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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTPN14
Full Name:
Tyrosine-protein phosphatase non-receptor type 14
Alias:
EC 3.1.3.48; PEZ; Protein-tyrosine phosphatase pez; PTN14; PTP36
Type:
EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Mass (Da):
135261
Number AA:
1187
UniProt ID:
Q15678
International Prot ID:
IPI00018914
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
F
G
L
K
L
R
R
T
R
R
Y
N
V
L
S
Site 2
Y13
K
L
R
R
T
R
R
Y
N
V
L
S
K
N
C
Site 3
T36
D
S
N
V
I
E
C
T
L
S
V
E
S
T
G
Site 4
S38
N
V
I
E
C
T
L
S
V
E
S
T
G
Q
E
Site 5
T42
C
T
L
S
V
E
S
T
G
Q
E
C
L
E
A
Site 6
S70
G
L
W
F
L
S
K
S
Q
Q
A
R
W
V
E
Site 7
Y116
L
Q
Q
E
A
T
R
Y
Q
Y
Y
L
Q
V
K
Site 8
Y118
Q
E
A
T
R
Y
Q
Y
Y
L
Q
V
K
K
D
Site 9
Y119
E
A
T
R
Y
Q
Y
Y
L
Q
V
K
K
D
V
Site 10
Y153
V
Q
A
D
F
G
D
Y
N
Q
F
D
S
Q
D
Site 11
S158
G
D
Y
N
Q
F
D
S
Q
D
F
L
R
E
Y
Site 12
Y165
S
Q
D
F
L
R
E
Y
V
L
F
P
M
D
L
Site 13
Y252
I
G
R
Q
A
V
I
Y
R
W
N
D
M
G
N
Site 14
Y290
D
D
I
E
N
A
K
Y
I
S
R
L
F
A
T
Site 15
S312
N
K
I
C
T
E
Q
S
N
S
P
P
P
I
R
Site 16
S314
I
C
T
E
Q
S
N
S
P
P
P
I
R
R
Q
Site 17
T323
P
P
I
R
R
Q
P
T
W
S
R
S
S
L
P
Site 18
S325
I
R
R
Q
P
T
W
S
R
S
S
L
P
R
Q
Site 19
S327
R
Q
P
T
W
S
R
S
S
L
P
R
Q
Q
P
Site 20
S328
Q
P
T
W
S
R
S
S
L
P
R
Q
Q
P
Y
Site 21
Y335
S
L
P
R
Q
Q
P
Y
I
L
P
P
V
H
V
Site 22
T353
E
H
Y
S
E
T
H
T
S
Q
D
S
I
F
H
Site 23
S354
H
Y
S
E
T
H
T
S
Q
D
S
I
F
H
G
Site 24
Y367
H
G
N
E
E
A
L
Y
C
N
S
H
N
S
L
Site 25
Y378
H
N
S
L
D
L
N
Y
L
N
G
T
V
T
N
Site 26
T382
D
L
N
Y
L
N
G
T
V
T
N
G
S
V
C
Site 27
S396
C
S
V
H
S
V
N
S
L
N
C
S
Q
S
F
Site 28
S400
S
V
N
S
L
N
C
S
Q
S
F
I
Q
A
S
Site 29
S402
N
S
L
N
C
S
Q
S
F
I
Q
A
S
P
V
Site 30
S407
S
Q
S
F
I
Q
A
S
P
V
S
S
N
L
S
Site 31
S411
I
Q
A
S
P
V
S
S
N
L
S
I
P
G
S
Site 32
S414
S
P
V
S
S
N
L
S
I
P
G
S
D
I
M
Site 33
S418
S
N
L
S
I
P
G
S
D
I
M
R
A
D
Y
Site 34
Y425
S
D
I
M
R
A
D
Y
I
P
S
H
R
H
S
Site 35
S432
Y
I
P
S
H
R
H
S
A
I
I
V
P
S
Y
Site 36
S438
H
S
A
I
I
V
P
S
Y
R
P
T
P
D
Y
Site 37
Y439
S
A
I
I
V
P
S
Y
R
P
T
P
D
Y
E
Site 38
T442
I
V
P
S
Y
R
P
T
P
D
Y
E
T
V
M
Site 39
Y445
S
Y
R
P
T
P
D
Y
E
T
V
M
R
Q
M
Site 40
T447
R
P
T
P
D
Y
E
T
V
M
R
Q
M
K
R
Site 41
T459
M
K
R
G
I
L
H
T
D
S
Q
S
Q
S
L
Site 42
S461
R
G
I
L
H
T
D
S
Q
S
Q
S
L
R
N
Site 43
S463
I
L
H
T
D
S
Q
S
Q
S
L
R
N
L
N
Site 44
S465
H
T
D
S
Q
S
Q
S
L
R
N
L
N
I
I
Site 45
T474
R
N
L
N
I
I
N
T
H
A
Y
N
Q
P
E
Site 46
Y477
N
I
I
N
T
H
A
Y
N
Q
P
E
D
L
V
Site 47
Y485
N
Q
P
E
D
L
V
Y
S
Q
P
E
M
R
E
Site 48
S486
Q
P
E
D
L
V
Y
S
Q
P
E
M
R
E
R
Site 49
Y496
E
M
R
E
R
H
P
Y
T
V
P
Y
G
P
Q
Site 50
T497
M
R
E
R
H
P
Y
T
V
P
Y
G
P
Q
G
Site 51
Y500
R
H
P
Y
T
V
P
Y
G
P
Q
G
V
Y
S
Site 52
Y506
P
Y
G
P
Q
G
V
Y
S
N
K
L
V
S
P
Site 53
S507
Y
G
P
Q
G
V
Y
S
N
K
L
V
S
P
S
Site 54
S512
V
Y
S
N
K
L
V
S
P
S
D
Q
R
N
P
Site 55
S514
S
N
K
L
V
S
P
S
D
Q
R
N
P
K
N
Site 56
S526
P
K
N
N
V
V
P
S
K
P
G
A
S
A
I
Site 57
S534
K
P
G
A
S
A
I
S
H
T
V
S
T
P
E
Site 58
S538
S
A
I
S
H
T
V
S
T
P
E
L
A
N
M
Site 59
T539
A
I
S
H
T
V
S
T
P
E
L
A
N
M
Q
Site 60
S554
L
Q
G
S
H
N
Y
S
T
A
H
M
L
K
N
Site 61
Y562
T
A
H
M
L
K
N
Y
L
F
R
P
P
P
P
Site 62
Y570
L
F
R
P
P
P
P
Y
P
R
P
R
P
A
T
Site 63
T577
Y
P
R
P
R
P
A
T
S
T
P
D
L
A
S
Site 64
S578
P
R
P
R
P
A
T
S
T
P
D
L
A
S
H
Site 65
T579
R
P
R
P
A
T
S
T
P
D
L
A
S
H
R
Site 66
S584
T
S
T
P
D
L
A
S
H
R
H
K
Y
V
S
Site 67
Y589
L
A
S
H
R
H
K
Y
V
S
G
S
S
P
D
Site 68
S591
S
H
R
H
K
Y
V
S
G
S
S
P
D
L
V
Site 69
S593
R
H
K
Y
V
S
G
S
S
P
D
L
V
T
R
Site 70
S594
H
K
Y
V
S
G
S
S
P
D
L
V
T
R
K
Site 71
T599
G
S
S
P
D
L
V
T
R
K
V
Q
L
S
V
Site 72
S605
V
T
R
K
V
Q
L
S
V
K
T
F
Q
E
D
Site 73
T608
K
V
Q
L
S
V
K
T
F
Q
E
D
S
S
P
Site 74
S614
K
T
F
Q
E
D
S
S
P
V
V
H
Q
S
L
Site 75
S620
S
S
P
V
V
H
Q
S
L
Q
E
V
S
E
P
Site 76
T629
Q
E
V
S
E
P
L
T
A
T
K
H
H
G
T
Site 77
S642
G
T
V
N
K
R
H
S
L
E
V
M
N
S
M
Site 78
S648
H
S
L
E
V
M
N
S
M
V
R
G
M
E
A
Site 79
T670
L
P
M
A
R
R
N
T
L
R
E
Q
G
P
P
Site 80
S681
Q
G
P
P
E
E
G
S
G
S
H
E
V
P
Q
Site 81
S683
P
P
E
E
G
S
G
S
H
E
V
P
Q
L
P
Site 82
Y692
E
V
P
Q
L
P
Q
Y
H
H
K
K
T
F
S
Site 83
T697
P
Q
Y
H
H
K
K
T
F
S
D
A
T
M
L
Site 84
T702
K
K
T
F
S
D
A
T
M
L
I
H
S
S
E
Site 85
S708
A
T
M
L
I
H
S
S
E
S
E
E
E
E
E
Site 86
S720
E
E
E
E
A
P
E
S
V
P
Q
I
P
M
L
Site 87
Y733
M
L
R
E
K
M
E
Y
S
A
Q
L
Q
A
A
Site 88
Y752
P
N
K
P
P
P
E
Y
P
G
P
R
K
S
V
Site 89
S758
E
Y
P
G
P
R
K
S
V
S
N
G
A
L
R
Site 90
S760
P
G
P
R
K
S
V
S
N
G
A
L
R
Q
D
Site 91
S770
A
L
R
Q
D
Q
A
S
L
P
P
A
M
A
R
Site 92
S790
H
G
P
A
K
A
I
S
M
S
R
T
D
P
P
Site 93
S792
P
A
K
A
I
S
M
S
R
T
D
P
P
A
V
Site 94
T794
K
A
I
S
M
S
R
T
D
P
P
A
V
N
G
Site 95
S803
P
P
A
V
N
G
A
S
L
G
P
S
I
S
E
Site 96
S807
N
G
A
S
L
G
P
S
I
S
E
P
D
L
T
Site 97
S809
A
S
L
G
P
S
I
S
E
P
D
L
T
S
V
Site 98
T814
S
I
S
E
P
D
L
T
S
V
K
E
R
V
K
Site 99
S815
I
S
E
P
D
L
T
S
V
K
E
R
V
K
K
Site 100
S831
P
V
K
E
R
P
V
S
E
M
F
S
L
E
D
Site 101
S835
R
P
V
S
E
M
F
S
L
E
D
S
I
I
E
Site 102
S839
E
M
F
S
L
E
D
S
I
I
E
R
E
M
M
Site 103
S879
G
L
S
V
A
R
V
S
G
R
E
E
N
R
V
Site 104
T889
E
E
N
R
V
D
A
T
R
V
P
M
D
E
R
Site 105
T899
P
M
D
E
R
F
R
T
L
K
K
K
L
E
E
Site 106
Y913
E
G
M
V
F
T
E
Y
E
Q
I
P
K
K
K
Site 107
Y945
R
I
R
E
V
V
P
Y
E
E
N
R
V
E
L
Site 108
T955
N
R
V
E
L
I
P
T
K
E
N
N
T
G
Y
Site 109
Y962
T
K
E
N
N
T
G
Y
I
N
A
S
H
I
K
Site 110
Y979
V
G
G
A
E
W
H
Y
I
A
T
Q
G
P
L
Site 111
T982
A
E
W
H
Y
I
A
T
Q
G
P
L
P
H
T
Site 112
T1009
V
N
V
I
A
M
V
T
A
E
E
E
G
G
R
Site 113
T1017
A
E
E
E
G
G
R
T
K
S
H
R
Y
W
P
Site 114
S1019
E
E
G
G
R
T
K
S
H
R
Y
W
P
K
L
Site 115
Y1022
G
R
T
K
S
H
R
Y
W
P
K
L
G
S
K
Site 116
S1028
R
Y
W
P
K
L
G
S
K
H
S
S
A
T
Y
Site 117
S1031
P
K
L
G
S
K
H
S
S
A
T
Y
G
K
F
Site 118
S1032
K
L
G
S
K
H
S
S
A
T
Y
G
K
F
K
Site 119
Y1035
S
K
H
S
S
A
T
Y
G
K
F
K
V
T
T
Site 120
S1048
T
T
K
F
R
T
D
S
V
C
Y
A
T
T
G
Site 121
S1063
L
K
V
K
H
L
L
S
G
Q
E
R
T
V
W
Site 122
S1091
E
D
V
Q
G
F
L
S
Y
L
E
E
I
Q
S
Site 123
S1098
S
Y
L
E
E
I
Q
S
V
R
R
H
T
N
S
Site 124
T1103
I
Q
S
V
R
R
H
T
N
S
M
L
E
G
T
Site 125
S1105
S
V
R
R
H
T
N
S
M
L
E
G
T
K
N
Site 126
Y1170
M
I
Q
T
I
A
Q
Y
K
F
V
Y
Q
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation