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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UBE3C
Full Name:
Ubiquitin-protein ligase E3C
Alias:
EC 6.3.2.-; KIAA0010
Type:
Proteolysis - E3 ubiquitin-protein ligase
Mass (Da):
123923
Number AA:
1083
UniProt ID:
Q15386
International Prot ID:
IPI00784043
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0000502
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004842
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0000209
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
S
F
E
G
D
F
K
T
R
P
K
V
S
L
G
Site 2
S15
F
K
T
R
P
K
V
S
L
G
G
A
S
R
K
Site 3
S27
S
R
K
E
E
K
A
S
L
L
H
R
T
Q
E
Site 4
Y59
I
Q
S
F
I
R
G
Y
R
D
R
K
Q
Q
Y
Site 5
Y66
Y
R
D
R
K
Q
Q
Y
S
I
Q
R
S
A
F
Site 6
S67
R
D
R
K
Q
Q
Y
S
I
Q
R
S
A
F
D
Site 7
S71
Q
Q
Y
S
I
Q
R
S
A
F
D
R
C
A
T
Site 8
T78
S
A
F
D
R
C
A
T
L
S
Q
S
G
G
A
Site 9
S80
F
D
R
C
A
T
L
S
Q
S
G
G
A
F
P
Site 10
Y118
S
K
R
L
I
W
L
Y
Q
N
L
I
K
H
S
Site 11
S126
Q
N
L
I
K
H
S
S
L
F
V
K
Q
L
D
Site 12
T139
L
D
G
S
E
R
L
T
C
L
F
Q
I
K
R
Site 13
S162
L
Q
N
C
N
D
D
S
L
N
V
A
L
P
M
Site 14
S177
R
M
L
E
V
F
S
S
E
N
T
Y
L
P
V
Site 15
T180
E
V
F
S
S
E
N
T
Y
L
P
V
L
Q
D
Site 16
Y181
V
F
S
S
E
N
T
Y
L
P
V
L
Q
D
A
Site 17
Y207
H
Y
M
I
H
N
G
Y
Y
R
S
L
Y
L
L
Site 18
Y212
N
G
Y
Y
R
S
L
Y
L
L
I
N
S
K
L
Site 19
S221
L
I
N
S
K
L
P
S
S
I
E
Y
S
D
L
Site 20
S222
I
N
S
K
L
P
S
S
I
E
Y
S
D
L
S
Site 21
Y225
K
L
P
S
S
I
E
Y
S
D
L
S
R
V
P
Site 22
S226
L
P
S
S
I
E
Y
S
D
L
S
R
V
P
I
Site 23
S229
S
I
E
Y
S
D
L
S
R
V
P
I
A
K
I
Site 24
Y249
L
K
P
L
H
F
T
Y
N
S
C
P
E
G
A
Site 25
S251
P
L
H
F
T
Y
N
S
C
P
E
G
A
R
Q
Site 26
T262
G
A
R
Q
Q
V
F
T
A
F
T
E
E
F
L
Site 27
S306
N
A
L
L
L
I
E
S
R
C
S
R
K
S
G
Site 28
S309
L
L
I
E
S
R
C
S
R
K
S
G
G
A
P
Site 29
S312
E
S
R
C
S
R
K
S
G
G
A
P
W
L
F
Site 30
S358
Q
L
P
V
S
P
A
S
A
S
C
H
D
S
A
Site 31
S360
P
V
S
P
A
S
A
S
C
H
D
S
A
S
D
Site 32
S364
A
S
A
S
C
H
D
S
A
S
D
S
E
E
E
Site 33
S366
A
S
C
H
D
S
A
S
D
S
E
E
E
S
E
Site 34
S368
C
H
D
S
A
S
D
S
E
E
E
S
E
E
A
Site 35
S372
A
S
D
S
E
E
E
S
E
E
A
D
K
P
S
Site 36
S379
S
E
E
A
D
K
P
S
S
P
E
D
G
R
L
Site 37
S380
E
E
A
D
K
P
S
S
P
E
D
G
R
L
S
Site 38
S387
S
P
E
D
G
R
L
S
V
S
Y
I
T
E
E
Site 39
S389
E
D
G
R
L
S
V
S
Y
I
T
E
E
C
L
Site 40
Y390
D
G
R
L
S
V
S
Y
I
T
E
E
C
L
K
Site 41
T401
E
C
L
K
K
L
D
T
K
Q
Q
T
N
T
L
Site 42
S416
L
N
L
V
W
R
D
S
A
S
E
E
V
F
T
Site 43
S418
L
V
W
R
D
S
A
S
E
E
V
F
T
T
M
Site 44
S464
R
H
L
W
F
L
I
S
S
M
S
T
R
M
I
Site 45
S486
L
Q
V
I
S
R
G
S
P
M
S
F
E
D
S
Site 46
S489
I
S
R
G
S
P
M
S
F
E
D
S
S
R
I
Site 47
S493
S
P
M
S
F
E
D
S
S
R
I
I
P
L
F
Site 48
S494
P
M
S
F
E
D
S
S
R
I
I
P
L
F
Y
Site 49
S532
E
V
V
G
Q
R
Q
S
S
M
M
P
F
T
L
Site 50
S533
V
V
G
Q
R
Q
S
S
M
M
P
F
T
L
E
Site 51
Y572
K
P
E
V
R
E
E
Y
I
T
A
F
Q
S
I
Site 52
T574
E
V
R
E
E
Y
I
T
A
F
Q
S
I
G
V
Site 53
T582
A
F
Q
S
I
G
V
T
T
S
S
E
M
Q
Q
Site 54
S584
Q
S
I
G
V
T
T
S
S
E
M
Q
Q
C
I
Site 55
S585
S
I
G
V
T
T
S
S
E
M
Q
Q
C
I
Q
Site 56
S614
N
L
V
K
M
L
K
S
R
D
T
R
R
N
F
Site 57
T617
K
M
L
K
S
R
D
T
R
R
N
F
C
P
P
Site 58
T640
D
I
K
A
D
K
V
T
Q
L
Y
V
P
A
S
Site 59
Y643
A
D
K
V
T
Q
L
Y
V
P
A
S
R
H
V
Site 60
S664
G
R
I
G
P
L
Q
S
T
L
D
V
G
L
E
Site 61
T665
R
I
G
P
L
Q
S
T
L
D
V
G
L
E
S
Site 62
S672
T
L
D
V
G
L
E
S
P
P
L
S
V
S
E
Site 63
S676
G
L
E
S
P
P
L
S
V
S
E
E
R
Q
L
Site 64
S678
E
S
P
P
L
S
V
S
E
E
R
Q
L
A
V
Site 65
Y707
K
I
F
Q
R
L
I
Y
A
D
K
Q
E
V
Q
Site 66
Y731
N
V
T
I
R
R
N
Y
I
Y
E
D
A
Y
D
Site 67
Y733
T
I
R
R
N
Y
I
Y
E
D
A
Y
D
K
L
Site 68
Y737
N
Y
I
Y
E
D
A
Y
D
K
L
S
P
E
N
Site 69
S741
E
D
A
Y
D
K
L
S
P
E
N
E
P
D
L
Site 70
S783
F
L
N
E
L
L
K
S
G
F
N
P
N
Q
G
Site 71
T794
P
N
Q
G
F
F
K
T
T
N
E
G
L
L
Y
Site 72
Y801
T
T
N
E
G
L
L
Y
P
N
P
A
A
Q
M
Site 73
Y818
G
D
S
F
A
R
H
Y
Y
F
L
G
R
M
L
Site 74
Y819
D
S
F
A
R
H
Y
Y
F
L
G
R
M
L
G
Site 75
S861
V
D
I
H
H
L
A
S
L
D
P
E
V
Y
K
Site 76
S875
K
N
L
L
F
L
K
S
Y
E
D
D
V
E
E
Site 77
Y876
N
L
L
F
L
K
S
Y
E
D
D
V
E
E
L
Site 78
T888
E
E
L
G
L
N
F
T
V
V
N
N
D
L
G
Site 79
T912
G
G
K
D
I
P
V
T
S
A
N
R
I
A
Y
Site 80
S913
G
K
D
I
P
V
T
S
A
N
R
I
A
Y
I
Site 81
Y926
Y
I
H
L
V
A
D
Y
R
L
N
R
Q
I
R
Site 82
S972
S
G
A
Q
V
P
I
S
L
E
D
L
K
S
F
Site 83
S978
I
S
L
E
D
L
K
S
F
T
N
Y
S
G
G
Site 84
T980
L
E
D
L
K
S
F
T
N
Y
S
G
G
Y
S
Site 85
Y982
D
L
K
S
F
T
N
Y
S
G
G
Y
S
A
D
Site 86
S983
L
K
S
F
T
N
Y
S
G
G
Y
S
A
D
H
Site 87
S987
T
N
Y
S
G
G
Y
S
A
D
H
P
V
I
K
Site 88
T1016
R
K
L
L
K
F
V
T
S
C
S
R
P
P
L
Site 89
Y1030
L
L
G
F
K
E
L
Y
P
A
F
C
I
H
N
Site 90
T1047
S
D
L
E
R
L
P
T
A
S
T
C
M
N
L
Site 91
T1064
L
P
E
F
Y
D
E
T
L
L
R
S
K
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation