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Updated November 2019
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Protein Info
Short Name:
SCN9A
Full Name:
Sodium channel protein type 9 subunit alpha
Alias:
Neuroendocrine sodium channel;Peripheral sodium channel 1;Sodium channel protein type IX subunit alpha;Voltage-gated sodium channel subunit alpha Nav1.7
Type:
Mass (Da):
226342
Number AA:
1988
UniProt ID:
Q15858
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
L
P
P
P
G
P
Q
S
F
V
H
F
T
K
Q
Site 2
S32
Q
R
I
A
E
R
K
S
K
E
P
K
E
E
K
Site 3
S51
E
E
A
P
K
P
S
S
D
L
E
A
G
K
Q
Site 4
Y63
G
K
Q
L
P
F
I
Y
G
D
I
P
P
G
M
Site 5
S72
D
I
P
P
G
M
V
S
E
P
L
E
D
L
D
Site 6
Y81
P
L
E
D
L
D
P
Y
Y
A
D
K
K
T
F
Site 7
Y82
L
E
D
L
D
P
Y
Y
A
D
K
K
T
F
I
Site 8
T87
P
Y
Y
A
D
K
K
T
F
I
V
L
N
K
G
Site 9
S110
T
P
A
L
Y
M
L
S
P
F
S
P
L
R
R
Site 10
Y157
D
W
T
K
N
V
E
Y
T
F
T
G
I
Y
T
Site 11
T160
K
N
V
E
Y
T
F
T
G
I
Y
T
F
E
S
Site 12
Y163
E
Y
T
F
T
G
I
Y
T
F
E
S
L
V
K
Site 13
S279
K
H
K
C
F
R
N
S
L
E
N
N
E
T
L
Site 14
T285
N
S
L
E
N
N
E
T
L
E
S
I
M
N
T
Site 15
S288
E
N
N
E
T
L
E
S
I
M
N
T
L
E
S
Site 16
T292
T
L
E
S
I
M
N
T
L
E
S
E
E
D
F
Site 17
S295
S
I
M
N
T
L
E
S
E
E
D
F
R
K
Y
Site 18
Y302
S
E
E
D
F
R
K
Y
F
Y
Y
L
E
G
S
Site 19
Y304
E
D
F
R
K
Y
F
Y
Y
L
E
G
S
K
D
Site 20
Y305
D
F
R
K
Y
F
Y
Y
L
E
G
S
K
D
A
Site 21
S318
D
A
L
L
C
G
F
S
T
D
S
G
Q
C
P
Site 22
T319
A
L
L
C
G
F
S
T
D
S
G
Q
C
P
E
Site 23
S321
L
C
G
F
S
T
D
S
G
Q
C
P
E
G
Y
Site 24
Y328
S
G
Q
C
P
E
G
Y
T
C
V
K
I
G
R
Site 25
Y339
K
I
G
R
N
P
D
Y
G
Y
T
S
F
D
T
Site 26
Y341
G
R
N
P
D
Y
G
Y
T
S
F
D
T
F
S
Site 27
T359
L
A
L
F
R
L
M
T
Q
D
Y
W
E
N
L
Site 28
Y362
F
R
L
M
T
Q
D
Y
W
E
N
L
Y
Q
Q
Site 29
Y367
Q
D
Y
W
E
N
L
Y
Q
Q
T
L
R
A
A
Site 30
S449
A
A
A
A
E
Y
T
S
I
R
R
S
R
I
M
Site 31
S453
E
Y
T
S
I
R
R
S
R
I
M
G
L
S
E
Site 32
S459
R
S
R
I
M
G
L
S
E
S
S
S
E
T
S
Site 33
S461
R
I
M
G
L
S
E
S
S
S
E
T
S
K
L
Site 34
S463
M
G
L
S
E
S
S
S
E
T
S
K
L
S
S
Site 35
T465
L
S
E
S
S
S
E
T
S
K
L
S
S
K
S
Site 36
S466
S
E
S
S
S
E
T
S
K
L
S
S
K
S
A
Site 37
S469
S
S
E
T
S
K
L
S
S
K
S
A
K
E
R
Site 38
S470
S
E
T
S
K
L
S
S
K
S
A
K
E
R
R
Site 39
S489
K
K
N
Q
K
K
L
S
S
G
E
E
K
G
D
Site 40
S490
K
N
Q
K
K
L
S
S
G
E
E
K
G
D
A
Site 41
S501
K
G
D
A
E
K
L
S
K
S
E
S
E
D
S
Site 42
S503
D
A
E
K
L
S
K
S
E
S
E
D
S
I
R
Site 43
S505
E
K
L
S
K
S
E
S
E
D
S
I
R
R
K
Site 44
S508
S
K
S
E
S
E
D
S
I
R
R
K
S
F
H
Site 45
S513
E
D
S
I
R
R
K
S
F
H
L
G
V
E
G
Site 46
S530
R
A
H
E
K
R
L
S
T
P
N
Q
S
P
L
Site 47
T531
A
H
E
K
R
L
S
T
P
N
Q
S
P
L
S
Site 48
S535
R
L
S
T
P
N
Q
S
P
L
S
I
R
G
S
Site 49
S538
T
P
N
Q
S
P
L
S
I
R
G
S
L
F
S
Site 50
S542
S
P
L
S
I
R
G
S
L
F
S
A
R
R
S
Site 51
S545
S
I
R
G
S
L
F
S
A
R
R
S
S
R
T
Site 52
S549
S
L
F
S
A
R
R
S
S
R
T
S
L
F
S
Site 53
S550
L
F
S
A
R
R
S
S
R
T
S
L
F
S
F
Site 54
T552
S
A
R
R
S
S
R
T
S
L
F
S
F
K
G
Site 55
S553
A
R
R
S
S
R
T
S
L
F
S
F
K
G
R
Site 56
S556
S
S
R
T
S
L
F
S
F
K
G
R
G
R
D
Site 57
S566
G
R
G
R
D
I
G
S
E
T
E
F
A
D
D
Site 58
S583
S
I
F
G
D
N
E
S
R
R
G
S
L
F
V
Site 59
S587
D
N
E
S
R
R
G
S
L
F
V
P
H
R
P
Site 60
S599
H
R
P
Q
E
R
R
S
S
N
I
S
Q
A
S
Site 61
S600
R
P
Q
E
R
R
S
S
N
I
S
Q
A
S
R
Site 62
S603
E
R
R
S
S
N
I
S
Q
A
S
R
S
P
P
Site 63
S606
S
S
N
I
S
Q
A
S
R
S
P
P
M
L
P
Site 64
S608
N
I
S
Q
A
S
R
S
P
P
M
L
P
V
N
Site 65
T654
E
V
I
I
D
K
A
T
S
D
D
S
G
T
T
Site 66
S655
V
I
I
D
K
A
T
S
D
D
S
G
T
T
N
Site 67
S671
I
H
K
K
R
R
C
S
S
Y
L
L
S
E
D
Site 68
S672
H
K
K
R
R
C
S
S
Y
L
L
S
E
D
M
Site 69
Y673
K
K
R
R
C
S
S
Y
L
L
S
E
D
M
L
Site 70
S676
R
C
S
S
Y
L
L
S
E
D
M
L
N
D
P
Site 71
S691
N
L
R
Q
R
A
M
S
R
A
S
I
L
T
N
Site 72
S694
Q
R
A
M
S
R
A
S
I
L
T
N
T
V
E
Site 73
T697
M
S
R
A
S
I
L
T
N
T
V
E
E
L
E
Site 74
T699
R
A
S
I
L
T
N
T
V
E
E
L
E
E
S
Site 75
S706
T
V
E
E
L
E
E
S
R
Q
K
C
P
P
W
Site 76
T769
A
M
E
H
H
P
M
T
E
E
F
K
N
V
L
Site 77
Y801
K
L
I
A
M
D
P
Y
E
Y
F
Q
V
G
W
Site 78
T977
S
F
S
S
D
N
L
T
A
I
E
E
D
P
D
Site 79
Y1001
R
I
K
K
G
I
N
Y
V
K
Q
T
L
R
E
Site 80
T1005
G
I
N
Y
V
K
Q
T
L
R
E
F
I
L
K
Site 81
S1015
E
F
I
L
K
A
F
S
K
K
P
K
I
S
R
Site 82
T1032
R
Q
A
E
D
L
N
T
K
K
E
N
Y
I
S
Site 83
S1060
L
K
E
K
D
K
I
S
G
F
G
S
S
V
D
Site 84
S1064
D
K
I
S
G
F
G
S
S
V
D
K
H
L
M
Site 85
S1065
K
I
S
G
F
G
S
S
V
D
K
H
L
M
E
Site 86
S1074
D
K
H
L
M
E
D
S
D
G
Q
S
F
I
H
Site 87
S1078
M
E
D
S
D
G
Q
S
F
I
H
N
P
S
L
Site 88
T1088
H
N
P
S
L
T
V
T
V
P
I
A
P
G
E
Site 89
S1107
N
M
N
A
E
E
L
S
S
D
S
D
S
E
Y
Site 90
S1108
M
N
A
E
E
L
S
S
D
S
D
S
E
Y
S
Site 91
S1110
A
E
E
L
S
S
D
S
D
S
E
Y
S
K
V
Site 92
S1112
E
L
S
S
D
S
D
S
E
Y
S
K
V
R
L
Site 93
Y1114
S
S
D
S
D
S
E
Y
S
K
V
R
L
N
R
Site 94
S1115
S
D
S
D
S
E
Y
S
K
V
R
L
N
R
S
Site 95
S1122
S
K
V
R
L
N
R
S
S
S
S
E
C
S
T
Site 96
S1123
K
V
R
L
N
R
S
S
S
S
E
C
S
T
V
Site 97
S1124
V
R
L
N
R
S
S
S
S
E
C
S
T
V
D
Site 98
S1125
R
L
N
R
S
S
S
S
E
C
S
T
V
D
N
Site 99
S1128
R
S
S
S
S
E
C
S
T
V
D
N
P
L
P
Site 100
T1129
S
S
S
S
E
C
S
T
V
D
N
P
L
P
G
Site 101
S1148
A
E
A
E
P
M
N
S
D
E
P
E
A
C
F
Site 102
Y1215
A
L
A
F
E
D
I
Y
I
E
R
K
K
T
I
Site 103
T1221
I
Y
I
E
R
K
K
T
I
K
I
I
L
E
Y
Site 104
T1234
E
Y
A
D
K
I
F
T
Y
I
F
I
L
E
M
Site 105
S1288
S
D
L
G
P
I
K
S
L
R
T
L
R
A
L
Site 106
T1291
G
P
I
K
S
L
R
T
L
R
A
L
R
P
L
Site 107
S1302
L
R
P
L
R
A
L
S
R
F
E
G
M
R
V
Site 108
Y1348
N
L
F
A
G
K
F
Y
E
C
I
N
T
T
D
Site 109
T1353
K
F
Y
E
C
I
N
T
T
D
G
S
R
F
P
Site 110
S1357
C
I
N
T
T
D
G
S
R
F
P
A
S
Q
V
Site 111
S1362
D
G
S
R
F
P
A
S
Q
V
P
N
R
S
E
Site 112
S1368
A
S
Q
V
P
N
R
S
E
C
F
A
L
M
N
Site 113
S1418
I
M
Y
A
A
V
D
S
V
N
V
D
K
Q
P
Site 114
Y1427
N
V
D
K
Q
P
K
Y
E
Y
S
L
Y
M
Y
Site 115
T1475
G
G
Q
D
I
F
M
T
E
E
Q
K
K
Y
Y
Site 116
Y1481
M
T
E
E
Q
K
K
Y
Y
N
A
M
K
K
L
Site 117
Y1572
K
L
I
S
L
R
H
Y
Y
F
T
V
G
W
N
Site 118
Y1668
F
G
M
S
N
F
A
Y
V
K
K
E
D
G
I
Site 119
S1724
P
K
K
V
H
P
G
S
S
V
E
G
D
C
G
Site 120
S1725
K
K
V
H
P
G
S
S
V
E
G
D
C
G
N
Site 121
S1770
F
S
V
A
T
E
E
S
T
E
P
L
S
E
D
Site 122
S1775
E
E
S
T
E
P
L
S
E
D
D
F
E
M
F
Site 123
Y1783
E
D
D
F
E
M
F
Y
E
V
W
E
K
F
D
Site 124
T1794
E
K
F
D
P
D
A
T
Q
F
I
E
F
S
K
Site 125
S1853
T
K
R
V
L
G
E
S
G
E
M
D
S
L
R
Site 126
S1858
G
E
S
G
E
M
D
S
L
R
S
Q
M
E
E
Site 127
S1861
G
E
M
D
S
L
R
S
Q
M
E
E
R
F
M
Site 128
S1869
Q
M
E
E
R
F
M
S
A
N
P
S
K
V
S
Site 129
S1873
R
F
M
S
A
N
P
S
K
V
S
Y
E
P
I
Site 130
S1876
S
A
N
P
S
K
V
S
Y
E
P
I
T
T
T
Site 131
Y1877
A
N
P
S
K
V
S
Y
E
P
I
T
T
T
L
Site 132
T1882
V
S
Y
E
P
I
T
T
T
L
K
R
K
Q
E
Site 133
T1883
S
Y
E
P
I
T
T
T
L
K
R
K
Q
E
D
Site 134
S1892
K
R
K
Q
E
D
V
S
A
T
V
I
Q
R
A
Site 135
T1894
K
Q
E
D
V
S
A
T
V
I
Q
R
A
Y
R
Site 136
Y1900
A
T
V
I
Q
R
A
Y
R
R
Y
R
L
R
Q
Site 137
Y1903
I
Q
R
A
Y
R
R
Y
R
L
R
Q
N
V
K
Site 138
Y1916
V
K
N
I
S
S
I
Y
I
K
D
G
D
R
D
Site 139
S1942
D
N
V
N
E
N
S
S
P
E
K
T
D
A
T
Site 140
T1946
E
N
S
S
P
E
K
T
D
A
T
S
S
T
T
Site 141
T1949
S
P
E
K
T
D
A
T
S
S
T
T
S
P
P
Site 142
S1950
P
E
K
T
D
A
T
S
S
T
T
S
P
P
S
Site 143
S1951
E
K
T
D
A
T
S
S
T
T
S
P
P
S
Y
Site 144
T1952
K
T
D
A
T
S
S
T
T
S
P
P
S
Y
D
Site 145
S1954
D
A
T
S
S
T
T
S
P
P
S
Y
D
S
V
Site 146
S1957
S
S
T
T
S
P
P
S
Y
D
S
V
T
K
P
Site 147
Y1958
S
T
T
S
P
P
S
Y
D
S
V
T
K
P
D
Site 148
S1960
T
S
P
P
S
Y
D
S
V
T
K
P
D
K
E
Site 149
T1962
P
P
S
Y
D
S
V
T
K
P
D
K
E
K
Y
Site 150
Y1969
T
K
P
D
K
E
K
Y
E
Q
D
R
T
E
K
Site 151
T1974
E
K
Y
E
Q
D
R
T
E
K
E
D
K
G
K
Site 152
S1983
K
E
D
K
G
K
D
S
K
E
S
K
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation