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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPP2R4
Full Name:
Serine/threonine-protein phosphatase 2A activator
Alias:
PP2A subunit B'; PR53; PTPA
Type:
Protein phosphatase, regulatory subunit
Mass (Da):
40668
Number AA:
358
UniProt ID:
Q15257
International Prot ID:
IPI00293102
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0034704
GO:0000159
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0046982
GO:0042803
PhosphoSite+
KinaseNET
Biological Process:
GO:0032515
GO:0035308
GO:0032516
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
E
R
Q
P
P
P
D
S
S
E
E
A
P
P
A
Site 2
S13
R
Q
P
P
P
D
S
S
E
E
A
P
P
A
T
Site 3
T20
S
E
E
A
P
P
A
T
Q
N
F
I
I
P
K
Site 4
T32
I
P
K
K
E
I
H
T
V
P
D
M
G
K
W
Site 5
T65
G
V
K
G
K
K
L
T
F
E
Y
R
V
S
E
Site 6
Y68
G
K
K
L
T
F
E
Y
R
V
S
E
M
W
N
Site 7
S90
Q
A
A
K
Q
S
V
S
C
D
E
C
I
P
L
Site 8
T126
L
D
R
W
I
D
E
T
P
P
V
D
Q
P
S
Site 9
S133
T
P
P
V
D
Q
P
S
R
F
G
N
K
A
Y
Site 10
Y144
N
K
A
Y
R
T
W
Y
A
K
L
D
E
E
A
Site 11
S181
L
K
E
S
V
G
N
S
T
R
I
D
Y
G
T
Site 12
Y186
G
N
S
T
R
I
D
Y
G
T
G
H
E
A
A
Site 13
T188
S
T
R
I
D
Y
G
T
G
H
E
A
A
F
A
Site 14
Y223
V
F
K
V
F
N
R
Y
L
E
V
M
R
K
L
Site 15
T233
V
M
R
K
L
Q
K
T
Y
R
M
E
P
A
G
Site 16
S241
Y
R
M
E
P
A
G
S
Q
G
V
W
G
L
D
Site 17
Y267
S
Q
L
I
D
H
P
Y
L
E
P
R
H
F
V
Site 18
Y286
V
N
E
N
H
K
D
Y
M
F
L
E
C
I
L
Site 19
T300
L
F
I
T
E
M
K
T
G
P
F
A
E
H
S
Site 20
S314
S
N
Q
L
W
N
I
S
A
V
P
S
W
S
K
Site 21
Y330
N
Q
G
L
I
R
M
Y
K
A
E
C
L
E
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation