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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HERC3
Full Name:
Probable E3 ubiquitin-protein ligase HERC3
Alias:
HECT domain and RCC1-like domain-containing protein 3
Type:
Mass (Da):
117188
Number AA:
1050
UniProt ID:
Q15034
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
P
Q
V
C
G
F
I
S
D
R
S
V
K
E
V
Site 2
Y56
L
L
E
D
G
E
V
Y
T
C
G
L
N
T
K
Site 3
S96
V
A
C
G
E
S
H
S
L
A
L
S
D
R
G
Site 4
S100
E
S
H
S
L
A
L
S
D
R
G
Q
L
F
S
Site 5
S107
S
D
R
G
Q
L
F
S
W
G
A
G
S
D
G
Site 6
S177
G
L
G
K
E
F
P
S
Q
A
S
P
Q
R
V
Site 7
S180
K
E
F
P
S
Q
A
S
P
Q
R
V
R
S
L
Site 8
S186
A
S
P
Q
R
V
R
S
L
E
G
I
P
L
A
Site 9
S225
N
A
G
Q
L
G
L
S
D
E
K
D
R
E
S
Site 10
S232
S
D
E
K
D
R
E
S
P
C
H
V
K
L
L
Site 11
Y246
L
R
T
Q
K
V
V
Y
I
S
C
G
E
E
H
Site 12
T329
G
A
R
G
Q
L
G
T
G
H
T
C
N
V
K
Site 13
T332
G
Q
L
G
T
G
H
T
C
N
V
K
C
P
S
Site 14
S349
K
G
Y
W
A
A
H
S
G
Q
L
S
A
R
A
Site 15
S353
A
A
H
S
G
Q
L
S
A
R
A
D
R
F
K
Site 16
Y361
A
R
A
D
R
F
K
Y
H
I
V
K
Q
I
F
Site 17
T374
I
F
S
G
G
D
Q
T
F
V
L
C
S
K
Y
Site 18
Y381
T
F
V
L
C
S
K
Y
E
N
Y
S
P
A
V
Site 19
S385
C
S
K
Y
E
N
Y
S
P
A
V
D
F
R
T
Site 20
T392
S
P
A
V
D
F
R
T
M
N
Q
A
H
Y
T
Site 21
T406
T
S
L
I
N
D
E
T
I
A
V
W
R
Q
K
Site 22
S439
S
A
A
C
W
N
G
S
F
L
E
K
K
I
D
Site 23
T451
K
I
D
E
H
F
K
T
S
P
K
I
P
G
I
Site 24
S452
I
D
E
H
F
K
T
S
P
K
I
P
G
I
D
Site 25
S462
I
P
G
I
D
L
N
S
T
R
V
L
F
E
K
Site 26
S473
L
F
E
K
L
M
N
S
Q
H
S
M
I
L
E
Site 27
S495
S
C
L
I
P
Q
L
S
S
S
P
P
D
V
E
Site 28
S497
L
I
P
Q
L
S
S
S
P
P
D
V
E
A
M
Site 29
Y569
L
Y
K
G
A
V
L
Y
L
L
R
G
R
K
T
Site 30
Y598
L
K
L
L
E
K
L
Y
K
V
N
L
K
V
K
Site 31
T611
V
K
H
V
E
Y
D
T
F
Y
I
P
E
I
S
Site 32
Y613
H
V
E
Y
D
T
F
Y
I
P
E
I
S
N
L
Site 33
S642
A
G
M
K
A
R
P
S
I
I
Q
D
T
V
T
Site 34
T647
R
P
S
I
I
Q
D
T
V
T
L
C
S
Y
P
Site 35
Y653
D
T
V
T
L
C
S
Y
P
F
I
F
D
A
Q
Site 36
S720
G
D
A
L
R
E
L
S
I
H
S
D
I
D
L
Site 37
Y763
K
E
L
L
N
P
I
Y
G
M
F
T
Y
Y
Q
Site 38
Y768
P
I
Y
G
M
F
T
Y
Y
Q
D
S
N
L
L
Site 39
Y769
I
Y
G
M
F
T
Y
Y
Q
D
S
N
L
L
W
Site 40
S831
L
E
D
L
K
E
L
S
P
T
E
G
R
S
L
Site 41
T833
D
L
K
E
L
S
P
T
E
G
R
S
L
Q
E
Site 42
S837
L
S
P
T
E
G
R
S
L
Q
E
L
L
D
Y
Site 43
Y844
S
L
Q
E
L
L
D
Y
P
G
E
D
V
E
E
Site 44
T852
P
G
E
D
V
E
E
T
F
C
L
N
F
T
I
Site 45
S863
N
F
T
I
C
R
E
S
Y
G
V
I
E
Q
K
Site 46
Y864
F
T
I
C
R
E
S
Y
G
V
I
E
Q
K
K
Site 47
T880
I
P
G
G
D
N
V
T
V
C
K
D
N
R
Q
Site 48
Y893
R
Q
E
F
V
D
A
Y
V
N
Y
V
F
Q
I
Site 49
Y896
F
V
D
A
Y
V
N
Y
V
F
Q
I
S
V
H
Site 50
Y906
Q
I
S
V
H
E
W
Y
T
A
F
S
S
G
F
Site 51
T948
N
W
E
E
L
E
E
T
A
I
Y
K
G
D
Y
Site 52
Y951
E
L
E
E
T
A
I
Y
K
G
D
Y
S
A
T
Site 53
Y955
T
A
I
Y
K
G
D
Y
S
A
T
H
P
T
V
Site 54
S956
A
I
Y
K
G
D
Y
S
A
T
H
P
T
V
K
Site 55
Y1011
S
T
A
S
G
E
E
Y
L
P
V
A
H
T
C
Site 56
Y1027
N
L
L
D
L
P
K
Y
S
S
K
E
I
L
S
Site 57
S1028
L
L
D
L
P
K
Y
S
S
K
E
I
L
S
A
Site 58
S1029
L
D
L
P
K
Y
S
S
K
E
I
L
S
A
R
Site 59
S1034
Y
S
S
K
E
I
L
S
A
R
L
T
Q
A
L
Site 60
T1038
E
I
L
S
A
R
L
T
Q
A
L
D
N
Y
E
Site 61
Y1044
L
T
Q
A
L
D
N
Y
E
G
F
S
L
A
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation