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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MTF1
Full Name:
Metal regulatory transcription factor 1
Alias:
metal-regulatory transcription factor 1; MRE-binding transcription factor; MTF-1
Type:
Transcription factor; Transcription, coactivator/corepressor
Mass (Da):
80957
Number AA:
753
UniProt ID:
Q14872
International Prot ID:
IPI00025546
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003713
GO:0003700
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
GO:0010038
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
G
E
H
S
P
D
N
N
I
I
Y
Site 2
Y12
S
P
D
N
N
I
I
Y
F
E
A
E
E
D
E
Site 3
T21
E
A
E
E
D
E
L
T
P
D
D
K
M
L
R
Site 4
S38
D
K
N
G
L
V
P
S
S
S
G
T
V
Y
D
Site 5
S40
N
G
L
V
P
S
S
S
G
T
V
Y
D
R
T
Site 6
T42
L
V
P
S
S
S
G
T
V
Y
D
R
T
T
V
Site 7
Y44
P
S
S
S
G
T
V
Y
D
R
T
T
V
L
I
Site 8
T47
S
G
T
V
Y
D
R
T
T
V
L
I
E
Q
D
Site 9
T48
G
T
V
Y
D
R
T
T
V
L
I
E
Q
D
P
Site 10
T57
L
I
E
Q
D
P
G
T
L
E
D
E
D
D
D
Site 11
Y93
H
E
A
M
S
Q
G
Y
V
Q
H
I
I
S
P
Site 12
S99
G
Y
V
Q
H
I
I
S
P
D
Q
I
H
L
T
Site 13
T106
S
P
D
Q
I
H
L
T
I
N
P
G
S
T
P
Site 14
S111
H
L
T
I
N
P
G
S
T
P
M
P
R
N
I
Site 15
T112
L
T
I
N
P
G
S
T
P
M
P
R
N
I
E
Site 16
T124
N
I
E
G
A
T
L
T
L
Q
S
E
C
P
E
Site 17
S127
G
A
T
L
T
L
Q
S
E
C
P
E
T
K
R
Site 18
T132
L
Q
S
E
C
P
E
T
K
R
K
E
V
K
R
Site 19
Y140
K
R
K
E
V
K
R
Y
Q
C
T
F
E
G
C
Site 20
T143
E
V
K
R
Y
Q
C
T
F
E
G
C
P
R
T
Site 21
T150
T
F
E
G
C
P
R
T
Y
S
T
A
G
N
L
Site 22
Y151
F
E
G
C
P
R
T
Y
S
T
A
G
N
L
R
Site 23
S152
E
G
C
P
R
T
Y
S
T
A
G
N
L
R
T
Site 24
T163
N
L
R
T
H
Q
K
T
H
R
G
E
Y
T
F
Site 25
Y168
Q
K
T
H
R
G
E
Y
T
F
V
C
N
Q
E
Site 26
T169
K
T
H
R
G
E
Y
T
F
V
C
N
Q
E
G
Site 27
Y185
G
K
A
F
L
T
S
Y
S
L
R
I
H
V
R
Site 28
T195
R
I
H
V
R
V
H
T
K
E
K
P
F
E
C
Site 29
Y215
E
K
A
F
N
T
L
Y
R
L
K
A
H
Q
R
Site 30
T225
K
A
H
Q
R
L
H
T
G
K
T
F
N
C
E
Site 31
T228
Q
R
L
H
T
G
K
T
F
N
C
E
S
E
G
Site 32
S237
N
C
E
S
E
G
C
S
K
Y
F
T
T
L
S
Site 33
Y239
E
S
E
G
C
S
K
Y
F
T
T
L
S
D
L
Site 34
T241
E
G
C
S
K
Y
F
T
T
L
S
D
L
R
K
Site 35
T242
G
C
S
K
Y
F
T
T
L
S
D
L
R
K
H
Site 36
S244
S
K
Y
F
T
T
L
S
D
L
R
K
H
I
R
Site 37
T252
D
L
R
K
H
I
R
T
H
T
G
E
K
P
F
Site 38
T254
R
K
H
I
R
T
H
T
G
E
K
P
F
R
C
Site 39
T278
A
A
S
H
H
L
K
T
H
V
R
T
H
T
G
Site 40
T284
K
T
H
V
R
T
H
T
G
E
R
P
F
F
C
Site 41
T299
P
S
N
G
C
E
K
T
F
S
T
Q
Y
S
L
Site 42
S301
N
G
C
E
K
T
F
S
T
Q
Y
S
L
K
S
Site 43
T302
G
C
E
K
T
F
S
T
Q
Y
S
L
K
S
H
Site 44
Y304
E
K
T
F
S
T
Q
Y
S
L
K
S
H
M
K
Site 45
S305
K
T
F
S
T
Q
Y
S
L
K
S
H
M
K
G
Site 46
S308
S
T
Q
Y
S
L
K
S
H
M
K
G
H
D
N
Site 47
S335
G
S
E
D
T
N
H
S
L
C
L
S
D
L
S
Site 48
S345
L
S
D
L
S
L
L
S
T
D
S
E
L
R
E
Site 49
T346
S
D
L
S
L
L
S
T
D
S
E
L
R
E
N
Site 50
S348
L
S
L
L
S
T
D
S
E
L
R
E
N
S
S
Site 51
S354
D
S
E
L
R
E
N
S
S
T
T
Q
G
Q
D
Site 52
S355
S
E
L
R
E
N
S
S
T
T
Q
G
Q
D
L
Site 53
T356
E
L
R
E
N
S
S
T
T
Q
G
Q
D
L
S
Site 54
S373
S
P
A
I
I
F
E
S
M
F
Q
N
S
D
D
Site 55
T381
M
F
Q
N
S
D
D
T
A
I
Q
E
D
P
Q
Site 56
S392
E
D
P
Q
Q
T
A
S
L
T
E
S
F
N
G
Site 57
T394
P
Q
Q
T
A
S
L
T
E
S
F
N
G
D
A
Site 58
S396
Q
T
A
S
L
T
E
S
F
N
G
D
A
E
S
Site 59
S403
S
F
N
G
D
A
E
S
V
S
D
V
P
P
S
Site 60
S405
N
G
D
A
E
S
V
S
D
V
P
P
S
T
G
Site 61
S410
S
V
S
D
V
P
P
S
T
G
N
S
A
S
L
Site 62
T411
V
S
D
V
P
P
S
T
G
N
S
A
S
L
S
Site 63
S438
P
Q
P
L
L
P
A
S
A
P
S
A
P
P
P
Site 64
S441
L
L
P
A
S
A
P
S
A
P
P
P
A
P
S
Site 65
S448
S
A
P
P
P
A
P
S
L
G
P
G
S
Q
Q
Site 66
S453
A
P
S
L
G
P
G
S
Q
Q
A
A
F
G
N
Site 67
S475
P
E
V
P
V
P
H
S
T
Q
F
A
A
N
H
Site 68
S524
A
A
P
A
P
P
Q
S
T
T
E
P
L
P
A
Site 69
T525
A
P
A
P
P
Q
S
T
T
E
P
L
P
A
M
Site 70
T549
S
V
L
T
N
N
P
T
I
T
I
T
P
T
P
Site 71
T551
L
T
N
N
P
T
I
T
I
T
P
T
P
N
T
Site 72
T553
N
N
P
T
I
T
I
T
P
T
P
N
T
A
I
Site 73
S581
W
I
L
N
G
A
T
S
S
P
Q
N
Q
E
Q
Site 74
S582
I
L
N
G
A
T
S
S
P
Q
N
Q
E
Q
I
Site 75
S609
T
A
V
P
V
A
S
S
P
G
S
S
V
Q
Q
Site 76
S620
S
V
Q
Q
I
G
L
S
V
P
V
I
I
I
K
Site 77
S641
C
Q
C
A
C
R
D
S
A
K
E
R
A
S
S
Site 78
S647
D
S
A
K
E
R
A
S
S
R
R
K
G
C
S
Site 79
S648
S
A
K
E
R
A
S
S
R
R
K
G
C
S
S
Site 80
S654
S
S
R
R
K
G
C
S
S
P
P
P
P
E
P
Site 81
S655
S
R
R
K
G
C
S
S
P
P
P
P
E
P
S
Site 82
S662
S
P
P
P
P
E
P
S
P
Q
A
P
D
G
P
Site 83
S679
Q
L
P
A
Q
T
F
S
S
A
P
V
P
G
S
Site 84
S680
L
P
A
Q
T
F
S
S
A
P
V
P
G
S
S
Site 85
S686
S
S
A
P
V
P
G
S
S
S
S
T
L
P
S
Site 86
S687
S
A
P
V
P
G
S
S
S
S
T
L
P
S
S
Site 87
S688
A
P
V
P
G
S
S
S
S
T
L
P
S
S
C
Site 88
S689
P
V
P
G
S
S
S
S
T
L
P
S
S
C
E
Site 89
T690
V
P
G
S
S
S
S
T
L
P
S
S
C
E
Q
Site 90
S693
S
S
S
S
T
L
P
S
S
C
E
Q
S
R
Q
Site 91
S694
S
S
S
T
L
P
S
S
C
E
Q
S
R
Q
A
Site 92
S698
L
P
S
S
C
E
Q
S
R
Q
A
E
T
P
S
Site 93
T703
E
Q
S
R
Q
A
E
T
P
S
D
P
Q
T
E
Site 94
S705
S
R
Q
A
E
T
P
S
D
P
Q
T
E
T
L
Site 95
T709
E
T
P
S
D
P
Q
T
E
T
L
S
A
M
D
Site 96
T711
P
S
D
P
Q
T
E
T
L
S
A
M
D
V
S
Site 97
S713
D
P
Q
T
E
T
L
S
A
M
D
V
S
E
F
Site 98
S722
M
D
V
S
E
F
L
S
L
Q
S
L
D
T
P
Site 99
S725
S
E
F
L
S
L
Q
S
L
D
T
P
S
N
L
Site 100
T748
G
E
E
E
M
G
L
T
S
S
F
S
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation