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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SF3B3
Full Name:
Splicing factor 3B subunit 3
Alias:
KIAA0017; RSE1; SAP 130; SAP130; SF3b130; Spliceosome-associated 130; Spliceosome-associated protein 130; Splicing factor 3b, subunit 3, 130kDa; Splicing factor 3B3; STAF130
Type:
RNA binding protein
Mass (Da):
135577
Number AA:
1217
UniProt ID:
Q15393
International Prot ID:
IPI00300371
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005681
GO:0030529
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003723
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0000375
GO:0000377
GO:0000398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
K
Q
Q
E
I
V
V
S
R
G
K
I
L
E
L
Site 2
T47
L
L
R
P
D
P
N
T
G
K
V
H
T
L
L
Site 3
Y77
L
T
G
G
T
K
D
Y
I
V
V
G
S
D
S
Site 4
Y92
G
R
I
V
I
L
E
Y
Q
P
S
K
N
M
F
Site 5
T106
F
E
K
I
H
Q
E
T
F
G
K
S
G
C
R
Site 6
S110
H
Q
E
T
F
G
K
S
G
C
R
R
I
V
P
Site 7
S133
K
G
R
A
V
M
I
S
A
I
E
K
Q
K
L
Site 8
T153
R
D
A
A
A
R
L
T
I
S
S
P
L
E
A
Site 9
S156
A
A
R
L
T
I
S
S
P
L
E
A
H
K
A
Site 10
Y189
F
A
C
L
E
M
D
Y
E
E
A
D
N
D
P
Site 11
T209
A
N
T
Q
Q
T
L
T
F
Y
E
L
D
L
G
Site 12
Y211
T
Q
Q
T
L
T
F
Y
E
L
D
L
G
L
N
Site 13
Y224
L
N
H
V
V
R
K
Y
S
E
P
L
E
E
H
Site 14
S225
N
H
V
V
R
K
Y
S
E
P
L
E
E
H
G
Site 15
T237
E
H
G
N
F
L
I
T
V
P
G
G
S
D
G
Site 16
S246
P
G
G
S
D
G
P
S
G
V
L
I
C
S
E
Site 17
S290
R
G
M
I
F
V
C
S
A
T
H
K
T
K
S
Site 18
S297
S
A
T
H
K
T
K
S
M
F
F
F
L
A
Q
Site 19
T323
E
T
D
E
D
M
V
T
E
I
R
L
K
Y
F
Site 20
Y357
A
S
E
F
G
N
H
Y
L
Y
Q
I
A
H
L
Site 21
Y359
E
F
G
N
H
Y
L
Y
Q
I
A
H
L
G
D
Site 22
S374
D
D
E
E
P
E
F
S
S
A
M
P
L
E
E
Site 23
S375
D
E
E
P
E
F
S
S
A
M
P
L
E
E
G
Site 24
T384
M
P
L
E
E
G
D
T
F
F
F
Q
P
R
P
Site 25
T420
A
D
L
A
N
E
D
T
P
Q
L
Y
V
A
C
Site 26
Y424
N
E
D
T
P
Q
L
Y
V
A
C
G
R
G
P
Site 27
S433
A
C
G
R
G
P
R
S
S
L
R
V
L
R
H
Site 28
S434
C
G
R
G
P
R
S
S
L
R
V
L
R
H
G
Site 29
S450
E
V
S
E
M
A
V
S
E
L
P
G
N
P
N
Site 30
T461
G
N
P
N
A
V
W
T
V
R
R
H
I
E
D
Site 31
S497
T
V
E
E
V
T
D
S
G
F
L
G
T
T
P
Site 32
Y520
D
D
A
L
V
Q
V
Y
P
D
G
I
R
H
I
Site 33
T538
K
R
V
N
E
W
K
T
P
G
K
K
T
I
V
Site 34
Y565
L
T
G
G
E
L
V
Y
F
E
M
D
P
S
G
Site 35
Y577
P
S
G
Q
L
N
E
Y
T
E
R
K
E
M
S
Site 36
T578
S
G
Q
L
N
E
Y
T
E
R
K
E
M
S
A
Site 37
S618
D
N
T
V
R
I
I
S
L
D
P
S
D
C
L
Site 38
S622
R
I
I
S
L
D
P
S
D
C
L
Q
P
L
S
Site 39
S629
S
D
C
L
Q
P
L
S
M
Q
A
L
P
A
Q
Site 40
S659
D
E
L
G
E
R
G
S
I
G
F
L
Y
L
N
Site 41
T683
R
T
V
L
D
P
V
T
G
D
L
S
D
T
R
Site 42
S687
D
P
V
T
G
D
L
S
D
T
R
T
R
Y
L
Site 43
T689
V
T
G
D
L
S
D
T
R
T
R
Y
L
G
S
Site 44
T691
G
D
L
S
D
T
R
T
R
Y
L
G
S
R
P
Site 45
Y693
L
S
D
T
R
T
R
Y
L
G
S
R
P
V
K
Site 46
S696
T
R
T
R
Y
L
G
S
R
P
V
K
L
F
R
Site 47
S716
Q
E
A
V
L
A
M
S
S
R
S
W
L
S
Y
Site 48
S717
E
A
V
L
A
M
S
S
R
S
W
L
S
Y
S
Site 49
S719
V
L
A
M
S
S
R
S
W
L
S
Y
S
Y
Q
Site 50
S722
M
S
S
R
S
W
L
S
Y
S
Y
Q
S
R
F
Site 51
Y723
S
S
R
S
W
L
S
Y
S
Y
Q
S
R
F
H
Site 52
S724
S
R
S
W
L
S
Y
S
Y
Q
S
R
F
H
L
Site 53
Y725
R
S
W
L
S
Y
S
Y
Q
S
R
F
H
L
T
Site 54
T732
Y
Q
S
R
F
H
L
T
P
L
S
Y
E
T
L
Site 55
S735
R
F
H
L
T
P
L
S
Y
E
T
L
E
F
A
Site 56
S743
Y
E
T
L
E
F
A
S
G
F
A
S
E
Q
C
Site 57
S747
E
F
A
S
G
F
A
S
E
Q
C
P
E
G
I
Site 58
T784
V
A
F
P
L
Q
Y
T
P
R
K
F
V
I
H
Site 59
S850
L
N
E
N
L
P
E
S
I
F
G
A
P
K
A
Site 60
S890
E
Q
N
E
A
A
F
S
V
A
V
C
R
F
S
Site 61
Y904
S
N
T
G
E
D
W
Y
V
L
V
G
V
A
K
Site 62
Y928
A
G
G
F
V
Y
T
Y
K
L
V
N
N
G
E
Site 63
T943
K
L
E
F
L
H
K
T
P
V
E
E
V
P
A
Site 64
Y970
V
G
K
L
L
R
V
Y
D
L
G
K
K
K
L
Site 65
Y989
E
N
K
H
I
A
N
Y
I
S
G
I
Q
T
I
Site 66
Y1014
E
S
F
I
W
V
R
Y
K
R
N
E
N
Q
L
Site 67
Y1029
I
I
F
A
D
D
T
Y
P
R
W
V
T
T
A
Site 68
T1034
D
T
Y
P
R
W
V
T
T
A
S
L
L
D
Y
Site 69
S1037
P
R
W
V
T
T
A
S
L
L
D
Y
D
T
V
Site 70
Y1041
T
T
A
S
L
L
D
Y
D
T
V
A
G
A
D
Site 71
T1062
V
V
R
L
P
P
N
T
N
D
E
V
D
E
D
Site 72
T1071
D
E
V
D
E
D
P
T
G
N
K
A
L
W
D
Site 73
S1086
R
G
L
L
N
G
A
S
Q
K
A
E
V
I
M
Site 74
Y1166
D
H
L
S
F
R
S
Y
Y
F
P
V
K
N
V
Site 75
Y1167
H
L
S
F
R
S
Y
Y
F
P
V
K
N
V
I
Site 76
S1184
D
L
C
E
Q
F
N
S
M
E
P
N
K
Q
K
Site 77
S1194
P
N
K
Q
K
N
V
S
E
E
L
D
R
T
P
Site 78
T1200
V
S
E
E
L
D
R
T
P
P
E
V
S
K
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation