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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RASA2
Full Name:
Ras GTPase-activating protein 2
Alias:
GAP1M; GTPase-activating protein of RAS; RAS p21 protein activator 2; RASGAP
Type:
Intracellular, Cytoplasm protein; GTPase activating protein, Ras. Binds inositol tetrakisphosphate (IP4)
Mass (Da):
96527
Number AA:
849
UniProt ID:
Q15283
International Prot ID:
IPI00015811
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0005099
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0051056
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
S
S
E
A
P
A
A
S
A
T
A
E
P
E
A
Site 2
T21
E
A
P
A
A
S
A
T
A
E
P
E
A
G
D
Site 3
S31
P
E
A
G
D
Q
D
S
R
E
V
R
V
L
Q
Site 4
S39
R
E
V
R
V
L
Q
S
L
R
G
K
I
C
E
Site 5
Y53
E
A
K
N
L
L
P
Y
L
G
P
H
K
M
R
Site 6
T76
D
Q
E
E
V
Y
R
T
Q
V
V
E
K
S
L
Site 7
S82
R
T
Q
V
V
E
K
S
L
S
P
F
F
S
E
Site 8
S84
Q
V
V
E
K
S
L
S
P
F
F
S
E
E
F
Site 9
S88
K
S
L
S
P
F
F
S
E
E
F
Y
F
E
I
Site 10
Y92
P
F
F
S
E
E
F
Y
F
E
I
P
R
T
F
Site 11
Y101
E
I
P
R
T
F
Q
Y
L
S
F
Y
V
Y
D
Site 12
S103
P
R
T
F
Q
Y
L
S
F
Y
V
Y
D
K
N
Site 13
Y105
T
F
Q
Y
L
S
F
Y
V
Y
D
K
N
V
L
Site 14
Y107
Q
Y
L
S
F
Y
V
Y
D
K
N
V
L
Q
R
Site 15
T136
C
N
H
S
G
K
E
T
W
F
S
L
Q
P
V
Site 16
S139
S
G
K
E
T
W
F
S
L
Q
P
V
D
S
N
Site 17
S145
F
S
L
Q
P
V
D
S
N
S
E
V
Q
G
K
Site 18
S147
L
Q
P
V
D
S
N
S
E
V
Q
G
K
V
H
Site 19
T164
L
K
L
N
E
L
I
T
E
N
G
T
V
C
Q
Site 20
Y194
N
G
Q
S
C
D
P
Y
A
T
V
S
L
V
G
Site 21
T196
Q
S
C
D
P
Y
A
T
V
S
L
V
G
P
S
Site 22
S198
C
D
P
Y
A
T
V
S
L
V
G
P
S
R
N
Site 23
T216
K
T
K
V
K
K
K
T
S
N
P
Q
F
N
E
Site 24
S217
T
K
V
K
K
K
T
S
N
P
Q
F
N
E
I
Site 25
Y226
P
Q
F
N
E
I
F
Y
F
E
V
T
R
S
S
Site 26
T230
E
I
F
Y
F
E
V
T
R
S
S
S
Y
T
R
Site 27
S232
F
Y
F
E
V
T
R
S
S
S
Y
T
R
K
S
Site 28
S233
Y
F
E
V
T
R
S
S
S
Y
T
R
K
S
Q
Site 29
S234
F
E
V
T
R
S
S
S
Y
T
R
K
S
Q
F
Site 30
Y235
E
V
T
R
S
S
S
Y
T
R
K
S
Q
F
Q
Site 31
T236
V
T
R
S
S
S
Y
T
R
K
S
Q
F
Q
V
Site 32
S239
S
S
S
Y
T
R
K
S
Q
F
Q
V
E
E
E
Site 33
S283
V
N
V
L
R
T
D
S
S
H
Q
A
W
Y
L
Site 34
S284
N
V
L
R
T
D
S
S
H
Q
A
W
Y
L
L
Site 35
S300
P
R
D
N
G
N
K
S
S
K
T
D
D
L
G
Site 36
S301
R
D
N
G
N
K
S
S
K
T
D
D
L
G
S
Site 37
T303
N
G
N
K
S
S
K
T
D
D
L
G
S
L
R
Site 38
S308
S
K
T
D
D
L
G
S
L
R
L
N
I
C
Y
Site 39
Y319
N
I
C
Y
T
E
D
Y
V
L
P
S
E
Y
Y
Site 40
Y325
D
Y
V
L
P
S
E
Y
Y
G
P
L
K
T
L
Site 41
T331
E
Y
Y
G
P
L
K
T
L
L
L
K
S
P
D
Site 42
S343
S
P
D
V
Q
P
I
S
A
S
A
A
Y
I
L
Site 43
T389
A
E
L
D
L
K
D
T
Q
D
A
N
T
I
F
Site 44
T394
K
D
T
Q
D
A
N
T
I
F
R
G
N
S
L
Site 45
S400
N
T
I
F
R
G
N
S
L
A
T
R
C
L
D
Site 46
T421
G
G
H
Y
L
K
V
T
L
K
P
I
L
D
E
Site 47
S432
I
L
D
E
I
C
D
S
S
K
S
C
E
I
D
Site 48
S435
E
I
C
D
S
S
K
S
C
E
I
D
P
I
K
Site 49
Y458
N
N
K
E
N
L
R
Y
Y
V
D
K
L
F
N
Site 50
Y459
N
K
E
N
L
R
Y
Y
V
D
K
L
F
N
T
Site 51
T466
Y
V
D
K
L
F
N
T
I
V
K
S
S
M
S
Site 52
T490
Y
S
L
R
Q
M
A
T
Q
R
F
P
N
D
P
Site 53
Y501
P
N
D
P
H
V
Q
Y
S
A
V
S
S
F
V
Site 54
S502
N
D
P
H
V
Q
Y
S
A
V
S
S
F
V
F
Site 55
T522
V
A
V
V
S
P
H
T
F
H
L
R
P
H
H
Site 56
T534
P
H
H
P
D
A
Q
T
I
R
T
L
T
L
I
Site 57
T537
P
D
A
Q
T
I
R
T
L
T
L
I
S
K
T
Site 58
T544
T
L
T
L
I
S
K
T
I
Q
T
L
G
S
W
Site 59
S550
K
T
I
Q
T
L
G
S
W
G
S
L
S
K
S
Site 60
S553
Q
T
L
G
S
W
G
S
L
S
K
S
K
S
S
Site 61
S555
L
G
S
W
G
S
L
S
K
S
K
S
S
F
K
Site 62
S557
S
W
G
S
L
S
K
S
K
S
S
F
K
E
T
Site 63
S559
G
S
L
S
K
S
K
S
S
F
K
E
T
F
M
Site 64
S560
S
L
S
K
S
K
S
S
F
K
E
T
F
M
C
Site 65
T564
S
K
S
S
F
K
E
T
F
M
C
E
F
F
K
Site 66
S590
K
K
F
L
D
E
I
S
S
T
E
T
K
E
S
Site 67
S591
K
F
L
D
E
I
S
S
T
E
T
K
E
S
S
Site 68
T592
F
L
D
E
I
S
S
T
E
T
K
E
S
S
G
Site 69
T594
D
E
I
S
S
T
E
T
K
E
S
S
G
T
S
Site 70
S597
S
S
T
E
T
K
E
S
S
G
T
S
E
P
V
Site 71
S598
S
T
E
T
K
E
S
S
G
T
S
E
P
V
H
Site 72
T600
E
T
K
E
S
S
G
T
S
E
P
V
H
L
K
Site 73
S601
T
K
E
S
S
G
T
S
E
P
V
H
L
K
E
Site 74
Y612
H
L
K
E
G
E
M
Y
K
R
A
Q
G
R
T
Site 75
T619
Y
K
R
A
Q
G
R
T
R
I
G
K
K
N
F
Site 76
T639
C
L
T
S
R
E
L
T
Y
H
K
Q
P
G
K
Site 77
Y650
Q
P
G
K
D
A
I
Y
T
I
P
V
K
N
I
Site 78
S667
V
E
K
L
E
E
S
S
F
N
K
K
N
M
F
Site 79
Y684
I
H
T
E
K
P
L
Y
V
Q
A
N
N
C
V
Site 80
T758
D
I
D
E
D
R
E
T
E
R
I
Y
S
L
F
Site 81
Y762
D
R
E
T
E
R
I
Y
S
L
F
T
L
S
L
Site 82
T781
K
M
E
E
A
C
G
T
I
A
V
Y
Q
G
P
Site 83
Y785
A
C
G
T
I
A
V
Y
Q
G
P
Q
K
E
P
Site 84
Y795
P
Q
K
E
P
D
D
Y
S
N
F
V
I
E
D
Site 85
S796
Q
K
E
P
D
D
Y
S
N
F
V
I
E
D
S
Site 86
T809
D
S
V
T
T
F
K
T
I
Q
Q
I
K
S
I
Site 87
S815
K
T
I
Q
Q
I
K
S
I
I
E
K
L
D
E
Site 88
Y827
L
D
E
P
H
E
K
Y
R
K
K
R
S
S
S
Site 89
S832
E
K
Y
R
K
K
R
S
S
S
A
K
Y
G
S
Site 90
S833
K
Y
R
K
K
R
S
S
S
A
K
Y
G
S
K
Site 91
S834
Y
R
K
K
R
S
S
S
A
K
Y
G
S
K
E
Site 92
Y837
K
R
S
S
S
A
K
Y
G
S
K
E
N
P
I
Site 93
S839
S
S
S
A
K
Y
G
S
K
E
N
P
I
V
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation