
A
P
S
P
T
K
P
K
T
K
Site 86
T796
S
C
G
A
P
S
P
T
K
P
K
T
K
P
T
Site 87
T800
P
S
P
T
K
P
K
T
K
P
T
W
R
C
E
Site 88
T803
T
K
P
K
T
K
P
T
W
R
C
E
V
C
D
Site 89
Y811
W
R
C
E
V
C
D
Y
E
T
N
V
A
R
N
Site 90
S852
N
R
H
L
G
L
G
S
L
P
S
P
A
E
A
Site 91
Y862
S
P
A
E
A
E
L
Y
Q
Y
Y
L
A
Q
N
Site 92
Y864
A
E
A
E
L
Y
Q
Y
Y
L
A
Q
N
M
N
Site 93
Y865
E
A
E
L
Y
Q
Y
Y
L
A
Q
N
M
N
L
Site 94
S879
L
P
N
L
K
M
D
S
A
A
S
D
A
Q
F
Site 95
S882
L
K
M
D
S
A
A
S
D
A
Q
F
M
M
S
Site 96
S933
E
L
M
N
L
G
E
S
F
I
Q
T
N
D
P
Site 97
T937
L
G
E
S
F
I
Q
T
N
D
P
S
L
K
L
Site 98
S970
L
H
M
N
V
E
R
S
L
S
E
D
E
W
K
Site 99
S972
M
N
V
E
R
S
L
S
E
D
E
W
K
A
V
Site 100
Y984
K
A
V
M
G
D
S
Y
Q
C
K
L
C
R
Y
Site 101
Y1012
T
D
K
H
V
Q
K
Y
Q
L
V
A
H
I
K
Site 102
Y1047
L
K
C
N
A
C
D
Y
Y
T
N
S
L
E
K
Site 103
Y1048
K
C
N
A
C
D
Y
Y
T
N
S
L
E
K
L
Site 104
S1051
A
C
D
Y
Y
T
N
S
L
E
K
L
R
L
H
Site 105
T1059
L
E
K
L
R
L
H
T
V
N
S
R
H
E
A
Site 106
S1062
L
R
L
H
T
V
N
S
R
H
E
A
S
L
K
Site 107
Y1071
H
E
A
S
L
K
L
Y
K
H
L
Q
Q
H
E
Site 108
S1079
K
H
L
Q
Q
H
E
S
G
V
E
G
E
S
C
Site 109
Y1088
V
E
G
E
S
C
Y
Y
H
C
V
L
C
N
Y
Site 110
S1115
R
S
M
K
H
Q
R
S
E
S
L
R
K
L
Q
Site 111
S1117
M
K
H
Q
R
S
E
S
L
R
K
L
Q
R
L
Site 112
T1140
E
D
L
G
Q
I
F
T
I
R
R
C
P
S
T
Site 113
S1146
F
T
I
R
R
C
P
S
T
D
P
E
E
A
I
Site 114
T1147
T
I
R
R
C
P
S
T
D
P
E
E
A
I
E
Site 115
S1180
Q
E
G
G
A
S
S
S
Q
A
E
K
E
L
T
Site 116
T1187
S
Q
A
E
K
E
L
T
D
S
P
A
T
S
K
Site 117
S1189
A
E
K
E
L
T
D
S
P
A
T
S
K
R
I
Site 118
S1193
L
T
D
S
P
A
T
S
K
R
I
S
F
P
G
Site 119
S1197
P
A
T
S
K
R
I
S
F
P
G
S
S
E
S
Site 120
S1201
K
R
I
S
F
P
G
S
S
E
S
P
L
S
S
Site 121
S1202
R
I
S
F
P
G
S
S
E
S
P
L
S
S
K
Site 122
S1204
S
F
P
G
S
S
E
S
P
L
S
S
K
R
P
Site 123
S1207
G
S
S
E
S
P
L
S
S
K
R
P
K
T
A
Site 124
S1208
S
S
E
S
P
L
S
S
K
R
P
K
T
A
E
Site 125
T1213
L
S
S
K
R
P
K
T
A
E
E
I
K
P
E
Site 126
Y1223
E
I
K
P
E
Q
M
Y
Q
C
P
Y
C
K
Y
Site 127
T1244
R
L
R
V
H
A
M
T
Q
H
S
V
Q
P
M
Site 128
S1247
V
H
A
M
T
Q
H
S
V
Q
P
M
L
R
C
Site 129
S1313
V
P
D
R
D
G
N
S
N
L
E
E
A
G
K
Site 130
S1335
L
G
K
N
I
L
P
S
A
S
T
E
Q
S
G
Site 131
S1337
K
N
I
L
P
S
A
S
T
E
Q
S
G
D
L
Site 132
S1341
P
S
A
S
T
E
Q
S
G
D
L
K
P
S
P
Site 133
S1347
Q
S
G
D
L
K
P
S
P
A
D
P
G
S
V
Site 134
S1353
P
S
P
A
D
P
G
S
V
R
E
D
S
G
F
Site 135
S1358
P
G
S
V
R
E
D
S
G
F
I
C
W
K
K
Site 136
S1394
K
R
P
Q
L
P
V
S
D
R
H
V
Y
K
Y
Site 137
Y1399
P
V
S
D
R
H
V
Y
K
Y
R
C
N
Q
C
Site 138
Y1401
S
D
R
H
V
Y
K
Y
R
C
N
Q
C
S
L
Site 139
T1440
L
C
Q
R
S
F
R
T
F
Q
A
L
K
K
H
Site 140
S1451
L
K
K
H
L
E
T
S
H
L
E
L
S
E
A
Site 141
S1456
E
T
S
H
L
E
L
S
E
A
D
I
Q
Q
L
Site 142
Y1464
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P
S
S
I
Site 294
S2801
L
S
P
R
T
L
L
S
P
S
S
I
K
V
E
Site 295
S2803
P
R
T
L
L
S
P
S
S
I
K
V
E
G
I
Site 296
S2804
R
T
L
L
S
P
S
S
I
K
V
E
G
I
E
Site 297
S2815
E
G
I
E
D
F
E
S
P
S
M
S
S
V
N
Site 298
S2817
I
E
D
F
E
S
P
S
M
S
S
V
N
L
N
Site 299
S2819
D
F
E
S
P
S
M
S
S
V
N
L
N
F
D
Site 300
T2828
V
N
L
N
F
D
Q
T
K
L
D
N
D
D
C
Site 301
S2836
K
L
D
N
D
D
C
S
S
V
N
T
A
I
T
Site 302
S2837
L
D
N
D
D
C
S
S
V
N
T
A
I
T
D
Site 303
T2846
N
T
A
I
T
D
T
T
T
G
D
E
G
N
A
Site 304
S2857
E
G
N
A
D
N
D
S
A
T
G
I
A
T
E
Site 305
T2863
D
S
A
T
G
I
A
T
E
T
K
S
S
S
A
Site 306
T2865
A
T
G
I
A
T
E
T
K
S
S
S
A
P
N
Site 307
S2867
G
I
A
T
E
T
K
S
S
S
A
P
N
E
G
Site 308
S2868
I
A
T
E
T
K
S
S
S
A
P
N
E
G
L
Site 309
S2869
A
T
E
T
K
S
S
S
A
P
N
E
G
L
T
Site 310
T2876
S
A
P
N
E
G
L
T
K
A
A
M
M
A
M
Site 311
Y2886
A
M
M
A
M
S
E
Y
E
D
R
L
S
S
G
Site 312
S2891
S
E
Y
E
D
R
L
S
S
G
L
V
S
P
A
Site 313
S2892
E
Y
E
D
R
L
S
S
G
L
V
S
P
A
P
Site 314
S2896
R
L
S
S
G
L
V
S
P
A
P
S
F
Y
S
Site 315
S2900
G
L
V
S
P
A
P
S
F
Y
S
K
E
Y
D
Site 316
Y2906
P
S
F
Y
S
K
E
Y
D
N
E
G
T
V
D
Site 317
T2911
K
E
Y
D
N
E
G
T
V
D
Y
S
E
T
S
Site 318
Y2914
D
N
E
G
T
V
D
Y
S
E
T
S
S
L
A
Site 319
S2915
N
E
G
T
V
D
Y
S
E
T
S
S
L
A
D
Site 320
S2919
V
D
Y
S
E
T
S
S
L
A
D
P
C
S
P
Site 321
S2925
S
S
L
A
D
P
C
S
P
S
P
G
A
S
G
Site 322
S2927
L
A
D
P
C
S
P
S
P
G
A
S
G
S
A
Site 323
S2931
C
S
P
S
P
G
A
S
G
S
A
G
K
S
G
Site 324
S2933
P
S
P
G
A
S
G
S
A
G
K
S
G
D
S
Site 325
S2937
A
S
G
S
A
G
K
S
G
D
S
G
D
R
P
Site 326
S2940
S
A
G
K
S
G
D
S
G
D
R
P
G
Q
K
Site 327
T2951
P
G
Q
K
R
F
R
T
Q
M
T
N
L
Q
L
Site 328
S2963
L
Q
L
K
V
L
K
S
C
F
N
D
Y
R
T
Site 329
Y2968
L
K
S
C
F
N
D
Y
R
T
P
T
M
L
E
Site 330
T2970
S
C
F
N
D
Y
R
T
P
T
M
L
E
C
E
Site 331
T2972
F
N
D
Y
R
T
P
T
M
L
E
C
E
V
L
Site 332
S3004
A
R
A
K
E
K
K
S
K
L
S
M
A
K
H
Site 333
S3007
K
E
K
K
S
K
L
S
M
A
K
H
F
G
I
Site 334
Y3019
F
G
I
N
Q
T
S
Y
E
G
P
K
T
E
C
Site 335
T3024
T
S
Y
E
G
P
K
T
E
C
T
L
C
G
I
Site 336
T3027
E
G
P
K
T
E
C
T
L
C
G
I
K
Y
S
Site 337
S3034
T
L
C
G
I
K
Y
S
A
R
L
S
V
R
D
Site 338
S3038
I
K
Y
S
A
R
L
S
V
R
D
H
I
F
S
Site 339
S3045
S
V
R
D
H
I
F
S
Q
Q
H
I
S
K
V
Site 340
Y3066
Q
L
D
K
E
K
E
Y
F
D
P
A
T
V
R
Site 341
T3071
K
E
Y
F
D
P
A
T
V
R
Q
L
M
A
Q
Site 342
T3104
Q
Q
G
M
F
D
N
T
P
L
Q
A
L
N
L
Site 343
S3133
L
P
G
L
N
S
P
S
L
P
G
F
T
P
S
Site 344
T3138
S
P
S
L
P
G
F
T
P
S
N
T
A
L
T
Site 345
S3140
S
L
P
G
F
T
P
S
N
T
A
L
T
S
P
Site 346
T3142
P
G
F
T
P
S
N
T
A
L
T
S
P
K
P
Site 347
S3146
P
S
N
T
A
L
T
S
P
K
P
N
L
M
G
Site 348
S3156
P
N
L
M
G
L
P
S
T
T
V
P
S
P
G
Site 349
S3161
L
P
S
T
T
V
P
S
P
G
L
P
T
S
G
Site 350
S3167
P
S
P
G
L
P
T
S
G
L
P
N
K
P
S
Site 351
S3174
S
G
L
P
N
K
P
S
S
A
S
L
S
S
P
Site 352
S3175
G
L
P
N
K
P
S
S
A
S
L
S
S
P
T
Site 353
S3177
P
N
K
P
S
S
A
S
L
S
S
P
T
P
A
Site 354
S3179
K
P
S
S
A
S
L
S
S
P
T
P
A
Q
A
Site 355
S3180
P
S
S
A
S
L
S
S
P
T
P
A
Q
A
T
Site 356
T3182
S
A
S
L
S
S
P
T
P
A
Q
A
T
M
A
Site 357
T3221
P
A
A
Q
P
P
P
T
P
Q
L
P
L
Q
Q
Site 358
S3237
Q
Q
R
K
D
K
D
S
E
K
V
K
E
K
E
Site 359
S3316
P
Y
F
V
P
G
F
S
P
Y
Y
A
P
Q
I
Site 360
Y3319
V
P
G
F
S
P
Y
Y
A
P
Q
I
P
G
A
Site 361
S3329
Q
I
P
G
A
L
Q
S
G
Y
L
Q
P
M
Y
Site 362
Y3331
P
G
A
L
Q
S
G
Y
L
Q
P
M
Y
G
M
Site 363
Y3336
S
G
Y
L
Q
P
M
Y
G
M
E
G
L
F
P
Site 364
S3359
L
M
G
L
S
P
G
S
L
L
Q
Q
Y
Q
Q
Site 365
Y3364
P
G
S
L
L
Q
Q
Y
Q
Q
Y
Q
Q
S
L
Site 366
S3399
Q
Q
Q
Q
P
K
A
S
Q
T
P
V
P
P
G
Site 367
T3401
Q
Q
P
K
A
S
Q
T
P
V
P
P
G
A
P
Site 368
S3409
P
V
P
P
G
A
P
S
P
D
K
D
P
A
K
Site 369
S3418
D
K
D
P
A
K
E
S
P
K
P
E
E
Q
K
Site 370
T3427
K
P
E
E
Q
K
N
T
P
R
E
V
S
P
L
Site 371
S3432
K
N
T
P
R
E
V
S
P
L
L
P
K
L
P
Site 372
S3448
E
P
E
A
E
S
K
S
A
D
S
L
Y
D
P
Site 373
S3451
A
E
S
K
S
A
D
S
L
Y
D
P
F
I
V
Site 374
Y3453
S
K
S
A
D
S
L
Y
D
P
F
I
V
P
K
Site 375
S3475
R
K
C
Q
A
G
F
S
D
E
E
A
A
R
S
Site 376
S3482
S
D
E
E
A
A
R
S
H
L
K
S
L
C
F
Site 377
S3486
A
A
R
S
H
L
K
S
L
C
F
F
G
Q
S
Site 378
S3513
T
G
G
G
G
G
G
S
G
G
G
G
G
G
G
Site 379
S3528
G
G
G
G
G
G
G
S
Y
H
C
L
A
C
E
Site 380
Y3529
G
G
G
G
G
G
S
Y
H
C
L
A
C
E
S
Site 381
S3545
L
C
G
E
E
A
L
S
Q
H
L
E
S
A
L
Site 382
T3557
S
A
L
H
K
H
R
T
I
T
R
A
A
R
N
Site 383
T3559
L
H
K
H
R
T
I
T
R
A
A
R
N
A
K
Site 384
S3570
R
N
A
K
E
H
P
S
L
L
P
H
S
A
C
Site 385
S3575
H
P
S
L
L
P
H
S
A
C
F
P
D
P
S
Site 386
S3582
S
A
C
F
P
D
P
S
T
A
S
T
S
Q
S
Site 387
T3583
A
C
F
P
D
P
S
T
A
S
T
S
Q
S
A
Site 388
S3585
F
P
D
P
S
T
A
S
T
S
Q
S
A
A
H
Site 389
T3586
P
D
P
S
T
A
S
T
S
Q
S
A
A
H
S
Site 390
S3587
D
P
S
T
A
S
T
S
Q
S
A
A
H
S
N
Site 391
S3589
S
T
A
S
T
S
Q
S
A
A
H
S
N
D
S
Site 392
S3593
T
S
Q
S
A
A
H
S
N
D
S
P
P
P
P
Site 393
S3596
S
A
A
H
S
N
D
S
P
P
P
P
S
A
A
Site 394
S3601
N
D
S
P
P
P
P
S
A
A
A
P
S
S
A
Site 395
S3606
P
P
S
A
A
A
P
S
S
A
S
P
H
A
S
Site 396
S3607
P
S
A
A
A
P
S
S
A
S
P
H
A
S
R
Site 397
S3609
A
A
A
P
S
S
A
S
P
H
A
S
R
K
S
Site 398
S3613
S
S
A
S
P
H
A
S
R
K
S
W
P
Q
V
Site 399
S3616
S
P
H
A
S
R
K
S
W
P
Q
V
V
S
R
Site 400
S3625
P
Q
V
V
S
R
A
S
A
A
K
P
P
S
F
Site 401
S3631
A
S
A
A
K
P
P
S
F
P
P
L
S
S
S
Site 402
S3636
P
P
S
F
P
P
L
S
S
S
S
T
V
T
S
Site 403
S3637
P
S
F
P
P
L
S
S
S
S
T
V
T
S
S
Site 404
S3638
S
F
P
P
L
S
S
S
S
T
V
T
S
S
S
Site 405
S3639
F
P
P
L
S
S
S
S
T
V
T
S
S
S
C
Site 406
T3640
P
P
L
S
S
S
S
T
V
T
S
S
S
C
S
Site 407
T3642
L
S
S
S
S
T
V
T
S
S
S
C
S
T
S
Site 408
S3643
S
S
S
S
T
V
T
S
S
S
C
S
T
S
G
Site 409
S3644
S
S
S
T
V
T
S
S
S
C
S
T
S
G
V
Site 410
S3645
S
S
T
V
T
S
S
S
C
S
T
S
G
V
Q
Site 411
S3647
T
V
T
S
S
S
C
S
T
S
G
V
Q
P
S
Site 412
T3648
V
T
S
S
S
C
S
T
S
G
V
Q
P
S
M
Site 413
S3649
T
S
S
S
C
S
T
S
G
V
Q
P
S
M
P
Site 414
S3654
S
T
S
G
V
Q
P
S
M
P
T
D
D
Y
S
Site 415
Y3660
P
S
M
P
T
D
D
Y
S
E
E
S
D
T
D
Site 416
S3661
S
M
P
T
D
D
Y
S
E
E
S
D
T
D
L
Site 417
S3664
T
D
D
Y
S
E
E
S
D
T
D
L
S
Q
K
Site 418
T3666
D
Y
S
E
E
S
D
T
D
L
S
Q
K
S
D
Site 419
S3669
E
E
S
D
T
D
L
S
Q
K
S
D
G
P
A
Site 420
S3672
D
T
D
L
S
Q
K
S
D
G
P
A
S
P
V
Site 421
S3677
Q
K
S
D
G
P
A
S
P
V
E
G
P
K
D
Site 422
S3686
V
E
G
P
K
D
P
S
C
P
K
D
S
G
L
Site 423
S3691
D
P
S
C
P
K
D
S
G
L
T
S
V
G
T
Site 424
S3695
P
K
D
S
G
L
T
S
V
G
T
D
T
F
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation