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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SKIV2L
Full Name:
Helicase SKI2W
Alias:
170A; DDX13; Helicase-like protein; HLP; SKI2W; SKIV2; SKIW; Superkiller viralicidic activity 2-like
Type:
EC 3.6.1.-; Helicase
Mass (Da):
137799
Number AA:
1246
UniProt ID:
Q15477
International Prot ID:
IPI00414819
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004004
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T4
_
_
_
_
M
M
E
T
E
R
L
V
L
P
P
Site 2
T27
R
A
V
E
L
G
C
T
G
H
W
E
L
L
N
Site 3
S41
N
L
P
G
A
P
E
S
S
L
P
H
G
L
P
Site 4
S42
L
P
G
A
P
E
S
S
L
P
H
G
L
P
P
Site 5
S77
P
L
H
G
V
E
H
S
A
R
K
W
Q
R
K
Site 6
T85
A
R
K
W
Q
R
K
T
D
P
W
S
L
L
A
Site 7
S89
Q
R
K
T
D
P
W
S
L
L
A
V
L
G
A
Site 8
T109
L
Q
A
Q
R
H
P
T
T
G
Q
I
L
G
Y
Site 9
Y116
T
T
G
Q
I
L
G
Y
K
E
V
L
L
E
N
Site 10
T129
E
N
T
N
L
S
A
T
T
S
L
S
L
R
R
Site 11
S131
T
N
L
S
A
T
T
S
L
S
L
R
R
P
P
Site 12
S133
L
S
A
T
T
S
L
S
L
R
R
P
P
G
P
Site 13
S142
R
R
P
P
G
P
A
S
Q
S
L
W
G
N
P
Site 14
S144
P
P
G
P
A
S
Q
S
L
W
G
N
P
T
R
Site 15
T163
P
G
G
M
D
E
P
T
I
T
D
L
N
T
R
Site 16
T165
G
M
D
E
P
T
I
T
D
L
N
T
R
E
E
Site 17
T185
D
F
E
K
D
L
L
T
I
P
P
G
F
K
K
Site 18
T203
F
A
P
K
D
C
P
T
P
A
P
G
L
L
S
Site 19
T241
P
G
G
P
R
G
D
T
V
S
A
S
P
C
S
Site 20
S243
G
P
R
G
D
T
V
S
A
S
P
C
S
A
P
Site 21
S245
R
G
D
T
V
S
A
S
P
C
S
A
P
L
A
Site 22
S248
T
V
S
A
S
P
C
S
A
P
L
A
R
A
S
Site 23
S255
S
A
P
L
A
R
A
S
S
L
E
D
L
V
L
Site 24
S256
A
P
L
A
R
A
S
S
L
E
D
L
V
L
K
Site 25
S270
K
E
A
S
T
A
V
S
T
P
E
A
P
E
P
Site 26
T271
E
A
S
T
A
V
S
T
P
E
A
P
E
P
P
Site 27
S279
P
E
A
P
E
P
P
S
Q
E
Q
W
A
I
P
Site 28
Y297
T
S
P
V
G
D
F
Y
R
L
I
P
Q
P
A
Site 29
S327
L
H
L
E
R
H
D
S
V
F
V
A
A
H
T
Site 30
T356
A
Q
K
H
M
T
R
T
I
Y
T
S
P
I
K
Site 31
Y358
K
H
M
T
R
T
I
Y
T
S
P
I
K
A
L
Site 32
S360
M
T
R
T
I
Y
T
S
P
I
K
A
L
S
N
Site 33
S366
T
S
P
I
K
A
L
S
N
Q
K
F
R
D
F
Site 34
T376
K
F
R
D
F
R
N
T
F
G
D
V
G
L
L
Site 35
S405
M
T
T
E
I
L
R
S
M
L
Y
S
G
S
D
Site 36
Y408
E
I
L
R
S
M
L
Y
S
G
S
D
V
I
R
Site 37
S409
I
L
R
S
M
L
Y
S
G
S
D
V
I
R
D
Site 38
S411
R
S
M
L
Y
S
G
S
D
V
I
R
D
L
E
Site 39
Y427
V
I
F
D
E
V
H
Y
I
N
D
V
E
R
G
Site 40
Y476
R
L
K
R
R
Q
I
Y
V
I
S
T
V
T
R
Site 41
S479
R
R
Q
I
Y
V
I
S
T
V
T
R
P
V
P
Site 42
Y490
R
P
V
P
L
E
H
Y
L
F
T
G
N
S
S
Site 43
T493
P
L
E
H
Y
L
F
T
G
N
S
S
K
T
Q
Site 44
S496
H
Y
L
F
T
G
N
S
S
K
T
Q
G
E
L
Site 45
T515
D
S
R
G
A
F
H
T
K
G
Y
Y
A
A
V
Site 46
Y518
G
A
F
H
T
K
G
Y
Y
A
A
V
E
A
K
Site 47
Y519
A
F
H
T
K
G
Y
Y
A
A
V
E
A
K
K
Site 48
S530
E
A
K
K
E
R
M
S
K
H
A
Q
T
F
G
Site 49
T535
R
M
S
K
H
A
Q
T
F
G
A
K
Q
P
T
Site 50
S556
Q
D
R
G
V
Y
L
S
L
L
A
S
L
R
T
Site 51
T573
Q
L
P
V
V
V
F
T
F
S
R
G
R
C
D
Site 52
S575
P
V
V
V
F
T
F
S
R
G
R
C
D
E
Q
Site 53
S584
G
R
C
D
E
Q
A
S
G
L
T
S
L
D
L
Site 54
S588
E
Q
A
S
G
L
T
S
L
D
L
T
T
S
S
Site 55
T592
G
L
T
S
L
D
L
T
T
S
S
E
K
S
E
Site 56
S594
T
S
L
D
L
T
T
S
S
E
K
S
E
I
H
Site 57
S595
S
L
D
L
T
T
S
S
E
K
S
E
I
H
L
Site 58
S598
L
T
T
S
S
E
K
S
E
I
H
L
F
L
Q
Site 59
S614
C
L
A
R
L
R
G
S
D
R
Q
L
P
Q
V
Site 60
S680
A
R
T
V
V
F
D
S
M
R
K
H
D
G
S
Site 61
S687
S
M
R
K
H
D
G
S
T
F
R
D
L
L
P
Site 62
T688
M
R
K
H
D
G
S
T
F
R
D
L
L
P
G
Site 63
Y697
R
D
L
L
P
G
E
Y
V
Q
M
A
G
R
A
Site 64
S738
R
M
M
M
G
K
P
S
Q
L
Q
S
Q
F
R
Site 65
S742
G
K
P
S
Q
L
Q
S
Q
F
R
L
T
Y
T
Site 66
S769
V
E
D
M
M
K
R
S
F
S
E
F
P
S
R
Site 67
S771
D
M
M
K
R
S
F
S
E
F
P
S
R
K
D
Site 68
S775
R
S
F
S
E
F
P
S
R
K
D
S
K
A
H
Site 69
S779
E
F
P
S
R
K
D
S
K
A
H
E
Q
A
L
Site 70
T802
A
L
E
E
P
D
M
T
G
Q
L
V
D
L
P
Site 71
Y811
Q
L
V
D
L
P
E
Y
Y
S
W
G
E
E
L
Site 72
S813
V
D
L
P
E
Y
Y
S
W
G
E
E
L
T
E
Site 73
S832
I
Q
R
R
I
M
E
S
V
N
G
L
K
S
L
Site 74
T867
L
Q
V
S
S
N
S
T
S
R
V
F
T
T
L
Site 75
S868
Q
V
S
S
N
S
T
S
R
V
F
T
T
L
V
Site 76
S882
V
L
C
D
K
P
L
S
Q
D
P
Q
D
R
G
Site 77
T892
P
Q
D
R
G
P
A
T
A
E
V
P
Y
P
D
Site 78
Y897
P
A
T
A
E
V
P
Y
P
D
D
L
V
G
F
Site 79
T916
P
E
G
P
C
D
H
T
V
V
K
L
Q
P
G
Site 80
S945
E
K
I
L
E
D
F
S
K
R
Q
Q
P
K
F
Site 81
T981
A
H
P
A
G
P
P
T
L
D
P
V
N
D
L
Site 82
S994
D
L
Q
L
K
D
M
S
V
V
E
G
G
L
R
Site 83
S1017
Q
G
A
Q
C
V
H
S
P
R
F
P
A
Q
Y
Site 84
Y1024
S
P
R
F
P
A
Q
Y
L
K
L
R
E
R
M
Site 85
T1064
Q
R
V
E
V
L
R
T
L
G
Y
V
D
E
A
Site 86
S1101
L
M
F
D
N
A
L
S
T
L
R
P
E
E
I
Site 87
T1102
M
F
D
N
A
L
S
T
L
R
P
E
E
I
A
Site 88
S1119
L
S
G
L
V
C
Q
S
P
G
D
A
G
D
Q
Site 89
T1130
A
G
D
Q
L
P
N
T
L
K
Q
G
I
E
R
Site 90
S1209
R
L
A
E
M
C
R
S
L
R
G
A
A
R
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation