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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STXBP2
Full Name:
Syntaxin-binding protein 2
Alias:
Hunc18b; STXB2; Syntaxin binding protein 2; Unc-18 homolog 2; UNC18B; Unc-18B
Type:
Protein trafficking protein
Mass (Da):
66439
Number AA:
593
UniProt ID:
Q15833
International Prot ID:
IPI00019971
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0042582
GO:0005829
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0030348
PhosphoSite+
KinaseNET
Biological Process:
GO:0043312
GO:0015031
GO:0043304
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
V
V
G
E
K
I
L
S
G
V
I
R
S
V
K
Site 2
S21
I
L
S
G
V
I
R
S
V
K
K
D
G
E
W
Site 3
S37
V
L
I
M
D
H
P
S
M
R
I
L
S
S
C
Site 4
S42
H
P
S
M
R
I
L
S
S
C
C
K
M
S
D
Site 5
S70
K
R
R
E
P
I
P
S
L
E
A
I
Y
L
L
Site 6
S78
L
E
A
I
Y
L
L
S
P
T
E
K
S
V
Q
Site 7
S83
L
L
S
P
T
E
K
S
V
Q
A
L
I
K
D
Site 8
T94
L
I
K
D
F
Q
G
T
P
T
F
T
Y
K
A
Site 9
T96
K
D
F
Q
G
T
P
T
F
T
Y
K
A
A
H
Site 10
Y99
Q
G
T
P
T
F
T
Y
K
A
A
H
I
F
F
Site 11
S116
T
C
P
E
P
L
F
S
E
L
G
R
S
R
L
Site 12
S146
P
Y
E
A
Q
V
F
S
L
D
A
P
H
S
T
Site 13
Y154
L
D
A
P
H
S
T
Y
N
L
Y
C
P
F
R
Site 14
Y157
P
H
S
T
Y
N
L
Y
C
P
F
R
A
E
E
Site 15
Y186
L
C
A
T
L
Q
E
Y
P
A
I
R
Y
R
K
Site 16
T216
L
N
A
F
K
A
D
T
P
S
L
G
E
G
P
Site 17
S218
A
F
K
A
D
T
P
S
L
G
E
G
P
E
K
Site 18
T226
L
G
E
G
P
E
K
T
R
S
Q
L
L
I
M
Site 19
S228
E
G
P
E
K
T
R
S
Q
L
L
I
M
D
R
Site 20
S241
D
R
A
A
D
P
V
S
P
L
L
H
E
L
T
Site 21
T263
L
L
D
I
E
Q
D
T
Y
R
Y
E
T
T
G
Site 22
Y264
L
D
I
E
Q
D
T
Y
R
Y
E
T
T
G
L
Site 23
Y266
I
E
Q
D
T
Y
R
Y
E
T
T
G
L
S
E
Site 24
T268
Q
D
T
Y
R
Y
E
T
T
G
L
S
E
A
R
Site 25
S272
R
Y
E
T
T
G
L
S
E
A
R
E
K
A
V
Site 26
T309
K
V
T
E
L
L
R
T
F
C
E
S
K
R
L
Site 27
S313
L
L
R
T
F
C
E
S
K
R
L
T
T
D
K
Site 28
T317
F
C
E
S
K
R
L
T
T
D
K
A
N
I
K
Site 29
T318
C
E
S
K
R
L
T
T
D
K
A
N
I
K
D
Site 30
S327
K
A
N
I
K
D
L
S
Q
I
L
K
K
M
P
Site 31
Y336
I
L
K
K
M
P
Q
Y
Q
K
E
L
N
K
Y
Site 32
Y343
Y
Q
K
E
L
N
K
Y
S
T
H
L
H
L
A
Site 33
S375
E
Q
D
L
A
M
G
S
D
A
E
G
E
K
I
Site 34
Y401
L
D
A
A
V
P
A
Y
D
K
I
R
V
L
L
Site 35
S436
A
N
V
Q
A
H
S
S
L
I
R
N
L
E
Q
Site 36
T447
N
L
E
Q
L
G
G
T
V
T
N
P
G
G
S
Site 37
T449
E
Q
L
G
G
T
V
T
N
P
G
G
S
G
T
Site 38
S454
T
V
T
N
P
G
G
S
G
T
S
S
R
L
E
Site 39
S457
N
P
G
G
S
G
T
S
S
R
L
E
P
R
E
Site 40
S458
P
G
G
S
G
T
S
S
R
L
E
P
R
E
R
Site 41
T469
P
R
E
R
M
E
P
T
Y
Q
L
S
R
W
T
Site 42
Y470
R
E
R
M
E
P
T
Y
Q
L
S
R
W
T
P
Site 43
T476
T
Y
Q
L
S
R
W
T
P
V
I
K
D
V
M
Site 44
S500
R
N
L
W
P
F
V
S
D
P
A
P
T
A
S
Site 45
S507
S
D
P
A
P
T
A
S
S
Q
A
A
V
S
A
Site 46
S508
D
P
A
P
T
A
S
S
Q
A
A
V
S
A
R
Site 47
S513
A
S
S
Q
A
A
V
S
A
R
F
G
H
W
H
Site 48
Y551
M
S
E
M
R
A
A
Y
E
V
T
R
A
T
E
Site 49
T557
A
Y
E
V
T
R
A
T
E
G
K
W
E
V
L
Site 50
T572
I
G
S
S
H
I
L
T
P
T
R
F
L
D
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation