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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRIP4
Full Name:
Activating signal cointegrator 1
Alias:
ASC-1; HsT17391; Nuclear receptor coactivator ASC-1 testis specific form; Thyroid hormone receptor interactor 4; Thyroid receptor interacting 4; Thyroid receptor-interacting protein 4; TRI4; TRIP-4
Type:
Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Mass (Da):
66146
Number AA:
581
UniProt ID:
Q15650
International Prot ID:
IPI00018840
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003712
GO:0003713
GO:0005102
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006351
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
C
T
Q
Q
L
R
K
T
F
G
L
D
V
S
E
Site 2
Y48
S
A
E
E
I
R
E
Y
V
T
D
L
L
Q
G
Site 3
S80
K
N
D
Q
E
L
I
S
D
P
L
Q
Q
C
F
Site 4
S98
E
I
L
D
G
Q
K
S
G
D
H
L
K
R
G
Site 5
T123
P
A
F
T
E
P
D
T
T
A
E
V
K
T
P
Site 6
T124
A
F
T
E
P
D
T
T
A
E
V
K
T
P
F
Site 7
T129
D
T
T
A
E
V
K
T
P
F
D
L
A
K
A
Site 8
S142
K
A
Q
E
N
S
N
S
V
K
K
K
T
K
F
Site 9
T147
S
N
S
V
K
K
K
T
K
F
V
N
L
Y
T
Site 10
Y153
K
T
K
F
V
N
L
Y
T
R
E
G
Q
D
R
Site 11
T209
F
C
G
T
L
V
C
T
H
E
E
Q
D
I
L
Site 12
S220
Q
D
I
L
Q
R
D
S
N
K
S
Q
K
L
L
Site 13
S223
L
Q
R
D
S
N
K
S
Q
K
L
L
K
K
L
Site 14
S232
K
L
L
K
K
L
M
S
G
V
E
N
S
G
K
Site 15
S237
L
M
S
G
V
E
N
S
G
K
V
D
I
S
T
Site 16
S243
N
S
G
K
V
D
I
S
T
K
D
L
L
P
H
Site 17
T244
S
G
K
V
D
I
S
T
K
D
L
L
P
H
Q
Site 18
S257
H
Q
E
L
R
I
K
S
G
L
E
K
A
I
K
Site 19
T275
K
L
L
E
F
D
R
T
S
I
R
R
T
Q
V
Site 20
S276
L
L
E
F
D
R
T
S
I
R
R
T
Q
V
I
Site 21
T280
D
R
T
S
I
R
R
T
Q
V
I
D
D
E
S
Site 22
S287
T
Q
V
I
D
D
E
S
D
Y
F
A
S
D
S
Site 23
Y289
V
I
D
D
E
S
D
Y
F
A
S
D
S
N
Q
Site 24
S292
D
E
S
D
Y
F
A
S
D
S
N
Q
W
L
S
Site 25
S294
S
D
Y
F
A
S
D
S
N
Q
W
L
S
K
L
Site 26
S299
S
D
S
N
Q
W
L
S
K
L
E
R
E
T
L
Site 27
T305
L
S
K
L
E
R
E
T
L
Q
K
R
E
E
E
Site 28
S320
L
R
E
L
R
H
A
S
R
L
S
K
K
V
T
Site 29
S323
L
R
H
A
S
R
L
S
K
K
V
T
I
D
F
Site 30
T327
S
R
L
S
K
K
V
T
I
D
F
A
G
R
K
Site 31
S341
K
I
L
E
E
E
N
S
L
A
E
Y
H
S
R
Site 32
Y345
E
E
N
S
L
A
E
Y
H
S
R
L
D
E
T
Site 33
S347
N
S
L
A
E
Y
H
S
R
L
D
E
T
I
Q
Site 34
T366
G
T
L
N
Q
P
L
T
K
L
D
R
S
S
E
Site 35
S371
P
L
T
K
L
D
R
S
S
E
E
P
L
G
V
Site 36
S372
L
T
K
L
D
R
S
S
E
E
P
L
G
V
L
Site 37
Y385
V
L
V
N
P
N
M
Y
Q
S
P
P
Q
W
V
Site 38
S387
V
N
P
N
M
Y
Q
S
P
P
Q
W
V
D
H
Site 39
T395
P
P
Q
W
V
D
H
T
G
A
A
S
Q
K
K
Site 40
S399
V
D
H
T
G
A
A
S
Q
K
K
A
F
R
S
Site 41
S406
S
Q
K
K
A
F
R
S
S
G
F
G
L
E
F
Site 42
S407
Q
K
K
A
F
R
S
S
G
F
G
L
E
F
N
Site 43
S415
G
F
G
L
E
F
N
S
F
Q
H
Q
L
R
I
Site 44
S458
I
K
R
V
E
G
R
S
W
Y
T
P
H
R
G
Site 45
Y460
R
V
E
G
R
S
W
Y
T
P
H
R
G
R
L
Site 46
T461
V
E
G
R
S
W
Y
T
P
H
R
G
R
L
W
Site 47
T472
G
R
L
W
I
A
A
T
A
K
K
P
S
P
Q
Site 48
S477
A
A
T
A
K
K
P
S
P
Q
E
V
S
E
L
Site 49
S482
K
P
S
P
Q
E
V
S
E
L
Q
A
T
Y
R
Site 50
T487
E
V
S
E
L
Q
A
T
Y
R
L
L
R
G
K
Site 51
Y502
D
V
E
F
P
N
D
Y
P
S
G
C
L
L
G
Site 52
S518
V
D
L
I
D
C
L
S
Q
K
Q
F
K
E
Q
Site 53
S530
K
E
Q
F
P
D
I
S
Q
E
S
D
S
P
F
Site 54
S533
F
P
D
I
S
Q
E
S
D
S
P
F
V
F
I
Site 55
S535
D
I
S
Q
E
S
D
S
P
F
V
F
I
C
K
Site 56
S564
P
K
I
W
K
L
D
S
K
I
H
Q
G
A
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation