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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MEF2D
Full Name:
Myocyte-specific enhancer factor 2D
Alias:
MEFD; myocyte enhancer factor 2D
Type:
Transcription protein
Mass (Da):
55938
Number AA:
521
UniProt ID:
Q14814
International Prot ID:
IPI00000784
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0043565
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0007517
GO:0007399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
K
I
Q
I
Q
R
I
T
D
E
R
N
R
Q
V
Site 2
T20
D
E
R
N
R
Q
V
T
F
T
K
R
K
F
G
Site 3
T22
R
N
R
Q
V
T
F
T
K
R
K
F
G
L
M
Site 4
Y57
H
S
N
K
L
F
Q
Y
A
S
T
D
M
D
K
Site 5
S59
N
K
L
F
Q
Y
A
S
T
D
M
D
K
V
L
Site 6
Y69
M
D
K
V
L
L
K
Y
T
E
Y
N
E
P
H
Site 7
T70
D
K
V
L
L
K
Y
T
E
Y
N
E
P
H
E
Site 8
Y72
V
L
L
K
Y
T
E
Y
N
E
P
H
E
S
R
Site 9
S78
E
Y
N
E
P
H
E
S
R
T
N
A
D
I
I
Site 10
T87
T
N
A
D
I
I
E
T
L
R
K
K
G
F
N
Site 11
S98
K
G
F
N
G
C
D
S
P
E
P
D
G
E
D
Site 12
S106
P
E
P
D
G
E
D
S
L
E
Q
S
P
L
L
Site 13
S110
G
E
D
S
L
E
Q
S
P
L
L
E
D
K
Y
Site 14
Y117
S
P
L
L
E
D
K
Y
R
R
A
S
E
E
L
Site 15
S121
E
D
K
Y
R
R
A
S
E
E
L
D
G
L
F
Site 16
Y131
L
D
G
L
F
R
R
Y
G
S
T
V
P
A
P
Site 17
S133
G
L
F
R
R
Y
G
S
T
V
P
A
P
N
F
Site 18
T134
L
F
R
R
Y
G
S
T
V
P
A
P
N
F
A
Site 19
T145
P
N
F
A
M
P
V
T
V
P
V
S
N
Q
S
Site 20
S149
M
P
V
T
V
P
V
S
N
Q
S
S
L
Q
F
Site 21
S153
V
P
V
S
N
Q
S
S
L
Q
F
S
N
P
S
Site 22
S157
N
Q
S
S
L
Q
F
S
N
P
S
G
S
L
V
Site 23
S160
S
L
Q
F
S
N
P
S
G
S
L
V
T
P
S
Site 24
T165
N
P
S
G
S
L
V
T
P
S
L
V
T
S
S
Site 25
T174
S
L
V
T
S
S
L
T
D
P
R
L
L
S
P
Site 26
S180
L
T
D
P
R
L
L
S
P
Q
Q
P
A
L
Q
Site 27
S190
Q
P
A
L
Q
R
N
S
V
S
P
G
L
P
Q
Site 28
S192
A
L
Q
R
N
S
V
S
P
G
L
P
Q
R
P
Site 29
S201
G
L
P
Q
R
P
A
S
A
G
A
M
L
G
G
Site 30
S212
M
L
G
G
D
L
N
S
A
N
G
A
C
P
S
Site 31
S219
S
A
N
G
A
C
P
S
P
V
G
N
G
Y
V
Site 32
Y225
P
S
P
V
G
N
G
Y
V
S
A
R
A
S
P
Site 33
S227
P
V
G
N
G
Y
V
S
A
R
A
S
P
G
L
Site 34
S231
G
Y
V
S
A
R
A
S
P
G
L
L
P
V
A
Site 35
S251
N
K
V
I
P
A
K
S
P
P
P
P
T
H
S
Site 36
T256
A
K
S
P
P
P
P
T
H
S
T
Q
L
G
A
Site 37
S258
S
P
P
P
P
T
H
S
T
Q
L
G
A
P
S
Site 38
T259
P
P
P
P
T
H
S
T
Q
L
G
A
P
S
R
Site 39
S265
S
T
Q
L
G
A
P
S
R
K
P
D
L
R
V
Site 40
T274
K
P
D
L
R
V
I
T
S
Q
A
G
K
G
L
Site 41
S275
P
D
L
R
V
I
T
S
Q
A
G
K
G
L
M
Site 42
T286
K
G
L
M
H
H
L
T
E
D
H
L
D
L
N
Site 43
S301
N
A
Q
R
L
G
V
S
Q
S
T
H
S
L
T
Site 44
S303
Q
R
L
G
V
S
Q
S
T
H
S
L
T
T
P
Site 45
S306
G
V
S
Q
S
T
H
S
L
T
T
P
V
V
S
Site 46
T309
Q
S
T
H
S
L
T
T
P
V
V
S
V
A
T
Site 47
T316
T
P
V
V
S
V
A
T
P
S
L
L
S
Q
G
Site 48
S327
L
S
Q
G
L
P
F
S
S
M
P
T
A
Y
N
Site 49
T331
L
P
F
S
S
M
P
T
A
Y
N
T
D
Y
Q
Site 50
T335
S
M
P
T
A
Y
N
T
D
Y
Q
L
T
S
A
Site 51
Y337
P
T
A
Y
N
T
D
Y
Q
L
T
S
A
E
L
Site 52
S341
N
T
D
Y
Q
L
T
S
A
E
L
S
S
L
P
Site 53
S345
Q
L
T
S
A
E
L
S
S
L
P
A
F
S
S
Site 54
S352
S
S
L
P
A
F
S
S
P
G
G
L
S
L
G
Site 55
S405
Q
Q
P
P
Q
Q
Q
S
H
L
V
P
V
S
L
Site 56
S437
V
T
T
H
P
H
I
S
I
K
S
E
P
V
S
Site 57
S440
H
P
H
I
S
I
K
S
E
P
V
S
P
S
R
Site 58
S444
S
I
K
S
E
P
V
S
P
S
R
E
R
S
P
Site 59
S446
K
S
E
P
V
S
P
S
R
E
R
S
P
A
P
Site 60
S450
V
S
P
S
R
E
R
S
P
A
P
P
P
P
A
Site 61
S471
P
E
P
G
D
G
L
S
S
P
A
G
G
S
Y
Site 62
S472
E
P
G
D
G
L
S
S
P
A
G
G
S
Y
E
Site 63
S477
L
S
S
P
A
G
G
S
Y
E
T
G
D
R
D
Site 64
S508
P
E
P
E
A
E
G
S
A
V
K
R
M
R
L
Site 65
T517
V
K
R
M
R
L
D
T
W
T
L
K
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation