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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TTF1
Full Name:
Transcription termination factor 1
Alias:
RP11-203M2.1-001; Transcription termination factor, RNA polymerase I; TTF-I
Type:
DNA binding protein
Mass (Da):
103051
Number AA:
905
UniProt ID:
Q15361
International Prot ID:
IPI00385712
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005654
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003682
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006275
GO:0006325
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
S
S
R
F
E
I
H
T
P
V
S
D
K
K
K
Site 2
S15
F
E
I
H
T
P
V
S
D
K
K
K
K
K
C
Site 3
S23
D
K
K
K
K
K
C
S
I
H
K
E
R
P
Q
Site 4
S33
K
E
R
P
Q
K
H
S
H
E
I
F
R
D
S
Site 5
S40
S
H
E
I
F
R
D
S
S
L
V
N
E
Q
S
Site 6
S41
H
E
I
F
R
D
S
S
L
V
N
E
Q
S
Q
Site 7
S47
S
S
L
V
N
E
Q
S
Q
I
T
R
R
K
K
Site 8
S64
K
D
F
Q
H
L
I
S
S
P
L
K
K
S
R
Site 9
S65
D
F
Q
H
L
I
S
S
P
L
K
K
S
R
I
Site 10
T76
K
S
R
I
C
D
E
T
A
N
A
T
S
T
L
Site 11
T82
E
T
A
N
A
T
S
T
L
K
K
R
K
K
R
Site 12
Y91
K
K
R
K
K
R
R
Y
S
A
L
E
V
D
E
Site 13
S92
K
R
K
K
R
R
Y
S
A
L
E
V
D
E
E
Site 14
T115
D
K
E
N
I
N
N
T
P
K
H
F
R
K
D
Site 15
S131
D
V
V
C
V
D
M
S
I
E
Q
K
L
P
R
Site 16
T142
K
L
P
R
K
P
K
T
D
K
F
Q
V
L
A
Site 17
S151
K
F
Q
V
L
A
K
S
H
A
H
K
S
E
A
Site 18
S156
A
K
S
H
A
H
K
S
E
A
L
H
S
K
V
Site 19
S161
H
K
S
E
A
L
H
S
K
V
R
E
K
K
N
Site 20
S180
R
K
A
A
S
W
E
S
Q
R
A
R
D
T
L
Site 21
T186
E
S
Q
R
A
R
D
T
L
P
Q
S
E
S
H
Site 22
S190
A
R
D
T
L
P
Q
S
E
S
H
Q
E
E
S
Site 23
S192
D
T
L
P
Q
S
E
S
H
Q
E
E
S
W
L
Site 24
S197
S
E
S
H
Q
E
E
S
W
L
S
V
G
P
G
Site 25
S200
H
Q
E
E
S
W
L
S
V
G
P
G
G
E
I
Site 26
T208
V
G
P
G
G
E
I
T
E
L
P
A
S
A
H
Site 27
S213
E
I
T
E
L
P
A
S
A
H
K
N
K
S
K
Site 28
S219
A
S
A
H
K
N
K
S
K
K
K
K
K
K
S
Site 29
S226
S
K
K
K
K
K
K
S
S
N
R
E
Y
E
T
Site 30
S227
K
K
K
K
K
K
S
S
N
R
E
Y
E
T
L
Site 31
Y231
K
K
S
S
N
R
E
Y
E
T
L
A
M
P
E
Site 32
S240
T
L
A
M
P
E
G
S
Q
A
G
R
E
A
G
Site 33
S253
A
G
T
D
M
Q
E
S
Q
P
T
V
G
L
D
Site 34
T256
D
M
Q
E
S
Q
P
T
V
G
L
D
D
E
T
Site 35
T263
T
V
G
L
D
D
E
T
P
Q
L
L
G
P
T
Site 36
S275
G
P
T
H
K
K
K
S
K
K
K
K
K
K
K
Site 37
S283
K
K
K
K
K
K
K
S
N
H
Q
E
F
E
A
Site 38
S297
A
L
A
M
P
E
G
S
Q
V
G
S
E
V
G
Site 39
S301
P
E
G
S
Q
V
G
S
E
V
G
A
D
M
Q
Site 40
S310
V
G
A
D
M
Q
E
S
R
P
A
V
G
L
H
Site 41
Y328
A
G
I
P
A
P
A
Y
K
N
K
S
K
K
K
Site 42
S332
A
P
A
Y
K
N
K
S
K
K
K
K
K
K
S
Site 43
S339
S
K
K
K
K
K
K
S
N
H
Q
E
F
E
A
Site 44
S352
E
A
V
A
M
P
E
S
L
E
S
A
Y
P
E
Site 45
S355
A
M
P
E
S
L
E
S
A
Y
P
E
G
S
Q
Site 46
Y357
P
E
S
L
E
S
A
Y
P
E
G
S
Q
V
G
Site 47
S361
E
S
A
Y
P
E
G
S
Q
V
G
S
E
V
G
Site 48
S365
P
E
G
S
Q
V
G
S
E
V
G
T
V
E
G
Site 49
S373
E
V
G
T
V
E
G
S
T
A
L
K
G
F
K
Site 50
S384
K
G
F
K
E
S
N
S
T
K
K
K
S
K
K
Site 51
T385
G
F
K
E
S
N
S
T
K
K
K
S
K
K
R
Site 52
S389
S
N
S
T
K
K
K
S
K
K
R
K
L
T
S
Site 53
T395
K
S
K
K
R
K
L
T
S
V
K
R
A
R
V
Site 54
S396
S
K
K
R
K
L
T
S
V
K
R
A
R
V
S
Site 55
S403
S
V
K
R
A
R
V
S
G
D
D
F
S
V
P
Site 56
S408
R
V
S
G
D
D
F
S
V
P
S
K
N
S
E
Site 57
S411
G
D
D
F
S
V
P
S
K
N
S
E
S
T
L
Site 58
T417
P
S
K
N
S
E
S
T
L
F
D
S
V
E
G
Site 59
S421
S
E
S
T
L
F
D
S
V
E
G
D
G
A
M
Site 60
S435
M
M
E
E
G
V
K
S
R
P
R
Q
K
K
T
Site 61
T442
S
R
P
R
Q
K
K
T
Q
A
C
L
A
S
K
Site 62
S472
N
V
E
T
A
E
D
S
E
I
R
Y
L
S
A
Site 63
Y476
A
E
D
S
E
I
R
Y
L
S
A
D
S
G
D
Site 64
S478
D
S
E
I
R
Y
L
S
A
D
S
G
D
A
D
Site 65
S481
I
R
Y
L
S
A
D
S
G
D
A
D
D
S
D
Site 66
S487
D
S
G
D
A
D
D
S
D
A
D
L
G
S
A
Site 67
S493
D
S
D
A
D
L
G
S
A
V
K
Q
L
Q
E
Site 68
T510
P
N
I
K
D
R
A
T
S
T
I
K
R
M
Y
Site 69
S511
N
I
K
D
R
A
T
S
T
I
K
R
M
Y
R
Site 70
Y517
T
S
T
I
K
R
M
Y
R
D
D
L
E
R
F
Site 71
Y568
E
S
A
D
K
L
L
Y
T
D
R
Y
P
E
E
Site 72
T569
S
A
D
K
L
L
Y
T
D
R
Y
P
E
E
K
Site 73
Y572
K
L
L
Y
T
D
R
Y
P
E
E
K
S
V
I
Site 74
S577
D
R
Y
P
E
E
K
S
V
I
T
N
L
K
R
Site 75
Y586
I
T
N
L
K
R
R
Y
S
F
R
L
H
I
G
Site 76
S587
T
N
L
K
R
R
Y
S
F
R
L
H
I
G
R
Site 77
Y604
A
R
P
W
K
L
I
Y
Y
R
A
K
K
M
F
Site 78
Y605
R
P
W
K
L
I
Y
Y
R
A
K
K
M
F
D
Site 79
Y616
K
M
F
D
V
N
N
Y
K
G
R
Y
S
E
G
Site 80
S621
N
N
Y
K
G
R
Y
S
E
G
D
T
E
K
L
Site 81
T625
G
R
Y
S
E
G
D
T
E
K
L
K
M
Y
H
Site 82
Y631
D
T
E
K
L
K
M
Y
H
S
L
L
G
N
D
Site 83
S633
E
K
L
K
M
Y
H
S
L
L
G
N
D
W
K
Site 84
T641
L
L
G
N
D
W
K
T
I
G
E
M
V
A
R
Site 85
S658
L
S
V
A
L
K
F
S
Q
I
S
S
Q
R
N
Site 86
S662
L
K
F
S
Q
I
S
S
Q
R
N
R
G
A
W
Site 87
S672
N
R
G
A
W
S
K
S
E
T
R
K
L
I
K
Site 88
T674
G
A
W
S
K
S
E
T
R
K
L
I
K
A
V
Site 89
S690
E
V
I
L
K
K
M
S
P
Q
E
L
K
E
V
Site 90
S707
K
L
Q
E
N
P
E
S
C
L
S
I
V
R
E
Site 91
S710
E
N
P
E
S
C
L
S
I
V
R
E
K
L
Y
Site 92
Y717
S
I
V
R
E
K
L
Y
K
G
I
S
W
V
E
Site 93
S721
E
K
L
Y
K
G
I
S
W
V
E
V
E
A
K
Site 94
T746
S
K
W
T
E
I
L
T
K
R
M
T
N
G
R
Site 95
T750
E
I
L
T
K
R
M
T
N
G
R
R
I
Y
Y
Site 96
Y756
M
T
N
G
R
R
I
Y
Y
G
M
N
A
L
R
Site 97
Y757
T
N
G
R
R
I
Y
Y
G
M
N
A
L
R
A
Site 98
S767
N
A
L
R
A
K
V
S
L
I
E
R
L
Y
E
Site 99
Y773
V
S
L
I
E
R
L
Y
E
I
N
V
E
D
T
Site 100
S790
I
D
W
E
D
L
A
S
A
I
G
D
V
P
P
Site 101
S798
A
I
G
D
V
P
P
S
Y
V
Q
T
K
F
S
Site 102
Y799
I
G
D
V
P
P
S
Y
V
Q
T
K
F
S
R
Site 103
T802
V
P
P
S
Y
V
Q
T
K
F
S
R
L
K
A
Site 104
Y811
F
S
R
L
K
A
V
Y
V
P
F
W
Q
K
K
Site 105
T848
K
M
M
E
K
K
G
T
K
I
Q
T
P
A
A
Site 106
T852
K
K
G
T
K
I
Q
T
P
A
A
P
K
Q
V
Site 107
Y867
F
P
F
R
D
I
F
Y
Y
E
D
D
S
E
G
Site 108
Y868
P
F
R
D
I
F
Y
Y
E
D
D
S
E
G
E
Site 109
S872
I
F
Y
Y
E
D
D
S
E
G
E
D
I
E
K
Site 110
S895
M
A
H
A
C
N
S
S
T
L
G
G
Q
G
R
Site 111
T896
A
H
A
C
N
S
S
T
L
G
G
Q
G
R
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation