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Updated November 2019
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Protein Info
Short Name:
LTBP2
Full Name:
Latent-transforming growth factor beta-binding protein 2
Alias:
C14orf141; latent transforming growth factor beta binding protein 2; latent-transforming growth factor beta-binding 2; LTBP-2; LTBP3
Type:
Mass (Da):
195046
Number AA:
1821
UniProt ID:
Q14767
International Prot ID:
IPI00292150
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0019838
PhosphoSite+
KinaseNET
Biological Process:
GO:0009306
GO:0006605
GO:0007179
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
R
P
R
T
K
A
R
S
P
G
R
Site 2
S9
R
P
R
T
K
A
R
S
P
G
R
A
L
R
N
Site 3
Y43
Q
R
D
P
V
G
R
Y
E
P
A
G
G
D
A
Site 4
S59
R
L
R
R
P
G
G
S
Y
P
A
A
A
A
A
Site 5
Y60
L
R
R
P
G
G
S
Y
P
A
A
A
A
A
K
Site 6
S70
A
A
A
A
K
V
Y
S
L
F
R
E
Q
D
A
Site 7
S94
R
A
Q
P
G
W
G
S
P
R
R
P
T
E
A
Site 8
T99
W
G
S
P
R
R
P
T
E
A
E
A
R
R
P
Site 9
S107
E
A
E
A
R
R
P
S
R
A
Q
Q
S
R
R
Site 10
S112
R
P
S
R
A
Q
Q
S
R
R
V
Q
P
P
A
Site 11
T121
R
V
Q
P
P
A
Q
T
R
R
S
T
P
L
G
Site 12
S124
P
P
A
Q
T
R
R
S
T
P
L
G
Q
Q
Q
Site 13
T125
P
A
Q
T
R
R
S
T
P
L
G
Q
Q
Q
P
Site 14
T147
P
A
L
P
R
L
G
T
P
Q
R
S
G
A
A
Site 15
S151
R
L
G
T
P
Q
R
S
G
A
A
P
P
T
P
Site 16
T157
R
S
G
A
A
P
P
T
P
P
R
G
R
L
T
Site 17
T164
T
P
P
R
G
R
L
T
G
R
N
V
C
G
G
Site 18
S200
P
P
C
Q
N
R
G
S
C
S
R
P
Q
L
C
Site 19
S243
P
R
R
W
A
E
R
S
P
N
L
R
R
S
S
Site 20
S249
R
S
P
N
L
R
R
S
S
A
A
G
E
G
T
Site 21
S250
S
P
N
L
R
R
S
S
A
A
G
E
G
T
L
Site 22
T256
S
S
A
A
G
E
G
T
L
A
R
A
Q
P
P
Site 23
S267
A
Q
P
P
A
P
Q
S
P
P
A
P
Q
S
P
Site 24
S273
Q
S
P
P
A
P
Q
S
P
P
A
G
T
L
S
Site 25
T278
P
Q
S
P
P
A
G
T
L
S
G
L
S
Q
T
Site 26
S280
S
P
P
A
G
T
L
S
G
L
S
Q
T
H
P
Site 27
S283
A
G
T
L
S
G
L
S
Q
T
H
P
S
Q
Q
Site 28
S288
G
L
S
Q
T
H
P
S
Q
Q
H
V
G
L
S
Site 29
T297
Q
H
V
G
L
S
R
T
V
R
L
H
P
T
A
Site 30
T303
R
T
V
R
L
H
P
T
A
T
A
S
S
Q
L
Site 31
T305
V
R
L
H
P
T
A
T
A
S
S
Q
L
S
S
Site 32
S307
L
H
P
T
A
T
A
S
S
Q
L
S
S
N
A
Site 33
S308
H
P
T
A
T
A
S
S
Q
L
S
S
N
A
L
Site 34
S311
A
T
A
S
S
Q
L
S
S
N
A
L
P
P
G
Site 35
S312
T
A
S
S
Q
L
S
S
N
A
L
P
P
G
P
Site 36
T327
G
L
E
Q
R
D
G
T
Q
Q
A
V
P
L
E
Site 37
S337
A
V
P
L
E
H
P
S
S
P
W
G
L
N
L
Site 38
S338
V
P
L
E
H
P
S
S
P
W
G
L
N
L
T
Site 39
T345
S
P
W
G
L
N
L
T
E
K
I
K
K
I
K
Site 40
T356
K
K
I
K
I
V
F
T
P
T
I
C
K
Q
T
Site 41
T378
N
S
C
E
R
G
D
T
T
T
L
Y
S
Q
G
Site 42
T379
S
C
E
R
G
D
T
T
T
L
Y
S
Q
G
G
Site 43
T380
C
E
R
G
D
T
T
T
L
Y
S
Q
G
G
H
Site 44
Y382
R
G
D
T
T
T
L
Y
S
Q
G
G
H
G
H
Site 45
S383
G
D
T
T
T
L
Y
S
Q
G
G
H
G
H
D
Site 46
S443
R
E
P
P
G
R
G
S
R
P
R
A
L
L
E
Site 47
T457
E
A
P
L
K
Q
S
T
F
T
L
P
L
S
N
Site 48
T459
P
L
K
Q
S
T
F
T
L
P
L
S
N
Q
L
Site 49
S468
P
L
S
N
Q
L
A
S
V
N
P
S
L
V
K
Site 50
S506
E
E
A
L
V
E
N
S
V
E
T
R
P
P
P
Site 51
S518
P
P
P
W
L
P
A
S
P
G
H
S
L
W
D
Site 52
S522
L
P
A
S
P
G
H
S
L
W
D
S
N
N
I
Site 53
S526
P
G
H
S
L
W
D
S
N
N
I
P
A
R
S
Site 54
S533
S
N
N
I
P
A
R
S
G
E
P
P
R
P
L
Site 55
Y555
R
G
L
L
G
R
C
Y
L
N
T
V
N
G
Q
Site 56
S598
P
C
P
P
R
P
A
S
P
V
I
E
N
G
Q
Site 57
T618
G
Y
K
R
L
N
L
T
H
C
Q
D
I
N
E
Site 58
T640
K
D
A
E
C
V
N
T
R
G
S
Y
L
C
T
Site 59
Y644
C
V
N
T
R
G
S
Y
L
C
T
C
R
P
G
Site 60
S657
P
G
L
M
L
D
P
S
R
S
R
C
V
S
D
Site 61
S659
L
M
L
D
P
S
R
S
R
C
V
S
D
K
A
Site 62
S663
P
S
R
S
R
C
V
S
D
K
A
I
S
M
L
Site 63
Y675
S
M
L
Q
G
L
C
Y
R
S
L
G
P
G
T
Site 64
S707
R
V
G
K
A
W
G
S
E
C
E
K
C
P
L
Site 65
T717
E
K
C
P
L
P
G
T
E
A
F
R
E
I
C
Site 66
Y730
I
C
P
A
G
H
G
Y
T
Y
A
S
S
D
I
Site 67
Y732
P
A
G
H
G
Y
T
Y
A
S
S
D
I
R
L
Site 68
S734
G
H
G
Y
T
Y
A
S
S
D
I
R
L
S
M
Site 69
S735
H
G
Y
T
Y
A
S
S
D
I
R
L
S
M
R
Site 70
S740
A
S
S
D
I
R
L
S
M
R
K
A
E
E
E
Site 71
S760
P
R
E
Q
G
Q
R
S
S
G
A
L
P
G
P
Site 72
S761
R
E
Q
G
Q
R
S
S
G
A
L
P
G
P
A
Site 73
T777
R
Q
P
L
R
V
V
T
D
T
W
L
E
A
G
Site 74
S792
T
I
P
D
K
G
D
S
Q
A
G
Q
V
T
T
Site 75
T798
D
S
Q
A
G
Q
V
T
T
S
V
T
H
A
P
Site 76
T799
S
Q
A
G
Q
V
T
T
S
V
T
H
A
P
A
Site 77
S800
Q
A
G
Q
V
T
T
S
V
T
H
A
P
A
W
Site 78
T813
A
W
V
T
G
N
A
T
T
P
P
M
P
E
Q
Site 79
T814
W
V
T
G
N
A
T
T
P
P
M
P
E
Q
G
Site 80
T831
E
I
Q
E
E
Q
V
T
P
S
T
D
V
L
V
Site 81
Y876
R
C
V
C
S
P
G
Y
Q
L
H
P
S
Q
A
Site 82
S922
P
G
Y
T
L
A
T
S
G
A
T
Q
E
C
Q
Site 83
T948
S
G
G
Q
C
T
N
T
E
G
S
Y
H
C
E
Site 84
Y960
H
C
E
C
D
Q
G
Y
I
M
V
R
K
G
H
Site 85
S988
P
D
G
R
C
V
N
S
P
G
S
Y
T
C
L
Site 86
S991
R
C
V
N
S
P
G
S
Y
T
C
L
A
C
E
Site 87
Y1001
C
L
A
C
E
E
G
Y
R
G
Q
S
G
S
C
Site 88
S1005
E
E
G
Y
R
G
Q
S
G
S
C
V
D
V
N
Site 89
S1007
G
Y
R
G
Q
S
G
S
C
V
D
V
N
E
C
Site 90
T1026
V
C
A
H
G
K
C
T
N
L
E
G
S
F
R
Site 91
S1031
K
C
T
N
L
E
G
S
F
R
C
S
C
E
Q
Site 92
S1035
L
E
G
S
F
R
C
S
C
E
Q
G
Y
E
V
Site 93
Y1040
R
C
S
C
E
Q
G
Y
E
V
T
S
D
E
K
Site 94
S1044
E
Q
G
Y
E
V
T
S
D
E
K
G
C
Q
D
Site 95
S1057
Q
D
V
D
E
C
A
S
R
A
S
C
P
T
G
Site 96
T1111
P
S
G
V
C
T
N
T
A
G
S
F
S
C
K
Site 97
S1116
T
N
T
A
G
S
F
S
C
K
D
C
D
G
G
Site 98
Y1124
C
K
D
C
D
G
G
Y
R
P
S
P
L
G
D
Site 99
S1127
C
D
G
G
Y
R
P
S
P
L
G
D
S
C
E
Site 100
S1132
R
P
S
P
L
G
D
S
C
E
D
V
D
E
C
Site 101
S1144
D
E
C
E
D
P
Q
S
S
C
L
G
G
E
C
Site 102
T1154
L
G
G
E
C
K
N
T
V
G
S
Y
Q
C
L
Site 103
Y1158
C
K
N
T
V
G
S
Y
Q
C
L
C
P
Q
G
Site 104
S1215
V
S
A
E
G
G
T
S
C
Q
D
V
D
E
C
Site 105
S1251
C
E
T
G
F
Q
P
S
P
E
S
G
E
C
V
Site 106
S1254
G
F
Q
P
S
P
E
S
G
E
C
V
D
I
D
Site 107
Y1266
D
I
D
E
C
E
D
Y
G
D
P
V
C
G
T
Site 108
Y1283
C
E
N
S
P
G
S
Y
R
C
V
L
G
C
Q
Site 109
Y1379
C
A
S
D
L
E
E
Y
D
A
Q
E
G
H
C
Site 110
S1395
P
R
G
A
G
G
Q
S
M
S
E
A
P
T
G
Site 111
S1397
G
A
G
G
Q
S
M
S
E
A
P
T
G
D
H
Site 112
T1401
Q
S
M
S
E
A
P
T
G
D
H
A
P
A
P
Site 113
Y1414
A
P
T
R
M
D
C
Y
S
G
Q
K
G
H
A
Site 114
S1415
P
T
R
M
D
C
Y
S
G
Q
K
G
H
A
P
Site 115
S1424
Q
K
G
H
A
P
C
S
S
V
L
G
R
N
T
Site 116
S1425
K
G
H
A
P
C
S
S
V
L
G
R
N
T
T
Site 117
T1431
S
S
V
L
G
R
N
T
T
Q
A
E
C
C
C
Site 118
T1432
S
V
L
G
R
N
T
T
Q
A
E
C
C
C
T
Site 119
S1453
D
A
C
D
L
C
P
S
E
D
S
A
E
F
S
Site 120
S1456
D
L
C
P
S
E
D
S
A
E
F
S
E
I
C
Site 121
S1460
S
E
D
S
A
E
F
S
E
I
C
P
S
G
K
Site 122
S1465
E
F
S
E
I
C
P
S
G
K
G
Y
I
P
V
Site 123
Y1519
L
C
N
P
G
F
H
Y
D
A
S
H
K
K
C
Site 124
T1558
C
F
C
S
P
P
L
T
L
D
L
S
Q
Q
R
Site 125
S1562
P
P
L
T
L
D
L
S
Q
Q
R
C
M
N
S
Site 126
S1569
S
Q
Q
R
C
M
N
S
T
S
S
T
E
D
L
Site 127
T1570
Q
Q
R
C
M
N
S
T
S
S
T
E
D
L
P
Site 128
S1571
Q
R
C
M
N
S
T
S
S
T
E
D
L
P
D
Site 129
S1572
R
C
M
N
S
T
S
S
T
E
D
L
P
D
H
Site 130
T1573
C
M
N
S
T
S
S
T
E
D
L
P
D
H
D
Site 131
S1596
K
V
T
N
D
V
C
S
E
P
L
R
G
H
R
Site 132
T1604
E
P
L
R
G
H
R
T
T
Y
T
E
C
C
C
Site 133
Y1606
L
R
G
H
R
T
T
Y
T
E
C
C
C
Q
D
Site 134
Y1632
P
P
R
S
S
E
V
Y
A
Q
L
C
N
V
A
Site 135
Y1655
G
V
H
F
R
P
G
Y
E
Y
G
P
G
P
D
Site 136
Y1657
H
F
R
P
G
Y
E
Y
G
P
G
P
D
D
L
Site 137
Y1666
P
G
P
D
D
L
H
Y
S
I
Y
G
P
D
G
Site 138
S1667
G
P
D
D
L
H
Y
S
I
Y
G
P
D
G
A
Site 139
Y1669
D
D
L
H
Y
S
I
Y
G
P
D
G
A
P
F
Site 140
Y1677
G
P
D
G
A
P
F
Y
N
Y
L
G
P
E
D
Site 141
Y1679
D
G
A
P
F
Y
N
Y
L
G
P
E
D
T
V
Site 142
T1685
N
Y
L
G
P
E
D
T
V
P
E
P
A
F
P
Site 143
T1694
P
E
P
A
F
P
N
T
A
G
H
S
A
D
R
Site 144
T1702
A
G
H
S
A
D
R
T
P
I
L
E
S
P
L
Site 145
S1707
D
R
T
P
I
L
E
S
P
L
Q
P
S
E
L
Site 146
S1712
L
E
S
P
L
Q
P
S
E
L
Q
P
H
Y
V
Site 147
Y1718
P
S
E
L
Q
P
H
Y
V
A
S
H
P
E
P
Site 148
S1721
L
Q
P
H
Y
V
A
S
H
P
E
P
P
A
G
Site 149
Y1755
C
V
R
V
R
E
G
Y
T
C
D
C
F
E
G
Site 150
S1805
G
S
Y
R
C
H
C
S
P
G
Y
V
A
E
A
Site 151
Y1808
R
C
H
C
S
P
G
Y
V
A
E
A
G
P
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation