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Updated November 2019
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Protein Info
Short Name:
R3HDM1
Full Name:
R3H domain-containing protein 1
Alias:
KIAA0029; R3H domain (binds single-stranded nucleic acids) containing; R3H domain containing 1; R3H domain protein 1; R3HD1; R3HDM
Type:
RNA binding protein
Mass (Da):
120696
Number AA:
1099
UniProt ID:
Q15032
International Prot ID:
IPI00014214
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
R
M
S
D
T
V
T
V
K
D
E
T
A
T
Site 2
T26
L
E
A
E
V
K
D
T
T
R
V
E
N
L
I
Site 3
T27
E
A
E
V
K
D
T
T
R
V
E
N
L
I
K
Site 4
S35
R
V
E
N
L
I
K
S
E
N
Y
G
K
I
L
Site 5
S62
D
L
Q
R
P
L
Q
S
F
G
Q
T
G
K
R
Site 6
T66
P
L
Q
S
F
G
Q
T
G
K
R
S
K
S
S
Site 7
S70
F
G
Q
T
G
K
R
S
K
S
S
S
K
L
K
Site 8
S72
Q
T
G
K
R
S
K
S
S
S
K
L
K
L
V
Site 9
S74
G
K
R
S
K
S
S
S
K
L
K
L
V
R
S
Site 10
S81
S
K
L
K
L
V
R
S
L
A
V
C
E
E
S
Site 11
S88
S
L
A
V
C
E
E
S
P
P
P
P
A
P
E
Site 12
S97
P
P
P
A
P
E
I
S
Q
E
N
Q
E
K
I
Site 13
T109
E
K
I
Q
I
Q
L
T
Q
S
F
E
K
E
E
Site 14
S111
I
Q
I
Q
L
T
Q
S
F
E
K
E
E
K
P
Site 15
S138
K
L
P
R
K
M
L
S
R
D
S
S
Q
E
Y
Site 16
S141
R
K
M
L
S
R
D
S
S
Q
E
Y
T
D
S
Site 17
S142
K
M
L
S
R
D
S
S
Q
E
Y
T
D
S
T
Site 18
Y145
S
R
D
S
S
Q
E
Y
T
D
S
T
G
I
D
Site 19
T146
R
D
S
S
Q
E
Y
T
D
S
T
G
I
D
L
Site 20
S148
S
S
Q
E
Y
T
D
S
T
G
I
D
L
H
E
Site 21
T149
S
Q
E
Y
T
D
S
T
G
I
D
L
H
E
F
Site 22
T160
L
H
E
F
L
V
N
T
L
K
N
N
P
R
D
Site 23
S187
D
F
I
G
N
N
E
S
P
R
K
K
F
P
P
Site 24
T196
R
K
K
F
P
P
M
T
S
Y
H
R
M
L
L
Site 25
Y198
K
F
P
P
M
T
S
Y
H
R
M
L
L
H
R
Site 26
Y209
L
L
H
R
V
A
A
Y
F
G
L
D
H
N
V
Site 27
S222
N
V
D
Q
S
G
K
S
V
I
V
N
K
T
S
Site 28
S229
S
V
I
V
N
K
T
S
N
T
R
I
P
D
Q
Site 29
Y254
G
E
D
F
Q
K
R
Y
I
L
K
R
D
N
S
Site 30
S261
Y
I
L
K
R
D
N
S
S
F
D
K
D
D
N
Site 31
S262
I
L
K
R
D
N
S
S
F
D
K
D
D
N
Q
Site 32
S280
R
L
K
D
D
R
R
S
K
S
I
E
E
R
E
Site 33
S282
K
D
D
R
R
S
K
S
I
E
E
R
E
E
E
Site 34
Y290
I
E
E
R
E
E
E
Y
Q
R
A
R
D
R
I
Site 35
S299
R
A
R
D
R
I
F
S
Q
D
S
L
C
S
Q
Site 36
S302
D
R
I
F
S
Q
D
S
L
C
S
Q
E
N
Y
Site 37
S305
F
S
Q
D
S
L
C
S
Q
E
N
Y
I
I
D
Site 38
Y309
S
L
C
S
Q
E
N
Y
I
I
D
K
R
L
Q
Site 39
S322
L
Q
D
E
D
A
S
S
T
Q
Q
R
R
Q
I
Site 40
S337
P
A
V
T
K
A
S
S
F
S
G
I
S
V
L
Site 41
S340
N
K
D
A
S
G
R
S
T
N
S
H
Q
S
S
Site 42
T341
K
D
A
S
G
R
S
T
N
S
H
Q
S
S
T
Site 43
S343
A
S
G
R
S
T
N
S
H
Q
S
S
T
E
N
Site 44
S347
S
T
N
S
H
Q
S
S
T
E
N
E
L
K
Y
Site 45
Y354
S
T
E
N
E
L
K
Y
S
E
P
R
P
W
S
Site 46
S355
T
E
N
E
L
K
Y
S
E
P
R
P
W
S
S
Site 47
S361
Y
S
E
P
R
P
W
S
S
T
D
S
D
S
S
Site 48
S362
S
E
P
R
P
W
S
S
T
D
S
D
S
S
L
Site 49
T363
E
P
R
P
W
S
S
T
D
S
D
S
S
L
R
Site 50
S365
R
P
W
S
S
T
D
S
D
S
S
L
R
N
L
Site 51
S367
W
S
S
T
D
S
D
S
S
L
R
N
L
K
P
Site 52
S368
S
S
T
D
S
D
S
S
L
R
N
L
K
P
A
Site 53
T377
R
N
L
K
P
A
V
T
K
A
S
S
F
S
G
Site 54
S380
K
P
A
V
T
K
A
S
S
F
S
G
I
S
V
Site 55
S381
P
A
V
T
K
A
S
S
F
S
G
I
S
V
L
Site 56
S383
V
T
K
A
S
S
F
S
G
I
S
V
L
T
R
Site 57
S386
A
S
S
F
S
G
I
S
V
L
T
R
G
D
S
Site 58
T389
F
S
G
I
S
V
L
T
R
G
D
S
S
G
S
Site 59
S393
S
V
L
T
R
G
D
S
S
G
S
S
K
S
I
Site 60
S394
V
L
T
R
G
D
S
S
G
S
S
K
S
I
G
Site 61
S396
T
R
G
D
S
S
G
S
S
K
S
I
G
R
L
Site 62
S397
R
G
D
S
S
G
S
S
K
S
I
G
R
L
S
Site 63
S399
D
S
S
G
S
S
K
S
I
G
R
L
S
K
T
Site 64
S404
S
K
S
I
G
R
L
S
K
T
G
S
E
S
S
Site 65
T406
S
I
G
R
L
S
K
T
G
S
E
S
S
G
S
Site 66
S408
G
R
L
S
K
T
G
S
E
S
S
G
S
V
G
Site 67
S410
L
S
K
T
G
S
E
S
S
G
S
V
G
S
S
Site 68
S411
S
K
T
G
S
E
S
S
G
S
V
G
S
S
T
Site 69
S413
T
G
S
E
S
S
G
S
V
G
S
S
T
G
S
Site 70
S416
E
S
S
G
S
V
G
S
S
T
G
S
L
S
H
Site 71
S417
S
S
G
S
V
G
S
S
T
G
S
L
S
H
I
Site 72
T418
S
G
S
V
G
S
S
T
G
S
L
S
H
I
Q
Site 73
S420
S
V
G
S
S
T
G
S
L
S
H
I
Q
Q
P
Site 74
S422
G
S
S
T
G
S
L
S
H
I
Q
Q
P
L
P
Site 75
T431
I
Q
Q
P
L
P
G
T
A
L
S
Q
S
S
H
Site 76
S434
P
L
P
G
T
A
L
S
Q
S
S
H
G
A
P
Site 77
S436
P
G
T
A
L
S
Q
S
S
H
G
A
P
V
V
Site 78
Y444
S
H
G
A
P
V
V
Y
P
T
V
S
T
H
S
Site 79
S452
P
T
V
S
T
H
S
S
L
S
F
D
G
G
L
Site 80
S454
V
S
T
H
S
S
L
S
F
D
G
G
L
N
G
Site 81
T491
S
I
L
I
N
P
Q
T
G
Q
P
F
I
N
P
Site 82
S501
P
F
I
N
P
D
G
S
P
V
V
Y
N
P
P
Site 83
Y505
P
D
G
S
P
V
V
Y
N
P
P
M
T
Q
Q
Site 84
T510
V
V
Y
N
P
P
M
T
Q
Q
P
V
R
S
Q
Site 85
S516
M
T
Q
Q
P
V
R
S
Q
V
P
G
P
P
Q
Site 86
S540
P
A
A
N
H
I
F
S
Q
D
N
L
G
S
Q
Site 87
S546
F
S
Q
D
N
L
G
S
Q
F
S
H
M
S
L
Site 88
S549
D
N
L
G
S
Q
F
S
H
M
S
L
A
R
Q
Site 89
S552
G
S
Q
F
S
H
M
S
L
A
R
Q
P
S
A
Site 90
S558
M
S
L
A
R
Q
P
S
A
D
G
S
D
P
H
Site 91
S562
R
Q
P
S
A
D
G
S
D
P
H
A
A
M
F
Site 92
S577
Q
S
T
V
V
L
Q
S
P
Q
Q
S
G
Y
I
Site 93
S581
V
L
Q
S
P
Q
Q
S
G
Y
I
M
T
A
A
Site 94
T586
Q
Q
S
G
Y
I
M
T
A
A
P
P
P
H
P
Site 95
Y617
Q
P
V
P
T
A
G
Y
P
A
S
G
H
P
V
Site 96
S620
P
T
A
G
Y
P
A
S
G
H
P
V
S
Q
P
Site 97
S625
P
A
S
G
H
P
V
S
Q
P
V
L
Q
Q
Q
Site 98
Y634
P
V
L
Q
Q
Q
G
Y
I
Q
Q
P
S
P
Q
Site 99
S654
C
A
P
G
H
Y
H
S
S
Q
P
Q
Y
R
P
Site 100
S655
A
P
G
H
Y
H
S
S
Q
P
Q
Y
R
P
V
Site 101
Y659
Y
H
S
S
Q
P
Q
Y
R
P
V
P
S
V
H
Site 102
S664
P
Q
Y
R
P
V
P
S
V
H
Y
N
S
H
L
Site 103
S669
V
P
S
V
H
Y
N
S
H
L
N
Q
P
L
P
Site 104
Y694
I
P
N
Q
Q
Q
N
Y
Q
G
I
V
G
V
Q
Site 105
S705
V
G
V
Q
Q
P
Q
S
Q
S
L
V
S
G
Q
Site 106
S707
V
Q
Q
P
Q
S
Q
S
L
V
S
G
Q
P
N
Site 107
S710
P
Q
S
Q
S
L
V
S
G
Q
P
N
S
I
G
Site 108
S715
L
V
S
G
Q
P
N
S
I
G
N
Q
I
Q
G
Site 109
Y733
P
Y
T
S
V
P
T
Y
Q
V
S
L
P
Q
G
Site 110
S736
S
V
P
T
Y
Q
V
S
L
P
Q
G
S
Q
G
Site 111
Y749
Q
G
I
P
H
Q
T
Y
Q
Q
P
V
M
F
P
Site 112
S759
P
V
M
F
P
N
Q
S
N
Q
G
S
M
P
T
Site 113
S763
P
N
Q
S
N
Q
G
S
M
P
T
T
G
M
P
Site 114
T767
N
Q
G
S
M
P
T
T
G
M
P
V
Y
Y
S
Site 115
Y773
T
T
G
M
P
V
Y
Y
S
V
I
P
P
G
Q
Site 116
S774
T
G
M
P
V
Y
Y
S
V
I
P
P
G
Q
Q
Site 117
S785
P
G
Q
Q
N
N
L
S
S
S
V
G
Y
L
Q
Site 118
S787
Q
Q
N
N
L
S
S
S
V
G
Y
L
Q
H
P
Site 119
Y790
N
L
S
S
S
V
G
Y
L
Q
H
P
G
S
E
Site 120
S796
G
Y
L
Q
H
P
G
S
E
Q
V
Q
F
P
R
Site 121
T804
E
Q
V
Q
F
P
R
T
T
S
P
C
S
S
Q
Site 122
T805
Q
V
Q
F
P
R
T
T
S
P
C
S
S
Q
Q
Site 123
S806
V
Q
F
P
R
T
T
S
P
C
S
S
Q
Q
L
Site 124
S809
P
R
T
T
S
P
C
S
S
Q
Q
L
Q
G
H
Site 125
S810
R
T
T
S
P
C
S
S
Q
Q
L
Q
G
H
Q
Site 126
S836
G
M
V
M
M
Q
L
S
V
P
N
N
P
Q
S
Site 127
S843
S
V
P
N
N
P
Q
S
C
A
H
S
P
P
Q
Site 128
S847
N
P
Q
S
C
A
H
S
P
P
Q
W
K
Q
N
Site 129
S879
V
D
N
I
V
Q
H
S
P
Q
L
S
S
P
I
Site 130
S883
V
Q
H
S
P
Q
L
S
S
P
I
I
S
P
A
Site 131
S884
Q
H
S
P
Q
L
S
S
P
I
I
S
P
A
Q
Site 132
S888
Q
L
S
S
P
I
I
S
P
A
Q
S
P
A
P
Site 133
S892
P
I
I
S
P
A
Q
S
P
A
P
A
Q
L
S
Site 134
S899
S
P
A
P
A
Q
L
S
T
L
K
T
V
R
P
Site 135
T903
A
Q
L
S
T
L
K
T
V
R
P
S
G
P
P
Site 136
S907
T
L
K
T
V
R
P
S
G
P
P
L
S
I
M
Site 137
S912
R
P
S
G
P
P
L
S
I
M
P
Q
F
S
R
Site 138
S918
L
S
I
M
P
Q
F
S
R
P
F
V
P
G
Q
Site 139
S928
F
V
P
G
Q
G
D
S
R
Y
P
L
L
G
Q
Site 140
Y930
P
G
Q
G
D
S
R
Y
P
L
L
G
Q
P
L
Site 141
S958
N
Q
Q
G
Q
P
G
S
R
H
G
N
R
G
R
Site 142
S973
R
Q
A
K
K
A
A
S
T
D
L
G
A
G
E
Site 143
S1023
R
W
L
R
D
P
Q
S
Q
P
R
R
H
P
L
Site 144
T1038
C
C
G
S
G
D
N
T
A
N
P
E
R
S
K
Site 145
S1044
N
T
A
N
P
E
R
S
K
P
S
D
L
A
S
Site 146
S1047
N
P
E
R
S
K
P
S
D
L
A
S
T
Y
T
Site 147
S1051
S
K
P
S
D
L
A
S
T
Y
T
V
L
A
T
Site 148
Y1053
P
S
D
L
A
S
T
Y
T
V
L
A
T
F
P
Site 149
S1075
A
L
K
K
Q
I
N
S
V
N
K
F
K
L
R
Site 150
Y1088
L
R
T
S
K
K
H
Y
D
F
H
I
L
E
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation