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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TESK1
Full Name:
Dual specificity testis-specific protein kinase 1
Alias:
TES1; Testicular protein kinase 1; testis specific kinase-1; testis-specific kinase 1; testis-specific kinase-1; Testis-specific protein kinase 1
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.12.1;
TKL
group; LISK family; TESK subfamily
Mass (Da):
67684
Number AA:
626
UniProt ID:
Q15569
International Prot ID:
IPI00018182
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0030145
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0007283
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S39
G
P
G
R
G
R
P
S
S
Y
R
A
L
R
S
Site 2
S40
P
G
R
G
R
P
S
S
Y
R
A
L
R
S
A
Site 3
S46
S
S
Y
R
A
L
R
S
A
V
S
S
L
A
R
Site 4
S69
K
I
G
A
G
F
F
S
E
V
Y
K
V
R
H
Site 5
Y72
A
G
F
F
S
E
V
Y
K
V
R
H
R
Q
S
Site 6
S79
Y
K
V
R
H
R
Q
S
G
Q
V
M
V
L
K
Site 7
S92
L
K
M
N
K
L
P
S
N
R
G
N
T
L
R
Site 8
T97
L
P
S
N
R
G
N
T
L
R
E
V
Q
L
M
Site 9
T129
Q
G
Q
L
H
A
L
T
E
Y
M
N
G
G
T
Site 10
Y131
Q
L
H
A
L
T
E
Y
M
N
G
G
T
L
E
Site 11
S142
G
T
L
E
Q
L
L
S
S
P
E
P
L
S
W
Site 12
S143
T
L
E
Q
L
L
S
S
P
E
P
L
S
W
P
Site 13
S148
L
S
S
P
E
P
L
S
W
P
V
R
L
H
L
Site 14
Y165
D
I
A
R
G
L
R
Y
L
H
S
K
G
V
F
Site 15
S168
R
G
L
R
Y
L
H
S
K
G
V
F
H
R
D
Site 16
T177
G
V
F
H
R
D
L
T
S
K
N
C
L
V
R
Site 17
S178
V
F
H
R
D
L
T
S
K
N
C
L
V
R
R
Site 18
T191
R
R
E
D
R
G
F
T
A
V
V
G
D
F
G
Site 19
Y206
L
A
E
K
I
P
V
Y
R
E
G
A
R
K
E
Site 20
S220
E
P
L
A
V
V
G
S
P
Y
W
M
A
P
E
Site 21
Y234
E
V
L
R
G
E
L
Y
D
E
K
A
D
V
F
Site 22
Y260
R
V
P
A
D
P
D
Y
L
P
R
T
E
D
F
Site 23
T264
D
P
D
Y
L
P
R
T
E
D
F
G
L
D
V
Site 24
T300
C
C
N
L
E
P
S
T
R
A
P
F
T
E
I
Site 25
T325
L
P
E
P
A
P
L
T
R
T
A
L
T
H
N
Site 26
S335
A
L
T
H
N
Q
G
S
V
A
R
G
G
P
S
Site 27
S342
S
V
A
R
G
G
P
S
A
T
L
P
R
P
D
Site 28
T344
A
R
G
G
P
S
A
T
L
P
R
P
D
P
R
Site 29
S353
P
R
P
D
P
R
L
S
R
S
R
S
D
L
F
Site 30
S355
P
D
P
R
L
S
R
S
R
S
D
L
F
L
P
Site 31
S357
P
R
L
S
R
S
R
S
D
L
F
L
P
P
S
Site 32
S364
S
D
L
F
L
P
P
S
P
E
S
P
P
N
W
Site 33
S367
F
L
P
P
S
P
E
S
P
P
N
W
G
D
N
Site 34
T376
P
N
W
G
D
N
L
T
R
V
N
P
F
S
L
Site 35
S382
L
T
R
V
N
P
F
S
L
R
E
D
L
R
G
Site 36
T397
G
K
I
K
L
L
D
T
P
S
K
P
V
L
P
Site 37
T414
P
P
S
P
F
P
S
T
Q
L
P
L
V
T
T
Site 38
T424
P
L
V
T
T
P
E
T
L
V
Q
P
G
T
P
Site 39
T430
E
T
L
V
Q
P
G
T
P
A
R
R
C
R
S
Site 40
S437
T
P
A
R
R
C
R
S
L
P
S
S
P
E
L
Site 41
S440
R
R
C
R
S
L
P
S
S
P
E
L
P
R
R
Site 42
S441
R
C
R
S
L
P
S
S
P
E
L
P
R
R
M
Site 43
T450
E
L
P
R
R
M
E
T
A
L
P
G
P
G
P
Site 44
S463
G
P
P
A
V
G
P
S
A
E
E
K
M
E
C
Site 45
S473
E
K
M
E
C
E
G
S
S
P
E
P
E
P
P
Site 46
S474
K
M
E
C
E
G
S
S
P
E
P
E
P
P
G
Site 47
S497
V
A
T
D
N
F
I
S
T
C
S
S
A
S
Q
Site 48
T498
A
T
D
N
F
I
S
T
C
S
S
A
S
Q
P
Site 49
S500
D
N
F
I
S
T
C
S
S
A
S
Q
P
W
S
Site 50
S501
N
F
I
S
T
C
S
S
A
S
Q
P
W
S
P
Site 51
S503
I
S
T
C
S
S
A
S
Q
P
W
S
P
R
S
Site 52
S507
S
S
A
S
Q
P
W
S
P
R
S
G
P
V
L
Site 53
S510
S
Q
P
W
S
P
R
S
G
P
V
L
N
N
N
Site 54
S525
P
P
A
V
V
V
N
S
P
Q
G
W
A
G
E
Site 55
S540
P
W
N
R
A
Q
H
S
L
P
R
A
A
A
L
Site 56
S553
A
L
E
R
T
E
P
S
P
P
P
S
A
P
R
Site 57
S557
T
E
P
S
P
P
P
S
A
P
R
E
P
D
E
Site 58
T588
L
S
M
C
P
R
P
T
P
A
V
A
R
Y
R
Site 59
T616
G
H
H
A
K
P
P
T
P
S
L
Q
L
P
G
Site 60
S618
H
A
K
P
P
T
P
S
L
Q
L
P
G
A
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation