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Updated November 2019
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Protein Info
Short Name:
KIF14
Full Name:
Kinesin-like protein KIF14
Alias:
KIAA0042; kinesin family member 14; kinesin-like KIF14
Type:
Microtubule binding protein; Motor protein
Mass (Da):
186492
Number AA:
1648
UniProt ID:
Q15058
International Prot ID:
IPI00299554
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0005819
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003774
GO:0003777
PhosphoSite+
KinaseNET
Biological Process:
GO:0006810
GO:0007017
GO:0007018
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
S
T
H
N
R
N
N
S
G
D
I
L
D
I
P
Site 2
S20
G
D
I
L
D
I
P
S
S
Q
N
S
S
S
L
Site 3
S21
D
I
L
D
I
P
S
S
Q
N
S
S
S
L
N
Site 4
S24
D
I
P
S
S
Q
N
S
S
S
L
N
A
L
T
Site 5
S25
I
P
S
S
Q
N
S
S
S
L
N
A
L
T
H
Site 6
S26
P
S
S
Q
N
S
S
S
L
N
A
L
T
H
S
Site 7
T31
S
S
S
L
N
A
L
T
H
S
S
R
L
K
L
Site 8
S33
S
L
N
A
L
T
H
S
S
R
L
K
L
H
L
Site 9
S42
R
L
K
L
H
L
K
S
D
M
S
E
C
E
N
Site 10
S45
L
H
L
K
S
D
M
S
E
C
E
N
D
D
P
Site 11
T66
K
V
R
D
I
N
R
T
Y
V
I
S
A
S
R
Site 12
Y67
V
R
D
I
N
R
T
Y
V
I
S
A
S
R
K
Site 13
S70
I
N
R
T
Y
V
I
S
A
S
R
K
T
A
D
Site 14
T75
V
I
S
A
S
R
K
T
A
D
M
P
L
T
P
Site 15
T81
K
T
A
D
M
P
L
T
P
N
P
V
G
R
L
Site 16
T94
R
L
A
L
Q
R
R
T
T
R
N
K
E
S
S
Site 17
T95
L
A
L
Q
R
R
T
T
R
N
K
E
S
S
L
Site 18
S101
T
T
R
N
K
E
S
S
L
L
V
S
E
L
E
Site 19
S105
K
E
S
S
L
L
V
S
E
L
E
D
T
T
E
Site 20
T110
L
V
S
E
L
E
D
T
T
E
K
T
A
E
T
Site 21
T120
K
T
A
E
T
R
L
T
L
Q
R
R
A
K
T
Site 22
T127
T
L
Q
R
R
A
K
T
D
S
A
E
K
W
K
Site 23
S129
Q
R
R
A
K
T
D
S
A
E
K
W
K
T
A
Site 24
T135
D
S
A
E
K
W
K
T
A
E
I
D
S
V
K
Site 25
S140
W
K
T
A
E
I
D
S
V
K
M
T
L
N
V
Site 26
T144
E
I
D
S
V
K
M
T
L
N
V
G
G
E
T
Site 27
T151
T
L
N
V
G
G
E
T
E
N
N
G
V
S
K
Site 28
S177
A
K
N
S
F
V
A
S
S
V
P
L
D
E
D
Site 29
Y196
E
M
M
A
D
K
K
Y
K
E
T
F
S
A
P
Site 30
T199
A
D
K
K
Y
K
E
T
F
S
A
P
S
R
A
Site 31
Y214
N
E
N
V
A
L
K
Y
S
S
N
R
P
P
I
Site 32
S216
N
V
A
L
K
Y
S
S
N
R
P
P
I
A
S
Site 33
S223
S
N
R
P
P
I
A
S
L
S
Q
T
E
V
V
Site 34
S225
R
P
P
I
A
S
L
S
Q
T
E
V
V
R
S
Site 35
T227
P
I
A
S
L
S
Q
T
E
V
V
R
S
G
H
Site 36
S232
S
Q
T
E
V
V
R
S
G
H
L
T
T
K
P
Site 37
T236
V
V
R
S
G
H
L
T
T
K
P
T
Q
S
K
Site 38
T240
G
H
L
T
T
K
P
T
Q
S
K
L
D
I
K
Site 39
S242
L
T
T
K
P
T
Q
S
K
L
D
I
K
V
L
Site 40
Y255
V
L
G
T
G
N
L
Y
H
R
S
I
G
K
E
Site 41
T266
I
G
K
E
I
A
K
T
S
N
K
F
G
S
L
Site 42
S267
G
K
E
I
A
K
T
S
N
K
F
G
S
L
E
Site 43
S272
K
T
S
N
K
F
G
S
L
E
K
R
T
P
T
Site 44
T277
F
G
S
L
E
K
R
T
P
T
K
C
T
T
E
Site 45
T279
S
L
E
K
R
T
P
T
K
C
T
T
E
H
K
Site 46
T288
C
T
T
E
H
K
L
T
T
K
C
S
L
P
Q
Site 47
S292
H
K
L
T
T
K
C
S
L
P
Q
L
K
S
P
Site 48
S298
C
S
L
P
Q
L
K
S
P
A
P
S
I
L
K
Site 49
S302
Q
L
K
S
P
A
P
S
I
L
K
N
R
M
S
Site 50
S309
S
I
L
K
N
R
M
S
N
L
Q
V
K
Q
R
Site 51
S319
Q
V
K
Q
R
P
K
S
S
F
L
A
N
K
Q
Site 52
S320
V
K
Q
R
P
K
S
S
F
L
A
N
K
Q
E
Site 53
T333
Q
E
R
S
A
E
N
T
I
L
P
E
E
E
T
Site 54
T340
T
I
L
P
E
E
E
T
V
V
Q
N
T
S
A
Site 55
S357
D
P
L
K
V
E
N
S
Q
V
T
V
A
V
R
Site 56
T360
K
V
E
N
S
Q
V
T
V
A
V
R
V
R
P
Site 57
T369
A
V
R
V
R
P
F
T
K
R
E
K
I
E
K
Site 58
S378
R
E
K
I
E
K
A
S
Q
V
V
F
M
S
G
Site 59
T395
I
T
V
E
H
P
D
T
K
Q
V
Y
N
F
I
Site 60
Y403
K
Q
V
Y
N
F
I
Y
D
V
S
F
W
S
F
Site 61
Y417
F
D
E
C
H
P
H
Y
A
S
Q
T
T
V
Y
Site 62
Y446
F
N
T
C
L
F
A
Y
G
Q
T
G
S
G
K
Site 63
S454
G
Q
T
G
S
G
K
S
Y
T
M
M
G
F
S
Site 64
Y455
Q
T
G
S
G
K
S
Y
T
M
M
G
F
S
E
Site 65
T456
T
G
S
G
K
S
Y
T
M
M
G
F
S
E
E
Site 66
S461
S
Y
T
M
M
G
F
S
E
E
P
G
I
I
P
Site 67
S476
R
F
C
E
D
L
F
S
Q
V
A
R
K
Q
T
Site 68
T483
S
Q
V
A
R
K
Q
T
Q
E
V
S
Y
H
I
Site 69
Y498
E
M
S
F
F
E
V
Y
N
E
K
I
H
D
L
Site 70
Y527
R
V
R
E
H
P
V
Y
G
P
Y
V
E
A
L
Site 71
Y530
E
H
P
V
Y
G
P
Y
V
E
A
L
S
M
N
Site 72
S547
S
S
Y
A
D
I
Q
S
W
L
E
L
G
N
K
Site 73
T558
L
G
N
K
Q
R
A
T
A
A
T
G
M
N
D
Site 74
T561
K
Q
R
A
T
A
A
T
G
M
N
D
K
S
S
Site 75
S567
A
T
G
M
N
D
K
S
S
R
S
H
S
V
F
Site 76
S568
T
G
M
N
D
K
S
S
R
S
H
S
V
F
T
Site 77
S570
M
N
D
K
S
S
R
S
H
S
V
F
T
L
V
Site 78
S572
D
K
S
S
R
S
H
S
V
F
T
L
V
M
T
Site 79
T583
L
V
M
T
Q
T
K
T
E
F
V
E
G
E
E
Site 80
T596
E
E
H
D
H
R
I
T
S
R
I
N
L
I
D
Site 81
S597
E
H
D
H
R
I
T
S
R
I
N
L
I
D
L
Site 82
S607
N
L
I
D
L
A
G
S
E
R
C
S
T
A
H
Site 83
S611
L
A
G
S
E
R
C
S
T
A
H
T
N
G
D
Site 84
T612
A
G
S
E
R
C
S
T
A
H
T
N
G
D
R
Site 85
T615
E
R
C
S
T
A
H
T
N
G
D
R
L
K
E
Site 86
S625
D
R
L
K
E
G
V
S
I
N
K
S
L
L
T
Site 87
T632
S
I
N
K
S
L
L
T
L
G
K
V
I
S
A
Site 88
S641
G
K
V
I
S
A
L
S
E
Q
A
N
Q
R
S
Site 89
T659
P
Y
R
E
S
V
L
T
W
L
L
K
E
S
L
Site 90
S683
A
T
I
S
P
A
A
S
N
I
E
E
T
L
S
Site 91
S690
S
N
I
E
E
T
L
S
T
L
R
Y
A
N
Q
Site 92
T691
N
I
E
E
T
L
S
T
L
R
Y
A
N
Q
A
Site 93
Y694
E
T
L
S
T
L
R
Y
A
N
Q
A
R
L
I
Site 94
S733
L
K
A
A
Q
R
N
S
R
N
I
D
P
E
R
Site 95
S750
L
C
R
Q
E
I
T
S
L
R
M
K
L
H
Q
Site 96
T784
E
K
R
K
L
Q
E
T
K
E
L
Q
K
A
G
Site 97
T826
M
I
K
E
G
T
T
T
V
G
K
Y
K
P
N
Site 98
Y830
G
T
T
T
V
G
K
Y
K
P
N
S
S
H
D
Site 99
S834
V
G
K
Y
K
P
N
S
S
H
D
I
Q
L
S
Site 100
S835
G
K
Y
K
P
N
S
S
H
D
I
Q
L
S
G
Site 101
S841
S
S
H
D
I
Q
L
S
G
V
L
I
A
D
D
Site 102
T869
I
P
V
G
E
A
K
T
Y
V
N
G
K
H
I
Site 103
Y870
P
V
G
E
A
K
T
Y
V
N
G
K
H
I
L
Site 104
T880
G
K
H
I
L
E
I
T
V
L
R
H
G
D
R
Site 105
S911
V
Q
K
G
K
R
P
S
G
R
D
T
P
I
S
Site 106
T915
K
R
P
S
G
R
D
T
P
I
S
E
G
P
K
Site 107
S918
S
G
R
D
T
P
I
S
E
G
P
K
D
F
E
Site 108
S937
E
L
L
M
A
Q
R
S
Q
L
E
A
E
I
K
Site 109
S991
E
A
E
L
R
E
E
S
Q
R
K
K
M
Q
E
Site 110
Y1023
Q
H
L
E
Q
E
I
Y
V
N
K
K
R
L
E
Site 111
T1033
K
K
R
L
E
M
E
T
L
A
T
K
Q
A
L
Site 112
S1044
K
Q
A
L
E
D
H
S
I
R
H
A
R
I
L
Site 113
T1056
R
I
L
E
A
L
E
T
E
K
Q
K
I
A
K
Site 114
T1078
N
R
N
N
R
D
K
T
F
T
V
Q
T
T
W
Site 115
T1080
N
N
R
D
K
T
F
T
V
Q
T
T
W
S
S
Site 116
S1102
Q
E
A
N
A
I
S
S
K
L
K
T
Y
Y
V
Site 117
T1106
A
I
S
S
K
L
K
T
Y
Y
V
F
G
R
H
Site 118
Y1107
I
S
S
K
L
K
T
Y
Y
V
F
G
R
H
D
Site 119
Y1108
S
S
K
L
K
T
Y
Y
V
F
G
R
H
D
I
Site 120
S1116
V
F
G
R
H
D
I
S
D
K
S
S
S
D
T
Site 121
S1119
R
H
D
I
S
D
K
S
S
S
D
T
S
I
R
Site 122
S1120
H
D
I
S
D
K
S
S
S
D
T
S
I
R
V
Site 123
S1121
D
I
S
D
K
S
S
S
D
T
S
I
R
V
R
Site 124
T1123
S
D
K
S
S
S
D
T
S
I
R
V
R
N
L
Site 125
S1124
D
K
S
S
S
D
T
S
I
R
V
R
N
L
K
Site 126
S1135
R
N
L
K
L
G
I
S
T
F
W
S
L
E
K
Site 127
S1139
L
G
I
S
T
F
W
S
L
E
K
F
E
S
K
Site 128
S1145
W
S
L
E
K
F
E
S
K
L
A
A
M
K
E
Site 129
Y1154
L
A
A
M
K
E
L
Y
E
S
N
G
S
N
R
Site 130
S1156
A
M
K
E
L
Y
E
S
N
G
S
N
R
G
E
Site 131
S1159
E
L
Y
E
S
N
G
S
N
R
G
E
D
A
F
Site 132
T1178
D
E
W
E
P
D
I
T
D
A
P
V
S
S
L
Site 133
S1183
D
I
T
D
A
P
V
S
S
L
S
R
R
R
S
Site 134
S1184
I
T
D
A
P
V
S
S
L
S
R
R
R
S
R
Site 135
S1186
D
A
P
V
S
S
L
S
R
R
R
S
R
S
L
Site 136
S1190
S
S
L
S
R
R
R
S
R
S
L
M
K
N
R
Site 137
S1192
L
S
R
R
R
S
R
S
L
M
K
N
R
R
I
Site 138
S1200
L
M
K
N
R
R
I
S
G
C
L
H
D
I
Q
Site 139
S1216
H
P
I
K
N
L
H
S
S
H
S
S
G
L
M
Site 140
S1217
P
I
K
N
L
H
S
S
H
S
S
G
L
M
D
Site 141
S1219
K
N
L
H
S
S
H
S
S
G
L
M
D
K
S
Site 142
S1220
N
L
H
S
S
H
S
S
G
L
M
D
K
S
S
Site 143
S1226
S
S
G
L
M
D
K
S
S
T
I
Y
S
N
S
Site 144
S1227
S
G
L
M
D
K
S
S
T
I
Y
S
N
S
A
Site 145
Y1230
M
D
K
S
S
T
I
Y
S
N
S
A
E
S
F
Site 146
S1231
D
K
S
S
T
I
Y
S
N
S
A
E
S
F
L
Site 147
S1233
S
S
T
I
Y
S
N
S
A
E
S
F
L
P
G
Site 148
S1249
C
K
E
L
I
G
S
S
L
D
F
F
G
Q
S
Site 149
S1256
S
L
D
F
F
G
Q
S
Y
D
E
E
R
T
I
Site 150
Y1257
L
D
F
F
G
Q
S
Y
D
E
E
R
T
I
A
Site 151
T1262
Q
S
Y
D
E
E
R
T
I
A
D
S
L
I
N
Site 152
S1266
E
E
R
T
I
A
D
S
L
I
N
S
F
L
K
Site 153
Y1275
I
N
S
F
L
K
I
Y
N
G
L
F
A
I
S
Site 154
S1282
Y
N
G
L
F
A
I
S
K
A
H
E
E
Q
D
Site 155
S1292
H
E
E
Q
D
E
E
S
Q
D
N
L
F
S
S
Site 156
S1298
E
S
Q
D
N
L
F
S
S
D
R
A
I
Q
S
Site 157
S1299
S
Q
D
N
L
F
S
S
D
R
A
I
Q
S
L
Site 158
S1305
S
S
D
R
A
I
Q
S
L
T
I
Q
T
A
C
Site 159
S1326
V
L
M
K
H
W
L
S
D
L
L
P
C
T
N
Site 160
S1408
N
G
N
N
K
A
A
S
V
Q
E
E
F
M
D
Site 161
S1431
G
M
K
I
L
L
D
S
G
L
E
K
A
K
E
Site 162
T1448
H
E
L
F
R
Q
C
T
K
N
E
V
T
K
E
Site 163
T1458
E
V
T
K
E
M
K
T
N
A
M
G
L
I
R
Site 164
S1474
L
E
N
I
F
A
E
S
K
I
K
S
F
R
R
Site 165
S1478
F
A
E
S
K
I
K
S
F
R
R
Q
V
Q
E
Site 166
Y1490
V
Q
E
E
N
F
E
Y
Q
D
F
K
R
M
V
Site 167
S1526
S
A
L
K
G
C
H
S
D
I
N
L
L
Q
T
Site 168
T1533
S
D
I
N
L
L
Q
T
C
V
E
S
I
R
N
Site 169
S1543
E
S
I
R
N
L
A
S
D
F
Y
S
D
F
S
Site 170
Y1546
R
N
L
A
S
D
F
Y
S
D
F
S
V
P
S
Site 171
S1547
N
L
A
S
D
F
Y
S
D
F
S
V
P
S
T
Site 172
S1550
S
D
F
Y
S
D
F
S
V
P
S
T
S
V
G
Site 173
S1553
Y
S
D
F
S
V
P
S
T
S
V
G
S
Y
E
Site 174
T1554
S
D
F
S
V
P
S
T
S
V
G
S
Y
E
S
Site 175
S1555
D
F
S
V
P
S
T
S
V
G
S
Y
E
S
R
Site 176
Y1559
P
S
T
S
V
G
S
Y
E
S
R
V
T
H
I
Site 177
T1564
G
S
Y
E
S
R
V
T
H
I
V
H
Q
E
L
Site 178
S1587
F
C
F
E
S
E
E
S
P
D
L
L
K
P
W
Site 179
S1608
T
K
E
E
H
Q
Q
S
K
S
S
G
I
D
G
Site 180
S1610
E
E
H
Q
Q
S
K
S
S
G
I
D
G
S
K
Site 181
S1616
K
S
S
G
I
D
G
S
K
N
K
G
V
P
K
Site 182
Y1626
K
G
V
P
K
R
V
Y
E
L
H
G
S
S
P
Site 183
S1631
R
V
Y
E
L
H
G
S
S
P
A
V
S
S
E
Site 184
S1632
V
Y
E
L
H
G
S
S
P
A
V
S
S
E
E
Site 185
S1636
H
G
S
S
P
A
V
S
S
E
E
C
T
P
S
Site 186
S1637
G
S
S
P
A
V
S
S
E
E
C
T
P
S
R
Site 187
T1641
A
V
S
S
E
E
C
T
P
S
R
I
Q
W
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation