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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NWD1
Full Name:
NACHT and WD repeat domain-containing protein 1
Alias:
Type:
Mass (Da):
174581
Number AA:
1564
UniProt ID:
Q149M9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
K
P
C
R
A
L
P
T
L
K
F
Q
T
F
C
Site 2
T17
L
P
T
L
K
F
Q
T
F
C
Q
R
H
G
L
Site 3
T41
G
I
R
N
I
E
A
T
D
H
L
T
T
E
L
Site 4
T45
I
E
A
T
D
H
L
T
T
E
L
C
L
E
E
Site 5
T95
E
V
L
R
D
H
L
T
A
R
P
S
D
L
E
Site 6
S99
D
H
L
T
A
R
P
S
D
L
E
L
V
A
R
Site 7
Y107
D
L
E
L
V
A
R
Y
F
Q
R
D
E
N
A
Site 8
Y119
E
N
A
F
P
P
T
Y
V
L
Q
A
P
G
T
Site 9
T138
E
P
E
E
A
T
L
T
S
V
L
R
S
G
A
Site 10
S139
P
E
E
A
T
L
T
S
V
L
R
S
G
A
Q
Site 11
S143
T
L
T
S
V
L
R
S
G
A
Q
E
A
R
R
Site 12
T155
A
R
R
L
G
L
I
T
Q
E
Q
W
Q
H
Y
Site 13
S178
I
E
R
G
L
L
S
S
E
D
R
E
Q
G
A
Site 14
T186
E
D
R
E
Q
G
A
T
V
F
L
R
E
I
Q
Site 15
S225
T
D
A
Q
N
L
L
S
S
L
K
S
H
I
T
Site 16
S226
D
A
Q
N
L
L
S
S
L
K
S
H
I
T
D
Site 17
S229
N
L
L
S
S
L
K
S
H
I
T
D
M
H
P
Site 18
T241
M
H
P
G
V
L
K
T
H
R
L
P
W
S
R
Site 19
S247
K
T
H
R
L
P
W
S
R
D
L
V
N
P
K
Site 20
Y261
K
N
K
T
H
A
C
Y
L
K
E
L
G
E
Q
Site 21
T286
T
R
L
R
E
L
D
T
A
G
Q
E
L
A
W
Site 22
Y295
G
Q
E
L
A
W
L
Y
Q
E
I
R
H
H
L
Site 23
T311
Q
S
S
E
V
I
Q
T
F
C
G
R
Q
E
L
Site 24
S331
Q
Q
L
R
H
D
D
S
K
Q
H
T
P
L
V
Site 25
T335
H
D
D
S
K
Q
H
T
P
L
V
L
F
G
P
Site 26
T348
G
P
P
G
I
G
K
T
A
L
M
C
K
L
A
Site 27
S376
V
L
R
L
L
G
T
S
Q
M
S
S
D
A
R
Site 28
S380
L
G
T
S
Q
M
S
S
D
A
R
G
L
L
K
Site 29
S425
H
T
L
L
H
T
V
S
C
R
N
F
E
S
L
Site 30
S444
D
A
M
D
D
L
D
S
V
R
H
A
R
R
V
Site 31
Y489
V
L
L
D
P
E
A
Y
W
E
V
K
P
L
S
Site 32
S526
H
T
D
L
L
W
A
S
L
P
E
C
G
N
P
Site 33
S548
E
E
A
R
K
W
A
S
F
T
V
P
V
P
L
Site 34
S588
H
V
L
G
Y
I
V
S
S
R
H
G
L
S
E
Site 35
S594
V
S
S
R
H
G
L
S
E
A
E
L
K
D
V
Site 36
S603
A
E
L
K
D
V
L
S
L
D
D
E
V
L
Q
Site 37
Y613
D
E
V
L
Q
D
V
Y
R
D
W
T
P
P
S
Site 38
T617
Q
D
V
Y
R
D
W
T
P
P
S
K
E
L
L
Site 39
S620
Y
R
D
W
T
P
P
S
K
E
L
L
R
F
P
Site 40
Y640
R
L
R
R
D
L
G
Y
Y
L
A
R
R
P
V
Site 41
Y641
L
R
R
D
L
G
Y
Y
L
A
R
R
P
V
D
Site 42
T651
R
R
P
V
D
G
F
T
L
L
A
I
A
H
R
Site 43
Y668
V
E
V
V
R
E
R
Y
L
S
G
S
E
R
A
Site 44
S670
V
V
R
E
R
Y
L
S
G
S
E
R
A
K
R
Site 45
S672
R
E
R
Y
L
S
G
S
E
R
A
K
R
H
G
Site 46
T688
L
A
D
F
F
S
G
T
W
S
Q
G
T
K
K
Site 47
S690
D
F
F
S
G
T
W
S
Q
G
T
K
K
L
I
Site 48
T698
Q
G
T
K
K
L
I
T
L
P
L
V
G
K
P
Site 49
T722
Q
P
L
W
F
S
H
T
V
A
N
L
R
K
L
Site 50
Y734
R
K
L
K
E
L
P
Y
H
L
L
H
S
G
R
Site 51
S739
L
P
Y
H
L
L
H
S
G
R
L
E
E
L
K
Site 52
S752
L
K
Q
E
V
L
G
S
M
S
W
I
S
C
R
Site 53
S806
E
L
R
G
M
E
R
S
L
L
Y
T
E
L
L
Site 54
T810
M
E
R
S
L
L
Y
T
E
L
L
A
R
L
H
Site 55
T863
P
G
G
P
L
R
A
T
L
S
G
C
H
K
G
Site 56
S865
G
P
L
R
A
T
L
S
G
C
H
K
G
I
T
Site 57
S927
A
K
G
T
L
A
I
S
A
S
K
D
Y
T
L
Site 58
Y932
A
I
S
A
S
K
D
Y
T
L
H
L
W
N
L
Site 59
T947
L
S
G
Q
E
K
F
T
I
W
D
G
G
S
K
Site 60
S953
F
T
I
W
D
G
G
S
K
N
P
A
E
P
Q
Site 61
Y974
D
E
A
H
K
V
V
Y
S
A
S
G
S
K
I
Site 62
S975
E
A
H
K
V
V
Y
S
A
S
G
S
K
I
N
Site 63
S977
H
K
V
V
Y
S
A
S
G
S
K
I
N
A
W
Site 64
S1042
Q
G
K
Q
H
M
S
S
I
K
E
E
T
P
T
Site 65
T1047
M
S
S
I
K
E
E
T
P
T
C
A
V
S
V
Site 66
T1049
S
I
K
E
E
T
P
T
C
A
V
S
V
Q
K
Site 67
S1053
E
T
P
T
C
A
V
S
V
Q
K
Q
G
K
L
Site 68
S1070
G
F
S
N
G
S
I
S
L
V
S
S
K
G
D
Site 69
S1074
G
S
I
S
L
V
S
S
K
G
D
R
L
L
E
Site 70
T1162
W
S
L
S
E
Q
G
T
L
L
D
I
L
E
G
Site 71
S1186
R
G
G
A
L
V
A
S
A
S
P
Q
S
S
S
Site 72
S1188
G
A
L
V
A
S
A
S
P
Q
S
S
S
F
K
Site 73
S1191
V
A
S
A
S
P
Q
S
S
S
F
K
V
W
D
Site 74
S1192
A
S
A
S
P
Q
S
S
S
F
K
V
W
D
L
Site 75
S1193
S
A
S
P
Q
S
S
S
F
K
V
W
D
L
S
Site 76
S1200
S
F
K
V
W
D
L
S
D
A
H
R
S
R
V
Site 77
S1205
D
L
S
D
A
H
R
S
R
V
P
A
P
F
L
Site 78
T1215
P
A
P
F
L
D
R
T
G
L
T
A
V
S
H
Site 79
S1221
R
T
G
L
T
A
V
S
H
N
G
S
Y
V
Y
Site 80
S1225
T
A
V
S
H
N
G
S
Y
V
Y
F
P
K
I
Site 81
Y1226
A
V
S
H
N
G
S
Y
V
Y
F
P
K
I
G
Site 82
Y1228
S
H
N
G
S
Y
V
Y
F
P
K
I
G
D
K
Site 83
S1251
A
E
G
E
E
Q
D
S
L
D
T
S
S
E
I
Site 84
S1255
E
Q
D
S
L
D
T
S
S
E
I
R
C
L
E
Site 85
S1256
Q
D
S
L
D
T
S
S
E
I
R
C
L
E
V
Site 86
S1306
R
K
A
I
N
C
M
S
L
S
K
C
E
D
R
Site 87
S1308
A
I
N
C
M
S
L
S
K
C
E
D
R
L
A
Site 88
Y1341
P
V
I
D
G
P
R
Y
T
F
Y
T
Q
L
P
Site 89
T1342
V
I
D
G
P
R
Y
T
F
Y
T
Q
L
P
E
Site 90
Y1344
D
G
P
R
Y
T
F
Y
T
Q
L
P
E
T
L
Site 91
T1345
G
P
R
Y
T
F
Y
T
Q
L
P
E
T
L
S
Site 92
Y1364
L
T
D
Y
R
V
V
Y
S
M
T
N
G
D
L
Site 93
Y1374
T
N
G
D
L
F
L
Y
E
C
A
T
S
K
A
Site 94
T1386
S
K
A
F
P
L
E
T
H
R
S
R
V
A
C
Site 95
S1389
F
P
L
E
T
H
R
S
R
V
A
C
V
E
V
Site 96
Y1428
K
W
K
F
E
M
S
Y
T
S
S
Y
C
R
G
Site 97
Y1432
E
M
S
Y
T
S
S
Y
C
R
G
V
Q
C
A
Site 98
Y1447
C
F
S
K
D
D
K
Y
V
Y
V
G
L
K
D
Site 99
Y1449
S
K
D
D
K
Y
V
Y
V
G
L
K
D
R
S
Site 100
Y1495
I
A
P
T
R
H
G
Y
L
I
R
E
N
F
Q
Site 101
S1505
R
E
N
F
Q
C
L
S
A
K
A
S
P
Q
D
Site 102
S1509
Q
C
L
S
A
K
A
S
P
Q
D
P
L
K
N
Site 103
S1526
K
A
M
W
M
V
K
S
R
Q
R
E
E
L
V
Site 104
S1544
G
A
P
Q
D
L
E
S
E
S
A
Q
G
N
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation