PhosphoNET

           
Protein Info 
   
Short Name:  TWIST1
Full Name:  Twist-related protein 1
Alias:  Acrocephalosyndactyly 3; ACS3; B-HLH DNA binding protein; Blepharophimosis, epicanthus inversus and ptosis 3; Blepharophimosis, epicanthus inversus, and ptosis 2; BPES2; BPES3; H-twist; Saethre-Chotzen syndrome); SCS; TWIST; Twist homolog 1 (acrocephalosyndactyly 3; TWST1
Type:  Inhibitor protein
Mass (Da):  20954
Number AA:  202
UniProt ID:  Q15672
International Prot ID:  IPI00018907
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005634     Uniprot OncoNet
Molecular Function:  GO:0003677  GO:0004857  GO:0005515 PhosphoSite+ KinaseNET
Biological Process:  GO:0000122  GO:0001501  GO:0006350 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S6__MMQDVSSSPVSPA
Site 2S7_MMQDVSSSPVSPAD
Site 3S8MMQDVSSSPVSPADD
Site 4S11DVSSSPVSPADDSLS
Site 5S16PVSPADDSLSNSEEE
Site 6S18SPADDSLSNSEEEPD
Site 7S20ADDSLSNSEEEPDRQ
Site 8S31PDRQQPPSGKRGGRK
Site 9S41RGGRKRRSSRRSAGG
Site 10S42GGRKRRSSRRSAGGG
Site 11S45KRRSSRRSAGGGAGP
Site 12S68GGGDEPGSPAQGKRG
Site 13S78QGKRGKKSAGCGGGG
Site 14S93GAGGGGGSSSGGGSP
Site 15S94AGGGGGSSSGGGSPQ
Site 16S95GGGGGSSSGGGSPQS
Site 17S99GSSSGGGSPQSYEEL
Site 18S102SGGGSPQSYEELQTQ
Site 19Y103GGGSPQSYEELQTQR
Site 20T108QSYEELQTQRVMANV
Site 21T121NVRERQRTQSLNEAF
Site 22S123RERQRTQSLNEAFAA
Site 23T137ALRKIIPTLPSDKLS
Site 24S140KIIPTLPSDKLSKIQ
Site 25S144TLPSDKLSKIQTLKL
Site 26T148DKLSKIQTLKLAARY
Site 27Y160ARYIDFLYQVLQSDE
Site 28S165FLYQVLQSDELDSKM
Site 29S170LQSDELDSKMASCSY
Site 30S174ELDSKMASCSYVAHE
Site 31Y177SKMASCSYVAHERLS
Site 32Y185VAHERLSYAFSVWRM
Site 33S188ERLSYAFSVWRMEGA
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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