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Updated November 2019
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Protein Info
Short Name:
CHD4
Full Name:
Chromodomain-helicase-DNA-binding protein 4
Alias:
Chromodomain helicase DNA binding protein 4; Chromodomain helicase-DNA-binding protein 4; Mi-2 autoantigen 218 kDa protein; Mi-2b; Mi2-beta
Type:
EC 3.6.1.-; DNA binding protein; Helicase
Mass (Da):
217991
Number AA:
1912
UniProt ID:
Q14839
International Prot ID:
IPI00000846
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016581
GO:0000785
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004003
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0006333
GO:0016568
GO:0006357
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
S
G
L
G
S
P
S
P
C
S
A
G
S
E
Site 2
S12
L
G
S
P
S
P
C
S
A
G
S
E
E
E
D
Site 3
S15
P
S
P
C
S
A
G
S
E
E
E
D
M
D
A
Site 4
S27
M
D
A
L
L
N
N
S
L
P
P
P
H
P
E
Site 5
S44
E
D
P
E
E
D
L
S
E
T
E
T
P
K
L
Site 6
T46
P
E
E
D
L
S
E
T
E
T
P
K
L
K
K
Site 7
T48
E
D
L
S
E
T
E
T
P
K
L
K
K
K
K
Site 8
S68
R
D
P
K
I
P
K
S
K
R
Q
K
K
E
R
Site 9
S85
L
C
R
Q
L
G
D
S
S
G
E
G
P
E
F
Site 10
S86
C
R
Q
L
G
D
S
S
G
E
G
P
E
F
V
Site 11
S103
E
E
E
V
A
L
R
S
D
S
E
G
S
D
Y
Site 12
S105
E
V
A
L
R
S
D
S
E
G
S
D
Y
T
P
Site 13
S108
L
R
S
D
S
E
G
S
D
Y
T
P
G
K
K
Site 14
Y110
S
D
S
E
G
S
D
Y
T
P
G
K
K
K
K
Site 15
T111
D
S
E
G
S
D
Y
T
P
G
K
K
K
K
K
Site 16
S128
G
P
K
K
E
K
K
S
K
S
K
R
K
E
E
Site 17
S130
K
K
E
K
K
S
K
S
K
R
K
E
E
E
E
Site 18
S145
E
D
D
D
D
D
D
S
K
E
P
K
S
S
A
Site 19
S150
D
D
S
K
E
P
K
S
S
A
Q
L
L
E
D
Site 20
S151
D
S
K
E
P
K
S
S
A
Q
L
L
E
D
W
Site 21
Y172
H
V
F
S
E
E
D
Y
R
T
L
T
N
Y
K
Site 22
T174
F
S
E
E
D
Y
R
T
L
T
N
Y
K
A
F
Site 23
T176
E
E
D
Y
R
T
L
T
N
Y
K
A
F
S
Q
Site 24
Y178
D
Y
R
T
L
T
N
Y
K
A
F
S
Q
F
V
Site 25
S213
G
A
K
W
R
E
F
S
T
N
N
P
F
K
G
Site 26
S221
T
N
N
P
F
K
G
S
S
G
A
S
V
A
A
Site 27
S222
N
N
P
F
K
G
S
S
G
A
S
V
A
A
A
Site 28
T262
V
P
I
R
K
A
K
T
K
E
G
K
G
P
N
Site 29
S277
A
R
R
K
P
K
G
S
P
R
V
P
D
A
K
Site 30
S303
I
K
L
G
G
F
G
S
K
R
K
R
S
S
S
Site 31
S308
F
G
S
K
R
K
R
S
S
S
E
D
D
D
L
Site 32
S309
G
S
K
R
K
R
S
S
S
E
D
D
D
L
D
Site 33
S310
S
K
R
K
R
S
S
S
E
D
D
D
L
D
V
Site 34
S319
D
D
D
L
D
V
E
S
D
F
D
D
A
S
I
Site 35
S325
E
S
D
F
D
D
A
S
I
N
S
Y
S
V
S
Site 36
S328
F
D
D
A
S
I
N
S
Y
S
V
S
D
G
S
Site 37
Y329
D
D
A
S
I
N
S
Y
S
V
S
D
G
S
T
Site 38
S330
D
A
S
I
N
S
Y
S
V
S
D
G
S
T
S
Site 39
S332
S
I
N
S
Y
S
V
S
D
G
S
T
S
R
S
Site 40
S335
S
Y
S
V
S
D
G
S
T
S
R
S
S
R
S
Site 41
T336
Y
S
V
S
D
G
S
T
S
R
S
S
R
S
R
Site 42
S337
S
V
S
D
G
S
T
S
R
S
S
R
S
R
K
Site 43
S339
S
D
G
S
T
S
R
S
S
R
S
R
K
K
L
Site 44
S340
D
G
S
T
S
R
S
S
R
S
R
K
K
L
R
Site 45
T348
R
S
R
K
K
L
R
T
T
K
K
K
K
K
G
Site 46
T349
S
R
K
K
L
R
T
T
K
K
K
K
K
G
E
Site 47
T360
K
K
G
E
E
E
V
T
A
V
D
G
Y
E
T
Site 48
Y365
E
V
T
A
V
D
G
Y
E
T
D
H
Q
D
Y
Site 49
T367
T
A
V
D
G
Y
E
T
D
H
Q
D
Y
C
E
Site 50
Y372
Y
E
T
D
H
Q
D
Y
C
E
V
C
Q
Q
G
Site 51
S428
W
E
A
K
E
D
N
S
E
G
E
E
I
L
E
Site 52
S515
W
K
W
G
Q
P
P
S
P
T
P
V
P
R
P
Site 53
T517
W
G
Q
P
P
S
P
T
P
V
P
R
P
P
D
Site 54
T529
P
P
D
A
D
P
N
T
P
S
P
K
P
L
E
Site 55
S531
D
A
D
P
N
T
P
S
P
K
P
L
E
G
R
Site 56
S585
N
D
M
D
E
P
P
S
G
D
F
G
G
D
E
Site 57
S595
F
G
G
D
E
E
K
S
R
K
R
K
N
K
D
Site 58
Y613
A
E
M
E
E
R
F
Y
R
Y
G
I
K
P
E
Site 59
S631
I
H
R
I
L
N
H
S
V
D
K
K
G
H
V
Site 60
Y649
I
K
W
R
D
L
P
Y
D
Q
A
S
W
E
S
Site 61
S653
D
L
P
Y
D
Q
A
S
W
E
S
E
D
V
E
Site 62
Y664
E
D
V
E
I
Q
D
Y
D
L
F
K
Q
S
Y
Site 63
Y671
Y
D
L
F
K
Q
S
Y
W
N
H
R
E
L
M
Site 64
T703
K
L
E
R
P
P
E
T
P
T
V
D
P
T
V
Site 65
T705
E
R
P
P
E
T
P
T
V
D
P
T
V
K
Y
Site 66
T709
E
T
P
T
V
D
P
T
V
K
Y
E
R
Q
P
Site 67
Y712
T
V
D
P
T
V
K
Y
E
R
Q
P
E
Y
L
Site 68
Y718
K
Y
E
R
Q
P
E
Y
L
D
A
T
G
G
T
Site 69
Y729
T
G
G
T
L
H
P
Y
Q
M
E
G
L
N
W
Site 70
T747
S
W
A
Q
G
T
D
T
I
L
A
D
E
M
G
Site 71
S767
Q
T
A
V
F
L
Y
S
L
Y
K
E
G
H
S
Site 72
Y769
A
V
F
L
Y
S
L
Y
K
E
G
H
S
K
G
Site 73
S774
S
L
Y
K
E
G
H
S
K
G
P
F
L
V
S
Site 74
Y806
P
D
M
Y
V
V
T
Y
V
G
D
K
D
S
R
Site 75
S812
T
Y
V
G
D
K
D
S
R
A
I
I
R
E
N
Site 76
S822
I
I
R
E
N
E
F
S
F
E
D
N
A
I
R
Site 77
S842
S
R
M
K
K
E
A
S
V
K
F
H
V
L
L
Site 78
T901
L
Q
H
K
L
L
L
T
G
T
P
L
Q
N
N
Site 79
T903
H
K
L
L
L
T
G
T
P
L
Q
N
N
L
E
Site 80
T920
F
H
L
L
N
F
L
T
P
E
R
F
H
N
L
Site 81
S979
L
I
V
R
V
E
L
S
P
M
Q
K
K
Y
Y
Site 82
Y985
L
S
P
M
Q
K
K
Y
Y
K
Y
I
L
T
R
Site 83
Y986
S
P
M
Q
K
K
Y
Y
K
Y
I
L
T
R
N
Site 84
Y1040
P
K
M
P
N
G
M
Y
D
G
S
A
L
I
R
Site 85
S1043
P
N
G
M
Y
D
G
S
A
L
I
R
A
S
G
Site 86
Y1091
D
F
L
E
H
E
G
Y
K
Y
E
R
I
D
G
Site 87
Y1093
L
E
H
E
G
Y
K
Y
E
R
I
D
G
G
I
Site 88
Y1144
T
A
D
T
V
I
I
Y
D
S
D
W
N
P
H
Site 89
T1176
V
M
I
Y
R
F
V
T
R
A
S
V
E
E
R
Site 90
S1179
Y
R
F
V
T
R
A
S
V
E
E
R
I
T
Q
Site 91
T1185
A
S
V
E
E
R
I
T
Q
V
A
K
K
K
M
Site 92
S1205
V
V
R
P
G
L
G
S
K
T
G
S
M
S
K
Site 93
T1207
R
P
G
L
G
S
K
T
G
S
M
S
K
Q
E
Site 94
S1209
G
L
G
S
K
T
G
S
M
S
K
Q
E
L
D
Site 95
T1232
E
L
F
K
D
E
A
T
D
G
G
G
D
N
K
Site 96
S1244
D
N
K
E
G
E
D
S
S
V
I
H
Y
D
D
Site 97
S1245
N
K
E
G
E
D
S
S
V
I
H
Y
D
D
K
Site 98
Y1249
E
D
S
S
V
I
H
Y
D
D
K
A
I
E
R
Site 99
T1265
L
D
R
N
Q
D
E
T
E
D
T
E
L
Q
G
Site 100
T1268
N
Q
D
E
T
E
D
T
E
L
Q
G
M
N
E
Site 101
Y1276
E
L
Q
G
M
N
E
Y
L
S
S
F
K
V
A
Site 102
S1279
G
M
N
E
Y
L
S
S
F
K
V
A
Q
Y
V
Site 103
Y1285
S
S
F
K
V
A
Q
Y
V
V
R
E
E
E
M
Site 104
S1308
E
I
I
K
Q
E
E
S
V
D
P
D
Y
W
E
Site 105
Y1313
E
E
S
V
D
P
D
Y
W
E
K
L
L
R
H
Site 106
Y1322
E
K
L
L
R
H
H
Y
E
Q
Q
Q
E
D
L
Site 107
Y1345
R
I
R
K
Q
V
N
Y
N
D
G
S
Q
E
D
Site 108
S1349
Q
V
N
Y
N
D
G
S
Q
E
D
R
D
W
Q
Site 109
S1360
R
D
W
Q
D
D
Q
S
D
N
Q
S
D
Y
S
Site 110
S1364
D
D
Q
S
D
N
Q
S
D
Y
S
V
A
S
E
Site 111
Y1366
Q
S
D
N
Q
S
D
Y
S
V
A
S
E
E
G
Site 112
S1367
S
D
N
Q
S
D
Y
S
V
A
S
E
E
G
D
Site 113
S1370
Q
S
D
Y
S
V
A
S
E
E
G
D
E
D
F
Site 114
S1381
D
E
D
F
D
E
R
S
E
A
P
R
R
P
S
Site 115
S1388
S
E
A
P
R
R
P
S
R
K
G
L
R
N
D
Site 116
Y1431
F
L
N
A
I
M
R
Y
G
M
P
P
Q
D
A
Site 117
S1452
V
R
D
L
R
G
K
S
E
K
E
F
K
A
Y
Site 118
Y1459
S
E
K
E
F
K
A
Y
V
S
L
F
M
R
H
Site 119
T1477
P
G
A
D
G
A
E
T
F
A
D
G
V
P
R
Site 120
S1488
G
V
P
R
E
G
L
S
R
Q
H
V
L
T
R
Site 121
S1500
L
T
R
I
G
V
M
S
L
I
R
K
K
V
Q
Site 122
S1517
E
H
V
N
G
R
W
S
M
P
E
L
A
E
V
Site 123
S1531
V
E
E
N
K
K
M
S
Q
P
G
S
P
S
P
Site 124
S1535
K
K
M
S
Q
P
G
S
P
S
P
K
T
P
T
Site 125
S1537
M
S
Q
P
G
S
P
S
P
K
T
P
T
P
S
Site 126
T1540
P
G
S
P
S
P
K
T
P
T
P
S
T
P
G
Site 127
T1542
S
P
S
P
K
T
P
T
P
S
T
P
G
D
T
Site 128
S1544
S
P
K
T
P
T
P
S
T
P
G
D
T
Q
P
Site 129
T1545
P
K
T
P
T
P
S
T
P
G
D
T
Q
P
N
Site 130
T1549
T
P
S
T
P
G
D
T
Q
P
N
T
P
A
P
Site 131
T1553
P
G
D
T
Q
P
N
T
P
A
P
V
P
P
A
Site 132
S1570
G
I
K
I
E
E
N
S
L
K
E
E
E
S
I
Site 133
S1576
N
S
L
K
E
E
E
S
I
E
G
E
K
E
V
Site 134
S1585
E
G
E
K
E
V
K
S
T
A
P
E
T
A
I
Site 135
T1595
P
E
T
A
I
E
C
T
Q
A
P
A
P
A
S
Site 136
S1602
T
Q
A
P
A
P
A
S
E
D
E
K
V
V
V
Site 137
T1633
R
T
E
E
P
M
E
T
E
P
K
G
A
A
D
Site 138
S1648
V
E
K
V
E
E
K
S
A
I
D
L
T
P
I
Site 139
T1653
E
K
S
A
I
D
L
T
P
I
V
V
E
D
K
Site 140
T1679
V
M
L
Q
N
G
E
T
P
K
D
L
N
D
E
Site 141
S1710
G
G
F
T
E
L
H
S
L
W
Q
N
E
E
R
Site 142
T1720
Q
N
E
E
R
A
A
T
V
T
K
K
T
Y
E
Site 143
T1722
E
E
R
A
A
T
V
T
K
K
T
Y
E
I
W
Site 144
T1725
A
A
T
V
T
K
K
T
Y
E
I
W
H
R
R
Site 145
Y1746
A
G
I
I
N
H
G
Y
A
R
W
Q
D
I
Q
Site 146
Y1758
D
I
Q
N
D
P
R
Y
A
I
L
N
E
P
F
Site 147
Y1804
E
Q
L
R
R
A
A
Y
L
N
M
S
E
D
P
Site 148
S1808
R
A
A
Y
L
N
M
S
E
D
P
S
H
P
S
Site 149
S1812
L
N
M
S
E
D
P
S
H
P
S
M
A
L
N
Site 150
S1815
S
E
D
P
S
H
P
S
M
A
L
N
T
R
F
Site 151
S1836
A
E
S
H
Q
H
L
S
K
E
S
M
A
G
N
Site 152
S1839
H
Q
H
L
S
K
E
S
M
A
G
N
K
P
A
Site 153
S1862
K
Q
L
E
E
L
L
S
D
M
K
A
D
V
T
Site 154
T1869
S
D
M
K
A
D
V
T
R
L
P
A
T
I
A
Site 155
S1888
V
A
V
R
L
Q
M
S
E
R
N
I
L
S
R
Site 156
T1904
A
N
R
A
P
E
P
T
P
Q
Q
V
A
Q
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation