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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PI5PA
Full Name:
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
Alias:
Inositol polyphosphate 5-phosphatase J; Inositol polyphosphate-5-phosphatase J; INPP5; PIB5PA
Type:
EC 3.1.3.56; Phosphatase (non-protein); Carbohydrate Metabolism - inositol phosphate
Mass (Da):
107197
Number AA:
1006
UniProt ID:
Q15735
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0001726
Uniprot
OncoNet
Molecular Function:
GO:0017124
GO:0004445
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
E
G
Q
S
S
R
G
S
R
R
P
Site 2
S9
E
G
Q
S
S
R
G
S
R
R
P
G
T
R
A
Site 3
T14
R
G
S
R
R
P
G
T
R
A
G
L
G
S
L
Site 4
S20
G
T
R
A
G
L
G
S
L
P
M
P
Q
G
V
Site 5
S34
V
A
Q
T
G
A
P
S
K
V
D
S
S
F
Q
Site 6
S38
G
A
P
S
K
V
D
S
S
F
Q
L
P
A
K
Site 7
S39
A
P
S
K
V
D
S
S
F
Q
L
P
A
K
K
Site 8
S69
V
G
P
R
A
A
M
S
A
S
S
E
G
P
R
Site 9
T97
C
T
P
E
G
Q
K
T
A
T
A
H
R
S
S
Site 10
T99
P
E
G
Q
K
T
A
T
A
H
R
S
S
S
L
Site 11
S104
T
A
T
A
H
R
S
S
S
L
A
P
T
S
V
Site 12
S105
A
T
A
H
R
S
S
S
L
A
P
T
S
V
G
Site 13
S119
G
Q
L
V
M
S
A
S
A
G
P
K
P
P
P
Site 14
T128
G
P
K
P
P
P
A
T
T
G
S
V
L
A
P
Site 15
S150
P
A
S
A
G
P
R
S
P
P
V
T
L
G
P
Site 16
T154
G
P
R
S
P
P
V
T
L
G
P
N
L
A
P
Site 17
S163
G
P
N
L
A
P
T
S
R
D
Q
K
Q
E
P
Site 18
S173
Q
K
Q
E
P
P
A
S
V
G
P
K
P
T
L
Site 19
S200
E
Q
P
P
E
L
P
S
T
P
S
P
V
P
S
Site 20
T201
Q
P
P
E
L
P
S
T
P
S
P
V
P
S
P
Site 21
S203
P
E
L
P
S
T
P
S
P
V
P
S
P
V
L
Site 22
S207
S
T
P
S
P
V
P
S
P
V
L
S
P
T
Q
Site 23
S211
P
V
P
S
P
V
L
S
P
T
Q
E
Q
A
L
Site 24
T213
P
S
P
V
L
S
P
T
Q
E
Q
A
L
A
P
Site 25
S222
E
Q
A
L
A
P
A
S
T
A
S
G
A
A
S
Site 26
S229
S
T
A
S
G
A
A
S
V
G
Q
T
S
A
R
Site 27
S234
A
A
S
V
G
Q
T
S
A
R
K
R
D
A
P
Site 28
S249
A
P
R
P
L
P
A
S
E
G
H
L
Q
P
P
Site 29
S260
L
Q
P
P
A
Q
T
S
G
P
T
G
S
P
P
Site 30
S265
Q
T
S
G
P
T
G
S
P
P
C
I
Q
T
S
Site 31
S272
S
P
P
C
I
Q
T
S
P
D
P
R
L
S
P
Site 32
S278
T
S
P
D
P
R
L
S
P
S
F
R
A
R
P
Site 33
S280
P
D
P
R
L
S
P
S
F
R
A
R
P
E
A
Site 34
S290
A
R
P
E
A
L
H
S
S
P
E
D
P
V
L
Site 35
S291
R
P
E
A
L
H
S
S
P
E
D
P
V
L
P
Site 36
T303
V
L
P
R
P
P
Q
T
L
P
L
D
V
G
Q
Site 37
S313
L
D
V
G
Q
G
P
S
E
P
G
T
H
S
P
Site 38
T317
Q
G
P
S
E
P
G
T
H
S
P
G
L
L
S
Site 39
S319
P
S
E
P
G
T
H
S
P
G
L
L
S
P
T
Site 40
S324
T
H
S
P
G
L
L
S
P
T
F
R
P
G
A
Site 41
T326
S
P
G
L
L
S
P
T
F
R
P
G
A
P
S
Site 42
S333
T
F
R
P
G
A
P
S
G
Q
T
V
P
P
P
Site 43
T336
P
G
A
P
S
G
Q
T
V
P
P
P
L
P
K
Site 44
S347
P
L
P
K
P
P
R
S
P
S
R
S
P
S
H
Site 45
S349
P
K
P
P
R
S
P
S
R
S
P
S
H
S
P
Site 46
S351
P
P
R
S
P
S
R
S
P
S
H
S
P
N
R
Site 47
S353
R
S
P
S
R
S
P
S
H
S
P
N
R
S
P
Site 48
S355
P
S
R
S
P
S
H
S
P
N
R
S
P
C
V
Site 49
S359
P
S
H
S
P
N
R
S
P
C
V
P
P
A
P
Site 50
T375
M
A
L
P
R
L
G
T
Q
S
T
G
P
G
R
Site 51
S377
L
P
R
L
G
T
Q
S
T
G
P
G
R
C
L
Site 52
T378
P
R
L
G
T
Q
S
T
G
P
G
R
C
L
S
Site 53
S385
T
G
P
G
R
C
L
S
P
N
L
Q
A
Q
E
Site 54
T398
Q
E
A
P
A
P
V
T
T
S
S
S
T
S
T
Site 55
S400
A
P
A
P
V
T
T
S
S
S
T
S
T
L
S
Site 56
S401
P
A
P
V
T
T
S
S
S
T
S
T
L
S
S
Site 57
S402
A
P
V
T
T
S
S
S
T
S
T
L
S
S
S
Site 58
T403
P
V
T
T
S
S
S
T
S
T
L
S
S
S
P
Site 59
S404
V
T
T
S
S
S
T
S
T
L
S
S
S
P
W
Site 60
T405
T
T
S
S
S
T
S
T
L
S
S
S
P
W
S
Site 61
S407
S
S
S
T
S
T
L
S
S
S
P
W
S
A
Q
Site 62
S408
S
S
T
S
T
L
S
S
S
P
W
S
A
Q
P
Site 63
S409
S
T
S
T
L
S
S
S
P
W
S
A
Q
P
T
Site 64
S412
T
L
S
S
S
P
W
S
A
Q
P
T
W
K
S
Site 65
T416
S
P
W
S
A
Q
P
T
W
K
S
D
P
G
F
Site 66
S419
S
A
Q
P
T
W
K
S
D
P
G
F
R
I
T
Site 67
S453
H
L
G
G
G
D
D
S
D
G
A
D
M
I
A
Site 68
S468
I
G
L
Q
E
V
N
S
M
L
N
K
R
L
K
Site 69
T480
R
L
K
D
A
L
F
T
D
Q
W
S
E
L
F
Site 70
T526
P
F
L
R
D
V
Q
T
D
C
T
R
T
G
L
Site 71
T529
R
D
V
Q
T
D
C
T
R
T
G
L
G
G
Y
Site 72
Y536
T
R
T
G
L
G
G
Y
W
G
N
K
G
G
V
Site 73
S580
D
N
F
Q
T
I
L
S
L
Q
Q
F
Q
G
P
Site 74
S610
D
L
N
F
R
I
E
S
Y
D
L
H
F
V
K
Site 75
Y667
F
D
V
G
T
N
K
Y
D
T
S
A
K
K
R
Site 76
T669
V
G
T
N
K
Y
D
T
S
A
K
K
R
K
P
Site 77
T679
K
K
R
K
P
A
W
T
D
R
I
L
W
K
V
Site 78
S694
K
A
P
G
G
G
P
S
P
S
G
R
K
S
H
Site 79
S696
P
G
G
G
P
S
P
S
G
R
K
S
H
R
L
Site 80
S700
P
S
P
S
G
R
K
S
H
R
L
Q
V
T
Q
Site 81
T706
K
S
H
R
L
Q
V
T
Q
H
S
Y
R
S
H
Site 82
Y716
S
Y
R
S
H
M
E
Y
T
V
S
D
H
K
P
Site 83
S719
S
H
M
E
Y
T
V
S
D
H
K
P
V
A
A
Site 84
T763
V
V
R
Y
R
M
E
T
V
F
A
R
S
S
W
Site 85
Y786
G
F
R
H
C
K
D
Y
V
A
Y
V
W
A
K
Site 86
T801
H
E
D
V
D
G
N
T
Y
Q
V
T
F
S
E
Site 87
Y802
E
D
V
D
G
N
T
Y
Q
V
T
F
S
E
E
Site 88
T805
D
G
N
T
Y
Q
V
T
F
S
E
E
S
L
P
Site 89
S807
N
T
Y
Q
V
T
F
S
E
E
S
L
P
K
G
Site 90
S810
Q
V
T
F
S
E
E
S
L
P
K
G
H
G
D
Site 91
Y822
H
G
D
F
I
L
G
Y
Y
S
H
N
H
S
I
Site 92
Y823
G
D
F
I
L
G
Y
Y
S
H
N
H
S
I
L
Site 93
S843
P
F
Q
I
S
L
P
S
S
E
L
A
S
S
S
Site 94
S844
F
Q
I
S
L
P
S
S
E
L
A
S
S
S
T
Site 95
S848
L
P
S
S
E
L
A
S
S
S
T
D
S
S
G
Site 96
S849
P
S
S
E
L
A
S
S
S
T
D
S
S
G
T
Site 97
S850
S
S
E
L
A
S
S
S
T
D
S
S
G
T
S
Site 98
T851
S
E
L
A
S
S
S
T
D
S
S
G
T
S
S
Site 99
S853
L
A
S
S
S
T
D
S
S
G
T
S
S
E
G
Site 100
S854
A
S
S
S
T
D
S
S
G
T
S
S
E
G
E
Site 101
S857
S
T
D
S
S
G
T
S
S
E
G
E
D
D
S
Site 102
S858
T
D
S
S
G
T
S
S
E
G
E
D
D
S
T
Site 103
S864
S
S
E
G
E
D
D
S
T
L
E
L
L
A
P
Site 104
T865
S
E
G
E
D
D
S
T
L
E
L
L
A
P
K
Site 105
S873
L
E
L
L
A
P
K
S
R
S
P
S
P
G
K
Site 106
S875
L
L
A
P
K
S
R
S
P
S
P
G
K
S
K
Site 107
S877
A
P
K
S
R
S
P
S
P
G
K
S
K
R
H
Site 108
S881
R
S
P
S
P
G
K
S
K
R
H
R
S
R
S
Site 109
S886
G
K
S
K
R
H
R
S
R
S
P
G
L
A
R
Site 110
S888
S
K
R
H
R
S
R
S
P
G
L
A
R
F
P
Site 111
S902
P
G
L
A
L
R
P
S
S
R
E
R
R
G
A
Site 112
S903
G
L
A
L
R
P
S
S
R
E
R
R
G
A
S
Site 113
S910
S
R
E
R
R
G
A
S
R
S
P
S
P
Q
S
Site 114
S912
E
R
R
G
A
S
R
S
P
S
P
Q
S
R
R
Site 115
S914
R
G
A
S
R
S
P
S
P
Q
S
R
R
L
S
Site 116
S917
S
R
S
P
S
P
Q
S
R
R
L
S
R
V
A
Site 117
S921
S
P
Q
S
R
R
L
S
R
V
A
P
D
R
S
Site 118
S928
S
R
V
A
P
D
R
S
S
N
G
S
S
R
G
Site 119
S929
R
V
A
P
D
R
S
S
N
G
S
S
R
G
S
Site 120
S932
P
D
R
S
S
N
G
S
S
R
G
S
S
E
E
Site 121
S933
D
R
S
S
N
G
S
S
R
G
S
S
E
E
G
Site 122
S936
S
N
G
S
S
R
G
S
S
E
E
G
P
S
G
Site 123
S937
N
G
S
S
R
G
S
S
E
E
G
P
S
G
L
Site 124
S942
G
S
S
E
E
G
P
S
G
L
P
G
P
W
A
Site 125
T968
L
P
A
L
R
L
E
T
V
D
P
G
G
G
G
Site 126
S976
V
D
P
G
G
G
G
S
W
G
P
D
R
E
A
Site 127
S988
R
E
A
L
A
P
N
S
L
S
P
S
P
Q
G
Site 128
S990
A
L
A
P
N
S
L
S
P
S
P
Q
G
H
R
Site 129
S992
A
P
N
S
L
S
P
S
P
Q
G
H
R
G
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation