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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LTBP1
Full Name:
Latent-transforming growth factor beta-binding protein 1
Alias:
Latent transforming growth factor beta binding protein 1; Latent transforming growth factor beta-binding, isoform 1L; LTB1L; LTBP-1; TGF-beta1-BP-1; Transforming growth factor beta-1-binding 1
Type:
Chaperone
Mass (Da):
173230
Number AA:
1595
UniProt ID:
Q14766
International Prot ID:
IPI00302679
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0019838
GO:0005024
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
W
A
G
L
L
A
S
S
A
H
G
R
L
R
R
Site 2
T29
H
G
R
L
R
R
I
T
Y
V
V
H
P
G
P
Site 3
Y30
G
R
L
R
R
I
T
Y
V
V
H
P
G
P
G
Site 4
S46
A
A
G
A
L
P
L
S
G
P
P
R
S
R
T
Site 5
S51
P
L
S
G
P
P
R
S
R
T
F
N
V
A
L
Site 6
T53
S
G
P
P
R
S
R
T
F
N
V
A
L
N
A
Site 7
Y62
N
V
A
L
N
A
R
Y
S
R
S
S
A
A
A
Site 8
S63
V
A
L
N
A
R
Y
S
R
S
S
A
A
A
G
Site 9
S65
L
N
A
R
Y
S
R
S
S
A
A
A
G
A
P
Site 10
S66
N
A
R
Y
S
R
S
S
A
A
A
G
A
P
S
Site 11
S73
S
A
A
A
G
A
P
S
R
A
S
P
G
V
P
Site 12
S76
A
G
A
P
S
R
A
S
P
G
V
P
S
E
R
Site 13
S81
R
A
S
P
G
V
P
S
E
R
T
R
R
T
S
Site 14
T84
P
G
V
P
S
E
R
T
R
R
T
S
K
P
G
Site 15
T87
P
S
E
R
T
R
R
T
S
K
P
G
G
A
A
Site 16
S88
S
E
R
T
R
R
T
S
K
P
G
G
A
A
L
Site 17
S141
Q
G
R
Q
V
V
R
S
K
V
P
Q
E
T
Q
Site 18
T147
R
S
K
V
P
Q
E
T
Q
S
G
G
G
S
R
Site 19
S153
E
T
Q
S
G
G
G
S
R
L
Q
V
H
Q
K
Site 20
S183
G
W
S
K
A
P
G
S
Q
R
C
T
K
P
S
Site 21
T187
A
P
G
S
Q
R
C
T
K
P
S
C
V
P
P
Site 22
T226
E
T
I
A
A
Q
D
T
S
S
P
V
F
G
G
Site 23
S227
T
I
A
A
Q
D
T
S
S
P
V
F
G
G
Q
Site 24
S228
I
A
A
Q
D
T
S
S
P
V
F
G
G
Q
S
Site 25
S235
S
P
V
F
G
G
Q
S
P
G
A
A
S
S
W
Site 26
S241
Q
S
P
G
A
A
S
S
W
G
P
P
E
Q
A
Site 27
T259
T
S
S
K
K
A
D
T
L
P
R
V
S
P
V
Site 28
S278
L
T
L
K
P
K
P
S
V
G
L
P
Q
Q
I
Site 29
S287
G
L
P
Q
Q
I
H
S
Q
V
T
P
L
S
S
Site 30
T290
Q
Q
I
H
S
Q
V
T
P
L
S
S
Q
S
V
Site 31
S293
H
S
Q
V
T
P
L
S
S
Q
S
V
V
I
H
Site 32
S294
S
Q
V
T
P
L
S
S
Q
S
V
V
I
H
H
Site 33
S296
V
T
P
L
S
S
Q
S
V
V
I
H
H
G
Q
Site 34
Y307
H
H
G
Q
T
Q
E
Y
V
L
K
P
K
Y
F
Site 35
Y313
E
Y
V
L
K
P
K
Y
F
P
A
Q
K
G
I
Site 36
S325
K
G
I
S
G
E
Q
S
T
E
G
S
F
P
L
Site 37
T326
G
I
S
G
E
Q
S
T
E
G
S
F
P
L
R
Site 38
S329
G
E
Q
S
T
E
G
S
F
P
L
R
Y
V
Q
Site 39
Y334
E
G
S
F
P
L
R
Y
V
Q
D
Q
V
A
A
Site 40
S373
T
K
G
S
C
Q
N
S
C
E
K
G
N
T
T
Site 41
T379
N
S
C
E
K
G
N
T
T
T
L
I
S
E
N
Site 42
T380
S
C
E
K
G
N
T
T
T
L
I
S
E
N
G
Site 43
T392
E
N
G
H
A
A
D
T
L
T
A
T
N
F
R
Site 44
S438
Q
I
P
V
H
G
A
S
V
P
K
L
Y
Q
H
Site 45
Y443
G
A
S
V
P
K
L
Y
Q
H
S
Q
Q
P
G
Site 46
S446
V
P
K
L
Y
Q
H
S
Q
Q
P
G
K
A
L
Site 47
T467
S
T
H
T
L
P
L
T
V
T
S
Q
Q
G
V
Site 48
S501
S
V
Q
I
H
Q
V
S
R
I
D
G
P
T
G
Site 49
T507
V
S
R
I
D
G
P
T
G
Q
K
T
K
E
A
Site 50
T511
D
G
P
T
G
Q
K
T
K
E
A
Q
P
G
Q
Site 51
S519
K
E
A
Q
P
G
Q
S
Q
V
S
Y
Q
G
L
Site 52
S522
Q
P
G
Q
S
Q
V
S
Y
Q
G
L
P
V
Q
Site 53
Y523
P
G
Q
S
Q
V
S
Y
Q
G
L
P
V
Q
K
Site 54
T531
Q
G
L
P
V
Q
K
T
Q
T
I
H
S
T
Y
Site 55
Y548
Q
Q
V
I
P
H
V
Y
P
V
A
A
K
T
Q
Site 56
T563
L
G
R
C
F
Q
E
T
I
G
S
Q
C
G
K
Site 57
S566
C
F
Q
E
T
I
G
S
Q
C
G
K
A
L
P
Site 58
Y603
K
C
P
K
K
P
S
Y
H
G
Y
N
Q
M
M
Site 59
Y606
K
K
P
S
Y
H
G
Y
N
Q
M
M
E
C
L
Site 60
Y616
M
M
E
C
L
P
G
Y
K
R
V
N
N
T
F
Site 61
T661
I
G
F
G
P
D
P
T
F
S
S
C
V
P
D
Site 62
S663
F
G
P
D
P
T
F
S
S
C
V
P
D
P
P
Site 63
S664
G
P
D
P
T
F
S
S
C
V
P
D
P
P
V
Site 64
S673
V
P
D
P
P
V
I
S
E
E
K
G
P
C
Y
Site 65
Y680
S
E
E
K
G
P
C
Y
R
L
V
S
S
G
R
Site 66
S694
R
Q
C
M
H
P
L
S
V
H
L
T
K
Q
L
Site 67
T736
C
P
G
G
M
G
Y
T
V
S
G
V
H
R
R
Site 68
S738
G
G
M
G
Y
T
V
S
G
V
H
R
R
R
P
Site 69
S768
N
T
Q
P
V
A
K
S
T
H
P
P
P
L
P
Site 70
T769
T
Q
P
V
A
K
S
T
H
P
P
P
L
P
A
Site 71
T785
E
E
P
V
E
A
L
T
F
S
R
E
H
G
P
Site 72
S787
P
V
E
A
L
T
F
S
R
E
H
G
P
G
V
Site 73
T816
P
S
L
D
Q
E
K
T
K
L
E
P
G
Q
P
Site 74
S826
E
P
G
Q
P
Q
L
S
P
G
I
S
T
I
H
Site 75
S830
P
Q
L
S
P
G
I
S
T
I
H
L
H
P
Q
Site 76
S858
V
E
V
A
P
E
A
S
T
S
S
A
S
Q
V
Site 77
S863
E
A
S
T
S
S
A
S
Q
V
I
A
P
T
Q
Site 78
Y896
C
I
N
L
P
V
R
Y
T
C
I
C
Y
E
G
Site 79
T897
I
N
L
P
V
R
Y
T
C
I
C
Y
E
G
Y
Site 80
Y901
V
R
Y
T
C
I
C
Y
E
G
Y
R
F
S
E
Site 81
Y904
T
C
I
C
Y
E
G
Y
R
F
S
E
Q
Q
R
Site 82
T934
S
Q
G
R
C
E
N
T
E
G
S
F
L
C
I
Site 83
Y983
V
G
A
F
R
C
E
Y
C
D
S
G
Y
R
M
Site 84
Y988
C
E
Y
C
D
S
G
Y
R
M
T
Q
R
G
R
Site 85
T991
C
D
S
G
Y
R
M
T
Q
R
G
R
C
E
D
Site 86
T1007
D
E
C
L
N
P
S
T
C
P
D
E
Q
C
V
Site 87
S1016
P
D
E
Q
C
V
N
S
P
G
S
Y
Q
C
V
Site 88
Y1020
C
V
N
S
P
G
S
Y
Q
C
V
P
C
T
E
Site 89
Y1068
M
C
S
C
H
K
G
Y
T
R
T
P
D
H
K
Site 90
T1104
T
E
G
S
F
R
C
T
C
G
Q
G
Y
Q
L
Site 91
S1112
C
G
Q
G
Y
Q
L
S
A
A
K
D
Q
C
E
Site 92
Y1150
Q
C
V
C
D
Q
G
Y
R
A
S
G
L
G
D
Site 93
S1153
C
D
Q
G
Y
R
A
S
G
L
G
D
H
C
E
Site 94
Y1184
C
I
N
T
A
G
S
Y
D
C
T
C
P
D
G
Site 95
T1187
T
A
G
S
Y
D
C
T
C
P
D
G
F
Q
L
Site 96
S1236
C
Q
Q
G
F
S
I
S
A
D
G
R
T
C
E
Site 97
T1241
S
I
S
A
D
G
R
T
C
E
D
I
D
E
C
Site 98
Y1320
C
A
D
E
N
Q
E
Y
S
P
M
T
G
Q
C
Site 99
S1321
A
D
E
N
Q
E
Y
S
P
M
T
G
Q
C
R
Site 100
S1329
P
M
T
G
Q
C
R
S
R
T
S
T
D
L
D
Site 101
T1331
T
G
Q
C
R
S
R
T
S
T
D
L
D
V
D
Site 102
S1332
G
Q
C
R
S
R
T
S
T
D
L
D
V
D
V
Site 103
T1333
Q
C
R
S
R
T
S
T
D
L
D
V
D
V
D
Site 104
S1413
G
F
V
P
A
G
E
S
S
S
E
A
G
G
E
Site 105
S1415
V
P
A
G
E
S
S
S
E
A
G
G
E
N
Y
Site 106
Y1448
C
L
N
T
R
P
G
Y
E
C
Y
C
K
Q
G
Site 107
Y1451
T
R
P
G
Y
E
C
Y
C
K
Q
G
T
Y
Y
Site 108
Y1457
C
Y
C
K
Q
G
T
Y
Y
D
P
V
K
L
Q
Site 109
Y1458
Y
C
K
Q
G
T
Y
Y
D
P
V
K
L
Q
C
Site 110
S1502
H
P
M
V
L
D
A
S
E
K
R
C
I
R
P
Site 111
S1512
R
C
I
R
P
A
E
S
N
E
Q
I
E
E
T
Site 112
Y1522
Q
I
E
E
T
D
V
Y
Q
D
L
C
W
E
H
Site 113
Y1534
W
E
H
L
S
D
E
Y
V
C
S
R
P
L
V
Site 114
S1537
L
S
D
E
Y
V
C
S
R
P
L
V
G
K
Q
Site 115
T1545
R
P
L
V
G
K
Q
T
T
Y
T
E
C
C
C
Site 116
S1570
A
L
C
P
L
K
D
S
D
D
Y
A
Q
L
C
Site 117
Y1573
P
L
K
D
S
D
D
Y
A
Q
L
C
N
I
P
Site 118
T1582
Q
L
C
N
I
P
V
T
G
R
R
Q
P
Y
G
Site 119
Y1588
V
T
G
R
R
Q
P
Y
G
R
D
A
L
V
D
Site 120
S1597
R
D
A
L
V
D
F
S
E
Q
Y
T
P
E
A
Site 121
Y1600
L
V
D
F
S
E
Q
Y
T
P
E
A
D
P
Y
Site 122
T1601
V
D
F
S
E
Q
Y
T
P
E
A
D
P
Y
F
Site 123
Y1607
Y
T
P
E
A
D
P
Y
F
I
Q
D
R
F
L
Site 124
S1616
I
Q
D
R
F
L
N
S
F
E
E
L
Q
A
E
Site 125
Y1643
C
V
R
V
Q
E
G
Y
T
C
D
C
F
D
G
Site 126
Y1688
C
I
N
T
D
G
S
Y
K
C
L
C
L
P
G
Site 127
Y1696
K
C
L
C
L
P
G
Y
V
P
S
D
K
P
N
Site 128
Y1704
V
P
S
D
K
P
N
Y
C
T
P
L
N
T
A
Site 129
T1706
S
D
K
P
N
Y
C
T
P
L
N
T
A
L
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation