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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KPNB1
Full Name:
Importin subunit beta-1
Alias:
IMB1; Importin 90; Importin beta-1; Karyopherin beta-1; Karyopherin subunit beta-1; NTF97; Nuclear factor P97
Type:
Karyopherin
Mass (Da):
97170
Number AA:
876
UniProt ID:
Q14974
International Prot ID:
IPI00001639
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005643
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0008139
GO:0019904
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006607
GO:0044419
GO:0000060
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
E
L
I
T
I
L
E
K
T
V
S
Site 2
T10
L
I
T
I
L
E
K
T
V
S
P
D
R
L
E
Site 3
S12
T
I
L
E
K
T
V
S
P
D
R
L
E
L
E
Site 4
S64
A
G
L
Q
I
K
N
S
L
T
S
K
D
P
D
Site 5
Y76
D
P
D
I
K
A
Q
Y
Q
Q
R
W
L
A
I
Site 6
Y94
A
R
R
E
V
K
N
Y
V
L
Q
T
L
G
T
Site 7
T101
Y
V
L
Q
T
L
G
T
E
T
Y
R
P
S
S
Site 8
T103
L
Q
T
L
G
T
E
T
Y
R
P
S
S
A
S
Site 9
Y104
Q
T
L
G
T
E
T
Y
R
P
S
S
A
S
Q
Site 10
S107
G
T
E
T
Y
R
P
S
S
A
S
Q
C
V
A
Site 11
S108
T
E
T
Y
R
P
S
S
A
S
Q
C
V
A
G
Site 12
S110
T
Y
R
P
S
S
A
S
Q
C
V
A
G
I
A
Site 13
T138
P
Q
L
V
A
N
V
T
N
P
N
S
T
E
H
Site 14
S142
A
N
V
T
N
P
N
S
T
E
H
M
K
E
S
Site 15
S170
P
E
Q
L
Q
D
K
S
N
E
I
L
T
A
I
Site 16
T175
D
K
S
N
E
I
L
T
A
I
I
Q
G
M
R
Site 17
S187
G
M
R
K
E
E
P
S
N
N
V
K
L
A
A
Site 18
S201
A
T
N
A
L
L
N
S
L
E
F
T
K
A
N
Site 19
T205
L
L
N
S
L
E
F
T
K
A
N
F
D
K
E
Site 20
T231
E
A
T
Q
C
P
D
T
R
V
R
V
A
A
L
Site 21
Y249
V
K
I
M
S
L
Y
Y
Q
Y
M
E
T
Y
M
Site 22
Y255
Y
Y
Q
Y
M
E
T
Y
M
G
P
A
L
F
A
Site 23
T310
Q
G
R
P
P
E
H
T
S
K
F
Y
A
K
G
Site 24
T327
Q
Y
L
V
P
I
L
T
Q
T
L
T
K
Q
D
Site 25
T331
P
I
L
T
Q
T
L
T
K
Q
D
E
N
D
D
Site 26
Y382
I
K
N
P
D
W
R
Y
R
D
A
A
V
M
A
Site 27
S468
S
A
E
P
R
V
A
S
N
V
C
W
A
F
S
Site 28
T496
D
D
Q
E
E
P
A
T
Y
C
L
S
S
S
F
Site 29
Y497
D
Q
E
E
P
A
T
Y
C
L
S
S
S
F
E
Site 30
T514
V
Q
K
L
L
E
T
T
D
R
P
D
G
H
Q
Site 31
S526
G
H
Q
N
N
L
R
S
S
A
Y
E
S
L
M
Site 32
S527
H
Q
N
N
L
R
S
S
A
Y
E
S
L
M
E
Site 33
Y529
N
N
L
R
S
S
A
Y
E
S
L
M
E
I
V
Site 34
S531
L
R
S
S
A
Y
E
S
L
M
E
I
V
K
N
Site 35
Y544
K
N
S
A
K
D
C
Y
P
A
V
Q
K
T
T
Site 36
S566
Q
Q
V
L
Q
M
E
S
H
I
Q
S
T
S
D
Site 37
S570
Q
M
E
S
H
I
Q
S
T
S
D
R
I
Q
F
Site 38
S572
E
S
H
I
Q
S
T
S
D
R
I
Q
F
N
D
Site 39
T587
L
Q
S
L
L
C
A
T
L
Q
N
V
L
R
K
Site 40
S617
S
L
L
R
M
F
Q
S
T
A
G
S
G
G
V
Site 41
S621
M
F
Q
S
T
A
G
S
G
G
V
Q
E
D
A
Site 42
S708
G
N
E
N
V
H
R
S
V
K
P
Q
I
L
S
Site 43
S743
L
N
T
L
Q
Q
A
S
Q
A
Q
V
D
K
S
Site 44
S750
S
Q
A
Q
V
D
K
S
D
Y
D
M
V
D
Y
Site 45
Y752
A
Q
V
D
K
S
D
Y
D
M
V
D
Y
L
N
Site 46
Y757
S
D
Y
D
M
V
D
Y
L
N
E
L
R
E
S
Site 47
S764
Y
L
N
E
L
R
E
S
C
L
E
A
Y
T
G
Site 48
T848
P
M
I
H
E
L
L
T
E
G
R
R
S
K
T
Site 49
S853
L
L
T
E
G
R
R
S
K
T
N
K
A
K
T
Site 50
T855
T
E
G
R
R
S
K
T
N
K
A
K
T
L
A
Site 51
T860
S
K
T
N
K
A
K
T
L
A
T
W
A
T
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation