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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STIL
Full Name:
SCL-interrupting locus protein
Alias:
SCL interrupting locus; SCL/TAL1 interrupting locus; sil; stil; TAL1 (SCL) interrupting locus
Type:
Mass (Da):
142950
Number AA:
UniProt ID:
Q15468
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
F
A
R
P
Q
M
N
T
R
F
P
S
S
R
M
Site 2
S18
Q
M
N
T
R
F
P
S
S
R
M
V
P
F
H
Site 3
T37
K
C
A
L
W
N
P
T
P
T
G
D
F
I
Y
Site 4
Y44
T
P
T
G
D
F
I
Y
L
H
L
S
Y
Y
R
Site 5
T61
K
L
V
V
T
E
K
T
I
R
L
A
Y
R
H
Site 6
Y66
E
K
T
I
R
L
A
Y
R
H
A
K
Q
N
K
Site 7
S76
A
K
Q
N
K
K
N
S
S
C
F
L
L
G
S
Site 8
S77
K
Q
N
K
K
N
S
S
C
F
L
L
G
S
L
Site 9
S83
S
S
C
F
L
L
G
S
L
T
A
D
E
D
E
Site 10
T94
D
E
D
E
E
G
V
T
L
T
V
D
R
F
D
Site 11
T96
D
E
E
G
V
T
L
T
V
D
R
F
D
P
G
Site 12
S142
S
R
E
M
I
V
H
S
V
D
D
F
S
S
A
Site 13
S147
V
H
S
V
D
D
F
S
S
A
L
K
A
L
Q
Site 14
S148
H
S
V
D
D
F
S
S
A
L
K
A
L
Q
C
Site 15
S162
C
H
I
C
S
K
D
S
L
D
C
G
K
L
L
Site 16
T176
L
S
L
R
V
H
I
T
S
R
E
S
L
D
S
Site 17
S177
S
L
R
V
H
I
T
S
R
E
S
L
D
S
V
Site 18
S180
V
H
I
T
S
R
E
S
L
D
S
V
E
F
D
Site 19
S183
T
S
R
E
S
L
D
S
V
E
F
D
L
H
W
Site 20
S219
T
A
L
A
R
N
L
S
S
N
L
N
I
S
Q
Site 21
S225
L
S
S
N
L
N
I
S
Q
V
Q
G
T
Y
K
Site 22
Y235
Q
G
T
Y
K
Y
G
Y
L
T
M
D
E
T
R
Site 23
S294
S
V
Q
E
R
V
F
S
E
S
G
N
F
I
I
Site 24
Y314
T
H
K
E
P
E
F
Y
E
C
F
P
C
D
G
Site 25
T332
D
F
R
F
Q
L
L
T
S
K
E
T
L
H
L
Site 26
T336
Q
L
L
T
S
K
E
T
L
H
L
F
K
N
V
Site 27
S356
N
P
I
R
C
E
L
S
A
E
S
Q
N
A
E
Site 28
S368
N
A
E
T
E
F
F
S
K
A
S
K
N
F
S
Site 29
S375
S
K
A
S
K
N
F
S
I
K
R
S
S
Q
K
Site 30
S379
K
N
F
S
I
K
R
S
S
Q
K
L
S
S
G
Site 31
S380
N
F
S
I
K
R
S
S
Q
K
L
S
S
G
K
Site 32
S384
K
R
S
S
Q
K
L
S
S
G
K
M
P
I
H
Site 33
S385
R
S
S
Q
K
L
S
S
G
K
M
P
I
H
D
Site 34
S395
M
P
I
H
D
H
D
S
G
V
E
D
E
D
F
Site 35
S403
G
V
E
D
E
D
F
S
P
R
P
I
P
S
P
Site 36
S409
F
S
P
R
P
I
P
S
P
H
P
V
S
Q
K
Site 37
S414
I
P
S
P
H
P
V
S
Q
K
I
S
K
I
Q
Site 38
S418
H
P
V
S
Q
K
I
S
K
I
Q
P
S
V
P
Site 39
T443
I
E
S
N
P
L
P
T
P
L
E
M
V
N
N
Site 40
Y470
K
P
L
Q
P
Q
L
Y
D
E
K
H
S
P
E
Site 41
S475
Q
L
Y
D
E
K
H
S
P
E
V
E
A
G
E
Site 42
S484
E
V
E
A
G
E
P
S
L
R
G
I
P
N
Q
Site 43
Y511
K
V
R
Q
P
P
A
Y
K
K
G
N
P
H
T
Site 44
S521
G
N
P
H
T
R
N
S
I
K
P
S
S
H
N
Site 45
S525
T
R
N
S
I
K
P
S
S
H
N
G
P
S
H
Site 46
S526
R
N
S
I
K
P
S
S
H
N
G
P
S
H
D
Site 47
S531
P
S
S
H
N
G
P
S
H
D
I
F
E
K
L
Site 48
T540
D
I
F
E
K
L
Q
T
V
S
A
G
N
V
Q
Site 49
Y551
G
N
V
Q
N
E
E
Y
P
I
R
P
S
T
L
Site 50
S556
E
E
Y
P
I
R
P
S
T
L
N
S
R
Q
S
Site 51
T557
E
Y
P
I
R
P
S
T
L
N
S
R
Q
S
S
Site 52
S560
I
R
P
S
T
L
N
S
R
Q
S
S
L
A
P
Site 53
S563
S
T
L
N
S
R
Q
S
S
L
A
P
Q
S
Q
Site 54
S564
T
L
N
S
R
Q
S
S
L
A
P
Q
S
Q
P
Site 55
S569
Q
S
S
L
A
P
Q
S
Q
P
H
D
F
V
F
Site 56
S577
Q
P
H
D
F
V
F
S
P
H
N
S
G
R
P
Site 57
S581
F
V
F
S
P
H
N
S
G
R
P
M
E
L
Q
Site 58
T591
P
M
E
L
Q
I
P
T
P
P
L
P
S
Y
C
Site 59
Y597
P
T
P
P
L
P
S
Y
C
S
T
N
V
C
R
Site 60
S619
I
Q
Y
S
P
L
N
S
W
Q
G
A
N
T
V
Site 61
T625
N
S
W
Q
G
A
N
T
V
G
S
I
Q
D
V
Site 62
S634
G
S
I
Q
D
V
Q
S
E
A
L
Q
K
H
S
Site 63
S641
S
E
A
L
Q
K
H
S
L
F
H
P
S
G
C
Site 64
S661
N
A
F
C
S
S
S
S
P
I
A
L
R
P
Q
Site 65
S673
R
P
Q
G
D
M
G
S
C
S
P
H
S
N
I
Site 66
S675
Q
G
D
M
G
S
C
S
P
H
S
N
I
E
P
Site 67
S678
M
G
S
C
S
P
H
S
N
I
E
P
S
P
V
Site 68
S683
P
H
S
N
I
E
P
S
P
V
A
R
P
P
S
Site 69
S690
S
P
V
A
R
P
P
S
H
M
D
L
C
N
P
Site 70
T706
P
C
T
V
C
M
H
T
P
K
T
E
S
D
N
Site 71
S719
D
N
G
M
M
G
L
S
P
D
A
Y
R
F
L
Site 72
Y723
M
G
L
S
P
D
A
Y
R
F
L
T
E
Q
D
Site 73
T727
P
D
A
Y
R
F
L
T
E
Q
D
R
Q
L
R
Site 74
S748
Q
R
L
L
E
A
Q
S
L
M
P
C
S
P
K
Site 75
S753
A
Q
S
L
M
P
C
S
P
K
T
T
A
V
E
Site 76
T762
K
T
T
A
V
E
D
T
V
Q
A
G
R
Q
M
Site 77
S773
G
R
Q
M
E
L
V
S
V
E
A
Q
S
S
P
Site 78
S779
V
S
V
E
A
Q
S
S
P
G
L
H
M
R
K
Site 79
S811
G
E
D
Q
E
P
D
S
Q
M
K
Q
D
D
T
Site 80
T818
S
Q
M
K
Q
D
D
T
K
I
S
S
E
D
M
Site 81
T836
V
D
I
N
N
E
V
T
S
L
P
G
S
A
S
Site 82
S837
D
I
N
N
E
V
T
S
L
P
G
S
A
S
S
Site 83
S852
L
K
A
V
D
I
P
S
F
E
E
S
N
I
A
Site 84
S856
D
I
P
S
F
E
E
S
N
I
A
V
E
E
E
Site 85
S869
E
E
F
N
Q
P
L
S
V
S
N
S
S
L
V
Site 86
S871
F
N
Q
P
L
S
V
S
N
S
S
L
V
V
R
Site 87
S873
Q
P
L
S
V
S
N
S
S
L
V
V
R
K
E
Site 88
S874
P
L
S
V
S
N
S
S
L
V
V
R
K
E
P
Site 89
S895
P
S
G
Q
L
A
E
S
V
S
M
C
L
Q
T
Site 90
S909
T
G
P
T
G
G
A
S
N
N
S
E
T
S
E
Site 91
S915
A
S
N
N
S
E
T
S
E
E
P
K
I
E
H
Site 92
S932
Q
P
L
L
H
Q
P
S
D
N
Q
K
I
Y
Q
Site 93
Y938
P
S
D
N
Q
K
I
Y
Q
D
L
L
G
Q
V
Site 94
S951
Q
V
N
H
L
L
N
S
S
S
K
E
T
E
Q
Site 95
S953
N
H
L
L
N
S
S
S
K
E
T
E
Q
P
S
Site 96
T956
L
N
S
S
S
K
E
T
E
Q
P
S
T
K
A
Site 97
T961
K
E
T
E
Q
P
S
T
K
A
V
I
I
S
H
Site 98
S967
S
T
K
A
V
I
I
S
H
E
C
T
R
T
Q
Site 99
T973
I
S
H
E
C
T
R
T
Q
N
V
Y
H
T
K
Site 100
Y977
C
T
R
T
Q
N
V
Y
H
T
K
K
K
T
H
Site 101
T983
V
Y
H
T
K
K
K
T
H
H
S
R
L
V
D
Site 102
S986
T
K
K
K
T
H
H
S
R
L
V
D
K
D
C
Site 103
S1004
A
T
L
K
Q
L
R
S
L
G
V
K
I
D
S
Site 104
S1011
S
L
G
V
K
I
D
S
P
T
K
V
K
K
N
Site 105
T1013
G
V
K
I
D
S
P
T
K
V
K
K
N
A
H
Site 106
S1054
N
V
G
M
S
G
L
S
P
N
G
V
D
L
S
Site 107
Y1071
A
N
A
I
A
L
K
Y
L
N
E
N
Q
L
S
Site 108
S1078
Y
L
N
E
N
Q
L
S
Q
L
S
V
T
R
S
Site 109
S1081
E
N
Q
L
S
Q
L
S
V
T
R
S
N
Q
N
Site 110
S1085
S
Q
L
S
V
T
R
S
N
Q
N
N
C
D
P
Site 111
T1104
H
I
N
T
D
R
S
T
V
G
L
S
L
I
S
Site 112
S1108
D
R
S
T
V
G
L
S
L
I
S
P
N
N
M
Site 113
S1111
T
V
G
L
S
L
I
S
P
N
N
M
S
F
A
Site 114
S1116
L
I
S
P
N
N
M
S
F
A
T
K
K
Y
M
Site 115
Y1122
M
S
F
A
T
K
K
Y
M
K
R
Y
G
L
L
Site 116
S1131
K
R
Y
G
L
L
Q
S
S
D
N
S
E
D
E
Site 117
S1132
R
Y
G
L
L
Q
S
S
D
N
S
E
D
E
E
Site 118
S1135
L
L
Q
S
S
D
N
S
E
D
E
E
E
P
P
Site 119
S1147
E
P
P
D
N
A
D
S
K
S
E
Y
L
L
N
Site 120
S1149
P
D
N
A
D
S
K
S
E
Y
L
L
N
Q
N
Site 121
Y1151
N
A
D
S
K
S
E
Y
L
L
N
Q
N
L
R
Site 122
S1159
L
L
N
Q
N
L
R
S
I
P
E
Q
L
G
G
Site 123
S1171
L
G
G
Q
K
E
P
S
K
N
D
H
E
I
I
Site 124
T1188
S
N
C
E
S
V
G
T
N
A
D
T
P
V
L
Site 125
T1192
S
V
G
T
N
A
D
T
P
V
L
R
N
I
T
Site 126
T1199
T
P
V
L
R
N
I
T
N
E
V
L
Q
T
K
Site 127
T1212
T
K
A
K
Q
Q
L
T
E
K
P
A
F
L
V
Site 128
S1225
L
V
K
N
L
K
P
S
P
A
V
N
L
R
T
Site 129
T1238
R
T
G
K
A
E
F
T
Q
H
P
E
K
E
N
Site 130
T1250
K
E
N
E
G
D
I
T
I
F
P
E
S
L
Q
Site 131
S1255
D
I
T
I
F
P
E
S
L
Q
P
S
E
T
L
Site 132
S1259
F
P
E
S
L
Q
P
S
E
T
L
K
Q
M
N
Site 133
T1261
E
S
L
Q
P
S
E
T
L
K
Q
M
N
S
M
Site 134
S1267
E
T
L
K
Q
M
N
S
M
N
S
V
G
T
F
Site 135
S1270
K
Q
M
N
S
M
N
S
V
G
T
F
L
D
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation