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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DHCR24
Full Name:
24-dehydrocholesterol reductase
Alias:
24-dehydrocholesterol reductase; 3-beta- hydroxysterol delta-24-reductase; DHC24; DHCR; Diminuto/dwarf1 homolog; KIAA0018; Seladin-1
Type:
EC 1.3.1.-; Oxidoreductase; Lipid Metabolism - steroid biosynthesis
Mass (Da):
60101
Number AA:
516
UniProt ID:
Q15392
International Prot ID:
IPI00016703
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005789
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0050660
GO:0050614
GO:0019899
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0006915
GO:0007050
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T92
G
S
K
T
F
M
C
T
G
R
P
G
W
L
T
Site 2
T99
T
G
R
P
G
W
L
T
V
S
L
R
V
G
K
Site 3
S101
R
P
G
W
L
T
V
S
L
R
V
G
K
Y
K
Site 4
T110
R
V
G
K
Y
K
K
T
H
K
N
I
M
I
N
Site 5
S176
M
G
T
G
I
E
S
S
S
H
K
Y
G
L
F
Site 6
S177
G
T
G
I
E
S
S
S
H
K
Y
G
L
F
Q
Site 7
Y180
I
E
S
S
S
H
K
Y
G
L
F
Q
H
I
C
Site 8
T203
D
G
S
F
V
R
C
T
P
S
E
N
S
D
L
Site 9
S205
S
F
V
R
C
T
P
S
E
N
S
D
L
F
Y
Site 10
Y212
S
E
N
S
D
L
F
Y
A
V
P
W
S
C
G
Site 11
Y237
R
I
I
P
A
K
K
Y
V
K
L
R
F
E
P
Site 12
T285
V
I
M
T
G
V
M
T
D
E
A
E
P
S
K
Site 13
S291
M
T
D
E
A
E
P
S
K
L
N
S
I
G
N
Site 14
S295
A
E
P
S
K
L
N
S
I
G
N
Y
Y
K
P
Site 15
Y299
K
L
N
S
I
G
N
Y
Y
K
P
W
F
F
K
Site 16
Y300
L
N
S
I
G
N
Y
Y
K
P
W
F
F
K
H
Site 17
T314
H
V
E
N
Y
L
K
T
N
R
E
G
L
E
Y
Site 18
Y321
T
N
R
E
G
L
E
Y
I
P
L
R
H
Y
Y
Site 19
Y327
E
Y
I
P
L
R
H
Y
Y
H
R
H
T
R
S
Site 20
Y328
Y
I
P
L
R
H
Y
Y
H
R
H
T
R
S
I
Site 21
T373
L
K
L
T
Q
G
E
T
L
R
K
L
Y
E
Q
Site 22
Y378
G
E
T
L
R
K
L
Y
E
Q
H
H
V
V
Q
Site 23
Y434
K
G
N
E
A
E
L
Y
I
D
I
G
A
Y
G
Site 24
Y440
L
Y
I
D
I
G
A
Y
G
E
P
R
V
K
H
Site 25
S452
V
K
H
F
E
A
R
S
C
M
R
Q
L
E
K
Site 26
S463
Q
L
E
K
F
V
R
S
V
H
G
F
Q
M
L
Site 27
Y490
E
M
F
D
G
S
L
Y
H
K
L
R
E
K
L
Site 28
Y507
Q
D
A
F
P
E
V
Y
D
K
I
C
K
A
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation