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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PWP2
Full Name:
Periodic tryptophan protein 2 homolog
Alias:
EHOC-17
Type:
Uncharacterized protein
Mass (Da):
102452
Number AA:
919
UniProt ID:
Q15269
International Prot ID:
IPI00300078
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004175
GO:0004252
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
GO:0007154
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
R
F
S
N
L
L
G
T
V
Y
R
R
G
N
L
Site 2
Y15
S
N
L
L
G
T
V
Y
R
R
G
N
L
N
F
Site 3
T23
R
R
G
N
L
N
F
T
C
D
G
N
S
V
I
Site 4
S28
N
F
T
C
D
G
N
S
V
I
S
P
V
G
N
Site 5
S31
C
D
G
N
S
V
I
S
P
V
G
N
R
V
T
Site 6
T38
S
P
V
G
N
R
V
T
V
F
D
L
K
N
N
Site 7
S47
F
D
L
K
N
N
K
S
D
T
L
P
L
A
T
Site 8
T49
L
K
N
N
K
S
D
T
L
P
L
A
T
R
Y
Site 9
T54
S
D
T
L
P
L
A
T
R
Y
N
V
K
C
V
Site 10
S101
H
F
K
G
S
V
H
S
V
S
F
S
P
D
G
Site 11
S103
K
G
S
V
H
S
V
S
F
S
P
D
G
R
K
Site 12
S105
S
V
H
S
V
S
F
S
P
D
G
R
K
F
V
Site 13
T114
D
G
R
K
F
V
V
T
K
G
N
I
A
Q
M
Site 14
Y122
K
G
N
I
A
Q
M
Y
H
A
P
G
K
K
R
Site 15
T139
N
A
F
V
L
D
K
T
Y
F
G
P
Y
D
E
Site 16
Y140
A
F
V
L
D
K
T
Y
F
G
P
Y
D
E
T
Site 17
T168
V
G
S
K
D
M
S
T
W
V
F
G
A
E
R
Site 18
Y181
E
R
W
D
N
L
I
Y
Y
A
L
G
G
H
K
Site 19
Y182
R
W
D
N
L
I
Y
Y
A
L
G
G
H
K
D
Site 20
Y204
E
S
N
S
L
D
L
Y
S
L
S
Q
D
G
V
Site 21
S205
S
N
S
L
D
L
Y
S
L
S
Q
D
G
V
L
Site 22
T219
L
C
M
W
Q
C
D
T
P
P
E
G
L
R
L
Site 23
T255
D
Q
E
G
D
R
E
T
T
I
R
G
K
A
T
Site 24
T256
Q
E
G
D
R
E
T
T
I
R
G
K
A
T
P
Site 25
T262
T
T
I
R
G
K
A
T
P
A
E
E
E
K
T
Site 26
T269
T
P
A
E
E
E
K
T
G
K
V
K
Y
S
R
Site 27
Y274
E
K
T
G
K
V
K
Y
S
R
L
A
K
Y
F
Site 28
Y280
K
Y
S
R
L
A
K
Y
F
F
N
K
E
G
D
Site 29
T292
E
G
D
F
N
N
L
T
A
A
A
F
H
K
K
Site 30
S325
P
E
F
N
L
I
H
S
L
S
I
S
D
Q
S
Site 31
Y365
W
E
W
Q
S
E
S
Y
V
L
K
Q
Q
G
H
Site 32
S375
K
Q
Q
G
H
F
N
S
M
V
A
L
A
Y
S
Site 33
Y387
A
Y
S
P
D
G
Q
Y
I
V
T
G
G
D
D
Site 34
T438
V
T
S
S
M
D
G
T
V
R
A
F
D
L
H
Site 35
Y447
R
A
F
D
L
H
R
Y
R
N
F
R
T
F
T
Site 36
T452
H
R
Y
R
N
F
R
T
F
T
S
P
R
P
T
Site 37
T454
Y
R
N
F
R
T
F
T
S
P
R
P
T
Q
F
Site 38
S455
R
N
F
R
T
F
T
S
P
R
P
T
Q
F
S
Site 39
S462
S
P
R
P
T
Q
F
S
C
V
A
V
D
A
S
Site 40
S498
G
R
L
L
D
V
L
S
G
H
E
G
P
I
S
Site 41
S505
S
G
H
E
G
P
I
S
G
L
C
F
N
P
M
Site 42
S518
P
M
K
S
V
L
A
S
A
S
W
D
K
T
V
Site 43
S520
K
S
V
L
A
S
A
S
W
D
K
T
V
R
L
Site 44
T550
T
S
D
A
L
A
V
T
F
R
P
D
G
A
E
Site 45
T568
A
T
L
N
S
Q
I
T
F
W
D
P
E
N
A
Site 46
T589
E
G
R
H
D
L
K
T
G
R
K
E
L
D
K
Site 47
Y632
M
S
K
F
V
C
I
Y
H
V
R
E
Q
I
L
Site 48
S650
F
E
I
S
C
N
L
S
L
D
A
M
E
E
F
Site 49
T664
F
L
N
R
R
K
M
T
E
F
G
N
L
A
L
Site 50
S695
G
V
R
K
G
D
M
S
S
R
H
F
K
P
E
Site 51
S696
V
R
K
G
D
M
S
S
R
H
F
K
P
E
I
Site 52
T706
F
K
P
E
I
R
V
T
S
L
R
F
S
P
T
Site 53
S707
K
P
E
I
R
V
T
S
L
R
F
S
P
T
G
Site 54
S711
R
V
T
S
L
R
F
S
P
T
G
R
C
W
A
Site 55
T713
T
S
L
R
F
S
P
T
G
R
C
W
A
A
T
Site 56
S744
D
P
F
E
L
D
T
S
V
T
P
G
R
V
R
Site 57
T746
F
E
L
D
T
S
V
T
P
G
R
V
R
E
A
Site 58
T791
R
G
E
I
E
V
V
T
S
S
L
P
E
L
Y
Site 59
S792
G
E
I
E
V
V
T
S
S
L
P
E
L
Y
V
Site 60
S808
K
V
L
E
F
L
A
S
S
F
E
V
S
R
H
Site 61
Y819
V
S
R
H
L
E
F
Y
L
L
W
T
H
K
L
Site 62
S836
L
H
G
Q
K
L
K
S
R
A
G
T
L
L
P
Site 63
S851
V
I
Q
F
L
Q
K
S
I
Q
R
H
L
D
D
Site 64
T882
A
V
S
K
Q
R
G
T
K
R
S
L
D
P
L
Site 65
S885
K
Q
R
G
T
K
R
S
L
D
P
L
G
S
E
Site 66
S891
R
S
L
D
P
L
G
S
E
E
E
A
E
A
S
Site 67
S898
S
E
E
E
A
E
A
S
E
D
D
S
L
H
L
Site 68
S902
A
E
A
S
E
D
D
S
L
H
L
L
G
G
G
Site 69
S913
L
G
G
G
G
R
D
S
E
E
E
M
L
A
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation